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Machine Learning Based Depression,Anxiety,and Stress Predictive Model During COVID-19 Crisis
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作者 Fahd N.Al-Wesabi Hadeel Alsolai +3 位作者 Anwer Mustafa Hilal Manar Ahmed Hamza Mesfer Al Duhayyim Noha Negm 《Computers, Materials & Continua》 SCIE EI 2022年第3期5803-5820,共18页
Corona Virus Disease-2019(COVID-19)was reported at first in Wuhan city,China by December 2019.World Health Organization(WHO)declared COVID-19 as a pandemic i.e.,global health crisis onMarch 11,2020.The outbreak of COV... Corona Virus Disease-2019(COVID-19)was reported at first in Wuhan city,China by December 2019.World Health Organization(WHO)declared COVID-19 as a pandemic i.e.,global health crisis onMarch 11,2020.The outbreak of COVID-19 pandemic and subsequent lockdowns to curb the spread,not only affected the economic status of a number of countries,but it also resulted in increased levels of Depression,Anxiety,and Stress(DAS)among people.Therefore,there is a need exists to comprehend the relationship among psycho-social factors in a country that is hypothetically affected by high levels of stress and fear;with tremendously-limitingmeasures of social distancing and lockdown in force;and with high rates of new cases and mortalities.With this motivation,the current study aims at investigating theDAS levels among college students during COVID-19 lockdown since they are identified as a highly-susceptible population.The current study proposes to develop Intelligent Feature Subset Selection withMachine Learning-based DAS predictive(IFSSML-DAS)model.The presented IFSSML-DAS model involves data preprocessing,Feature Subset Selection(FSS),classification,and parameter tuning.Besides,IFSSML-DAS model uses Group Gray Wolf Optimization based FSS(GGWO-FSS)technique to reduce the curse of dimensionality.In addition,Beetle Swarm Optimization based Least Square Support Vector Machine(BSO-LSSVM)model is also employed for classification in which the weight and bias parameters of the LSSVM model are optimally adjusted using BSO algorithm.The performance of the proposed IFSSML-DAS model was tested using a benchmark DASS-21 dataset and the results were investigated under different measures.The outcome of the study suggests the development of specialized programs to handleDAS among population so as to overcome COVID-19 crisis. 展开更多
关键词 Psycho-social factors covid-19 crisis management predictive models decision making machine learning
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Exploring the Effects of the COVID-19 Crisis on Azerbaijan’s Financial Security
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作者 Shabnam Dadparvar Saeed Azizi 《International Relations and Diplomacy》 2021年第1期27-35,共9页
The emergence of the COVID-19 crisis,similar to the financial crisis of the 1980s and 1990s,has once more threatened the international economic systems.The rapid transmission of the Coronavirus has created travel bans... The emergence of the COVID-19 crisis,similar to the financial crisis of the 1980s and 1990s,has once more threatened the international economic systems.The rapid transmission of the Coronavirus has created travel bans and commuting restrictions on national and international scales,causing a severe recession in the world economy.This is more conspicuous in oil-exporting countries as petroleum products and prices have plummeted down.A good example of the countries that depend on oil and gas exports is Azerbaijan,a country whose domestic economy has not been unaffected by the COVID-19 crisis.This study explores how the COVID-19 crisis has affected Azerbaijan’s economic security.The hypothesis is that due to this pandemic and the reduction of petroleum prices on an international scale,the Azerbaijan’s economy now has declined and the government faces the reduction of oil production,and the devaluation of Azerbaijan’s currency,manat.Moreover,travel bans due to the Coronavirus have dramatically affected Azerbaijan’s other economic sectors and industries such as tourism.All these issues have seriously threatened Azerbaijan’s economic security and the economy will not grow significantly in the near future. 展开更多
关键词 covid-19 national security economic security AZERBAIJAN
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A Study on the Influences of the COVID-19 Pandemic-Related Depression, Anxiety, Stress, and Treatment-Crisis on Quality of Life in Cancer Patients - A Secondary Publication
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作者 So Hyoung Kim Kyung Hee Lim 《Proceedings of Anticancer Research》 2024年第2期73-87,共15页
Objective:To investigate the factors affecting the quality of life of cancer patients by examining the degree of the COVID-19 pandemic-related depression,anxiety,stress,and treatment crisis.Methods:Data were collected... Objective:To investigate the factors affecting the quality of life of cancer patients by examining the degree of the COVID-19 pandemic-related depression,anxiety,stress,and treatment crisis.Methods:Data were collected from 132 cancer patients undergoing surgery,chemotherapy,radiotherapy,and hormone therapy at K University Hospital in D City using a structured questionnaire.The period of data collection was from May 6 to May 28,2022.The collected data were analyzed using descriptive statistics,t-test,ANOVA,Pearson’s correlation,and stepwise multiple regression.Results:The mean scores of quality-of-life,depression,anxiety,stress,and treatment crisis during the COVID-19 pandemic were 84.64±29.09,15.14±6.49,4.66±5.27,75.83±17.70,and 78.52±19.95,respectively.In terms of factors affecting the quality of life related to the COVID-19 pandemic,COVID-19 pandemic-related stress(β=0.41,P<0.001)appeared to have the greatest impact,followed by COVID-19 pandemic-related treatment-crisis(β=0.28,P=0.002),anxiety(β=0.21,P=0.002),and gender(β=0.14,P=0.009),with a total explanatory power of 67.6%.Conclusion:To improve the quality of life during the COVID-19 pandemic,COVID-19 pandemic-related stress,treatment-crisis,and anxiety should be periodically monitored and nursing interventions such as education on infection prevention,management,and emotional support programs should be provided to decrease the COVID-19 pandemic-related stress,treatment-crisis,and anxiety. 展开更多
关键词 Cancer covid-19 Quality of life
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The use of facial expressions in measuring students’interaction with distance learning environments during the COVID-19 crisis
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作者 Waleed Maqableh Faisal Y.Alzyoud Jamal Zraqou 《Visual Informatics》 EI 2023年第1期1-17,共17页
Digital learning is becoming increasingly important in the crisis COVID-19 and is widespread in most countries.The proliferation of smart devices and 5G telecommunications systems are contributing to the development o... Digital learning is becoming increasingly important in the crisis COVID-19 and is widespread in most countries.The proliferation of smart devices and 5G telecommunications systems are contributing to the development of digital learning systems as an alternative to traditional learning systems.Digital learning includes blended learning,online learning,and personalized learning which mainly depends on the use of new technologies and strategies,so digital learning is widely developed to improve education and combat emerging disasters such as COVID-19 diseases.Despite the tremendous benefits of digital learning,there are many obstacles related to the lack of digitized curriculum and collaboration between teachers and students.Therefore,many attempts have been made to improve the learning outcomes through the following strategies:collaboration,teacher convenience,personalized learning,cost and time savings through professional development,and modeling.In this study,facial expressions and heart rates are used to measure the effectiveness of digital learning systems and the level of learners’engagement in learning environments.The results showed that the proposed approach outperformed the known related works in terms of learning effectiveness.The results of this research can be used to develop a digital learning environment. 展开更多
关键词 E-LEARNING covid-19 Face-to-face learning Facial expressions Heart pulse
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A Case of COVID-19 Related Myasthenic Crisis: Lessons Learned
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作者 Folajimi M. Otubogun Adegoke M. Fatunwase +3 位作者 Olaniyi M. Fowosola Khadijat M. Alli Ojuolape O. Okedara Bamidele S. Osalusi 《International Journal of Clinical Medicine》 2023年第8期333-337,共17页
Background: COVID-19 was initially described to affect the respiratory system, it is now known to affect other systems and present in a myriad of ways. This has often proved to be a diagnostic and therapeutic challeng... Background: COVID-19 was initially described to affect the respiratory system, it is now known to affect other systems and present in a myriad of ways. This has often proved to be a diagnostic and therapeutic challenge to clinicians and stretched healthcare resources, sometimes with poor outcomes. We report on an atypical presentation of SARS-CoV-2 infection as an acute exacerbation of myasthenia gravis in a low resource setting. Case Presentation: A middle aged male with myasthenia gravis presented with a three weeks’ history of worsening generalized weakness and three days’ history of new-onset dysphagia with no history of fever and cough. After a few days of apparent improvement, the patient developed progressive respiratory distress. Further evaluation confirmed bilateral pneumonia and COVID-19. Conclusion: There is a need for clinicians and health service providers to have a low threshold for suspicion and testing for COVID-19 in patients with pre-existing medical conditions and immunomodulatory therapy such as Myasthenia gravis. 展开更多
关键词 Myasthenia Gravis covid-19 SARS-COV-2 Low Resource Settings
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基于CiteSpace及VOSviewer的COVID-19相关心律失常的文献计量学分析
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作者 李敏 马晓娟 +2 位作者 赵小晗 刘敏 陈子怡 《中西医结合心脑血管病杂志》 2024年第7期1163-1172,共10页
目的:分析新型冠状病毒感染(COVID-19)相关心律失常的文献,探索该领域的研究现状、热点并预测未来的趋势,为后来的研究者提供借鉴。方法:选择Web of Science的核心合集数据库,每项研究都进行了文献计量和视觉分析,使用CiteSpace和VOSvie... 目的:分析新型冠状病毒感染(COVID-19)相关心律失常的文献,探索该领域的研究现状、热点并预测未来的趋势,为后来的研究者提供借鉴。方法:选择Web of Science的核心合集数据库,每项研究都进行了文献计量和视觉分析,使用CiteSpace和VOSviewer软件生成知识图谱。结果:共鉴定出768篇文章,发文涉及美国、意大利和中国为首的319个国家/地区和4 366个机构,领先的研究机构是梅奥诊所和哈佛医学院。New England Journal of Medicine是该领域最常被引用的期刊。在6 687位作者中,Arbelo Elena撰写的研究最多,Guo T被共同引用的次数最多,心房纤颤是最常见的关键词。结论:随着COVID-19的暴发,对COVID-19所致新发/进行性心律失常事件的研究蓬勃发展,未来的研究者可能会对COVID-19感染后新发或遗留的快速性心律失常/缓慢性心律失常的发生机制进行进一步的探索。 展开更多
关键词 新型冠状病毒感染 covid-19 心律失常 CITESPACE VOSviewer 文献计量分析
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麻杏石甘汤干预COVID-19肺炎的网络药理学研究及分子对接分析
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作者 武燕 马啸 李春雨 《产业与科技论坛》 2024年第12期42-43,共2页
目的:运用网络药理学与分子对接研究方法探讨麻杏石甘汤干预COVID-19肺炎的作用机制。方法:经TCMSP、HTDocking数据库检索麻杏石甘汤所有药物的成分并进行ADME筛选得到活性成分,在Uniport数据库检索其发挥治疗作用可能的基因靶点;借助Ge... 目的:运用网络药理学与分子对接研究方法探讨麻杏石甘汤干预COVID-19肺炎的作用机制。方法:经TCMSP、HTDocking数据库检索麻杏石甘汤所有药物的成分并进行ADME筛选得到活性成分,在Uniport数据库检索其发挥治疗作用可能的基因靶点;借助GeneCards、PharmGKB等数据库检索COVID-19肺炎相关基因靶点,利用Cytoscape软件构建药物-活性成分-靶基因-疾病网络;借助String系统构建PPI网络,并进行拓扑学特征分析,筛选核心基因;利用R语言的clusterProfiler包对核心基因进行GO、KEGG富集分析;利用AutoDock Vina软件对疾病靶蛋白及药物活性成分进行分子对接验证。结果:共筛选出麻杏石甘汤与COVID-19肺炎交集基因靶点67个。PPI网络分析显示,其发挥治疗作用的核心基因靶点有MAPK1、MAPK3、STAT1、JUN等8个。GO富集分析显示,相关生物过程1863个,分子功能95个,细胞成分36个;KEGG富集分析显示,相关作用通路167条。分子对接结果显示,麻杏石甘汤活性成分槲皮素、山奈酚、熊果酸等与核心基因靶点JUN、MAK1、IL2等有较好的结合活性。结论:麻杏石甘汤可能以槲皮素、山奈酚等为物质基础,多成分、多靶点、多通路、相互协同发挥抑制病毒活性,降低炎症反应,保护肺部组织,从而对COVID-19肺炎起到积极的干预作用。 展开更多
关键词 麻杏石甘汤 covid-19肺炎 网络药理学 分子对接
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COVID-19诊疗信息、中医证型分布及组方用药规律的文献研究 被引量:1
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作者 刘鑫瑶 臧凝子 +7 位作者 王琳琳 王梅 邹吉宇 王亚勤 孙婉宁 彭成飞 吕晓东 庞立健 《中华中医药学刊》 CAS 北大核心 2024年第1期9-15,共7页
目的利用数据挖掘技术深入探究新型冠状病毒感染(COVID-19,简称新冠感染)患者的诊断、中医证型分布以及药物使用规律,以期为中医药治疗新冠感染提供有效的参考依据。方法通过搜索,可以获取来自国家卫生健康委员会和全国各地的《新型冠... 目的利用数据挖掘技术深入探究新型冠状病毒感染(COVID-19,简称新冠感染)患者的诊断、中医证型分布以及药物使用规律,以期为中医药治疗新冠感染提供有效的参考依据。方法通过搜索,可以获取来自国家卫生健康委员会和全国各地的《新型冠状病毒肺炎诊疗方案》内涉及的中医证型和中医药防治方案,以及中国生物医学文献服务系统、知网、维普、万方数据库收录的治疗新冠感染相关文献共249份。对文献通过筛选、整理和去重并建立中药复方数据库、诊疗信息数据库、证型数据库,运用频数分析、频率分析进行探究。结果新冠感染患者常见的症状频数较高的为咳嗽、咽干咽痛、发热、纳差、乏力;大多数患者呈淡红舌、红舌,脉象为滑脉、滑数脉;中医证型频数较高的有湿毒郁肺证、湿热蕴肺证、肺脾气虚证、寒湿郁肺证、气阴两伤证、兼夹瘀血证。此外,共纳入491首治疗新冠感染中药复方,涉及中药227味,得到高频中药共64个,药物类别以清热药、补益药、解表药、化痰止咳平喘药、化湿药为主;药性以温、平、寒为主,药味以甘、辛、苦为主,归经中归肺、脾、胃经中药居多;聚类分析结果根据中药性能将治疗新冠感染的高频药物聚为8类较好。结论中医药治疗新型冠状病毒感染用药具有以下特点:补益药用药次数较多体现攻邪不忘扶正;解表、清热、攻下、化湿、利湿、渗湿药物俱全体现多种逐邪之法;药类以清热药、补益药、化湿药、化痰止咳平喘药、解表药为主,彰显新冠感染基本治法为清热化湿、止咳平喘、补养气阴。可为指导临床用药及研发新药提供一定的参考与借鉴。 展开更多
关键词 covid-19 诊疗信息 中医证型 中药复方 数据挖掘 关联规则分析
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低频脉冲磁场诱导TRPC1改善COVID-19患者康复期下肢的肌肉无力症状 被引量:1
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作者 厉中山 包义君 +6 位作者 刘洁 孔维签 李伟 陈琳 白石 杨铁黎 王春露 《中国组织工程研究》 CAS 北大核心 2024年第16期2605-2612,共8页
背景:肌肉无力是新型冠状病毒(COVID-19)感染后的常见症状,影响康复期人体日常活动能力。在强度1.5 mT,频率3300 Hz的低频脉冲磁场刺激下可通过诱导和激活经典瞬时感受器电位通1(classical transient receptor potential channel 1,TRPC... 背景:肌肉无力是新型冠状病毒(COVID-19)感染后的常见症状,影响康复期人体日常活动能力。在强度1.5 mT,频率3300 Hz的低频脉冲磁场刺激下可通过诱导和激活经典瞬时感受器电位通1(classical transient receptor potential channel 1,TRPC1),提升人体骨骼肌的最大自主收缩力与力量耐力,对肌肉组织产生一系列生理支持效应,该手段是否会改善新型冠状病毒肺炎患者康复期的肌无力症状尚无研究。目的:选用低频脉冲磁场对新型冠状病毒肺炎患者下肢肌群进行磁刺激,以观察该刺激对新型冠状病毒肺炎患者康复期下肢肌群肌无力改善的影响。方法:招募胶体金法抗原检测试剂(COVID-19)为阳性并伴有肌肉无力症状的新型冠状病毒(奥密克戎毒株)感染患者14例,将所有受试者随机分成2组,分别为接受磁场刺激的试验组和接受假治疗的对照组。试验总时长3周,试验组每隔48 h对腿部进行低频脉冲磁刺激,对照组与试验组干预流程一致但给予假刺激,两组患者均不被告知磁刺激仪器是否运行,两组患者共进行9次操作,随后观察两组患者下肢局部肌群最大自主收缩力、腿部爆发力与力量耐力的变化情况。结果与结论:①在采集的8个局部肌群中,试验组患者7个局部肌群在经过3周的低频脉冲磁场刺激,最大自主收缩力值均增长。对照组除3个肌群最大自主收缩力自行增长改善以外,其他肌群肌力无提升。②试验组的左腿前群与双腿后群提升率显著高于对照组。③两组的纵跳摸高高度与膝关节峰值角速度相比试验前测均提升,试验组摸高高度提升率高于对照组。④在疲劳状态下,试验组膝关节峰值角速度下降率显著下降,对照组膝关节峰值角速度下降率无显著性变化;试验组摸高高度下降率显著下降,而对照组摸高高度下降率无显著性变化。⑤上述数据证实,在强度1.5 mT,频率3300 Hz的低频脉冲磁场刺激方案下,新型冠状病毒肺炎患者在康复期经过3周的低频脉冲磁场刺激相比人体自愈过程可使更多的下肢局部肌群肌力获得提升,对基于腿部爆发力的全身协调发力能力及功能状态明显改善。因此,低频脉冲磁场刺激可作为一种改善新冠感染患者下肢肌肉无力症状的有效、非运动的康复手段。 展开更多
关键词 新型冠状病毒 covid-19 新型冠状病毒肺炎 脉冲磁场 经典瞬时感受器电位通道1 TRPC1 肌肉无力
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COVID-19疫情前后28个国家生育率变化及影响因素研究:线性模型和中断时间序列分析
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作者 陈益 陈卿 +2 位作者 刘涵 王大朋 曹佳 《陆军军医大学学报》 CAS CSCD 北大核心 2024年第17期2021-2028,F0003,共9页
目的分析COVID-19疫情暴发前后不同国家经季节和日历调整后的生育率(seasonally and calendar adjusted fertility rate,SAFR)趋势的变化及其影响因素。方法使用国际人类生育力数据库(Human Fertility Database,HFD)中28个国家自2012年... 目的分析COVID-19疫情暴发前后不同国家经季节和日历调整后的生育率(seasonally and calendar adjusted fertility rate,SAFR)趋势的变化及其影响因素。方法使用国际人类生育力数据库(Human Fertility Database,HFD)中28个国家自2012年1月至2022年12月的月度SAFR数据,以2020年12月(2020年3月疫情暴发起点加9个月妊娠过程)为节点划分为疫情前(2012.1-2020.11)和疫情后(2020.12-2022.12)进行比较,使用中断时间序列方法分析各国疫情前后的SAFR趋势(短期波动和长期趋势)是否发生变化,使用秩和检验分析疫情前SAFR、人均GDP、公共卫生和社会措施(public health and social measures,PHSM)和失业率是否与SAFR趋势变化有关。结果疫情后28个国家中19个国家的SAFR出现短期下降,随后反弹。对于长期趋势,2个国家由下降趋势转为上升趋势,8个国家由上升趋势转为下降趋势,6个国家的SAFR保持不变。SAFR变化率下降主要集中在部分中欧国家以及地中海西岸的国家,而SAFR变化率增加的国家主要分布在北欧以及西欧地区。SAFR无短期波动的国家疫情前的SAFR低于有短期波动的国家(P=0.041),SAFR变化率下降国家的疫情前SAFR(P=0.005)与人均GDP(P=0.027)均低于SAFR变化率上升国家。未发现SAFR短期波动或长期趋势与PHSM严重程度指数或失业率存在关联。结论COVID-19疫情对28个国家的SAFR造成了不同的短期和长期影响,特别是经济水平和疫情前SAFR相对较低的国家可能更易遭到进一步打击。COVID-19疫情对各国人口的更长期影响值得进一步关注。 展开更多
关键词 covid-19 生育率 中断时间序列分析 影响因素
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显微镜下多血管炎相关间质性肺病合并COVID-19患者疫苗保护作用初探
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作者 祁福敏 苏睿 +4 位作者 郝剑 苏丽 范倩 李昕 魏蔚 《天津医药》 CAS 2024年第7期683-686,共4页
目的分析显微镜下多血管炎(MPA)相关间质性肺病(ILD)患者合并新型冠状病毒肺炎(COVID-19)的临床特征,初步探究新型冠状病毒(SARS-CoV-2)疫苗的保护作用。方法纳入确诊的MPA-ILD患者,同时符合《新型冠状病毒感染诊疗方案(第十版)》制定的... 目的分析显微镜下多血管炎(MPA)相关间质性肺病(ILD)患者合并新型冠状病毒肺炎(COVID-19)的临床特征,初步探究新型冠状病毒(SARS-CoV-2)疫苗的保护作用。方法纳入确诊的MPA-ILD患者,同时符合《新型冠状病毒感染诊疗方案(第十版)》制定的COVID-19诊断标准,且均有明确SARS-CoV-2抗原或核酸检测阳性证据。收集并分析患者临床资料,ILD影像学分型,SARS-CoV-2疫苗接种情况、临床分型及预后。结果共纳入37例MPA-ILD患者,女14例,男23例。32例在并发COVID-19时MPA病情处于缓解期,31例同时维持免疫抑制剂或生物制剂治疗。ILD的影像学类型以寻常型间质性肺炎(15例)和非特异性间质性肺炎(14例)为主,剩余8例分型不确定。COVID-19分型中,27例为轻症,5例因COVID-19死亡。11例未接种疫苗,26例接种SARS-CoV-2灭活疫苗,其中11例完成3剂次加强免疫。接种疫苗患者COVID-19轻症比例高于未接种疫苗组(P=0.038)。多因素分析显示接种疫苗为MPA-ILD患者合并COVID-19住院(OR=0.045,95%CI:0.004~0.472,P=0.010)及非轻症感染(OR=0.049,95%CI:0.005~0.517,P=0.012)的独立保护因素。同时MPA处于缓解期为COVID-19非轻症感染的保护因素(OR=0.021,95%CI:0.001~0.459,P=0.014)。结论接种SARS-CoV-2疫苗及MPA病情处于缓解期有可能减轻MPA患者合并COVID-19的严重程度。 展开更多
关键词 显微镜下多血管炎 新型冠状病毒肺炎 covid-19疫苗
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全球COVID-19疫情主要预测模型比较分析
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作者 陈雅霖 洪秋棉 +3 位作者 温昊于 刘艳 喻勇 宇传华 《中国卫生统计》 CSCD 北大核心 2024年第3期382-386,共5页
目的新冠感染病死率预测对于深入理解新冠病毒严重性、合理配置医疗资源及开展针对性防疫策略有重大意义。方法本研究依据新冠病毒变异优势株,将疫情发展划分四个时期,选取美国、印度、巴西、墨西哥、秘鲁、中国六个国家以及全球平均水... 目的新冠感染病死率预测对于深入理解新冠病毒严重性、合理配置医疗资源及开展针对性防疫策略有重大意义。方法本研究依据新冠病毒变异优势株,将疫情发展划分四个时期,选取美国、印度、巴西、墨西哥、秘鲁、中国六个国家以及全球平均水平的病死率为研究对象。运用灰色模型、指数平滑模型、ARIMA模型、支持向量机、Prophet和LSTM模型六个模型进行拟合预测,探讨各模型的优缺点和适用性,选取效果最优的模型对全球和重点国家的病死率进行预测。结果模型比较显示多种模型各有优缺点,经预测,多数国家的累计确诊人数和累计死亡人数增长速度减缓,发展趋势逐渐平稳。结论传统时间序列模型适于发展趋势平稳、有限样本的预测;而机器学习模型更适用于波动型变化数据,可进行大样本预测,进一步外推,运用到其他卫生领域的研究。 展开更多
关键词 covid-19 预测模型 病死率
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系统性红斑狼疮合并COVID-19住院患者的临床特征分析
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作者 刘鹏程 张敏 +2 位作者 李建斌 余淑娇 吴锐 《中华临床免疫和变态反应杂志》 CAS 2024年第3期245-250,共6页
目的探讨系统性红斑狼疮(SLE)合并新型冠状病毒(SARS-CoV-2)感染住院患者的临床特点。方法选取2022年12月—2023年2月于南昌大学第一附属医院风湿免疫科就诊且确诊为COVID-19的SLE患者为研究对象,根据是否住院治疗将其分为未住院组和住... 目的探讨系统性红斑狼疮(SLE)合并新型冠状病毒(SARS-CoV-2)感染住院患者的临床特点。方法选取2022年12月—2023年2月于南昌大学第一附属医院风湿免疫科就诊且确诊为COVID-19的SLE患者为研究对象,根据是否住院治疗将其分为未住院组和住院组,比较两组患者的人口学数据、临床症状和实验室检查结果。评估淋巴细胞/单核细胞(LMR)、中性粒细胞/淋巴细胞(NLR)、血小板/淋巴细胞(PLR)、系统性免疫炎症指数(SⅡ)、SⅡ/白蛋白、红细胞沉降率/淋巴细胞(ELR)和C反应蛋白/淋巴细胞(CLR)等指标对SLE合并COVID-19患者住院的影响。结果两组患者在年龄、糖皮质激素剂量、SLEDAI评分、红细胞沉降率、C反应蛋白、血小板、淋巴细胞、白蛋白、NLR、PLR、LMR、CLR、ELR、SⅡ和SⅡ/ALB等方面存在统计学差异(P<0.05)。多因素Logistic回归分析显示,CLR(OR=1.16)、糖皮质激素剂量(OR=1.11)及SLEDAI评分(OR=1.23)为SLE合并COVID-19住院患者的临床特点。ROC曲线分析显示,CLR曲线下面积(AUC)为0.751,其灵敏度为50.0%,特异度为94.0%;糖皮质激素剂量的AUC为0.778,其灵敏度为76.9%,特异度为75.9%;SLEDAI的AUC为0.754,其灵敏度为50.0%,特异度为91.6%。结论对于SLE合并COVID-19住院患者而言,较高的CLR、糖皮质激素剂量及SLEDAI评分为其临床特点。 展开更多
关键词 系统性红斑狼疮 covid-19 住院患者 临床特点
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Mental health status among COVID-19 patients survivors of critical illness in Saudi Arabia:A 6-month follow-up questionnaire study 被引量:2
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作者 Abdullah M Alhammad Namareq F Aldardeer +10 位作者 Abdulaziz Alqahtani Mohammad H Aljawadi Bushra Alnefaie Raghad Alonazi Mansour Almuqbil Abdulrahman Alsaadon Rakan M Alqahtani Rashid Alballaa Bader Alshehri Mohammed I Alarifi Fahad D Alosaimi 《World Journal of Clinical Cases》 SCIE 2024年第15期2560-2567,共8页
BACKGROUND Psychological assessment after intensive care unit(ICU)discharge is increasingly used to assess patients'cognitive and psychological well-being.However,few studies have examined those who recovered from... BACKGROUND Psychological assessment after intensive care unit(ICU)discharge is increasingly used to assess patients'cognitive and psychological well-being.However,few studies have examined those who recovered from coronavirus disease 2019(COVID-19).There is a paucity of data from the Middle East assessing the post-ICU discharge mental health status of patients who had COVID-19.AIM To evaluate anxiety and depression among patients who had severe COVID-19.METHODS This is a prospective single-center follow-up questionnaire-based study of adults who were admitted to the ICU or under ICU consultation for>24 h for COVID-19.Eligible patients were contacted via telephone.The patient’s anxiety and depression six months after ICU discharge were assessed using the Hospital Anxiety and Depression Scale(HADS).The primary outcome was the mean HADS score.The secondary outcomes were risk factors of anxiety and/or depression.RESULTS Patients who were admitted to the ICU because of COVID-19 were screened(n=518).Of these,48 completed the questionnaires.The mean age was 56.3±17.2 years.Thirty patients(62.5%)were male.The main comorbidities were endocrine(n=24,50%)and cardiovascular(n=21,43.8%)diseases.The mean overall HADS score for anxiety and depression at 6 months post-ICU discharge was 11.4(SD±8.5).A HADS score of>7 for anxiety and depression was detected in 15 patients(30%)and 18 patients(36%),respectively.Results from the multivariable ordered logistic regression demonstrated that vasopressor use was associated with the development of anxiety and depression[odds ratio(OR)39.06,95% confidence interval:1.309-1165.8;P<0.05].CONCLUSION Six months after ICU discharge,30% of patients who had COVID-19 demonstrated a HADS score that confirmed anxiety and depression.To compare the psychological status of patients following an ICU admission(with vs without COVID-19),further studies are warranted. 展开更多
关键词 covid-19 Critically ill ANXIETY DEPRESSION HADS Saudi Arabia
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Hepatic angiotensin-converting enzyme 2 expression in metabolic dysfunction-associated steatotic liver disease and in patients with fatal COVID-19 被引量:1
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作者 Angus K Jacobs Steven D Morley +7 位作者 Kay Samuel Katie Morgan Lyndsey Boswell Timothy J Kendall David A Dorward Jonathan A Fallowfield Peter C Hayes John N Plevris 《World Journal of Gastroenterology》 SCIE CAS 2024年第31期3705-3716,共12页
BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD),characterised by hepatic lipid accumulation,causes inflammation and oxidative stress accompanied by cell damage and fibrosis.Liver injury(LI)i... BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD),characterised by hepatic lipid accumulation,causes inflammation and oxidative stress accompanied by cell damage and fibrosis.Liver injury(LI)is also frequently reported in patients hospitalised with coronavirus disease 2019(COVID-19),while preexisting MASLD increases the risk of LI and the development of COVID-19-associated cholangiopathy.Mechanisms of injury at the cellular level remain unclear,but it may be significant that severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)which causes COVID-19,uses angiotensin-converting expression enzyme 2(ACE2),a key regulator of the‘anti-inflammatory’arm of the renin-angiotensin system,for viral attachment and host cell invasion.AIM To determine if hepatic ACE2 levels are altered during progression of MASLD and in patients who died with severe COVID-19.METHODS ACE2 protein levels and localisation,and histological fibrosis and lipid droplet accumulation as markers of MASLD were determined in formalin-fixed liver tissue sections across the MASLD pathological spectrum(isolated hepatocellular steatosis,metabolic dysfunction-associated steatohepatitis(MASH)+/-fibrosis,end-stage cirrhosis)and in post-mortem tissues from patients who had died with severe COVID-19,using ACE2 immunohistochemistry and haematoxylin and eosin and picrosirius red staining of total collagen and lipid droplet areas,followed by quantification using machine learning-based image pixel classifiers.RESULTS ACE2 staining is primarily intracellular and concentrated in the cytoplasm of centrilobular hepatocytes and apical membranes of bile duct cholangiocytes.Strikingly,ACE2 protein levels are elevated in non-fibrotic MASH compared to healthy controls but not in the progression to MASH with fibrosis and in cirrhosis.ACE2 protein levels and histological fibrosis are not associated,but ACE2 and liver lipid droplet content are significantly correlated across the MASLD spectrum.Hepatic ACE2 levels are also increased in COVID-19 patients,especially those showing evidence of LI,but are not correlated with the presence of SARS-CoV-2 virus in the liver.However,there is a clear association between the hepatic lipid droplet content and the presence of the virus,suggesting a possible functional link.CONCLUSION Hepatic ACE2 levels were elevated in nonfibrotic MASH and COVID-19 patients with LI,while lipid accumulation may promote intra-hepatic SARS-CoV-2 replication,accelerating MASLD progression and COVID-19-mediated liver damage. 展开更多
关键词 Metabolic dysfunction-associated steatotic liver disease Angiotensin-converting enzyme 2 IMMUNOHISTOCHEMISTRY covid-19 covid-19-associated cholangiopathy
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Clinical application of COVID-19 vaccine in liver transplant recipients 被引量:1
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作者 Feng-Chao Liu Man Xie Wei Rao 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2024年第4期339-343,共5页
Background:Solid organ transplant(SOT)activities,such as liver transplant,have been greatly influenced by the pandemic of coronavirus disease 2019(COVID-19),a disease caused by severe acute respiratory syndrome corona... Background:Solid organ transplant(SOT)activities,such as liver transplant,have been greatly influenced by the pandemic of coronavirus disease 2019(COVID-19),a disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Immunosuppressed individuals of liver transplant recipients(LTRs)tend to have a high risk of COVID-19 infection and related complications.Therefore,COVID-19 vaccination has been recommended to be administered as early as possible in LTRs.Data sources:The keywords“liver transplant”,“SARS-CoV-2”,and“vaccine”were used to retrieve articles published in PubMed.Results:The antibody response following the 1st and 2nd doses of vaccination was disappointingly low,and the immune responses among LTRs remarkably improved after the 3rd or 4th dose of vaccination.Although the 3rd or 4th dose of COVID-19 vaccine increased the antibody titer,a proportion of patients remained unresponsive.Furthermore,recent studies showed that SARS-CoV-2 vaccine could trigger adverse events in LTRs,including allograft rejection and liver injury.Conclusions:This review provides the recently reported data on the antibody response of LTRs following various doses of vaccine,risk factors for poor serological response and adverse events after vaccination. 展开更多
关键词 Liver transplant covid-19 SARS-CoV-2 VACCINE Antibody response
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Immunobiology of COVID-19: Mechanistic and therapeutic insights from animal models 被引量:1
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作者 Hong-Yi Zheng Tian-Zhang Song Yong-Tang Zheng 《Zoological Research》 SCIE CSCD 2024年第4期747-766,共20页
The distribution of the immune system throughout the body complicates in vitro assessments of coronavirus disease 2019(COVID-19)immunobiology,often resulting in a lack of reproducibility when extrapolated to the whole... The distribution of the immune system throughout the body complicates in vitro assessments of coronavirus disease 2019(COVID-19)immunobiology,often resulting in a lack of reproducibility when extrapolated to the whole organism.Consequently,developing animal models is imperative for a comprehensive understanding of the pathology and immunology of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.This review summarizes current progress related to COVID-19 animal models,including non-human primates(NHPs),mice,and hamsters,with a focus on their roles in exploring the mechanisms of immunopathology,immune protection,and long-term effects of SARS-CoV-2 infection,as well as their application in immunoprevention and immunotherapy of SARS-CoV-2 infection.Differences among these animal models and their specific applications are also highlighted,as no single model can fully encapsulate all aspects of COVID-19.To effectively address the challenges posed by COVID-19,it is essential to select appropriate animal models that can accurately replicate both fatal and non-fatal infections with varying courses and severities.Optimizing animal model libraries and associated research tools is key to resolving the global COVID-19 pandemic,serving as a robust resource for future emerging infectious diseases. 展开更多
关键词 SARS-CoV-2 covid-19 Animal models Infection immunology Immunotherapy
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规律运动在防治COVID-19中的研究进展
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作者 何玉敏 刘军 《生理科学进展》 CAS 北大核心 2024年第2期107-115,共9页
新型冠状病毒病(coronavirus disease-19,COVID-19)是由严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染引起的以呼吸系统症状为主的疾病。多项研究证明,规律运动对预防COVID-19、增强治疗效果、避免不良预后具有重要作用。本文梳理了运动... 新型冠状病毒病(coronavirus disease-19,COVID-19)是由严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染引起的以呼吸系统症状为主的疾病。多项研究证明,规律运动对预防COVID-19、增强治疗效果、避免不良预后具有重要作用。本文梳理了运动在COVID-19防治前、中、后的作用及可能机制,运动可通过调节ACE2/Ang(1-7)/Mas轴、增强免疫力和心肺功能、抑制炎症因子和氧化应激、调节肠道菌群稳态以及改善心理状态等途径发挥作用,进而总结出COVID-19防治不同阶段的运动处方,在对运动防治COVID-19全面总结的同时,也为后疫情时代类似呼吸道传染疾病的预防和治疗提供借鉴和参考。 展开更多
关键词 规律运动 covid-19 ACE2 免疫系统 炎症
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COVID-19疫情防控常态化时期社会工作者心理健康水平调查及影响因素分析:以北京市朝阳区为例
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作者 张函 高媛 +6 位作者 马万欣 刘宏新 孟凡锐 张丹萍 刘春宇 刘璐 邢颖 《协和医学杂志》 CSCD 北大核心 2024年第4期845-854,共10页
目的了解COVID-19疫情防控常态化期间,社工焦虑、抑郁、睡眠障碍发生情况并分析其影响因素。方法采用分层整群抽样法,于2021年11月—2022年3月期间选取北京市朝阳区酒仙桥、望京、太阳宫、十八里店、孙河5个街道的全部社工为研究对象(... 目的了解COVID-19疫情防控常态化期间,社工焦虑、抑郁、睡眠障碍发生情况并分析其影响因素。方法采用分层整群抽样法,于2021年11月—2022年3月期间选取北京市朝阳区酒仙桥、望京、太阳宫、十八里店、孙河5个街道的全部社工为研究对象(社工组),并以该5个街道对应社区医院且具有相同年龄范围的在职一线医护人员(医护组)、社区居民(居民组)为对照人群。社工组、医护组、居民组比例为1∶1∶1。采用问卷星平台,向社工、医护人员、社区居民微信群发放电子问卷展开调查。比较3组焦虑、抑郁、睡眠障碍筛查阳性率,并采用多因素Logistic回归和决策树分析社工焦虑、抑郁、睡眠障碍的影响因素。结果共回收问卷954份,其中62份不合格予以剔除,最终纳入892份(935%)有效问卷进行数据分析。其中社工组372份(417%),医护组262份(294%),居民组258份(289%)。社工组焦虑、抑郁、睡眠障碍筛查阳性率分别为153%、220%、481%,较医护组(76%、103%、305%)和居民组(70%、85%、295%)明显升高(P均<0001)。多因素Logistic回归显示,家庭负担(OR=180,95%CI:109~296)、中文版压力知觉量表(Chinese perceived stress scale,CPSS)评分(OR=134,95%CI:124~145)是社工焦虑的独立影响因素,CPSS评分(OR=129,95%CI:120~139)、社会支持评定量表(social support rating scale,SSRS)评分(OR=096,95%CI:092~100)是社工抑郁的独立影响因素,有精神疾病家族史(OR=491,95%CI:127~1894)、CPSS评分(OR=120,95%CI:114~127)、SSRS评分(OR=095,95%CI:091~098)是社工睡眠障碍的独立影响因素。决策树分析结果与多因素Logistic回归分析结果基本一致,家庭负担、CPSS评分、SSRS评分是影响社工心理健康的重要变量,其中CPSS评分与社工焦虑、抑郁、睡眠障碍均呈强关联。结论在COVID-19疫情防控常态化时期,相较于医护人员和社区居民,社工表现出更高水平的心理健康问题。压力知觉、社会支持为社工心理健康的重要影响因素,尤其以压力知觉的影响为著。 展开更多
关键词 covid-19 社会工作者 焦虑 抑郁 睡眠障碍
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Diabetes and susceptibility to COVID-19:Risk factors and preventive and therapeutic strategies 被引量:1
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作者 Jing-Wen Liu Xiao Huang +1 位作者 Ming-Ke Wang Ji-Shun Yang 《World Journal of Diabetes》 SCIE 2024年第8期1663-1671,共9页
Coronavirus disease 2019(COVID-19)is a highly infectious disease caused by a novel human coronavirus called severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Diabetes is a well-known risk factor for infectio... Coronavirus disease 2019(COVID-19)is a highly infectious disease caused by a novel human coronavirus called severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Diabetes is a well-known risk factor for infectious diseases with high prevalence and increased severity.Here,we elucidated the possible factors for the increased vulnerability of diabetic patients to SARS-CoV-2 infection and the more severe COVID-19 illness.The worsened prognosis of patients with both COVID-19 and diabetes may be attributable to host receptor angiotensinconverting enzyme 2-assisted viral uptake.Moreover,insulin resistance is often associated with impaired mucosal and skin barrier integrity,resulting in microbiota dysbiosis,which increases susceptibility to viral infections.It may also be associated with higher levels of pro-inflammatory cytokines resulting from an impaired immune system in diabetics,inducing a cytokine storm and excessive inflammation.This review describes diabetes mellitus and its complications,explains the risk factors,such as disease characteristics and patient lifestyle,which may contribute to the high susceptibility of diabetic patients to COVID-19,and discusses preventive and therapeutic strategies for COVID-19-positive diabetic patients. 展开更多
关键词 Diabetes mellitus SARS-CoV-2 covid-19 SUSCEPTIBILITY Prevention Treatment
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