In an emerging trend, more and more Internet users search for information from Community Question and Answer （CQA） websites, as interactive communication in such websites provides users with a rare feeling of trust....In an emerging trend, more and more Internet users search for information from Community Question and Answer （CQA） websites, as interactive communication in such websites provides users with a rare feeling of trust. More often than not, end users look for instant help when they browse the CQA websites for the best answers. Hence, it is imperative that they should be warned of any potential commercial campaigns hidden behind the answers. Existing research focuses more on the quality of answers and does not meet the above need. Textual similarities between questions and answers are widely used in previous research. However, this feature will no longer be effective when facing commercial paid posters. More context information, such as writing templates and a user’s reputation track, needs to be combined together to form a new model to detect the potential campaign answers. In this paper, we develop a system that automatically analyzes the hidden patterns of commercial spam and raises alarms instantaneously to end users whenever a potential commercial campaign is detected. Our detection method integrates semantic analysis and posters’ track records and utilizes the special features of CQA websites largely different from those in other types of forums such as microblogs or news reports. Our system is adaptive and accommodates new evidence uncovered by the detection algorithms over time. Validated with real-world trace data from a popular Chinese CQA website over a period of three months, our system shows great potential towards adaptive detection of CQA spams.展开更多
Quality by Test was the only way to guarantee quality of drug products before FDA launched current Good Manufacturing Practice. To clearly understand the manufacture processes, FDA generalized Quality by Design(QbD) i...Quality by Test was the only way to guarantee quality of drug products before FDA launched current Good Manufacturing Practice. To clearly understand the manufacture processes, FDA generalized Quality by Design(QbD) in the field of pharmacy, which is based on the thorough understanding of how materials and process parameters affect the quality profile of final products. The application of QbD in drug formulation and process design is based on a good understanding of the sources of variability and the manufacture process. In this paper,the basic knowledge of QbD, the elements of QbD, steps and tools for QbD implementation in pharmaceutics field, including risk assessment, design of experiment, and process analytical technology(PAT), are introduced briefly. Moreover, the concrete applications of QbD in various pharmaceutical related unit operations are summarized and presented.展开更多
文摘In an emerging trend, more and more Internet users search for information from Community Question and Answer （CQA） websites, as interactive communication in such websites provides users with a rare feeling of trust. More often than not, end users look for instant help when they browse the CQA websites for the best answers. Hence, it is imperative that they should be warned of any potential commercial campaigns hidden behind the answers. Existing research focuses more on the quality of answers and does not meet the above need. Textual similarities between questions and answers are widely used in previous research. However, this feature will no longer be effective when facing commercial paid posters. More context information, such as writing templates and a user’s reputation track, needs to be combined together to form a new model to detect the potential campaign answers. In this paper, we develop a system that automatically analyzes the hidden patterns of commercial spam and raises alarms instantaneously to end users whenever a potential commercial campaign is detected. Our detection method integrates semantic analysis and posters’ track records and utilizes the special features of CQA websites largely different from those in other types of forums such as microblogs or news reports. Our system is adaptive and accommodates new evidence uncovered by the detection algorithms over time. Validated with real-world trace data from a popular Chinese CQA website over a period of three months, our system shows great potential towards adaptive detection of CQA spams.
基金financially supported by Talents Project of Liaoning Province, China (LR2013047)
文摘Quality by Test was the only way to guarantee quality of drug products before FDA launched current Good Manufacturing Practice. To clearly understand the manufacture processes, FDA generalized Quality by Design(QbD) in the field of pharmacy, which is based on the thorough understanding of how materials and process parameters affect the quality profile of final products. The application of QbD in drug formulation and process design is based on a good understanding of the sources of variability and the manufacture process. In this paper,the basic knowledge of QbD, the elements of QbD, steps and tools for QbD implementation in pharmaceutics field, including risk assessment, design of experiment, and process analytical technology(PAT), are introduced briefly. Moreover, the concrete applications of QbD in various pharmaceutical related unit operations are summarized and presented.
