The objective of this study is to investigate themethods for soil liquefaction discrimination. Typically, predicting soilliquefaction potential involves conducting the standard penetration test (SPT), which requires f...The objective of this study is to investigate themethods for soil liquefaction discrimination. Typically, predicting soilliquefaction potential involves conducting the standard penetration test (SPT), which requires field testing and canbe time-consuming and labor-intensive. In contrast, the cone penetration test (CPT) provides a more convenientmethod and offers detailed and continuous information about soil layers. In this study, the feature matrix based onCPT data is proposed to predict the standard penetration test blow count N. The featurematrix comprises the CPTcharacteristic parameters at specific depths, such as tip resistance qc, sleeve resistance f s, and depth H. To fuse thefeatures on the matrix, the convolutional neural network (CNN) is employed for feature extraction. Additionally,Genetic Algorithm (GA) is utilized to obtain the best combination of convolutional kernels and the number ofneurons. The study evaluated the robustness of the proposed model using multiple engineering field data sets.Results demonstrated that the proposed model outperformed conventional methods in predicting N values forvarious soil categories, including sandy silt, silty sand, and clayey silt. Finally, the proposed model was employedfor liquefaction discrimination. The liquefaction discrimination based on the predicted N values was comparedwith the measured N values, and the results showed that the discrimination results were in 75% agreement. Thestudy has important practical application value for foundation liquefaction engineering. Also, the novel methodadopted in this research provides new ideas and methods for research in related fields, which is of great academicsignificance.展开更多
The cone penetration test(CPT)contributes to the design and analysis of piles regarding geometry,installation effect,and pile capacity(shaft and toe resistance).MiniCone,as an alternative to CPT sounding,has been used...The cone penetration test(CPT)contributes to the design and analysis of piles regarding geometry,installation effect,and pile capacity(shaft and toe resistance).MiniCone,as an alternative to CPT sounding,has been used to carry outfield and laboratory investigations by physical modeling.More tests can be practically carried out through light equipment and small soil mass,involving fewer errors caused by boundary conditions.Furthermore,it can be used for in situ testing,such as quality control,assessment of ground improvement,and subgrade characterization.A database comprising MiniCone and CPT records infield and physical modeling is proposed with a variety of cone diameters.The case study records in the database have been obtained from 140 tests compiled from data from 26 sources.The sources include the results of 20 physical modelings andfield data from six sites in 10 countries.The data comprise MiniCone and CPT cone tip resistance(qc),and sleeve friction(fs).The different cones are used in sandy,silty sand,and clayey soils via simple chambers(1 g),calibration chambers,and frustum confining vessels.In addition,correlations were found in penetration records in terms of physical modeling types,cone diameters,penetration rates,and soil densities.Moreover,qc and fs are related to capacities of pile toes and shafts using proper correlation coefficients less than unity,respectively.Correlations and dominant factors in geotechnical practice between MiniCone,CPT,and pile have been reviewed and discussed.展开更多
Metabolic reprogramming frequently occurs in the majority of cancers,wherein fatty acid oxidation(FAO)is usually induced and serves as a compensatory mechanism to improve energy consumption.Carnitine palmitoyltransfer...Metabolic reprogramming frequently occurs in the majority of cancers,wherein fatty acid oxidation(FAO)is usually induced and serves as a compensatory mechanism to improve energy consumption.Carnitine palmitoyltransferase 1A(CPT1A)is the rate-limiting enzyme for FAO and is widely involved in tumor growth,metastasis,and chemo-/radio-resistance.This review summarizes the most recent advances in understanding the oncogenic roles and mechanisms of CPT1A in tumorigenesis,including in proliferation and tumor growth,invasion and metastasis,and the tumor microenvironment.Importantly,CPT1A has been shown to be a biomarker for diagnosis and prognosis prediction and proved to be a candidate therapeutic target,especially for the treatment of drug-and radiation-resistant tumors.In summary,CPT1A plays remarkable roles in promoting cancer progression and is a potential anticancer therapeutic target.展开更多
基金the Center University(Grant No.B220202013)Qinglan Project of Jiangsu Province(2022).
文摘The objective of this study is to investigate themethods for soil liquefaction discrimination. Typically, predicting soilliquefaction potential involves conducting the standard penetration test (SPT), which requires field testing and canbe time-consuming and labor-intensive. In contrast, the cone penetration test (CPT) provides a more convenientmethod and offers detailed and continuous information about soil layers. In this study, the feature matrix based onCPT data is proposed to predict the standard penetration test blow count N. The featurematrix comprises the CPTcharacteristic parameters at specific depths, such as tip resistance qc, sleeve resistance f s, and depth H. To fuse thefeatures on the matrix, the convolutional neural network (CNN) is employed for feature extraction. Additionally,Genetic Algorithm (GA) is utilized to obtain the best combination of convolutional kernels and the number ofneurons. The study evaluated the robustness of the proposed model using multiple engineering field data sets.Results demonstrated that the proposed model outperformed conventional methods in predicting N values forvarious soil categories, including sandy silt, silty sand, and clayey silt. Finally, the proposed model was employedfor liquefaction discrimination. The liquefaction discrimination based on the predicted N values was comparedwith the measured N values, and the results showed that the discrimination results were in 75% agreement. Thestudy has important practical application value for foundation liquefaction engineering. Also, the novel methodadopted in this research provides new ideas and methods for research in related fields, which is of great academicsignificance.
基金National Key Research and Development Program(2018YFE0109500)National Natural Science Foundation of China(51939010,51779221,U1806230)Key Research and Development Program of Zhejiang Province(2018C03031).
文摘The cone penetration test(CPT)contributes to the design and analysis of piles regarding geometry,installation effect,and pile capacity(shaft and toe resistance).MiniCone,as an alternative to CPT sounding,has been used to carry outfield and laboratory investigations by physical modeling.More tests can be practically carried out through light equipment and small soil mass,involving fewer errors caused by boundary conditions.Furthermore,it can be used for in situ testing,such as quality control,assessment of ground improvement,and subgrade characterization.A database comprising MiniCone and CPT records infield and physical modeling is proposed with a variety of cone diameters.The case study records in the database have been obtained from 140 tests compiled from data from 26 sources.The sources include the results of 20 physical modelings andfield data from six sites in 10 countries.The data comprise MiniCone and CPT cone tip resistance(qc),and sleeve friction(fs).The different cones are used in sandy,silty sand,and clayey soils via simple chambers(1 g),calibration chambers,and frustum confining vessels.In addition,correlations were found in penetration records in terms of physical modeling types,cone diameters,penetration rates,and soil densities.Moreover,qc and fs are related to capacities of pile toes and shafts using proper correlation coefficients less than unity,respectively.Correlations and dominant factors in geotechnical practice between MiniCone,CPT,and pile have been reviewed and discussed.
基金funded by the National Natural Science Foundation of China(Nos.82160585 and 81760526)the Yunnan Provincial Research Foundation for Basic Research,China(No.202001AT070028).
文摘Metabolic reprogramming frequently occurs in the majority of cancers,wherein fatty acid oxidation(FAO)is usually induced and serves as a compensatory mechanism to improve energy consumption.Carnitine palmitoyltransferase 1A(CPT1A)is the rate-limiting enzyme for FAO and is widely involved in tumor growth,metastasis,and chemo-/radio-resistance.This review summarizes the most recent advances in understanding the oncogenic roles and mechanisms of CPT1A in tumorigenesis,including in proliferation and tumor growth,invasion and metastasis,and the tumor microenvironment.Importantly,CPT1A has been shown to be a biomarker for diagnosis and prognosis prediction and proved to be a candidate therapeutic target,especially for the treatment of drug-and radiation-resistant tumors.In summary,CPT1A plays remarkable roles in promoting cancer progression and is a potential anticancer therapeutic target.
