Paraneoplastic neurological syndrome refers to certain malignant tumors that have affected the distant nervous system and caused corresponding dysfunction in the absence of tumor metastasis.Patients with this syndrome...Paraneoplastic neurological syndrome refers to certain malignant tumors that have affected the distant nervous system and caused corresponding dysfunction in the absence of tumor metastasis.Patients with this syndrome produce multiple antibodies,each targeting a different antigen and causing different symptoms and signs.The CV2/collapsin response mediator protein 5(CRMP5)antibody is a major antibody of this type.It damages the nervous system,which often manifests as limbic encephalitis,chorea,ocular manifestation,cerebellar ataxia,myelopathy,and peripheral neuropathy.Detecting CV2/CRMP5 antibody is crucial for the clinical diagnosis of paraneoplastic neurological syndrome,and anti-tumor and immunological therapies can help to alleviate symptoms and improve prognosis.However,because of the low incidence of this disease,few repo rts and no reviews have been published about it so far.This article intends to review the research on CV2/CRMP5antibody-associated paraneoplastic neurological syndrome and summarize its clinical features to help clinicians comprehensively understand the disease.Additionally,this review discusses the curre nt challenges that this disease poses,and the application prospects of new detection and diagnostic techniques in the field of paraneoplastic neurological syndrom e,including CV2/CRMP5-associated paraneoplastic neurological syndrome,in recent years.展开更多
Vehicular ad-hoc networks(VANETs)are mobile networks that use and transfer data with vehicles as the network nodes.Thus,VANETs are essentially mobile ad-hoc networks(MANETs).They allow all the nodes to communicate and...Vehicular ad-hoc networks(VANETs)are mobile networks that use and transfer data with vehicles as the network nodes.Thus,VANETs are essentially mobile ad-hoc networks(MANETs).They allow all the nodes to communicate and connect with one another.One of the main requirements in a VANET is to provide self-decision capability to the vehicles.Cognitive memory,which stores all the previous routes,is used by the vehicles to choose the optimal route.In networks,communication is crucial.In cellular-based vehicle-to-everything(CV2X)communication,vital information is shared using the cooperative awareness message(CAM)that is broadcast by each vehicle.Resources are allocated in a distributed manner,which is known as Mode 4 communication.The support vector machine(SVM)algorithm is used in the SVM-CV2X-M4 system proposed in this study.The k-fold model with different values of k is used to evaluate the accuracy of the SVM-CV2XM4 system.The results show that the proposed system achieves an accuracy of 99.6%.Thus,the proposed system allows vehicles to choose the optimal route and is highly convenient for users.展开更多
基金National Natural Science Foundation of China,No.U1604181Henan Province Key R&D and Promotion Special Project (Science and Technology Tackle),No.212102310834+1 种基金Henan Medical Education Research Project,No.Wjlx2020531the Joint project of Medical Science and Technology Research Program of Henan Province,No.LHGJ20190078 (all to JW)。
文摘Paraneoplastic neurological syndrome refers to certain malignant tumors that have affected the distant nervous system and caused corresponding dysfunction in the absence of tumor metastasis.Patients with this syndrome produce multiple antibodies,each targeting a different antigen and causing different symptoms and signs.The CV2/collapsin response mediator protein 5(CRMP5)antibody is a major antibody of this type.It damages the nervous system,which often manifests as limbic encephalitis,chorea,ocular manifestation,cerebellar ataxia,myelopathy,and peripheral neuropathy.Detecting CV2/CRMP5 antibody is crucial for the clinical diagnosis of paraneoplastic neurological syndrome,and anti-tumor and immunological therapies can help to alleviate symptoms and improve prognosis.However,because of the low incidence of this disease,few repo rts and no reviews have been published about it so far.This article intends to review the research on CV2/CRMP5antibody-associated paraneoplastic neurological syndrome and summarize its clinical features to help clinicians comprehensively understand the disease.Additionally,this review discusses the curre nt challenges that this disease poses,and the application prospects of new detection and diagnostic techniques in the field of paraneoplastic neurological syndrom e,including CV2/CRMP5-associated paraneoplastic neurological syndrome,in recent years.
文摘Vehicular ad-hoc networks(VANETs)are mobile networks that use and transfer data with vehicles as the network nodes.Thus,VANETs are essentially mobile ad-hoc networks(MANETs).They allow all the nodes to communicate and connect with one another.One of the main requirements in a VANET is to provide self-decision capability to the vehicles.Cognitive memory,which stores all the previous routes,is used by the vehicles to choose the optimal route.In networks,communication is crucial.In cellular-based vehicle-to-everything(CV2X)communication,vital information is shared using the cooperative awareness message(CAM)that is broadcast by each vehicle.Resources are allocated in a distributed manner,which is known as Mode 4 communication.The support vector machine(SVM)algorithm is used in the SVM-CV2X-M4 system proposed in this study.The k-fold model with different values of k is used to evaluate the accuracy of the SVM-CV2XM4 system.The results show that the proposed system achieves an accuracy of 99.6%.Thus,the proposed system allows vehicles to choose the optimal route and is highly convenient for users.
