目的研究参与雌激素代谢的细胞色素P45017(Cytochrome P45017,CYP17)MspA1I位点基因多态性与山东地区汉族人乙型肝炎病毒(hepatitis B virus,HBV)感染后肝硬化、肝细胞癌(HCC)的关系。方法应用聚合酶链反应-限制性片段长度多态性(PCR-RF...目的研究参与雌激素代谢的细胞色素P45017(Cytochrome P45017,CYP17)MspA1I位点基因多态性与山东地区汉族人乙型肝炎病毒(hepatitis B virus,HBV)感染后肝硬化、肝细胞癌(HCC)的关系。方法应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,对山东地区96例乙肝相关性HCC患者、107例乙肝后肝硬化患者、82例慢性乙型肝炎患者、91例乙型肝炎表面抗原(HBsAg)携带者、80例健康对照组的CYP17基因MspA1I位点的T/C多态进行研究。结果与携带者相比,CYP17 A2/A2基因型明显增加了女性HBV感染患者HCC的发病风险(OR=5.93,P=0.002),尤其在绝经后的妇女,OR增加至6.18,P=0.003,而在男性患者中差异无统计学意义。乙肝肝硬化患者与携带者相比,A2/A2基因型频率差异亦无统计学意义(P>0.05)。结论CYP17 MspA1I多态位点A2/A2基因型与山东地区女性HBV感染后HCC的易感性有关。展开更多
We studied 259 consecutive unselected white patients with the polycystic ovary syndrome (PCOS) and 161 matched controls for a common polymorphism of CYP17, the gene encoding for P450c17α , and did not observe an impo...We studied 259 consecutive unselected white patients with the polycystic ovary syndrome (PCOS) and 161 matched controls for a common polymorphism of CYP17, the gene encoding for P450c17α , and did not observe an important modulatory effect of this variant on circulating DHEAS. It does not appear that this common variant of CYP17, a T to C substitution in the 5′ promoter region, plays a significant role in the adrenal androgen excess of PCOS.展开更多
文摘We studied 259 consecutive unselected white patients with the polycystic ovary syndrome (PCOS) and 161 matched controls for a common polymorphism of CYP17, the gene encoding for P450c17α , and did not observe an important modulatory effect of this variant on circulating DHEAS. It does not appear that this common variant of CYP17, a T to C substitution in the 5′ promoter region, plays a significant role in the adrenal androgen excess of PCOS.
