This article proposes a diffused hepatitis B virus (HBV) model with CTL immune response and nonlinear incidence for the control of viral infections. By means of different Lyapunov functions, the global asymptotical ...This article proposes a diffused hepatitis B virus (HBV) model with CTL immune response and nonlinear incidence for the control of viral infections. By means of different Lyapunov functions, the global asymptotical properties of the viral-free equilibrium and immune-free equilibrium of the model are obtained. Global stability of the positive equilibrium of the model is also considered. The results show that the free diffusion of the virus has no effect on the global stability of such HBV infection problem with Neumann homogeneous boundary conditions.展开更多
In this paper,dynamics analysis of a delayed HIV infection model with CTL immune response and antibody immune response is investigated.The model involves the concentrations of uninfected cells,infected cells,free viru...In this paper,dynamics analysis of a delayed HIV infection model with CTL immune response and antibody immune response is investigated.The model involves the concentrations of uninfected cells,infected cells,free virus,CTL response cells,and antibody antibody response cells.There are three delays in the model:the intracellular delay,virus replication delay and the antibody delay.The basic reproductive number of viral infection,the antibody immune reproductive number,the CTL immune reproductive number,the CTL immune competitive reproductive number and the antibody immune competitive reproductive number are derived.By means of Lyapunov functionals and LaSalle’s invariance principle,sufficient conditions for the stability of each equilibrium is established.The results show that the intracellular delay and virus replication delay do not impact upon the stability of each equilibrium,but when the antibody delay is positive,Hopf bifurcation at the antibody response and the interior equilibrium will exist by using the antibody delay as a bifurcation parameter.Numerical simulations are carried out to justify the analytical results.展开更多
In this paper, a virus infection model with standard incidence rate and delayed CTL immune response is investigated. By analyzing corresponding characteristic equations,the local stability of each of feasible equilibr...In this paper, a virus infection model with standard incidence rate and delayed CTL immune response is investigated. By analyzing corresponding characteristic equations,the local stability of each of feasible equilibria and the existence of Hopf bifurcations at the CTL-activated infection equilibrium are established, respectively. By means of comparison arguments, it is verified that the infection-free equilibrium is globally asymptotically stable if the basic reproduction ratio is less than unity. By using suitable Lyapunov functional and LaSalle's invariance principle, it is shown that the CTL-inactivated infection equilibrium of the system is globally asymptotically stable if the immune response reproduction ratio is less than unity and the basic reproduction ratio is greater than unity. Numerical simulations are carried out to illustrate the theoretical result.展开更多
In this work, we investigate an HIV-1 infection model with a general incidence rate and delayed CTL immune response. The model admits three possible equilibria, an infection-free equilibrium <span><em>E<...In this work, we investigate an HIV-1 infection model with a general incidence rate and delayed CTL immune response. The model admits three possible equilibria, an infection-free equilibrium <span><em>E</em></span><sup>*</sup><sub style="margin-left:-6px;">0</sub>, CTL-inactivated infection equilibrium <span><em>E</em></span><sup>*</sup><sub style="margin-left:-6px;">1</sub> and CTL-activated infection equilibrium <span><em>E</em></span><sup>*</sup><sub style="margin-left:-6px;">2</sub>. We prove that in the absence of CTL immune delay, the model has exactly the basic behaviour model, for all positive intracellular delays, the global dynamics are determined by two threshold parameters <em>R</em><sub>0</sub> and <em>R</em><sub>1</sub>, if <em>R</em><sub>0</sub> <span style="font-size:12px;white-space:nowrap;">≤</span> 1, <span><em>E</em></span><sup>*</sup><span style="margin-left:-6px;"><sub>0</sub> </span>is globally asymptotically stable, if <em>R</em><sub>1</sub> <span style="font-size:12px;white-space:nowrap;">≤</span> 1 < <em>R</em><sub>0</sub>, <span><em>E</em></span><sup>*</sup><span style="margin-left:-6px;"><sub>1</sub> </span>is globally asymptotically stable and if <em>R</em><sub>1</sub> >1, <span><em>E</em></span><sup>*</sup><span style="margin-left:-6px;"><sub>2</sub> </span>is globally asymptotically stable. But if the CTL immune response delay is different from zero, then the behaviour of the model at <span><em>E</em></span><sup>*</sup><span style="margin-left:-6px;"><sub>2</sub> </span>changes completely, although <em>R</em><sub>1</sub> > 1, a Hopf bifurcation at <span><em>E</em></span><sup>*</sup><span style="margin-left:-6px;"><sub>2</sub> </span>is established. In the end, we present some numerical simulations.展开更多
This paper mainly investigates the effect of the lévy jumps on the stochastic HIV infection model with cytotoxic T lymphocytes (CTLs) immune response. First, we prove that there is a unique global positive soluti...This paper mainly investigates the effect of the lévy jumps on the stochastic HIV infection model with cytotoxic T lymphocytes (CTLs) immune response. First, we prove that there is a unique global positive solution in any population dynamics, then we find sufficient conditions for the extinction of the disease. For proofing the persistence in mean, a special Lyapunov function be established, we obtain that if the infected CD4<sup>+</sup> T-cells and virus particles will persistence in mean. Finally, numerical simulations are carried out to illustrate the theoretical results.展开更多
基金supported by the National Natural Science Foundation of China(10971166,10901131)the National High Technology Research and Development Program of China(863 Program,2009AA01A135)the Natural Science Foundation of Xinjiang Province(2010211B04)
文摘This article proposes a diffused hepatitis B virus (HBV) model with CTL immune response and nonlinear incidence for the control of viral infections. By means of different Lyapunov functions, the global asymptotical properties of the viral-free equilibrium and immune-free equilibrium of the model are obtained. Global stability of the positive equilibrium of the model is also considered. The results show that the free diffusion of the virus has no effect on the global stability of such HBV infection problem with Neumann homogeneous boundary conditions.
基金The work was supported by NSF of China(11201002)Natural Science Foundation of Universities in Anhui Province(KJ2017A815).
文摘In this paper,dynamics analysis of a delayed HIV infection model with CTL immune response and antibody immune response is investigated.The model involves the concentrations of uninfected cells,infected cells,free virus,CTL response cells,and antibody antibody response cells.There are three delays in the model:the intracellular delay,virus replication delay and the antibody delay.The basic reproductive number of viral infection,the antibody immune reproductive number,the CTL immune reproductive number,the CTL immune competitive reproductive number and the antibody immune competitive reproductive number are derived.By means of Lyapunov functionals and LaSalle’s invariance principle,sufficient conditions for the stability of each equilibrium is established.The results show that the intracellular delay and virus replication delay do not impact upon the stability of each equilibrium,but when the antibody delay is positive,Hopf bifurcation at the antibody response and the interior equilibrium will exist by using the antibody delay as a bifurcation parameter.Numerical simulations are carried out to justify the analytical results.
基金Supported by the NNSF of China(11371368,11071254)Supported by the NSF of Hebei Province(A2014506015)Supported by the NSF for Young Scientists of Hebei Province(A2013506012)
文摘In this paper, a virus infection model with standard incidence rate and delayed CTL immune response is investigated. By analyzing corresponding characteristic equations,the local stability of each of feasible equilibria and the existence of Hopf bifurcations at the CTL-activated infection equilibrium are established, respectively. By means of comparison arguments, it is verified that the infection-free equilibrium is globally asymptotically stable if the basic reproduction ratio is less than unity. By using suitable Lyapunov functional and LaSalle's invariance principle, it is shown that the CTL-inactivated infection equilibrium of the system is globally asymptotically stable if the immune response reproduction ratio is less than unity and the basic reproduction ratio is greater than unity. Numerical simulations are carried out to illustrate the theoretical result.
文摘In this work, we investigate an HIV-1 infection model with a general incidence rate and delayed CTL immune response. The model admits three possible equilibria, an infection-free equilibrium <span><em>E</em></span><sup>*</sup><sub style="margin-left:-6px;">0</sub>, CTL-inactivated infection equilibrium <span><em>E</em></span><sup>*</sup><sub style="margin-left:-6px;">1</sub> and CTL-activated infection equilibrium <span><em>E</em></span><sup>*</sup><sub style="margin-left:-6px;">2</sub>. We prove that in the absence of CTL immune delay, the model has exactly the basic behaviour model, for all positive intracellular delays, the global dynamics are determined by two threshold parameters <em>R</em><sub>0</sub> and <em>R</em><sub>1</sub>, if <em>R</em><sub>0</sub> <span style="font-size:12px;white-space:nowrap;">≤</span> 1, <span><em>E</em></span><sup>*</sup><span style="margin-left:-6px;"><sub>0</sub> </span>is globally asymptotically stable, if <em>R</em><sub>1</sub> <span style="font-size:12px;white-space:nowrap;">≤</span> 1 < <em>R</em><sub>0</sub>, <span><em>E</em></span><sup>*</sup><span style="margin-left:-6px;"><sub>1</sub> </span>is globally asymptotically stable and if <em>R</em><sub>1</sub> >1, <span><em>E</em></span><sup>*</sup><span style="margin-left:-6px;"><sub>2</sub> </span>is globally asymptotically stable. But if the CTL immune response delay is different from zero, then the behaviour of the model at <span><em>E</em></span><sup>*</sup><span style="margin-left:-6px;"><sub>2</sub> </span>changes completely, although <em>R</em><sub>1</sub> > 1, a Hopf bifurcation at <span><em>E</em></span><sup>*</sup><span style="margin-left:-6px;"><sub>2</sub> </span>is established. In the end, we present some numerical simulations.
文摘This paper mainly investigates the effect of the lévy jumps on the stochastic HIV infection model with cytotoxic T lymphocytes (CTLs) immune response. First, we prove that there is a unique global positive solution in any population dynamics, then we find sufficient conditions for the extinction of the disease. For proofing the persistence in mean, a special Lyapunov function be established, we obtain that if the infected CD4<sup>+</sup> T-cells and virus particles will persistence in mean. Finally, numerical simulations are carried out to illustrate the theoretical results.