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Three new C_(20)-diterpenoid alkaloids from Delphinium anthriscifolium var.savatieri 被引量:2
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作者 Xiao Yu Liu Qiao Hong Chen Feng Peng Wang 《Chinese Chemical Letters》 SCIE CAS CSCD 2009年第6期698-701,共4页
Three new C20-diterpenoid alkaloids, designated as anthriscifolmines A-C (1-3), together with two known alkaloids denudatine and delgramine, were isolated from the whole herb of Delphinium anthriscifolium var. savat... Three new C20-diterpenoid alkaloids, designated as anthriscifolmines A-C (1-3), together with two known alkaloids denudatine and delgramine, were isolated from the whole herb of Delphinium anthriscifolium var. savatieri. The structures of these new alkaloids were elucidated on the basis of spectral data. 展开更多
关键词 Delphinium anthriscifolium vat. savatieri c20-diterpenoid alkaloid Anthriscifolmines A-c
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一种新的DENUDATINE型C_(20)二萜生物碱结构的NMR研究 被引量:4
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作者 缪振春 冯锐 +3 位作者 周永新 李光玉 郝志刚 刘静涵 《波谱学杂志》 CAS CSCD 北大核心 1999年第6期547-552,共6页
从内蒙西伯利亚乌头中分离得一个新的C20二萜生物碱,采用选择性远程DEPT,同核和异核二维NMR技术相结合进行了研究,其结构确定为Lepenine的C-11基向立体异构体,定名为11a-hydroxylapenine.结果表明,选择性远程DEPTNMR技术对于连... 从内蒙西伯利亚乌头中分离得一个新的C20二萜生物碱,采用选择性远程DEPT,同核和异核二维NMR技术相结合进行了研究,其结构确定为Lepenine的C-11基向立体异构体,定名为11a-hydroxylapenine.结果表明,选择性远程DEPTNMR技术对于连接这类化合物中被季碳和杂原子分割的NMR自旋体系,测定基本骨架和确定信号归属都有独到之处. 展开更多
关键词 DENUDATINE型 20二萜生物碱 NMR
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天然C_(20)二萜生物碱 被引量:2
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作者 丁立生 陈耀祖 《天然产物研究与开发》 CAS CSCD 1990年第3期74-88,共15页
本文概述了C_(20)。二萜生物碱的化学结构类型,在植物界的分布和它们的光谱特征,并将迄今已知的这类生物碱及其植物来源列表于后。
关键词 二萜生物碱 化学结构 分类 分布
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毛茛科中C_(20)-二萜生物碱及其生物活性研究进展
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作者 李东旭 续洁琨 +8 位作者 殷伟峰 张帆 朱海 王东格 丁康 潘雪格 李玲芝 赫军 张维库 《中国中药杂志》 CAS CSCD 北大核心 2024年第15期4054-4068,共15页
C_(20)-二萜生物碱在毛茛科中主要分布在乌头属、翠雀属和飞燕草属植物中,其化学结构类型主要分为阿替生型、光翠雀碱型、海替定型和海替生型等9种类型。生物活性研究表明该类化合物在抗肿瘤、镇痛、抗心律失常和抗炎等方面均表现出较... C_(20)-二萜生物碱在毛茛科中主要分布在乌头属、翠雀属和飞燕草属植物中,其化学结构类型主要分为阿替生型、光翠雀碱型、海替定型和海替生型等9种类型。生物活性研究表明该类化合物在抗肿瘤、镇痛、抗心律失常和抗炎等方面均表现出较好的活性。该文对2002年至今从毛茛科植物中报道的190个C_(20)-二萜生物碱的化学结构和生物活性进行了总结,以期对毛茛科植物中C_(20)-二萜生物碱的研究提供参考。 展开更多
关键词 毛茛科 c_(20)-二萜生物碱 乌头属 翠雀属 飞燕草属
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Aconapelsulfonines A and B,seco C_(20)-diterpenoid alkaloids deriving via Criegee rearrangements of napelline skeleton from Aconitum carmichaelii 被引量:8
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作者 Hui Liu Yuzhuo Wu +4 位作者 Qinglan Guo Shuai Shao Chengbo Xu Tiantai Zhang Jiangong Shi 《Chinese Chemical Letters》 SCIE CAS CSCD 2021年第1期33-36,共4页
Two sulfo nated seco C_(20)-diterpenoid alkaloids,aconapelsulfonines A(1) and B(2),were isolated from an aqueous extract of the raw material of "Fu Zi"(the Aconitum carmichaelii lateral roots),of which the s... Two sulfo nated seco C_(20)-diterpenoid alkaloids,aconapelsulfonines A(1) and B(2),were isolated from an aqueous extract of the raw material of "Fu Zi"(the Aconitum carmichaelii lateral roots),of which the structures were elucidated by various spectroscopic data,combined with X-ray crystallogra phic analysis.The unprecedented skeletons are biogenetically proposed to be derived via Criegee rearrangements of the napelline-type architecture.The two compounds exhibited dose-depended analgesic activities on an acetic acid-induced mice writhing test. 展开更多
关键词 RANUNcULAcEAE Aconitum carmichaelii c_(20)-diterpenoid alkaloid Aconapelsulfonine Analgesic activity
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Napelline-type C_(20)-diterpenoid alkaloid iminiums from an aqueous extract of ‘‘fu zi'': Solvent-/base-/acid-dependent transformation and equilibration between alcohol iminium and aza acetal forms 被引量:13
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作者 Xian-Hua Meng Zhi-Bo Jiang +3 位作者 Cheng-Gen Zhu Qing-Lan Guo Cheng-Bo Xu Jian-Gong Shi 《Chinese Chemical Letters》 SCIE CAS CSCD 2016年第7期993-1003,共11页
Three new napelline-type C20-diterpenoid alkaloids,named aconicarmichinium A and B trifluoroacetates(1 and 2) and aconicarmichinium C chloride(3),were isolated from an aqueous extract of "fu zi",the lateral root... Three new napelline-type C20-diterpenoid alkaloids,named aconicarmichinium A and B trifluoroacetates(1 and 2) and aconicarmichinium C chloride(3),were isolated from an aqueous extract of "fu zi",the lateral roots of Aconitum carmichaelii.Their structures were elucidated by extensive spectroscopic data analysis.Compounds 1-3 represent the first examples of napelline-type C20 diterpenoid alkaloid alcohol iminiums,of which the structures were fully characterized.In addition,transformation and equilibration between the alcohol iminiums(1-3) and the aza acetals la-3a were investigated by measurements of the NMR spectra in protic and aprotic deuterium solvents including alkali pyridine-d5,along with evaporation under reduced pressure and gradual additions of TFA,AcOH,and HC1.The results demonstrated that the transformation and equilibration were solvent-,base-,and acid-dependent.Especially,in aqueous biological fluid,these C20-diterpenoid alkaloids would more likely exist as the alcohol iminiums accompanied by anion counterparts in biosystems to increase their solubility, bioavailability, transportations, and functions.The absolute configurations of 1-3 were confirmed by X-ray crystallographic analysis of 2a. 展开更多
关键词 Aconitum carmichaelii Ranunculaceae Napelline-type c20-diterpenoid alkaloid Aconicarmichiniums A–c Alcohol iminium and aza acetal forms of the diterpenoid alkaloid Transformation and equilibration
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Efficient synthesis of the C/D rings of atisine-type C_(20)-diterpenoid alkaloids 被引量:2
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作者 De Lin Chen Feng Peng Wang 《Chinese Chemical Letters》 SCIE CAS CSCD 2012年第12期1378-1380,共3页
A bicyclo[2.2.2]octane C/D ring system, with a lactonic ring at C-8 and C-9, of the atisine-type C20-diterpenoid alkaloids, was successfully synthesized, using an oxidative dearomatization/intramolecular Diels-Alder r... A bicyclo[2.2.2]octane C/D ring system, with a lactonic ring at C-8 and C-9, of the atisine-type C20-diterpenoid alkaloids, was successfully synthesized, using an oxidative dearomatization/intramolecular Diels-Alder reaction. 展开更多
关键词 c20-diterpenoid alkaloids Oxidative dearomatization/intrarnolecular Diels-Alder reaction
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A minor arcutine-type C20-diterpenoid alkaloid iminium constituent of“fu zi” 被引量:11
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作者 Xian-Hua Meng Zhi-Bo Jiang +1 位作者 Qing-Lan Guo Jian-Gong Shi 《Chinese Chemical Letters》 SCIE CAS CSCD 2017年第3期588-592,共5页
A rare arcutine-type C_(20)-diterpenoid alkaloid, named aconicarmicharcutinium A and obtained as hydroxide(1) and trifluoroacetate(1a), was characterized as a minor constituent of "fu zi"(the lateral roots of... A rare arcutine-type C_(20)-diterpenoid alkaloid, named aconicarmicharcutinium A and obtained as hydroxide(1) and trifluoroacetate(1a), was characterized as a minor constituent of "fu zi"(the lateral roots of Aconitum carmichaelii). The structures of 1 and 1a were elucidated by comprehensive analysis of spectroscopic data including^(19)F and 2D NMR experiments. Compounds 1 and 1a represent the first examples of the arcutine-type C_(20)-diterpenoid alkaloid iminium. 展开更多
关键词 Aconitum carmichaelii Ranunculaceae Arcutine-type c_(20-diterpenoid alkaloid iminium Aconicarmicharcutinium A
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关白附化学成分的研究——关附甲素结晶水化合物的结构鉴定 被引量:2
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作者 刘静涵 韩英 +4 位作者 郝志刚 孙为东 赵守训 吴斌 郑启泰 《中国药科大学学报》 CAS CSCD 北大核心 1991年第2期104-105,共2页
关白附系毛茛科黄花乌头(Aconitum careanum(Levi.)Rapaics)的块根。本文报道从东北产该植物中分得一化合物(1)。化合物(1)的IR,MS,~1HNMR和坞^(13)C—NHR谱结果与关附甲素基本一致。
关键词 关白附 化学成分 结构鉴定
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Structure, property, biogenesis, and activity of diterpenoid alkaloids containing a sulfonic acid group from Aconitum carmichaelii 被引量:7
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作者 Qinglan Guoy Huan Xiay +4 位作者 Yuzhuo Wu Shuai Shao Chengbo Xu Tiantai Zhang Jiangong Shi 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2020年第10期1954-1965,共12页
Three new C20-diterpenoid alkaloids with a sulfonic acid unit,named aconicarmisulfonines B and C(1 and 2)and chuanfusulfonine A(3),respectively,were isolated from the Aconitum carmichaelii lateral roots("fu zi&qu... Three new C20-diterpenoid alkaloids with a sulfonic acid unit,named aconicarmisulfonines B and C(1 and 2)and chuanfusulfonine A(3),respectively,were isolated from the Aconitum carmichaelii lateral roots("fu zi"in Chinese).Structures of 1-3 were determined by spectroscopic data analysis.Intriguing chemical properties and reactions were observed for the C20-diterpenoid alkaloids:(a)specific selective nucleophilic addition of the carbonyl(C-12)in 1 with CD3 OD;(b)interconversion between 1 and 2 in D2 O;(c)stereo-and/or regioselective deuterations of H-11αin 1-3 and both H-11αand H-11βin aconicarmisulfonine A(4);(d)TMSP-2,2,3,3-d4 promoted cleavage of the C-12-C-13 bond of 4 in D2 O;(e)dehydrogenation of 4 in pyridine-d5,and(f)Na2 SO3-assisted dehydrogenation and N-deethylation of songorine(5,a putative precursor of 1-4).Biogenetically,1 and 2 are correlated with 4,for which the same novel carbon skeleton is proposed to be derived from semipinacol rearrangements via migrations of C-13-C-16 and C-15-C-16 bonds of the napelline-type skeleton,respectively.Meanwhile,3 is a highly possible precursor or a concurrent product in the biosynthetic pathways of 1,2,and 4.In the acetic acid-induced mice writhing assay,at 1.0 mg/kg(i.p.),compounds 1,2,5,5 a,and 5 b exhibited analgesic effects against mice writhing. 展开更多
关键词 RANUNcULAcEAE Aconitum carmichaelii Sulfonated c20-diterpenoid alkaloid Aconicarmisulfonines chuanfusulfonine A Analgesic effect
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Two New Diterpenoid Alkaloids from Spiraea japonica L. f. var.fortunei (Planchon) Rehd. 被引量:3
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作者 Li-MingFAN Hong-PingHE Yue-MaoSHEN Xiao-JiangHAO 《Journal of Integrative Plant Biology》 SCIE CAS CSCD 2005年第1期120-123,共4页
Abstract: Two new hetisine-type C20-diterpenoid alkaloids named spiraqine (1) and 6-hydroxylspiraqine (2), and four known alkaloids, namely spiredine (3), spiradine A (4), spiradine B (5), and spirasine V/VI (6), were... Abstract: Two new hetisine-type C20-diterpenoid alkaloids named spiraqine (1) and 6-hydroxylspiraqine (2), and four known alkaloids, namely spiredine (3), spiradine A (4), spiradine B (5), and spirasine V/VI (6), were isolated from Spiraea japonica L. f. var. fortunei(Planchon) Rehd. The structures of the alkaloids were elucidated using nuclear magnetic resonance analysis (1H-NMR, 13C-NMR, DEPT, HMQC, and HMBC) and mass spectrometry data. 展开更多
关键词 c20-diterpenoid alkaloids hetisine type 6-hydroxylspiraqine ROSAcEAE Spiraea japonica L. f. var.fortunei(Planchon) Rehd. spiraqine
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