To compare the efficacy and safety of CO_(2)laser plus 5-aminolevulinic acid(ALA)photodynamic therapy(PDT)with CO_(2)laser for the treatment of multiple condyloma acuminatum(CA),120 patients with multiple CA were allo...To compare the efficacy and safety of CO_(2)laser plus 5-aminolevulinic acid(ALA)photodynamic therapy(PDT)with CO_(2)laser for the treatment of multiple condyloma acuminatum(CA),120 patients with multiple CA were allocated into two groups—combined group(CO_(2)laser plus ALA-PDT,n=60)and CO_(2)laser group(CO_(2)laser plus placebo-PDT,n=60).After CO_(2)laser,a 20%ALA or a placebo solution was applied to the CA area 3 h before illumination with red light(635 nm,100mW/cm^(2),80 J/cm^(2)).The treatment was repeated seven days after the first treatment if the lesions were not completely resolved.The complete response rate,recurrence rate and adverse effects in the two groups were analyzed.After two treatments,the complete response rates in the CO_(2)laser group and combined group were 100%(509/509)and 100%(507/507)in the CA(p>0:05),respectively.The recurrence rates in the CO_(2)laser group and combined group were 44.9%(229/509)and 10.6%(54/507)in the CA(p<0:05),respectively.The adverse effects in CO_(2)laser group was more than that in combined group.The combined group is a more effective treatment for multiple CA compared with CO_(2)laser group.T/S.Style the highlighted text as abstract.展开更多
目的:探究重组贻贝粘蛋白水凝胶敷料(Recombined mussel adhesive protein hydrogel dressing,Rmaphd)在点阵CO_(2)激光治疗面部痤疮萎缩性瘢痕术后创面修复中的应用效果。方法:选择2022年6月-2023年2月面部痤疮萎缩性瘢痕患者117例,分...目的:探究重组贻贝粘蛋白水凝胶敷料(Recombined mussel adhesive protein hydrogel dressing,Rmaphd)在点阵CO_(2)激光治疗面部痤疮萎缩性瘢痕术后创面修复中的应用效果。方法:选择2022年6月-2023年2月面部痤疮萎缩性瘢痕患者117例,分为Rmaphd组、重组人表皮生长因子(Recombinant human epidermal growth factor,rhEGF)组和对照组,每组39例,三组均给予点阵CO_(2)激光术治疗,术后分别给予Rmaphd、rhEGF及生理盐水处理,比较三组疗效、ECCA评分、症状持续时间以及生活质量评分。结果:Rmaphd组和rhEGF组总有效率分别为92.31%和94.87%,均高于对照组76.92%(P<0.05),术后ECCA评分低于对照组(P<0.05),术后疼痛、红斑、痂皮持续时间短于对照组(P<0.05),Acne-QoL各指标得分优于对照组(P<0.05);上述各临床Rmaphd组与rhEGF组差异无统计学意义(P>0.05)。结论:Rmaphd用于点阵CO_(2)激光治疗面部痤疮萎缩性瘢痕术后创面修复疗效显著,具备在临床上辅助激光治疗术后修复的应用潜力。展开更多
目的:探究点阵CO_(2)激光联合米诺地尔治疗雄激素性脱发(Androgenetic alopecia,AGA)的疗效及安全性分析。方法:选取2020年1月-2021年12月笔者医院收治的114例雄激素性脱发患者,采用单双球法随机分为对照组(n=57)和观察组(n=57),对照组...目的:探究点阵CO_(2)激光联合米诺地尔治疗雄激素性脱发(Androgenetic alopecia,AGA)的疗效及安全性分析。方法:选取2020年1月-2021年12月笔者医院收治的114例雄激素性脱发患者,采用单双球法随机分为对照组(n=57)和观察组(n=57),对照组给予米诺地尔治疗,观察组给予点阵CO_(2)激光与米诺地尔联合治疗。比较治疗6个月后两组患者的临床症状改善情况,对比治疗前和治疗6个月后两组患者治疗效果、毛发镜评价、生活质量[流调中心抑郁表(The center for epidemiological studies depression scale,CES-D)、皮肤病生活质量指数(Dermatology life quality index,DLQI)],记录治疗期间不良反应发生情况。结果:治疗6个月后,观察组临床症状改善评分高于对照组(P<0.05);两组脱发评分、新生发评、毳毛比例、CES-D、DLQI评分均较治疗前降低,观察组低于对照组(P<0.05);两组毛发密度、毛囊密度均较治疗前增大,观察组大于对照组(P<0.05);两组患者不良反应差异无统计学意义(P>0.05)。结论:点阵CO_(2)激光联合米诺地尔可改善AGA患者瘙痒、出油、头屑、毛囊炎等症状及毛发镜指标,改善患者生活质量,且不增加不良反应发生率。展开更多
目的:探究30%超分子水杨酸联合小光斑点阵CO_(2)激光治疗轻中度寻常痤疮的有效性和安全性。方法:选取2022年11月-2023年6月就诊于吉林大学中日联谊医院30例面部轻、中度寻常痤疮患者,以患者面部矢状线为界,按照随机数表将患者的双侧面...目的:探究30%超分子水杨酸联合小光斑点阵CO_(2)激光治疗轻中度寻常痤疮的有效性和安全性。方法:选取2022年11月-2023年6月就诊于吉林大学中日联谊医院30例面部轻、中度寻常痤疮患者,以患者面部矢状线为界,按照随机数表将患者的双侧面部随机分为对照侧和观察侧。对照侧(n=30),给予30%超分子水杨酸治疗(每4周治疗1次);观察侧(n=30),给予小光斑点阵CO_(2)激光治疗后即刻30%超分子水杨酸治疗(每4周治疗1次)。通过拍照、皮肤检测仪、皮损计数和痤疮综合分级系统(The global acne grading system,GAGS)评分等评估治疗的有效性;通过皮损清除率判定临床疗效,同时观察不良反应以评估安全性。治疗结束后12周对患者进行随访,评估复发情况。结果:治疗12周后,患者观察侧的临床疗效优于对照侧(P<0.05);观察侧的皮损清除效果明显优于对照侧(P<0.001);观察侧的GAGS评分改善程度明显优于对照侧(P<0.001)。治疗期间两侧均未出现严重不良反应。结论:30%超分子水杨酸联合小光斑点阵CO_(2)激光疗法对清除轻中度痤疮皮损优于30%超分子水杨酸单一治疗,具有见效快、安全性高、操作简单、患者满意度高等优点,且不增加患者相关不良反应。展开更多
基金This research was funded in part by the National Natural Sciences Foundation of China(No.30872272 and No.30872273)by the program for New Century Excellent Talents from Ministry of Education of China(NCET-09-0390).
文摘To compare the efficacy and safety of CO_(2)laser plus 5-aminolevulinic acid(ALA)photodynamic therapy(PDT)with CO_(2)laser for the treatment of multiple condyloma acuminatum(CA),120 patients with multiple CA were allocated into two groups—combined group(CO_(2)laser plus ALA-PDT,n=60)and CO_(2)laser group(CO_(2)laser plus placebo-PDT,n=60).After CO_(2)laser,a 20%ALA or a placebo solution was applied to the CA area 3 h before illumination with red light(635 nm,100mW/cm^(2),80 J/cm^(2)).The treatment was repeated seven days after the first treatment if the lesions were not completely resolved.The complete response rate,recurrence rate and adverse effects in the two groups were analyzed.After two treatments,the complete response rates in the CO_(2)laser group and combined group were 100%(509/509)and 100%(507/507)in the CA(p>0:05),respectively.The recurrence rates in the CO_(2)laser group and combined group were 44.9%(229/509)and 10.6%(54/507)in the CA(p<0:05),respectively.The adverse effects in CO_(2)laser group was more than that in combined group.The combined group is a more effective treatment for multiple CA compared with CO_(2)laser group.T/S.Style the highlighted text as abstract.
文摘目的:探究重组贻贝粘蛋白水凝胶敷料(Recombined mussel adhesive protein hydrogel dressing,Rmaphd)在点阵CO_(2)激光治疗面部痤疮萎缩性瘢痕术后创面修复中的应用效果。方法:选择2022年6月-2023年2月面部痤疮萎缩性瘢痕患者117例,分为Rmaphd组、重组人表皮生长因子(Recombinant human epidermal growth factor,rhEGF)组和对照组,每组39例,三组均给予点阵CO_(2)激光术治疗,术后分别给予Rmaphd、rhEGF及生理盐水处理,比较三组疗效、ECCA评分、症状持续时间以及生活质量评分。结果:Rmaphd组和rhEGF组总有效率分别为92.31%和94.87%,均高于对照组76.92%(P<0.05),术后ECCA评分低于对照组(P<0.05),术后疼痛、红斑、痂皮持续时间短于对照组(P<0.05),Acne-QoL各指标得分优于对照组(P<0.05);上述各临床Rmaphd组与rhEGF组差异无统计学意义(P>0.05)。结论:Rmaphd用于点阵CO_(2)激光治疗面部痤疮萎缩性瘢痕术后创面修复疗效显著,具备在临床上辅助激光治疗术后修复的应用潜力。
文摘目的:探究点阵CO_(2)激光联合米诺地尔治疗雄激素性脱发(Androgenetic alopecia,AGA)的疗效及安全性分析。方法:选取2020年1月-2021年12月笔者医院收治的114例雄激素性脱发患者,采用单双球法随机分为对照组(n=57)和观察组(n=57),对照组给予米诺地尔治疗,观察组给予点阵CO_(2)激光与米诺地尔联合治疗。比较治疗6个月后两组患者的临床症状改善情况,对比治疗前和治疗6个月后两组患者治疗效果、毛发镜评价、生活质量[流调中心抑郁表(The center for epidemiological studies depression scale,CES-D)、皮肤病生活质量指数(Dermatology life quality index,DLQI)],记录治疗期间不良反应发生情况。结果:治疗6个月后,观察组临床症状改善评分高于对照组(P<0.05);两组脱发评分、新生发评、毳毛比例、CES-D、DLQI评分均较治疗前降低,观察组低于对照组(P<0.05);两组毛发密度、毛囊密度均较治疗前增大,观察组大于对照组(P<0.05);两组患者不良反应差异无统计学意义(P>0.05)。结论:点阵CO_(2)激光联合米诺地尔可改善AGA患者瘙痒、出油、头屑、毛囊炎等症状及毛发镜指标,改善患者生活质量,且不增加不良反应发生率。
文摘目的:探究30%超分子水杨酸联合小光斑点阵CO_(2)激光治疗轻中度寻常痤疮的有效性和安全性。方法:选取2022年11月-2023年6月就诊于吉林大学中日联谊医院30例面部轻、中度寻常痤疮患者,以患者面部矢状线为界,按照随机数表将患者的双侧面部随机分为对照侧和观察侧。对照侧(n=30),给予30%超分子水杨酸治疗(每4周治疗1次);观察侧(n=30),给予小光斑点阵CO_(2)激光治疗后即刻30%超分子水杨酸治疗(每4周治疗1次)。通过拍照、皮肤检测仪、皮损计数和痤疮综合分级系统(The global acne grading system,GAGS)评分等评估治疗的有效性;通过皮损清除率判定临床疗效,同时观察不良反应以评估安全性。治疗结束后12周对患者进行随访,评估复发情况。结果:治疗12周后,患者观察侧的临床疗效优于对照侧(P<0.05);观察侧的皮损清除效果明显优于对照侧(P<0.001);观察侧的GAGS评分改善程度明显优于对照侧(P<0.001)。治疗期间两侧均未出现严重不良反应。结论:30%超分子水杨酸联合小光斑点阵CO_(2)激光疗法对清除轻中度痤疮皮损优于30%超分子水杨酸单一治疗,具有见效快、安全性高、操作简单、患者满意度高等优点,且不增加患者相关不良反应。
