Effect of drying-wetting cycles on pore characteristics and mechanical properties of enzyme-induced carbonate precipitation-reinforced sea sand

Enzyme-induced carbonate precipitation(EICP)is an emanating,eco-friendly and potentially sound technique that has presented promise in various geotechnical applications.However,the durability and microscopic characteristics of EICP-treated specimens against the impact of drying-wetting(D-W)cycles is under-explored yet.This study investigates the evolution of mechanical behavior and pore charac-teristics of EICP-treated sea sand subjected to D-W cycles.The uniaxial compressive strength(UCS)tests,synchrotron radiation micro-computed tomography(micro-CT),and three-dimensional(3D)recon-struction of CT images were performed to study the multiscale evolution characteristics of EICP-reinforced sea sand under the effect of D-W cycles.The potential correlations between microstructure characteristics and macro-mechanical property deterioration were investigated using gray relational analysis(GRA).Results showed that the UCS of EICP-treated specimens decreases by 63.7% after 15 D-W cycles.The proportion of mesopores gradually decreases whereas the proportion of macropores in-creases due to the exfoliated calcium carbonate with increasing number of D-W cycles.The micro-structure in EICP-reinforced sea sand was gradually disintegrated,resulting in increasing pore size and development of pore shape from ellipsoidal to columnar and branched.The gray relational degree suggested that the weight loss rate and UCS deterioration were attributed to the development of branched pores with a size of 100-1000 m m under the action of D-W cycles.Overall,the results in this study provide a useful guidancee for the long-term stability and evolution characteristics of EICP-reinforced sea sand under D-W weathering conditions.

Coupling Effect of Cryogenic Freeze-Thaw Cycles and Chloride Ion Erosion Effect in Pre-Cracked Reinforced Concrete

Chloride (Cl−) ion erosion effects can seriously impact the safety and service life of marine liquefied natural gas(LNG) storage tanks and other polar offshore structures. This study investigates the impact of different low-temperaturecycles (20°C, –80°C, and −160°C) and concrete specimen crack widths (0, 0.3, and 0.6 mm) on the Cl−ion diffusion performance through rapid erosion tests conducted on pre-cracked concrete. The results show thatthe minimum temperature and crack width of freeze-thaw cycles enhance the erosive effect of chloride ions. TheCl− ion concentration and growth rate increased with the increasing crack width. Based on the experimental modeland in accordance with Fick’s second law of diffusion, the Cl− ion diffusion equation was modified by introducingcorrection factors in consideration of the freeze-thaw temperature, crack width, and their coupling effect.The experimental and fitting results obtained from this model can provide excellent reference for practical engineeringapplications.

Jovian Planet Influence on the Forcing of Sunspot Cycles

The history of our solar system has been greatly influenced by the fact that there is a large gas giant planet, Jupiter that has a nearly circular orbit. This has allowed relics of the early solar system formation to still be observable today. Since Jupiter orbits the Sun with a period of approximately 12 years, it has always been thought that this could be connected to the nearly 11-year periodic peak in the number of sunspots observed. In this paper, the Sun and planets are considered to be moving about a center of mass point as the different planets orbit the Sun. This is the action of gravity that holds the solar system together. The center of mass for the Jupiter-Sun system actually lies outside the Sun. The four gas giant planets dominate such effects and the four gas giant Jovian planets can be projected together to determine an effective distance from the Sun’s center. Taken together these effects do seem to function as a sunspot forcing factor with a periodicity very close to 11 years. These predictions are made without consideration of any details of what is happening in the interior of the Sun. From these estimates, sunspot cycle 25 will be expected to peak in about September-October of 2025. Sunspot cycle 26 should peak in the year March of 2037.

Conjuncture Cycles and Monetary Anomalies Are Unwelcome Guests for Sustainability

Economic cycles are not economic evils but rather healing agents for returning to equilibrium,just as inflation and deflation are not economic misfortunes but the sign of bad governance and a bitter medicine for returning to calm monetary.Unfortunately,signs of poor governance are mistaken for unfortunate events,but are instead tools offered to restore economic systems.Politics seeks consensus and does not accept the bitter cure of recession.Monetary policy is therefore called into question even if monetary anomalies also depend on errors in the management of the economy;the result is the gradual increase in interest rates.Is the idea that we can achieve the goal of complete neutrality with nature acceptable in a global economic framework pervaded by inflation and denunciation?Can we similarly argue that economic problems can coexist once the goal of neutrality has been achieved?The answer is negative.We must correct these anomalies and dysfunctions of the economy,which cannot coexist in the new context of complete and indefinite equilibrium of tomorrow.And not even the idea that conflicts can be resolved with war seems to find a place in the renewed scenario of neutrality.In this regard we can remember that,when we have reached the economic optimum of complete neutrality,or at least we are close to it,the most socially and economically advanced territories and continents will benefit from an acceleration of productivity and development.Scarcity itself will give way to the new,long-awaited reality.A condition that approaches the state of abundance and which will produce surpluses to be allocated to countries and territories that are struggling towards the condition of neutrality.The acceleration of lagging continents and the recovery of altered economic systems are therefore preconditions that can allow us to access the state of global neutrality.As we get closer to the great objective,it is to be believed that the pretense of regulating conflicts through war will also disappear.With the new reality of abundance,the economic reason for war disappears,while the aspiration of peoples-inscribed in their DNA-for solidarity and peaceful aggregation towards substantial unity becomes clear.

Statistical Study of the Geoeffectivity of Halo Coronal Mass Ejections Associated with X-Class Flares during Solar Cycles 23 and 24

By analysing a long series of data (1996-2019), we show that solar cycle 23 was more marked by violent solar flares and coronal mass ejections (CMEs) compared to solar cycle 24. In particular, the halo coronal mass ejections associated with X-class flares appear to be among the most energetic events in solar activity given the size of the flares, the speed of the CMEs and the intense geomagnetic storms they produce. Out of eighty-six (86) X-class halo CMEs, thirty-seven (37) or 43% are highly geoeffective;twenty-four (24) or approximately 28% are moderately geoeffective and twenty-five (25) or 29% are not geoeffective. Over the two solar cycles (1996 to 2019), 71% of storms were geoeffective and 29% were not. For solar cycle 23, about 78% of storms were geoeffective, while for solar cycle 24, about 56% were geoeffective. For the statistical study based on speed, 85 halo CMEs associated with X-class flares were selected because the CME of 6 December 2006 has no recorded speed value. For both solar cycles, 75.29% of the halo CMEs associated with X-class flares have a speed greater than 1000 km/s. The study showed that 42.18% of halo (X) CMEs with speeds above 1000 km/s could cause intense geomagnetic disturbances. These results show the contribution (in terms of speed) of each class of halo (X) CMEs to the perturbation of the Earth’s magnetic field. Coronal mass ejections then become one of the key indicators of solar activity, especially as they affect the Earth.

Heteroclinic Cycles in a Class of 3-Dimensional Piecewise Affine Systems

This paper explores the existence of heteroclinic cycles and corresponding chaotic dynamics in a class of 3-dimensional two-zone piecewise affine systems. Moreover, the heteroclinic cycles connect two saddle foci and intersect the switching manifold at two points and the switching manifold is composed of two perpendicular planes.

CO2 Air-Water Exchanges during Seasonal and Glacial Cycles

Based on the photosynthesis-respiration reversible reaction and the available statistics, we attempted to quantify the planetary seasonal exchanges of CO2 between air and water from 1970 and compared them to the glacial ACC cycles as reported from ice cores archives. In 2020, the overall continental absorption (AW) was 8.0 giga tonnes of carbon per year (GtC/y). Emissions into the atmosphere (EW) resulting from mineral degradation by respiration and combustion of biomass and fossil hydrocarbons were 14.7 GtC/y, an increase of 2.4% per year since 1970. The continental surplus balance (-AW+EW) of 6.7 GtC/y was shared between the atmosphere, which received 5.1 GtC/y (GATM), and the ocean which absorbed 1.6 GtC/y. This ocean contribution (OC) corresponded to 17% of the 9.2 GtC/y emissions by combustion of fossil hydrocarbons (EFOS). Analysis of the ACC oscillations during 2020 in the northern hemisphere showed that the ocean absorbed 11.1 GtC during the warm season and outgassed 9.5 GtC during the cold season. Assuming proportionality to world population, the ACC, 414 parts per million (ppm) in 2021, would reach 584 ppm in 2080, still growing at a rate of 0.6% per year. The gain of atmospheric CO2 (GATM) and its absorption by the ocean (OC) were expected to peak at 7.0 and 2.2 GtC/y, respectively, in 2080. This increase in the availability of atmospheric CO2 resulted in improved yields of agriculture which more than compensated for the reduction by half of food-producing areas per capita from 1970.

Effect of High Temperature Curing on the Frost Resistance of Recycled Aggregate Concrete and the Physical Properties of Second-Generation Recycled Coarse Aggregate under Freeze-Thaw Cycles

With the emphasis on environmental issues,the recycling of waste concrete,even recycled concrete,has become a hot spot in the field of architecture.But the repeated recycling of waste concrete used in harsh environments is still a complex problem.This paper discusses the durability and recyclability of recycled aggregate concrete(RAC)as a prefabricated material in the harsh environment,the effect of high-temperature curing(60℃,80℃,and 100℃)on the frost resistance of RAC and physical properties of the second generation recycled coarse aggregate(RCA_(2))of RAC after 300 freeze-thaw cycles were studied.The frost resistance of RAC was characterized by compressive strength,relative dynamic elastic modulus,and mass loss.As the physical properties of RCA_(2),the apparent density,water absorption,and crushing value were measured.And the SEM images of RAC after 300 freeze-thaw cycles were shown.The results indicated that the frost resistance of RAC cured at 80℃ for 7 days was comparable to that cured in the standard condition(cured for 28 days at 20℃±2℃ and 95%humidity),and the RAC cured at 100℃ was slightly worse.However,the frost resistance of RAC cured at 60℃ deteriorated seriously.The RAC cured at 80℃ for 7 days is the best.Whether after the freeze-thaw cycle or not,the RCA that curd at 60℃,80℃,and 100℃ for 7 days can also meet the requirements of Grade III RCA and be used as the aggregate of non-bearing part of prefabricated concrete components.RCA_(2) which is cured at 80℃ for 7 days had the best physical properties.

Stability analysis of gravity anchor foundation of layered argillaceous sandstone under dry-wet cycles

To investigate the stability of gravity anchors of suspension bridges,in-situ tests of the vertical bearing capacity of the bedrock,shear resistance of the anchor-rock interface,shear resistance of the bedrock were conducted in a suspension bridge project.Under dry-wet cycles,the deterioration law of the mechanical properties of argillaceous sandstone was identified in laboratory tests:the elastic modulus,cohesion and friction of the argillaceous sandstone deteriorated significantly at first few dry-wet cycles and then declined slowly after 10 cycles,ultimately these three mechanical parameters were reduced to about 1/3,1/3,2/3 of the initial value respectively.Moreover,numerical simulation was used to restore in-situ shear tests and a good agreement was obtained.Base on the results of in-situ and laboratory tests,the stability of the gravity anchor foundation under natural conditions and drywet cycles was calculated and its failure modes were analyzed.The results demonstrated that the dry-wet cycles caused uneven settlement of the anchor foundation,resulting in more serious stress concentration in the substrate.The dry-wet cycles remarkably reduced the stability coefficient of the anchor foundation,whose failure mode shifted from overturning failure under natural conditions to sliding failure.When there was weak interlayer in the rock layer,the anti-sliding stability of the anchor foundation was affected drastically.

Mechanical and acoustic emission characteristics of anhydrite rock under freeze-thaw cycles

To study the damage mechanisms of anhydrite rock under freeze-thaw cycles, the physicalmechanical properties and the microcracking activities of anhydrite rock were investigated through mass variation, nuclear magnetic resonance, scanning electron microscope tests, and uniaxial compression combined with acoustic emission(AE) tests. Results show that with the increase of freeze-thaw processes,the mass, uniaxial compression strength, and elastic modulus of the anhydrite specimens decrease while the porosity and plasticity characteristics increase.For example, after 120 cycles, the uniaxial compression strength and elastic modulus decrease by 46.54% and 60.16%, and the porosity increase by 75%. Combined with the evolution trend of stressstrain curves and the detected events, three stages were labeled to investigate the AE characteristics in freeze-thaw weathered anhydrite rock. It is found that with the increase of freeze-thaw cycles, the proportions of AE counts in stage Ⅰ and stage Ⅱ show a decaying exponential trend. Contrarily, the proportion of AE counts in stage Ⅲ displays an exponential ascending trend. Meanwhile, as the freeze-thaw cycles increase, the low-frequency AE signals increase while the intermediate-frequency AE signals decrease. After 120 cycles, the proportion of low-frequency AE signals increases by 168.95%, and the proportion of intermediate-frequency AE signals reduces by 81.14%. It is concluded that the microtensile cracking events occupy a dominant position during the loading process. With the increase of freeze-thaw cycles, the b value of samples decreases.After 120 cycles, b value decreases by 27.2%, which means that the proportion of cracking events in rocks with small amplitude decreases. Finally, it is proposed that the freeze-thaw damage mechanism of anhydrite is also characterized by the water chemical softening effect.

Frost heaving force considering synchronous damage to tunnel lining and surrounding rocks under freeze—thaw cycles

In areas with seasonal freezing,when the tunnel lining concrete is saturated with water infiltrating the interior,the lining and the surrounding rocks will simultaneously freeze.However,the current calculation of the frost heaving force fails to consider the synchronous damage to the lining and surrounding rocks under freeze-thaw cycles.Therefore,as per the elastic calculation model of the frost heaving force and model of steady-state heat transfer of circular tunnels,this study introduces the frost heaving rate of lining and surrounding rocks.First,the analytical solution of frost heaving force is obtained for simultaneous frost heaving of lining and surrounding rocks under any steady-state temperature field.Then,based on the fracture theory and meso-damage mechanics,the damage variables of lining and surrounding rocks under freeze-thaw cycles are extracted,representing their elastic modulus and porosity.Finally,the formula of frost heaving force for synchronous damage to the lining and surrounding rocks at any steady-state temperature field is obtained.The calculation results demonstrate that the lower the temperature inside the lining,the greater the frost heaving force.With the increasing number of freeze-thaw cycles,frost heaving force tends to gradually increase initially,reaching a peak value at 85 freeze-thaw cycles,decreasing to 80%of the peak value at 140 cycles before reaching a constant value.The lining participates in frost heaving,increasing the frost heaving force.The initial increase rate of frost heaving force is 15.7%.Changing the fitting coefficients s1 and s2 of the lining and surrounding rocks can effectively control the magnitude of the frost heaving force in the tunnels.

Dynamic mechanical characteristics of frozen subgrade soil subjected to freeze-thaw cycles

As a widely-applied engineering material in cold regions, the frozen subgrade soils are usually subjected to seismic loading, which are also dramatically influenced by the freeze-thaw(F-T)cycles due to the varying temperature. A series of dynamic cyclic triaxial experiments were conducted through a cryogenic triaxial apparatus for exploring the influences of F-T cycles on the dynamic mechanical properties of frozen subgrade clay.According to the experimental results of frozen clay at the temperature of-10℃, the dynamic responses and microstructure variation at different times of F-T cycles(0, 1, 5, and 20 cycles) were explored in detail.It is experimentally demonstrated that the dynamic stress-strain curves and dynamic volumetric strain curves of frozen clay are significantly sparse after 20F-T cycles. Meanwhile, the cyclic number at failure(Nf) of the frozen specimen reduces by 89% after 20freeze-thaw cycles at a low ratio of the dynamic stress amplitude. In addition, with the increasing F-T cycles,the axial accumulative strain, residual deformation,and the value of damage variable of frozen clay increase, while the dynamic resilient modulus and dynamic strength decrease. Finally, the influence of the F-T cycles on the failure mechanisms of frozen clay was discussed in terms of the microstructure variation. These studies contribute to a better understanding of the fundamental changes in the dynamic mechanical of frozen soils exposed to F-T cycles in cold and seismic regions.

The Effect of Different Freeze-Thaw Cycles on Mortar Gas Permeability and Pore Structure

Two different freeze-thaw cycles(FTC)are considered in this study to assess the related impact on gas permeability and micro-pore structure of a mortar.These are the water-freezing/water-thawing(WF-WT)and the air-freezing/air-thawing(AF-AT)cycles.The problem is addressed experimentally through an advanced nuclear magnetic resonance(NMR)technique able to provide meaningful information on the relationships among gas permeability,pore structure,mechanical properties,and the number of cycles.It is shown that the mortar gas permeability increases with the number of FTCs,the increase factor being 20 and 12.83 after 40 cycles for the WF-WT and AF-AT,respectively.The results also confirm that gas permeability hysteresis phenomena occur during the confining pressure loading and unloading process.

Effect of Dry-Wet Cycles on the Transport and Mechanical Properties of Cement Mortar Subjected to Sulfate Attack

This study deals with the analysis of the detrimental effects of a“sulfate attack”on cement mortar for different dry-wet cycles.The mass loss,tensile strength,and gas permeability coefficient were determined and analyzed under different exposure conditions.At the same time,nitrogen adsorption(NAD),scanning electron microscopy(SEM),and X-ray diffraction(XRD)techniques were used to analyze the corresponding variations in the microstructure and the corrosion products.The results show that certain properties of the cement mortar evolve differently according to the durations of the dry-wet cycles and that some damage is caused to the mortars in aqueous solution.The pores fill with corrosion products,increasing the mortar specimen mass and tensile strength while reducing the permeability coefficient and pore size distribution.As corrosion proceeds,the crystallization pressure of the corrosion products increases,resulting in a 16%reduction in tensile strength from the initial value and a 2.6-factor increase in the permeability coefficient,indicating sensitivity to sulfate attack damage.Furthermore,the main corrosion products generated in the experiment are gypsum and ettringite.Application of osmotic pressure and extension of the immersion time can accelerate the erosion process.

Influence of relative compaction and degree of saturation on the deformation characteristics of bentonite under freeze-thaw cycles

Bentonite,consisting of clay minerals of the montmorillonite group,has been widely used as an adsorbent and backfill material in nuclear waste disposal and groundwater remediation.It is challenging to use bentonite as a filling material in cold regions since bentonite is highly sensitive to thermal environmental changes,during which its bulk volume and microstructure change significantly.In this study,a series of one-dimensional and three-dimensional freeze-thaw tests were carried out within a closed system to investigate the influencing factors of the deformation of bentonite under freeze-thaw cycles.Results show that the initial soil water content greatly impacts bentonite's deformation during freeze-thaw cycles.For an initial higher degree of saturation(Sr),the expansion caused by the formation of ice lenses has a greater impact than the shrinkage induced by dehydration,ice-cementation,and so on.Conversely,bentonite tends to shrink at a lower degree of saturation during freezing.And the critical degree of saturation that determines bentonite's behavior of frost heave or frost shrinkage seems to be roughly 0.8.As the number of freeze-thaw cycles rises,initially uncompacted bentonite clay becomes more compacted,and initially compacted bentonite clay remains unchanged.

Prognostic effect of excessive chemotherapy cycles for stage Ⅱ and Ⅲ gastric cancer patients after D2 + gastrectomy

BACKGROUND According to relevant investigation and analysis,there are few research studies on the effect of excessive chemotherapy cycles after D2 gastrectomy on the survival of patients with gastric cancer.AIM To determine whether excessive chemotherapy cycles provide extra survival benefits,reduce recurrence rate,and improve survival rate in patients with stage Ⅱ or Ⅲ gastric cancer.METHODS We analyzed and summarized 412 patients with stage Ⅱ gastric cancer and 902 patients with stage Ⅲ gastric cancer who received D2 gastrectomy plus adjuvant chemotherapy or neoadjuvant chemotherapy.Analysis and comparison at a ratio of 1:1 is aimed at reducing realistic baseline differences(n=97 in each group of stage Ⅱ,n=242 in each group of stage Ⅲ).Progression-free survival,overall survival and recurrence were the main outcome indicators.RESULTS When the propensity score was matched,the baseline features of stage Ⅱ and Ⅲ gastric cancer patients were similar between the two groups.After a series of investigations,Kaplan-Meier found that the progression-free survival and overall survival of stage Ⅱ and Ⅲ gastric cancer patients were consistent between the two groups.The local metastasis rate(P=0.002),total recurrence rate(P<0.001)and distant metastasis rate(P=0.001)in the≥9 cycle group of stage Ⅲ gastric cancer were statistically lower than those in the<9 cycle group.The interaction analysis by Cox proportional hazard regression model showed that intestinal type,proximal gastrectomy,and≥6 cm maximum diameter of tumor had a higher risk of total mortality in the<9 cycles group.CONCLUSION Overall,≥9 chemotherapy cycles is not recommended for patients with stage Ⅱ and stage Ⅲ gastric cancer because it has an insignificant role in the prognosis of gastric cancer.However,for patients with stage Ⅲ gastric cancer,≥9 cycles of chemotherapy was shown to significantly decrease recurrence.

Pulmonary reversed halo cycles and consolidations after immunotherapy:A case report

BACKGROUND Immune checkpoint inhibitor-associated interstitial lung disease(ICI-ILD)and opportunistic pneumonias are the main pulmonary complications during immunotherapy for malignancies.The organizing pneumonia(OP)pattern is one of the common radiological manifestations of ICI-ILD,and OP is the most common cause of reversed halo cycles and consolidations.However,opportunistic pneumonias should be excluded.CASE SUMMARY In this report,we described a case of a 44-year-old man with esophageal cancer who showed multiple reversed-halo cycles and consolidations on chest computed tomography(CT)after he had a cold during immunotherapy.He was diagnosed with esophageal squamous-cell cancer(T2NIM0)after surgery.Then,he was successfully treated with 6 cycles of chemotherapy plus tislelizumab,one cycle of radiotherapy and 9 cycles of tislelizumab.Two months later,he complained of low-grade fever and cough with nonpurulent sputum after he had a cold.Community-acquired pneumonia was considered,but moxifloxacin was ineffective.Chest CT showed multiple reversed-halo cycles and consolidations.Mycobacterium tuberculosis was identified with next-generation sequence analysis of bronchoalveolar lavage fluid(BALF).Two months later,he improved with standard anti-tuberculosis medications.Both the cycles and consolidations disappeared in the repeat CT after 6 mo of medications.CONCLUSION When chest CT shows reversed-halo cycles and consolidations in patients during anticancer immunotherapy,both ICI-ILD and infectious pneumonia should be considered.BALF microbiological analysis was helpful to differentiate them.

Crossing Limit Cycles of Planar Piecewise Hamiltonian Systems with Linear Centers Separated by Two Parallel Straight Lines

In this paper, we have studied several classes of planar piecewise Hamiltonian systems with three zones separated by two parallel straight lines. Firstly, we give the maximal number of limit cycles in these classes of systems with a center in two zones and without equilibrium points in the other zone (or with a center in one zone and without equilibrium points in the other zones). In addition, we also give examples to illustrate that it can reach the maximal number.

Integrated strategies for chemotherapy cycles in nasopharyngeal carcinoma patients: Real-world data from two epidemic centers guiding decision-making

objective:Two cycles of induction chemotherapy(IC)followed by 2 cycles of platinum-based concurrent chemoradiotherapy(CCRT)(2IC+2CCRT)for locoregionally advanced nasopharyngeal carcinoma(LA-NPC)is widely adopted but not evidence-confirmed.This study aimed to determine the clinical value of 2IC+2CCRT regarding efficacy,toxicity and cost-effectiveness.Methods:This real-world study from two epidemic centers used propensity score matching(PSM)and inverse probability of treatment weighting(IPTW)analyses.The enrolled patients were divided into three groups based on treatment modality:Group A(2IC+2CCRT),Group B(3IC+2CCRT or 2IC+3CCRT)and Group C(3IC+3CCRT).Long-term survival,acute toxicities and cost-effectiveness were compared among the groups.We developed a prognostic model dividing the population into high-and low-risk cohorts,and survivals including overall survival(OS),progression-free survival(PFS),distant metastasis-free survival(DMFS)and locoregional relapse-free survival(LRRFS)were compared among the three groups according to certain risk stratifications.Results:Of 4,042 patients,1,175 were enrolled,with 660,419,and 96 included in Groups A,B and C,respectively.Five-year survivals were similar among the three groups after PSM and confirmed by IPTW.Grade 3-4 neutropenia and leukocytopenia were significantly higher in Groups C and B than in Group A(52.1%vs.41.5%vs.25.2%;41.7%vs.32.7%vs.25.0%)as were grade 3-4 nausea/vomiting and oral mucositis(29.2%vs.15.0%vs.6.1%;32.3%vs.25.3%vs.18.0%).Cost-effective analysis suggested that 2IC+2CCRT was the least expensive,while the health benefits were similar to those of the other groups.Further exploration showed that 2IC+2CCRT tended to be associated with a shorter PFS in high-risk patients,while 3IC+3CCRT potentially contributed to poor PFS in low-risk individuals,mainly reflected by LRRFS.Conclusions:In LA-NPC patients,2IC+2CCRT was the optimal choice regarding efficacy,toxicity and costeffectiveness;however,2IC+2CCRT and 3IC+3CCRT probably shortened LRRFS in high-and low-risk populations,respectively.

The law of strength damage and deterioration of jointed sandstone after dry-wet cycles

Under the periodic rise and fall of the water level in the Three Gorges Reservoir in China,the rock mass in the ebb and flow zone of the slope is always in a state of a dry-wet cycle.In order to explore the influence of dry-wet cycle on mechanical properties of jointed sandstone,the triaxial and uniaxial compression tests of dry-wet cycle of jointed sandstone were carried out.For the experiment,four groups of samples with different numbers of joints were set up,and the jointed rock samples were subjected to 20 dry-wet cycles.Using both the triaxial compression test and the Mohr-Coulomb(M-C)rock fracture criterion,the strength envelope of the sandstone samples was fitted,and their strength degradation was further analyzed and studied.The results show that:(1)The peak intensity and elastic modulus of the sandstone samples decrease with increased number of dry-wet cycles.(2)The total deterioration of mechanical properties of intact rock samples is bigger than that of jointed sandstone samples as the number of dry-wet cycles increases.(3)With the increase of confining pressure,the peak intensity of intact sandstone samples increases much more than that of jointed sandstone samples,which indicates that joints and their numbers have obvious influence.(4)Joints and their numbers play an important role in guiding the damage effects of sandstone samples,which weaken the damage caused by dry-wet cycles.Therefore,the envelope of the M-C strength criterion of intact sandstone samples moves more than that of jointed sandstone samples.