A series of SrIn2 O4 ：Eu^3＋ phosphors are synthesized by a high temperature solid-state method, and their luminescent properties are investigated. They can be excited by 395-nm radiation, and produce red emission （...A series of SrIn2 O4 ：Eu^3＋ phosphors are synthesized by a high temperature solid-state method, and their luminescent properties are investigated. They can be excited by 395-nm radiation, and produce red emission （619 nm）; however, they have a low absorption of near-ultraviolet light with the wavelength of 400nm–405 nm. When co-doped with A^＋ （A=Li, Na, K）, the emission intensity of SrIn2O4 ：Eu^3＋ is significantly enhanced, but its emission and excitation spectral profile is unchanged. With co-doping Sm^3＋ , not only is the emission intensity of SrIn2 O4 ：Eu^3＋ enhanced, but also the absorption is broadened and strengthened in the range of 400 nm–405nm. The effect of Sm^3＋ -doped content on the emission intensity of SrIn2O4 ：Eu^3＋ , Sm^3＋ is investigated, and the optimal Sm^3＋ content is 0.02 mol.展开更多
BACKGROUND Intestinal ischemia/reperfusion(I/R)injury is a fatal syndrome that occurs under many clinical scenarios.The apoptosis of intestinal cells caused by ischemia can cause cell damage and provoke systemic dysfu...BACKGROUND Intestinal ischemia/reperfusion(I/R)injury is a fatal syndrome that occurs under many clinical scenarios.The apoptosis of intestinal cells caused by ischemia can cause cell damage and provoke systemic dysfunction during reperfusion.However,the mechanism of I/R-induced apoptosis remains unclear.Cystic fibrosis transmembrane conductance regulator(CFTR)is a cAMP-activated chloride channel.Few researchers have paid attention to its role in intestinal I/R injury,or the relationship between CFTR and intestinal apoptosis induced by hypoxia/reoxygenation(H/R).AIM To investigate the effects of CFTR on I/R-induced intestinal apoptosis and its underlying molecular mechanisms.METHODS An intestinal I/R injury model was established in mice with superior mesenteric artery occlusion, and Caco2 cells were subjected to H/R for the simulation of I/R in vivo.RESULTSThe results suggested that CFTR overexpression significantly increased the Caco2 cell viability anddecreased cell apoptosis induced by the H/R. Interestingly, we found that the translocation of p65,an NF-κB member, from the cytoplasm to the nucleus after H/R treatment can be reversed by theoverexpression of CFTR, the NF-κB P65 would return from the nucleus to the cytoplasm asdetermined by immunostaining. We also discovered that CFTR inhibited cell apoptosis in theH/R-treated cells, and this effect was significantly curbed by the NF-κB activator BA, AKTinhibitor GSK690693 and the PI3K inhibitor LY294002. Moreover, we demonstrated that CFTRoverexpression could reverse the decreased PI3K/AKT expression induced by the I/R treatment invivo or H/R treatment in vitro.CONCLUSIONThe results of the present study indicate that the overexpression of CFTR protects Caco2 cells fromH/R-induced apoptosis;furthermore, it also inhibits H/R-induced apoptosis through thePI3K/AKT/NF-κB signaling pathway in H/R-treated Caco2 cells and intestinal tissues.展开更多
K2Ba（MoO4）2：Eu3＋ phosphors were synthesized by solid-state reaction. The emission and excitation spectra of K2 Ba（MoO4）2：Eu3＋ phosphors exhibited that the phosphors could be effectively excited by near ultravi...K2Ba（MoO4）2：Eu3＋ phosphors were synthesized by solid-state reaction. The emission and excitation spectra of K2 Ba（MoO4）2：Eu3＋ phosphors exhibited that the phosphors could be effectively excited by near ultraviolet （394 nm） and blue （465 nm） light, and emitted red light at 616 nm. The influence of Eu3＋concentration, sintering temperature and charge compensators （K＋, Na＋ or Li＋ ） on the emission intensity were investigated. The results indicated that concentration quenching of Eu3＋ was not observed within 30mol.% Eu 3＋, 600 oC was a suitable sintering temperature for preparation of K2 Ba（MoO4）2：Eu3＋phosphors, and K＋ ions gave the best improvement to enhance the emission intensity. The CIE chromaticity coordinates of K2 Ba（MoO4）2：0.05Eu3＋phosphor were calculated to be （0.68, 0.32）, and color purity was 97.4%.展开更多
基金Project supported by the National Natural Science Foundation of China (Grant No. 50902042)the Natural Science Foundation of Hebei Province, China(Grant Nos. E2009000209 and E2010000283)+1 种基金the Education Bureau Foundation of Hebei Province, China (Grant No. 2009313)the Key Laboratory of Luminescence and Optical Information, Beijing Jiaotong University, Ministry of Education, China (Grant No. 2010LOI12)
文摘A series of SrIn2 O4 ：Eu^3＋ phosphors are synthesized by a high temperature solid-state method, and their luminescent properties are investigated. They can be excited by 395-nm radiation, and produce red emission （619 nm）; however, they have a low absorption of near-ultraviolet light with the wavelength of 400nm–405 nm. When co-doped with A^＋ （A=Li, Na, K）, the emission intensity of SrIn2O4 ：Eu^3＋ is significantly enhanced, but its emission and excitation spectral profile is unchanged. With co-doping Sm^3＋ , not only is the emission intensity of SrIn2 O4 ：Eu^3＋ enhanced, but also the absorption is broadened and strengthened in the range of 400 nm–405nm. The effect of Sm^3＋ -doped content on the emission intensity of SrIn2O4 ：Eu^3＋ , Sm^3＋ is investigated, and the optimal Sm^3＋ content is 0.02 mol.
基金Supported by National Natural Science Foundation of China, No.81800473"Young Eagle Project"of Air Force Medical University, No.KT2021DX007
文摘BACKGROUND Intestinal ischemia/reperfusion(I/R)injury is a fatal syndrome that occurs under many clinical scenarios.The apoptosis of intestinal cells caused by ischemia can cause cell damage and provoke systemic dysfunction during reperfusion.However,the mechanism of I/R-induced apoptosis remains unclear.Cystic fibrosis transmembrane conductance regulator(CFTR)is a cAMP-activated chloride channel.Few researchers have paid attention to its role in intestinal I/R injury,or the relationship between CFTR and intestinal apoptosis induced by hypoxia/reoxygenation(H/R).AIM To investigate the effects of CFTR on I/R-induced intestinal apoptosis and its underlying molecular mechanisms.METHODS An intestinal I/R injury model was established in mice with superior mesenteric artery occlusion, and Caco2 cells were subjected to H/R for the simulation of I/R in vivo.RESULTSThe results suggested that CFTR overexpression significantly increased the Caco2 cell viability anddecreased cell apoptosis induced by the H/R. Interestingly, we found that the translocation of p65,an NF-κB member, from the cytoplasm to the nucleus after H/R treatment can be reversed by theoverexpression of CFTR, the NF-κB P65 would return from the nucleus to the cytoplasm asdetermined by immunostaining. We also discovered that CFTR inhibited cell apoptosis in theH/R-treated cells, and this effect was significantly curbed by the NF-κB activator BA, AKTinhibitor GSK690693 and the PI3K inhibitor LY294002. Moreover, we demonstrated that CFTRoverexpression could reverse the decreased PI3K/AKT expression induced by the I/R treatment invivo or H/R treatment in vitro.CONCLUSIONThe results of the present study indicate that the overexpression of CFTR protects Caco2 cells fromH/R-induced apoptosis;furthermore, it also inhibits H/R-induced apoptosis through thePI3K/AKT/NF-κB signaling pathway in H/R-treated Caco2 cells and intestinal tissues.
基金Project supported by Natural Science Foundation of Fujian Province (2011J033)
文摘K2Ba（MoO4）2：Eu3＋ phosphors were synthesized by solid-state reaction. The emission and excitation spectra of K2 Ba（MoO4）2：Eu3＋ phosphors exhibited that the phosphors could be effectively excited by near ultraviolet （394 nm） and blue （465 nm） light, and emitted red light at 616 nm. The influence of Eu3＋concentration, sintering temperature and charge compensators （K＋, Na＋ or Li＋ ） on the emission intensity were investigated. The results indicated that concentration quenching of Eu3＋ was not observed within 30mol.% Eu 3＋, 600 oC was a suitable sintering temperature for preparation of K2 Ba（MoO4）2：Eu3＋phosphors, and K＋ ions gave the best improvement to enhance the emission intensity. The CIE chromaticity coordinates of K2 Ba（MoO4）2：0.05Eu3＋phosphor were calculated to be （0.68, 0.32）, and color purity was 97.4%.
