Two novel epimeric eremophilane sesquiterpenes, 7β-H-3α-angeloyl-9(10)-ene-11, 12-epoxy-8-oxoeremophilane (1) and 7β-H-3α-angeloyl-9(10)-ene-11, 12-epoxy-8-oxoeremophi- lane (2) were isolated from the methanol ext...Two novel epimeric eremophilane sesquiterpenes, 7β-H-3α-angeloyl-9(10)-ene-11, 12-epoxy-8-oxoeremophilane (1) and 7β-H-3α-angeloyl-9(10)-ene-11, 12-epoxy-8-oxoeremophi- lane (2) were isolated from the methanol extract of the flower of Cacalia tangutica (Franch.) Hand-Mazz. Their structures were characterized by 1D-, 2D-NMR (1H-1H COSY, HMQC, HMBC, 1H-1H NOESY) and HRESI-MS techniques.展开更多
Essential oil of the subterranean part of Cacalia tangutica(Maxim.)Hand.-Mazz was analyzed by gas chromatography(GC)-mass spectrum(MS)technique in two different capillary columns of different polarities.Thirty-one com...Essential oil of the subterranean part of Cacalia tangutica(Maxim.)Hand.-Mazz was analyzed by gas chromatography(GC)-mass spectrum(MS)technique in two different capillary columns of different polarities.Thirty-one components were identified in the oil and the main compounds were a-zingiberene(13.49%),germacrene D(10.76%),α-pinene(8.54%),caryophyllene(Z-)(6.36%),linalool(6.16%),β-myrcene(4.89%),β-ocimene(Z-)(4.40%)and ocimenone(Z-)(3.58%).The antimicrobial activity of the oil was evaluated against 2 fungi and 12 bacteria including 6 clinically isolated strains using the agar disc diffusion and broth microdilution methods.The results show that the oil presented a broad antimicrobial spectrum and had better antimicrobial activity against yeast and gram-positive bacteria.The minimum inhibitory concentration values were 0.16–5.00 g/L and minimum bactericidal concentration values were 0.16–5.00 g/L.展开更多
基金supported by Foundation of“Bairen Jihua”of CAS in 2000NNSFC(No.20372029 and 20475057).
文摘Two novel epimeric eremophilane sesquiterpenes, 7β-H-3α-angeloyl-9(10)-ene-11, 12-epoxy-8-oxoeremophilane (1) and 7β-H-3α-angeloyl-9(10)-ene-11, 12-epoxy-8-oxoeremophi- lane (2) were isolated from the methanol extract of the flower of Cacalia tangutica (Franch.) Hand-Mazz. Their structures were characterized by 1D-, 2D-NMR (1H-1H COSY, HMQC, HMBC, 1H-1H NOESY) and HRESI-MS techniques.
基金This work was supported by the Natural Science Foundation of China(Grant Nos.30370366,30670464).
文摘Essential oil of the subterranean part of Cacalia tangutica(Maxim.)Hand.-Mazz was analyzed by gas chromatography(GC)-mass spectrum(MS)technique in two different capillary columns of different polarities.Thirty-one components were identified in the oil and the main compounds were a-zingiberene(13.49%),germacrene D(10.76%),α-pinene(8.54%),caryophyllene(Z-)(6.36%),linalool(6.16%),β-myrcene(4.89%),β-ocimene(Z-)(4.40%)and ocimenone(Z-)(3.58%).The antimicrobial activity of the oil was evaluated against 2 fungi and 12 bacteria including 6 clinically isolated strains using the agar disc diffusion and broth microdilution methods.The results show that the oil presented a broad antimicrobial spectrum and had better antimicrobial activity against yeast and gram-positive bacteria.The minimum inhibitory concentration values were 0.16–5.00 g/L and minimum bactericidal concentration values were 0.16–5.00 g/L.
