In the absence of organic solvents,the Lewis acid catalyzed cyclocondensation reactions between 1-naphthol and benzils gave 3-aryl-3-aryl'naphtho[1,2-b]furan-2(3H)-ones(NFs) in good yields(62%~70%)An electrophili...In the absence of organic solvents,the Lewis acid catalyzed cyclocondensation reactions between 1-naphthol and benzils gave 3-aryl-3-aryl'naphtho[1,2-b]furan-2(3H)-ones(NFs) in good yields(62%~70%)An electrophilic substitution mechanism involving formation of n-EPD/v- EPA complexes and rearrangement of aryl group was proposed.展开更多
Mesoporous MCM-41 supported Schiff base and Cu SO4· 5H2 O shows high catalytic activity in the cyclocondensation of mercaptoacetic acid with imines(or aldehydes and amines) to afford pharmaceutically important ...Mesoporous MCM-41 supported Schiff base and Cu SO4· 5H2 O shows high catalytic activity in the cyclocondensation of mercaptoacetic acid with imines(or aldehydes and amines) to afford pharmaceutically important thiazolidinone derivatives. The catalytic reactions involving twocomponents or three-components afforded the desired product in high yields(up to 98% and 99%).Moreover, the catalyst works well with respect to recyclability, giving the product in 85% and 83% yields after recycling six times.展开更多
Although the NHC-catalyzed cyclization reactions have been well established for the synthesis of various heterocycles,the corresponding all carbon cyclization reaction for the synthesis of carbocycles is far less esta...Although the NHC-catalyzed cyclization reactions have been well established for the synthesis of various heterocycles,the corresponding all carbon cyclization reaction for the synthesis of carbocycles is far less established.In this note,the NHC-catalyzed all carbon[4+2]cyclocondensation of α,β-unsaturated acyl chlorides and 3-alkenyloxindoles was developed to give the corresponding spirocarbocyclic oxindoles in good yield with good to high diastereoselectivities.展开更多
Oxidative cyclocondensation of o-aminobenzamide with various aldehydes in water using I2/KI as catalyst and oxidizing agent is carded out giving the corresponding quinazolin-4(3H)-ones 3a-n in good to excellent yields.
A facile one-pot synthesis of new 3-arylthieno[2,3-d]pyrimidine-2,4(1H,3H)-diones via base-catalyzed cyclocondensation of ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate with aryl isocyanates is described.
2H-3,l-Pyrazolo[3,4-e]oxazines (5a-c) and tacrine analogies (6a-c) were designed and prepared using 5-amino-4-cyanopyrazole (7) and cycloketones (2a-c) as reactants. The study demonstrated that the new conversion exis...2H-3,l-Pyrazolo[3,4-e]oxazines (5a-c) and tacrine analogies (6a-c) were designed and prepared using 5-amino-4-cyanopyrazole (7) and cycloketones (2a-c) as reactants. The study demonstrated that the new conversion existed in the Friedlander reaction of o-aminocyanopyrazole with cycloketones. (C) 2007 Jia Rong Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.展开更多
A cheap and recyclable ZnO-beta zeolite was used as catalyst for the synthesis of benzothiazole derivatives.This method provides several advantages such as environmental friendliness,short reaction times,high yields,s...A cheap and recyclable ZnO-beta zeolite was used as catalyst for the synthesis of benzothiazole derivatives.This method provides several advantages such as environmental friendliness,short reaction times,high yields,simple work-up procedure and catalyst was successfully reused for four cycles without significant loss of activity.展开更多
Two different skeletons of heterocyclic compounds, quinoline and quinazolinone analogs could be obtained by a novel one-pot synthesis from substituted 3-amino- 1H-benzo[f]chromene-2-carbonitrile derivatives and cycloh...Two different skeletons of heterocyclic compounds, quinoline and quinazolinone analogs could be obtained by a novel one-pot synthesis from substituted 3-amino- 1H-benzo[f]chromene-2-carbonitrile derivatives and cyclohexanone in DMF in the catalyst of anhydrous Zinc chloride under reflux. A plausible mechanism was proposed. 2007 Jia Rong Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.展开更多
A new compound 3-(2-(3,5-diphenyl-4,5-dihydropyrazol-1-yl)thiazol-4-yl)-2Hchromen-2-one was synthesized by cyclocondensation of 3,5-diphenyl-4,5-dihydropyrazole-1-carbothioamide with 3-(2-bromoacetyl)-2H-chromen...A new compound 3-(2-(3,5-diphenyl-4,5-dihydropyrazol-1-yl)thiazol-4-yl)-2Hchromen-2-one was synthesized by cyclocondensation of 3,5-diphenyl-4,5-dihydropyrazole-1-carbothioamide with 3-(2-bromoacetyl)-2H-chromen-2-one in ethanol at reflux for 2hrs. The compound was characterized by IR, 1H-NMR, 13C-NMR and single-crystal X-ray diffraction analysis. The newly synthesized compound(C27H19N3O2S) crystallizes in the triclinic system, space group P1 with a = 5.2476(6), b = 18.289(2), c = 23.115(3) , α = 93.546(7), β = 94.715(6), γ = 92.347(7)°, V = 2204.3(4)3, Z = 4, Mr = 449.51, crystal size = 0.38 mm × 0.22 mm × 0.16 mm,(I 2σ(I)) = 35317, 9736, 3785, Rint = 0.081,(Δρ)max = 0.19 and(Δρ)min = –0.24 e·-3. DNA interaction studies revealed that the target compound strongly interacts with DNA through an intercalation binding mode and the binding constant of the compound is 7.45 × 104 M-1.展开更多
Eight new compounds containing in their structures substituted quinoline and pyrazole entity were synthesized in good to excellent yield by cyclocondensation reaction of chalcones and hydrazine hydrate. This reaction ...Eight new compounds containing in their structures substituted quinoline and pyrazole entity were synthesized in good to excellent yield by cyclocondensation reaction of chalcones and hydrazine hydrate. This reaction was conducted in formic acid in presence of BF3·Et2O or in acetic acid. These approaches were extended to bis-chalcones, which delivered functionalized bispyrazolines. The structures of the prepared compounds were confirmed by IR, 1HNMR, 13CNMR and mass spectral analysis.展开更多
We discovered that a-chymotrypsin has a promiscuous ability to catalyze the cyclocondensation of aromatic and aliphatic aldehydes with 2-aminobenzamides to afford the corresponding 2,3-dihydroquinazolin-4(1H)-ones s...We discovered that a-chymotrypsin has a promiscuous ability to catalyze the cyclocondensation of aromatic and aliphatic aldehydes with 2-aminobenzamides to afford the corresponding 2,3-dihydroquinazolin-4(1H)-ones successfully in high yields(90%–98%) under alcohol solvent. The catalytic activity of a-chymotrypsin was evaluated through investigating the temperature, the enzyme loading and the ratio of substrates in the enzyme-catalyzed reactions. The present method proves to be efficient and environmentally friendly in terms of short reaction time, high yield, green catalyst and the clean products obtained without further purification processes.展开更多
A convenient synthesis of 6-amino-2H,4H-pyrano[2,3-F]pyrazole-5-carbonitriles has been accomplished by one pot four-component cyclocondensation of aromatic aldehydes(1a-o) malanonitrile(2), ethyl acetoacetate(3)...A convenient synthesis of 6-amino-2H,4H-pyrano[2,3-F]pyrazole-5-carbonitriles has been accomplished by one pot four-component cyclocondensation of aromatic aldehydes(1a-o) malanonitrile(2), ethyl acetoacetate(3), and hydrazine hydrate(4) in freshly prepared deep eutectic solvent, DES(choline chloride:urea). This protocol has afforded corresponding pyrano[2,3-F]pyrazoles in shorter reaction time with high yields, and it avoids the use of typical toxic catalysts and solvents.展开更多
Microwave irradiation was used to accelerate the cyclocondensation of i soflavones and 5-amino-1H-imidazole- 4-carboxamide in the presence of sodium hydroxide to produce 3,4-diphenyl-imidazo[ 1,5-a]pyrimidines in good...Microwave irradiation was used to accelerate the cyclocondensation of i soflavones and 5-amino-1H-imidazole- 4-carboxamide in the presence of sodium hydroxide to produce 3,4-diphenyl-imidazo[ 1,5-a]pyrimidines in good to moderate yields.展开更多
A simple method for the cyclocondensation of substituted isoflavones with cyanoacetamide in the presence of sodium hydroxide to give an array of 3-cyano-5,6-diarylpyridin-2(1H)-ones in good yields is reported.
Macrocyctic tri- and tetra-amines containing a hydroxyl group in the ring have been prepared in moderate yields by a. 1:1 cyclocondensation of 1,3-dichloro-2-propanol with the disodium salt of N-tosylated diethylenetr...Macrocyctic tri- and tetra-amines containing a hydroxyl group in the ring have been prepared in moderate yields by a. 1:1 cyclocondensation of 1,3-dichloro-2-propanol with the disodium salt of N-tosylated diethylenetriamine and triethylenetetraamine. In the case of condensation of 1,3-dichoro-2-propanol with the disodium salt of N-tosylated diethylenetriamine, the 2:2 cyclocondensation product, dihydroxyl macrocyclic hexaamine, was also isolated.展开更多
文摘In the absence of organic solvents,the Lewis acid catalyzed cyclocondensation reactions between 1-naphthol and benzils gave 3-aryl-3-aryl'naphtho[1,2-b]furan-2(3H)-ones(NFs) in good yields(62%~70%)An electrophilic substitution mechanism involving formation of n-EPD/v- EPA complexes and rearrangement of aryl group was proposed.
基金the National Natural Science Foundation of China(Nos.21162026,21262034 and 21362036)Doctoral Fund of Xinjiang University(No.BS110111)for financial support,Xinjiang University Analytical&Testing Center for instrumental analyses,and Adamas-beta Chemical Co.,for all chemical reagents
文摘Mesoporous MCM-41 supported Schiff base and Cu SO4· 5H2 O shows high catalytic activity in the cyclocondensation of mercaptoacetic acid with imines(or aldehydes and amines) to afford pharmaceutically important thiazolidinone derivatives. The catalytic reactions involving twocomponents or three-components afforded the desired product in high yields(up to 98% and 99%).Moreover, the catalyst works well with respect to recyclability, giving the product in 85% and 83% yields after recycling six times.
基金Financial support from National Natural Science Foundation of China(No.21272237)the Ministry of Science and Technology of China(No.2011CB808600)the Chinese Academy of Sciences is gratefully acknowledged.
文摘Although the NHC-catalyzed cyclization reactions have been well established for the synthesis of various heterocycles,the corresponding all carbon cyclization reaction for the synthesis of carbocycles is far less established.In this note,the NHC-catalyzed all carbon[4+2]cyclocondensation of α,β-unsaturated acyl chlorides and 3-alkenyloxindoles was developed to give the corresponding spirocarbocyclic oxindoles in good yield with good to high diastereoselectivities.
文摘Oxidative cyclocondensation of o-aminobenzamide with various aldehydes in water using I2/KI as catalyst and oxidizing agent is carded out giving the corresponding quinazolin-4(3H)-ones 3a-n in good to excellent yields.
文摘A facile one-pot synthesis of new 3-arylthieno[2,3-d]pyrimidine-2,4(1H,3H)-diones via base-catalyzed cyclocondensation of ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate with aryl isocyanates is described.
文摘2H-3,l-Pyrazolo[3,4-e]oxazines (5a-c) and tacrine analogies (6a-c) were designed and prepared using 5-amino-4-cyanopyrazole (7) and cycloketones (2a-c) as reactants. The study demonstrated that the new conversion existed in the Friedlander reaction of o-aminocyanopyrazole with cycloketones. (C) 2007 Jia Rong Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
文摘A cheap and recyclable ZnO-beta zeolite was used as catalyst for the synthesis of benzothiazole derivatives.This method provides several advantages such as environmental friendliness,short reaction times,high yields,simple work-up procedure and catalyst was successfully reused for four cycles without significant loss of activity.
文摘Two different skeletons of heterocyclic compounds, quinoline and quinazolinone analogs could be obtained by a novel one-pot synthesis from substituted 3-amino- 1H-benzo[f]chromene-2-carbonitrile derivatives and cyclohexanone in DMF in the catalyst of anhydrous Zinc chloride under reflux. A plausible mechanism was proposed. 2007 Jia Rong Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
基金supported by the Higher Education Commission(HEC),Govt.of Pakistan
文摘A new compound 3-(2-(3,5-diphenyl-4,5-dihydropyrazol-1-yl)thiazol-4-yl)-2Hchromen-2-one was synthesized by cyclocondensation of 3,5-diphenyl-4,5-dihydropyrazole-1-carbothioamide with 3-(2-bromoacetyl)-2H-chromen-2-one in ethanol at reflux for 2hrs. The compound was characterized by IR, 1H-NMR, 13C-NMR and single-crystal X-ray diffraction analysis. The newly synthesized compound(C27H19N3O2S) crystallizes in the triclinic system, space group P1 with a = 5.2476(6), b = 18.289(2), c = 23.115(3) , α = 93.546(7), β = 94.715(6), γ = 92.347(7)°, V = 2204.3(4)3, Z = 4, Mr = 449.51, crystal size = 0.38 mm × 0.22 mm × 0.16 mm,(I 2σ(I)) = 35317, 9736, 3785, Rint = 0.081,(Δρ)max = 0.19 and(Δρ)min = –0.24 e·-3. DNA interaction studies revealed that the target compound strongly interacts with DNA through an intercalation binding mode and the binding constant of the compound is 7.45 × 104 M-1.
文摘Eight new compounds containing in their structures substituted quinoline and pyrazole entity were synthesized in good to excellent yield by cyclocondensation reaction of chalcones and hydrazine hydrate. This reaction was conducted in formic acid in presence of BF3·Et2O or in acetic acid. These approaches were extended to bis-chalcones, which delivered functionalized bispyrazolines. The structures of the prepared compounds were confirmed by IR, 1HNMR, 13CNMR and mass spectral analysis.
基金the financial support of the National Natural Science Foundation of China (Nos. 21262002, 21462001 and 21465002)the Program for Changjiang Scholars and Innovative Research Team in University (IRT13054)+1 种基金the Natural Science Foundation of Jiangxi No. 20142BAB203008)the Science and Technology Foundation of the Jiangxi Education Department (Nos. KJLD12006, GJJ14466 and KJLD14050)
文摘We discovered that a-chymotrypsin has a promiscuous ability to catalyze the cyclocondensation of aromatic and aliphatic aldehydes with 2-aminobenzamides to afford the corresponding 2,3-dihydroquinazolin-4(1H)-ones successfully in high yields(90%–98%) under alcohol solvent. The catalytic activity of a-chymotrypsin was evaluated through investigating the temperature, the enzyme loading and the ratio of substrates in the enzyme-catalyzed reactions. The present method proves to be efficient and environmentally friendly in terms of short reaction time, high yield, green catalyst and the clean products obtained without further purification processes.
文摘A convenient synthesis of 6-amino-2H,4H-pyrano[2,3-F]pyrazole-5-carbonitriles has been accomplished by one pot four-component cyclocondensation of aromatic aldehydes(1a-o) malanonitrile(2), ethyl acetoacetate(3), and hydrazine hydrate(4) in freshly prepared deep eutectic solvent, DES(choline chloride:urea). This protocol has afforded corresponding pyrano[2,3-F]pyrazoles in shorter reaction time with high yields, and it avoids the use of typical toxic catalysts and solvents.
文摘Microwave irradiation was used to accelerate the cyclocondensation of i soflavones and 5-amino-1H-imidazole- 4-carboxamide in the presence of sodium hydroxide to produce 3,4-diphenyl-imidazo[ 1,5-a]pyrimidines in good to moderate yields.
文摘A simple method for the cyclocondensation of substituted isoflavones with cyanoacetamide in the presence of sodium hydroxide to give an array of 3-cyano-5,6-diarylpyridin-2(1H)-ones in good yields is reported.
基金Project (No. 29502010) supported by the National Natural Science Foundation of China
文摘Macrocyctic tri- and tetra-amines containing a hydroxyl group in the ring have been prepared in moderate yields by a. 1:1 cyclocondensation of 1,3-dichloro-2-propanol with the disodium salt of N-tosylated diethylenetriamine and triethylenetetraamine. In the case of condensation of 1,3-dichoro-2-propanol with the disodium salt of N-tosylated diethylenetriamine, the 2:2 cyclocondensation product, dihydroxyl macrocyclic hexaamine, was also isolated.