Studies have shown that estrogen has neuroprotective effects on the nigrostriatal system. The present study established a Parkinson＇s disease model in C57BL/6 mice by intraperitoneal injection of 1-methyl-4-phenyl-1,...Studies have shown that estrogen has neuroprotective effects on the nigrostriatal system. The present study established a Parkinson＇s disease model in C57BL/6 mice by intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrapyridine. The mice were subjected to 1713 estradiol injection into the lateral ventricle. Immunofluorescence double staining showed that estrogen increased tyrosine hydroxylase and calbindin-D28K expression and co-expression in dopaminergic neurons of midbrain substantia nigra pars compacta of model mice. Behavior experiments showed that estrogen improved swimming and hanging behaviors in this mouse model of Parkinson＇s disease.展开更多
Neuron is a fundamental unit of the brain, which is specialized to transmit information throughout the body through electrical and chemical signals. Calcium (Ca2^+) ions are known as second messengers which play impor...Neuron is a fundamental unit of the brain, which is specialized to transmit information throughout the body through electrical and chemical signals. Calcium (Ca2^+) ions are known as second messengers which play important roles in the movement of the neurotransmitter. Calbindin-D28k is a Ca2^+ binding protein which is involved in regulation of intracellular Ca2^+ ions and main tains homeos tasis level, it also alters the cytosolic calcium concentration ([Ca2^+]) in nerve cells to keep the cell alive. Parkinson's disease (PD) is a chronic progressive neurodegenerative brain disorder of the nervous system. Several regions of the brain indicate the hallmark of the PD. The symptoms of PD are plainly linked with the degeneration and death of dopamine neurons in the substantia nigra pars compacta located in midbrain which is accompanied by depletion in calbindin-Z?28fc - In the present paper, the neuroprotective role of calbindin-￡>28fc in the cytoplasmic [Ca2^+] distribution is studied. The elicitation in [Ca2^+] is due to the presence of low amount of calbindin-D28k which can be portrayed and is a hallmark of PD. A one-dimensional space time fractional reaction diffusion equation is designed by keeping in mind the physiological condition taking place inside Parkinson's brain. Computational results are performed in MATLAB.展开更多
文摘Studies have shown that estrogen has neuroprotective effects on the nigrostriatal system. The present study established a Parkinson＇s disease model in C57BL/6 mice by intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrapyridine. The mice were subjected to 1713 estradiol injection into the lateral ventricle. Immunofluorescence double staining showed that estrogen increased tyrosine hydroxylase and calbindin-D28K expression and co-expression in dopaminergic neurons of midbrain substantia nigra pars compacta of model mice. Behavior experiments showed that estrogen improved swimming and hanging behaviors in this mouse model of Parkinson＇s disease.
文摘Neuron is a fundamental unit of the brain, which is specialized to transmit information throughout the body through electrical and chemical signals. Calcium (Ca2^+) ions are known as second messengers which play important roles in the movement of the neurotransmitter. Calbindin-D28k is a Ca2^+ binding protein which is involved in regulation of intracellular Ca2^+ ions and main tains homeos tasis level, it also alters the cytosolic calcium concentration ([Ca2^+]) in nerve cells to keep the cell alive. Parkinson's disease (PD) is a chronic progressive neurodegenerative brain disorder of the nervous system. Several regions of the brain indicate the hallmark of the PD. The symptoms of PD are plainly linked with the degeneration and death of dopamine neurons in the substantia nigra pars compacta located in midbrain which is accompanied by depletion in calbindin-Z?28fc - In the present paper, the neuroprotective role of calbindin-￡>28fc in the cytoplasmic [Ca2^+] distribution is studied. The elicitation in [Ca2^+] is due to the presence of low amount of calbindin-D28k which can be portrayed and is a hallmark of PD. A one-dimensional space time fractional reaction diffusion equation is designed by keeping in mind the physiological condition taking place inside Parkinson's brain. Computational results are performed in MATLAB.
