The Centenary of the CPC: Leading the Times by Grasping the Laws and Trends of Historical Development

Discussions on grasping the laws and trends of historical development take a fundamental theoretical position in the scientific system of Xi Jinping Thought on Socialism with Chinese Characteristics for a New Era.Xi Jinping’s important statements have systematically answered such questions as what type of laws and trends of historical development should be followed,how did the Party follow the laws and trends of historical development in its centennial history,and how should the laws and trends of historical development be followed in a new era.The birth of the Communist Party of China(CPC),the victory of China’s War of Resistance against Japanese Aggression,the founding of the People’s Republic of China,and the unveiling of a new era for reform and opening up and socialism with Chinese characteristics are all the results of grasping the laws and trends of historical development.Over the past century,the Party has followed the laws and trends of historical development and continuously advanced the sinicization of Marxism on the basis of adhering to the unification between truth and values.In pursuit of“putting people first,”the Party has courageously been reforming itself and made relentless progress in the great endeavor of Party building.History shows that a keen appreciation of the laws and trends of historical development is an important sign of political maturity for a proletarian party.Only by applying Marxism according to current times and conditions will we keep abreast with the laws and trends of historical development.We should establish a broader concept of history and identify the laws and trends of historical development from the interactions and linkages between China and the rest of the world.We must recognize and promote the outstanding role of great leaders in steering the country in line with the laws and trends of historical development.

The Centenary of the CPC:Socialist Industrial Development and Historical Experience

Socialist industrialization in a populous agrarian country like China is a complex,arduous,and long-term task.Under the leadership of the Communist Party of China(CPC),the Chinese people have initiated a new way of socialist industrialization suitable to China’s national conditions after assiduous efforts.Brilliant achievements of historic importance have been made in China’s industrial development.In just a few decades,China completed an industrialization process that took centuries in the developed world and established the world’s most complete modern industrial system,becoming the second-largest economy and the largest manufacturing nation in the world.This achievement is of great historic and worldwide significance.Over its centennial history,CPC has completed the historic task of opposing imperialism and feudalism during the New Democratic Revolution,which created political conditions essential for the nation’s socialist industrialization.During this socialist revolution and development,the CPC has led the nation to build complete industrial and economic systems.In the era of reform and opening up and socialist modernization,the CPC has led the nation to industrialize and become the equal of more advanced economies.In the new era of Chinese socialism,the CPC has led the nation to accomplish the goal of building a moderately prosperous society in all respects and pursuing high-quality industrial development.China’s industrial achievements can be attributed to the following factors:First,the CPC’s strong leadership,adherence to its founding aspiration and unwavering commitment to socialist industrialization;second,the application of the Marxist principles taking into account China’s actual conditions;third,proactively exploring and following the laws of industrialization for China as a large country and keeping industrial development in alignment with evolving conditions.

Natural history and long-term clinical course of Crohn's disease

Crohn’s disease is a chronic inflammatory disease process involving different sites in the gastrointestinal tract. Occasionally, so-called metastatic disease occurs in extra-intestinal sites. Granulomatous inflammation may be detected in endoscopic biopsies or resected tissues. Genetic, epigenetic and environmental factors appear to play a role. Multiple susceptibility genes have been described in both familial and non-familial forms while the disease is phenotypically heterogeneous with a female predominance. The disorder occurs over a broad age spectrum, from early childhood to late adulthood. More than 80% are diagnosed before age 40 years usually with terminal ileal and colonic involvement. Pediatric-onset disease is more severe and more extensive, usually with a higher chance of upper gastrointestinal tract disease, compared to adult-onset disease. Long-term studies have shown that the disorder may evolve with time into more complex disease with stricture formation and penetrating disease complications (i.e., fistula, abscess). Although prolonged remission may occur, discrete periods of symptomatic disease may re-appear over many decades suggesting recurrence or re-activation of this inflammatory process. Eventual development of a cure will likely depend on identification of an etiologic cause and a fundamental understanding of its pathogenesis. Until now, treatment has focused on removing risk factors, particularly cigarette smoking, and improving symptoms. In clinical trials, clinical remission is largely defined as improved numerical and endoscopic indices for “mucosal healing”. “Deep remission” is a conceptual, more “extended” goal that may or may not alter the long-term natural history of the disease in selected patients, albeit at a significant risk for treatment complications, including serious and unusual opportunistic infections.

Family history and disease outcomes in patients with Crohn's disease:A comparison between China and the United States

AIM To investigate the differences in family history of inflammatory bowel disease(IBD) and clinical outcomes among individuals with Crohn's disease(CD) residing in China and the United States.METHODS We performed a survey-based cross-sectional study of participants with CD recruited from China and the United States.We compared the prevalence of IBD family history and history of ileal involvement,CD-related surgeries and IBD medications in China and the United States,adjusting for potential confounders.RESULTS We recruited 49 participants from China and 145 from the United States.The prevalence of family history of IBD was significantly lower in China compared with the United States(China:4.1%,United States:39.3%).The three most commonly affected types of relatives were cousin,sibling,and parent in the United States compared with child and sibling in China.Ileal involvement(China:63.3%,United States:63.5%) and surgery for CD(China:51.0%,United States:49.7%) were nearly equivalent in the two countries.CONCLUSION The lower prevalence of familial clustering of IBD in China may suggest that the etiology of CD is less attributed to genetic background or a family-shared environment compared with the United States.Despite the potential difference in etiology,surgery and ileal involvement were similar in the two countries.Examining the changes in family history during the continuing rise in IBD may provide further insight into the etiology of CD.

Long-term natural history of Crohn’s disease

Crohn’s disease is a chronic inflammatory granulomatous process that usually involves different sites in the intestinal tract. Genetic and environmental factors are thought to play a role in its etiology and pathogenesis. The disorder has a heterogeneous clinical expression and data from tertiary care settings have documented its female predominance, occasional familial nature, and high rate of stricture formation and penetrating disease. It may appear from early childhood to late adulthood, although over 80% are currently diagnosed before age 40 years, usually with terminal ileal and colonic involvement. Several studies have now shown differences in phenotypic clinical expression depending on the initial age at diagnosis, with pediatric-onset disease being more severe and more extensive with more involvement of the upper gastrointestinal tract compared to adult-onset disease. In addition, long- term studies from these tertiary care settings have documented that the disorder may evolve with time into a more complex disease with stricture formation and penetrating disease complications (i.e. fistula and abscess). Although prolonged remission with no evidence of inflammatory disease may occur, discrete periods of symptomatic and active granulomatous inflammatory disease may re-appear over many decades. Long-term studies on the natural history have also suggested that discrete events (or agents) may precipitate this granulomatous inflammatory process.

Crucial steps in the natural history of inflammatory bowel disease

Inflammatory bowel diseases(IBD),including ulcerative colitis(UC) and Crohn's disease(CD),are chronic,progressive and disabling disorders.Over the last few decades,new therapeutic approaches have been introduced which have led not only to a reduction in the mortality rate but also offered the possibility of a favorable modification in the natural history of IBD.The identification of clinical,genetic and serological prognostic factors has permitted a better stratification of the disease,thus allowing the opportunity to indicate the most appropriate therapy.Early treatment with immunosuppressive drugs and biologics has offered the opportunity to change,at least in the short term,the course of the disease by reducing,in a subset of patients with IBD,hospitalization and the need for surgery.In this review,the crucial steps in the natural history of both UC and CD will be discussed,as well as the factors that may change their clinical course.The methodological requirements for high quality studies on the course and prognosis of IBD,the true impact of environmental and dietary factors on the clinical course of IBD,the clinical,serological and genetic predictors of the IBD course(in particular,which of these are rel-evant and appropriate for use in clinical practice),the impact of the various forms of medical treatment on the IBD complication rate,the role of surgery for IBD in the biologic era,the true magnitude of risk of colorectal cancer associated with IBD,as well as the mortality rate related to IBD will be stressed;all topics that are extensively discussed in separate reviews included in this issue of World Journal of Gastroenterology.

Inflammatory bowel disease course in Crohn's disease:Is the natural history changing?

Crohn’s disease (CD) is a multifactorial potentially debilitating disease. It has a variable disease course, but the majority of patients eventually develop penetrating or stricturing complications leading to repeated surgeries and disability. Studies on the natural history of CD provide invaluable data on its course and clinical predictors, and may help to identify patient subsets based on clinical phenotype. Most data are available from referral centers, however these outcomes may be different from those in population-based cohorts. New data suggest the possibility of a change in the natural history in Crohn’s disease, with an increasing percentage of patients diagnosed with inflammatory disease behavior. Hospitalization rates remain high, while surgery rates seem to have decreased in the last decade. In addition, mortality rates still exceed that of the general population. The impact of changes in treatment strategy, including increased, earlier use of immunosuppressives, biological therapy, and patient monitoring on the natural history of the disease are still conflictive. In this review article, the authors summarize the available evidence on the natural history, current trends, and predictive factors for evaluating the disease course of CD.

西秦岭八卦庙金矿床原位S-Pb同位素组成对成矿物质来源和成矿过程的指示意义

八卦庙金矿床位于西秦岭造山带凤太多金属矿田北部,已探明金储量约106 t(平均金品位1.56 g/t),属于特大型金矿。金矿体受脆韧性剪切带控制,总体走向NWW,倾向北,赋矿地层为上泥盆统星红铺组下段。文章在成矿期次研究基础上,采用硫化物原位S-Pb同位素分析方法,对八卦庙金矿成矿过程和成矿物质来源进行了约束。基于详细的野外观察和矿相学研究,矿区识别出了2个金成矿期:顺层磁黄铁矿-石英成矿期和NE向黄铁矿-石英成矿期。顺层磁黄铁矿-石英成矿期可划分为自形黄铁矿-石英(Ⅰ)、磁黄铁矿-自然金-铁白云石(Ⅱ)、白云母-绿泥石-绿帘石-石英(Ⅲ)3个阶段;NE向黄铁矿-石英成矿期由自形磁黄铁矿-黄铁矿-粗粒石英(Ⅳ)、他形黄铁矿-细粒石英(Ⅴ)、他形磁黄铁矿-自然金-铁白云石(Ⅵ)和石英-黑云母(Ⅶ)4个阶段构成。顺层磁黄铁矿-石英成矿期硫化物的δ34S值集中在1.60‰~5.89‰和14.07‰~16.87‰两个区间;NE向黄铁矿-石英成矿期硫化物的δ34S值也集中在2.77‰~5.52‰和9.11‰~15.9‰两个区间,通过与围岩和区内岩浆岩对比,笔者认为2个成矿期成矿热液中硫的来源和演化具有相似之处,初始流体中的硫既有围岩硫的贡献,也有岩浆硫的加入,随着成矿作用和水-岩相互作用的进行,成矿流体中围岩硫的比例逐渐升高。顺层成矿期硫化物具有混合铅的铅同位素特征(206Pb/^(204)Pb=18.041~18.436,^(207)Pb/^(204)Pb=15.364~15.724,^(208)Pb/^(204)Pb=38.138~38.754),指示区内中酸性岩浆和赋矿地层来源铅的混合。NE向成矿期硫化物的铅同位素(206Pb/^(204)Pb=18.393~18.400,^(207)Pb/^(204)Pb=15.639~15.687,^(208)Pb/^(204)Pb=38.648~38.917)略低于围岩硫化物,指示成矿流体中的铅主要来源于地层,但有少量岩浆铅的混入。

Barrett’s esophagus:Review of natural history and comparative efficacy of endoscopic and surgical therapies

Barrett's esophagus(BE)is the precursor to esophageal adenocarcinoma(EAC).Progression to cancer typically occurs in a stepwise fashion through worsening dysplasia and ultimately,invasive neoplasia.Established EAC with deep involvement of the esophageal wall and/or metastatic disease is invariably associated with poor long-term survival rates.This guides the rationale of surveillance of Barrett’s in an attempt to treat lesions at an earlier,and potentially curative stage.The last two decades have seen a paradigm shift in management of Barrett’s with rapid expansion in the role of endoscopic eradication therapy(EET)for management of dysplastic and early neoplastic BE,and there have been substantial changes to international consensus guidelines for management of early BE based on evolving evidence.This review aims to assist the physician in the therapeutic decision-making process with patients by comprehensive review and summary of literature surrounding natural history of Barrett’s by histological stage,and the effectiveness of interventions in attenuating the risk posed by its natural history.Key findings were as follows.Non-dysplastic Barrett’s is associated with extremely low risk of progression,and interventions cannot be justified.The annual risk of cancer progression in low grade dysplasia is between 1%-3%;EET can be offered though evidence for its benefit remains confined to highly select settings.High-grade dysplasia progresses to cancer in 5%-10%per year;EET is similarly effective to and less morbid than surgery and should be routinely performed for this indication.Risk of nodal metastases in intramucosal cancer is 2%-4%,which is comparable to operative mortality rate,so EET is usually preferred.Submucosal cancer is associated with nodal metastases in 14%-41%hence surgery remains standard of care,except for select situations.

Xi Jinping's Discussion of Civilization History and the Discourse Construction of China's Road

The significance of discourse construction in the civilization discussion of Xi Jinping is explored in this paper: The 500-year history of world socialism and the 5000-year history of Chinese civilization, Xi Jinping' s studies of Socialism with Chinese characteristics in the long history of civilization development, highlighting Socialism with Chinese characteristics as a product in the development of human civilization, the great contribution to world civilization progress and the creative development of Marxism which has been the most distinctive feature in Chinese discourse structure since the 18 th National Congress of the CPC. As the conscious construction of epistemology, it has given unprecedented historical and cultural implications to China' s road and opened the new theory space for the discourse construction of Socialism with Chinese characteristics or the academic expression of China' s road.

Organized Fan Groups and Sports Journalism in Brazil： A Social History of Soccer Fans in the City of Rio de Janeiro

The article focuses on sources of Brazilian sports journalism and demonstrates the role of organized soccer fan groups in Rio de Janeiro between the 1940s and 1980s, this is achieved through reports provided by the Brazilian newspaper Jornal dos Sports. From the beginning, there are biographical notes made about the most well-known fan leaders in Rio, such as Jaime de Carvalho, who founded the Charanga （1942）. The emergence of dissent among the fans, in the late 1960s, is then covered, which establishes itself within the organized fans in Rio with these individuals beginning to question the authority of the old fan group leaders. This is against the principle of giving unconditional support to the club and it is postulated that the fans have the right to criticize and protest against the club＇s management, even if this means using forceful tactics. Along with the journalistic narrative, there is a break-off by the ＂Young Fans＂ and a process of emancipation begins which occurs over the 1970s, this happens by means of the use of fan coaches and the invention of a lifestyle that is associated with soccer. Finally, the 1980s is marked by the constructive and destructive potential that is linked to fan groups. On the one hand, creating an Association of fans--Astorj--is pointed to in order to reach a mutual understanding, but it should be noted, on the other, that there are feuds, in a scenario of spiraling violence, in which fights, beatings, and even murders begin to be commonplace.

Evolution of Principal Contradiction Facing Chinese Society and the CPC Leadership over Economic Work

Since the founding of the People’s Republic of China in 1949,the Communist Party of China(CPC)has separated China’s evolving principal social contradictions into four different stages.Based on the assessment of principal social contradictions at different points in time,the CPC enacted different economic policies.During 1949-1956,based on the recognition of class struggle as China’s principal social contradiction,the Party focused its economic policies on socialist transformation and established the foundation for the public sector of the economy.During 1956-1978,amid flip-flops in the Party’s assessment of whether class struggle or backward productive forces were the principal contradiction,China’s economic development suffered some setbacks,but the vision for building an industrial country remained unchanged,and resources were focused on developing major national industrial projects.During 1978-2019,the Party focused on economic development and reform and opening up in pursuit of the realization of grand economic development goals based on the assessment that China’s principal social contradiction was between people’s ever-growing material and cultural needs and China’s relatively backward social productive forces.In 2017,the 19th CPC National Congress made the important political assessment that China’s principal social contradiction had transformed into the contradiction between people’s ever-growing need for a better life and China’s unbalanced and inadequate development,and proposed new development concepts to lead the Chinese people on a new journey towards the second centennial goal.The most important experience of the CPC’s economic work is analyzing and solving problems based on Marxist ideology and methodology.

First Forum on China Casting Quality Standards & Overview of Revision History of China's National/Industrial Standards for Foundry Operations

Both national and local governments have been paying great attention to the work of industrial standardization with the enormous increase in international trade after China joined WTO. According to the standards revising plan of Standardization Administration Committee of China (SAC),TC54 has already revised a series of national standards and industrial standards for foundry operations,and proposed some new ones. As a result,some old fashioned standards containing low-level techniques have been gradually discontinued or replaced with new versions.……

Effect of fertility history and parity on Alzheimer’s disease:a mini review from animal to human studies

More women than men have Alzheimer's disease(AD)or other dementias.There are a number of potential biological and social reasons for the sex difference in the risk of AD,such as women live longer than men on average,and estrogen depletion after menopause in women,biological or genetic variations,and education,occupation or rates of heart disease.Recent studies showed a link between reproductive history and dementia risk in women.Women with fertility history showed lower risk of dementia compared to women with no child.Other studies also suggested that women's pregnancy history may influence AD's risk.In this review,we will focus on the relationship between women fertility and cognition and discuss the potential role of sex hormones in the brain and cognition,especially on AD pathogenesis.

Historical Reconstruction - Reread Kenzaburo Oe＇ s Banengannen＇ s Soccer Team

The novel Banengannen’s Soccer Team published in 1967has been classified as historical"meta narration"of Kenzaburo Oe.In the novel,there are two main characters—Mitsusaburo and Takashi,both of whom represent two ways of exploring the historical truth.In the process of exploration of the two characters,Kenzaburo Oe symbolically analyzed the value presetting of the Japanese people—getting one’s own value through projecting the"Emperor",recreating a new chapter of history from personal experience.

Continuities of Historical Crises and Discourses of Europe From the “Neo-Latin Past” to the 21st Century

Europe and the EU have been facing many crises and challenges in recent years.From Brexit and rising nationalism to economic problems and unanimous refugee policies,most of them remain unsolved.Instead of moving forward with the European integration project,Europe seems to regress in many instances.Considering this turmoil,it seems all the more important to historicize the affirmative discourse of Europe and to expand the knowledge of the European unification process with novel insights into its history.Only if a broad understanding of its roots and developments prevails,the conflicts of the present can be better evaluated and addressed.Particularly one set of so far neglected sources from Europe’s past serves as guiding light in that respect:the early modern Europe literature written in the Latin language.Between 1400 and 1800,Latin enjoyed a similar status in promoting scientific discoveries,negotiating political affairs and generally communicating on an international level as modern-day English.By offering a brief glance at some historically influential Latin texts from the early modern discourse of Europe,this article will show that the early modern European crises strikingly resemble Europe’s current crises despite the difference in political,social,and economic circumstances.The discourse of Europe has from the beginning been a stable discourse,characterized by the same recurring questions for centuries.When used as reference point for the crises of the 21st century,the prospects for the European integration look better than presumed.

JIANGSU SHOWCASES THE CPC'S ROLE IN DRIVING INNOVATION AND ECONOMIC TRANSFORMATION

The sound of Suzhou Pingtan,an art form which combines storytelling and ballad singing in the Suzhou dialect,swirled around a hall of the International Department of theCommunist Party of China’s Central Committee(IDCPC)in Beijing on August 31.The singing enchanted the audience,including 400 visiting political party leaders and ambassadors of

China's Public Diplomacy since the 18^(th) CPC National Congress

It is pointed out for the first time at the 18thCPC National Congress on November 8,2012 that"public diplomacy and cultural exchanges should be pushed forward",signifying integration of public diplomacy into China’s national strategy.Over the past year,China’s public diplomacy has made remarkable progress in institution-building,