目的:检测急性心肌梗死(acute myocardial infarction,AMI)患者血清C1q/肿瘤坏死因子相关蛋白-6(C1q/tumor necrosis factor related protein 6,CTRP6)表达水平与病情和预后的相关性。方法:选取河南科技大学第一附属医院2021年1月至2022...目的:检测急性心肌梗死(acute myocardial infarction,AMI)患者血清C1q/肿瘤坏死因子相关蛋白-6(C1q/tumor necrosis factor related protein 6,CTRP6)表达水平与病情和预后的相关性。方法:选取河南科技大学第一附属医院2021年1月至2022年1月收治的144例AMI患者为研究对象,检测血清CTRP6的表达含量,并分析及评估CTRP6表达与AMI患者的临床特征和MACE的相关性。结果:AMI组患者外周血CTRP6含量为119.32(78.4,165.8)μg/L,显著低于对照组的372.3(303.6,454.2)μg/L(P<0.05);与高表达组比较,低表达组患者血清CK-MB、NT-proBNP、Gensini评分和SYNTAX II评分明显升高(P<0.05),而LVEF明显降低(P<0.05);此外,CTRP6低表达组患者MACE的累积发生率显著高于CTRP6高表达组(P<0.05);CTRP6预测AMI患者发生MACE事件的ROC曲线下面积为0.851。当最佳截断值为当88.423μg/L时,此时的敏感性为75.3%,特异性87.4%。结论:AMI患者血清CTRP6的表达明显降低,且CTRP6低表达可能是识别AMI高危患者和优化治疗策略的重要靶点。展开更多
The utilization of CO2 as raw material for chemical synthesis has the potential for substantial economic and green benefits. Thermal decomposition of hexamethylene-1,6-dicarbamate （HDC） is a promising approach for i...The utilization of CO2 as raw material for chemical synthesis has the potential for substantial economic and green benefits. Thermal decomposition of hexamethylene-1,6-dicarbamate （HDC） is a promising approach for indirect utilization of CO2 to produce hexamethylene-1,6-diisocyanate （HDI）. In this work, a green route was developed for the synthesis of HD1 by thermal decomposition of HDC over Co3O4/ZSM-5 catalyst, using chlorobenzene as low boiling point solvent. Different metal oxide supported catalysts were prepared by incipient wetness impregnation （IWI）, PEG-additive （PEG） and deposition precipitation with ammonia evaporation （DP） methods. Their catalytic performances for the thermal decomposition of HDC were tested. The catalyst screening results showed that Co3O4/ZSM-525 catalysts prepared by different methods showed different performances in the order of Co3O4/ZSM-5 25（PEG） 〉 Co3O4/ZSM-525（IWI） 〉 Co3O4/ZSM-525（DP）. The physicochemical properties of Co3O4/ZSM- 52s catalyst were characterized by XRD, FTIR, N2 adsorption-desorption measurements, NH3-TPD and XPS. The superior catalytic performance of Co3O4/ZSM-52S（PEG） catalyst was attributed to its relative surface content of Co3 ＋, surface lattice oxygen content and total acidity. Under the optimized reaction conditions： 6.5% HDC concentration in chlorobenzene, 1 wt% Co3O4/ZSM-525（PEG） catalyst, 250℃ temperature, 2.5 h time, 800 ml.min 1 nitrogen flow rate and 1.0 MPa pressure, the HDC conversion and HDI yield could reach 100% and 92.8% respectively. The Co3O4/ZSM-525（PEG） catalyst could be facilely separated from the reaction mixture, and reused without degradation in catalytic performance. Furthermore, a possible reaction mechanism was proposed based on the physicochemical properties of the Co3O4/ZSM-5 25 catalysts.展开更多
目的:观察大黄灌肠对重症急性胰腺炎(severe acute pancreatitis,SAP)患者血清高迁移率族蛋白B1(high mobility group B1,HMGB1)、降钙素原(procalcitonin,PCT)、白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis fac...目的:观察大黄灌肠对重症急性胰腺炎(severe acute pancreatitis,SAP)患者血清高迁移率族蛋白B1(high mobility group B1,HMGB1)、降钙素原(procalcitonin,PCT)、白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factorsα,TNF-α)及疾病预后的影响。方法:收集SAP患者60例,随机分为大黄治疗观察组组(大黄灌肠,30例)和常规治疗对照组(肥皂水灌肠,30例),分别在入院后第1、3、5天动态监测各组患者血清的HMGB1、PCT、IL-6与TNF-α浓度变化,并观察患者腹痛腹胀缓解时间、排气排便时间、CRRT时间及2组患者的治疗效果。结果:治疗当天2组患者HMGB1、PCT、IL-6、TNF-α水平差异均无统计学意义(P值分别为0.535、0.876、0.973、0.419);不同时间点间各组炎症因子HMGB1、PCT、IL-6、TNF-α的变化存在统计学差异(P<0.01),并且观察组HMGB1、IL-6、TNF-α的水平较对照组低(P<0.01),而PCT表达差异不存在统计学意义(P=0.059)。Δ3-1HMGB1(第3天与第1天的HMGB1差值)与第3天急性生理与慢性健康(acute physiology and chronic health evaluation system,APACHE)Ⅱ评分呈明显负相关(P<0.01),而PCT、IL-6、TNF-α与第3天APACHEⅡ评分均无明显相关关系(P值均大于0.05)。治疗第5天时,急性胰腺炎严重程度床边指数(bedside index for severity in AP,BISAP)观察组明显较对照组低(P=0.038)。观察组的腹痛腹胀时间、排气排便时间、CRRT时间均较对照组短(P值均小于0.01)。观察组的总体有效率也明显高于对照组(P=0.023)。结论:大黄能够有效抑制重症急性胰腺炎患者炎症因子HMGB1、PCT、IL-6、TNF-α的表达,降低BISAP评分,并且能改善SAP患者的症状和转归,而HMGB1表达量变化可能与患者预后相关。展开更多
文摘目的:检测急性心肌梗死(acute myocardial infarction,AMI)患者血清C1q/肿瘤坏死因子相关蛋白-6(C1q/tumor necrosis factor related protein 6,CTRP6)表达水平与病情和预后的相关性。方法:选取河南科技大学第一附属医院2021年1月至2022年1月收治的144例AMI患者为研究对象,检测血清CTRP6的表达含量,并分析及评估CTRP6表达与AMI患者的临床特征和MACE的相关性。结果:AMI组患者外周血CTRP6含量为119.32(78.4,165.8)μg/L,显著低于对照组的372.3(303.6,454.2)μg/L(P<0.05);与高表达组比较,低表达组患者血清CK-MB、NT-proBNP、Gensini评分和SYNTAX II评分明显升高(P<0.05),而LVEF明显降低(P<0.05);此外,CTRP6低表达组患者MACE的累积发生率显著高于CTRP6高表达组(P<0.05);CTRP6预测AMI患者发生MACE事件的ROC曲线下面积为0.851。当最佳截断值为当88.423μg/L时,此时的敏感性为75.3%,特异性87.4%。结论:AMI患者血清CTRP6的表达明显降低,且CTRP6低表达可能是识别AMI高危患者和优化治疗策略的重要靶点。
基金National Natural Science Foundation of China(21476244 and 21406245)Youth Innovation Promotion Association CAS
文摘The utilization of CO2 as raw material for chemical synthesis has the potential for substantial economic and green benefits. Thermal decomposition of hexamethylene-1,6-dicarbamate （HDC） is a promising approach for indirect utilization of CO2 to produce hexamethylene-1,6-diisocyanate （HDI）. In this work, a green route was developed for the synthesis of HD1 by thermal decomposition of HDC over Co3O4/ZSM-5 catalyst, using chlorobenzene as low boiling point solvent. Different metal oxide supported catalysts were prepared by incipient wetness impregnation （IWI）, PEG-additive （PEG） and deposition precipitation with ammonia evaporation （DP） methods. Their catalytic performances for the thermal decomposition of HDC were tested. The catalyst screening results showed that Co3O4/ZSM-525 catalysts prepared by different methods showed different performances in the order of Co3O4/ZSM-5 25（PEG） 〉 Co3O4/ZSM-525（IWI） 〉 Co3O4/ZSM-525（DP）. The physicochemical properties of Co3O4/ZSM- 52s catalyst were characterized by XRD, FTIR, N2 adsorption-desorption measurements, NH3-TPD and XPS. The superior catalytic performance of Co3O4/ZSM-52S（PEG） catalyst was attributed to its relative surface content of Co3 ＋, surface lattice oxygen content and total acidity. Under the optimized reaction conditions： 6.5% HDC concentration in chlorobenzene, 1 wt% Co3O4/ZSM-525（PEG） catalyst, 250℃ temperature, 2.5 h time, 800 ml.min 1 nitrogen flow rate and 1.0 MPa pressure, the HDC conversion and HDI yield could reach 100% and 92.8% respectively. The Co3O4/ZSM-525（PEG） catalyst could be facilely separated from the reaction mixture, and reused without degradation in catalytic performance. Furthermore, a possible reaction mechanism was proposed based on the physicochemical properties of the Co3O4/ZSM-5 25 catalysts.
文摘目的:观察大黄灌肠对重症急性胰腺炎(severe acute pancreatitis,SAP)患者血清高迁移率族蛋白B1(high mobility group B1,HMGB1)、降钙素原(procalcitonin,PCT)、白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factorsα,TNF-α)及疾病预后的影响。方法:收集SAP患者60例,随机分为大黄治疗观察组组(大黄灌肠,30例)和常规治疗对照组(肥皂水灌肠,30例),分别在入院后第1、3、5天动态监测各组患者血清的HMGB1、PCT、IL-6与TNF-α浓度变化,并观察患者腹痛腹胀缓解时间、排气排便时间、CRRT时间及2组患者的治疗效果。结果:治疗当天2组患者HMGB1、PCT、IL-6、TNF-α水平差异均无统计学意义(P值分别为0.535、0.876、0.973、0.419);不同时间点间各组炎症因子HMGB1、PCT、IL-6、TNF-α的变化存在统计学差异(P<0.01),并且观察组HMGB1、IL-6、TNF-α的水平较对照组低(P<0.01),而PCT表达差异不存在统计学意义(P=0.059)。Δ3-1HMGB1(第3天与第1天的HMGB1差值)与第3天急性生理与慢性健康(acute physiology and chronic health evaluation system,APACHE)Ⅱ评分呈明显负相关(P<0.01),而PCT、IL-6、TNF-α与第3天APACHEⅡ评分均无明显相关关系(P值均大于0.05)。治疗第5天时,急性胰腺炎严重程度床边指数(bedside index for severity in AP,BISAP)观察组明显较对照组低(P=0.038)。观察组的腹痛腹胀时间、排气排便时间、CRRT时间均较对照组短(P值均小于0.01)。观察组的总体有效率也明显高于对照组(P=0.023)。结论:大黄能够有效抑制重症急性胰腺炎患者炎症因子HMGB1、PCT、IL-6、TNF-α的表达,降低BISAP评分,并且能改善SAP患者的症状和转归,而HMGB1表达量变化可能与患者预后相关。
