To stndy the fundamental characteristics and biosafety of the compound bone morphogenetic protein （ BMP ） and rhBMP- 2/CPC , and to provide a theoretical basis for the compound biologically active artificial bone ma...To stndy the fundamental characteristics and biosafety of the compound bone morphogenetic protein （ BMP ） and rhBMP- 2/CPC , and to provide a theoretical basis for the compound biologically active artificial bone made of calcium phosphate cement （CPC） and bone morphogenetic protein, simplex CPC was taken as the control group, and the compound with the blending ratio of 1g CPC to 5mg rhBMP-2 was taken as the experimentation group to determine the setting time, compressive, strength, acute toxicological and sub acute toxicological properties. The osteogenic characteristic of compound rhBMP- 2/CPC was measured by making animal model of radio discontinuous defect. The setting time of the two groups meets the clinical requirements, and the compressive strength of the solidified body of bone cement increases along with increasing the immersion time. Compound rhBMP- 2/ CPC has a favorable ostengenic characteristic for animal model of radio discontinuous deject. The fundamental characteristics of the compound rhBMP- 2 phosphate bone cement are basically the same as that of CPC, and also have a favorable biosafety and osteogenesis.展开更多
The aim of the study was to analyze the histologic and ultrastructural changes after maxillary sinus augmentation with simultaneous implant placement using engineered bone graft material.In this study,calcium phosphat...The aim of the study was to analyze the histologic and ultrastructural changes after maxillary sinus augmentation with simultaneous implant placement using engineered bone graft material.In this study,calcium phosphate cement(CPC)scaffolds combined with goat bone marrow stromal cells(BMSCs)were used to fill goat sinus floor space after maxillary sinus floor elevation with simultaneous implant placement comparing with those not filled any grafted materials and used as controls.After a healing period of 3 months,the goat maxillary sinus membrane was examined using light microscopy and scanning electronic microscopy.The results showed that the connective tissue thickness and the epithelium thickness of mucosa were not statistically significant difference between two groups.The tissue engineered bone complex might be an ideal graft for the sinus floor elevation and have no influence on the sinus membrane under the histological and ultrastructural observation.展开更多
文摘To stndy the fundamental characteristics and biosafety of the compound bone morphogenetic protein （ BMP ） and rhBMP- 2/CPC , and to provide a theoretical basis for the compound biologically active artificial bone made of calcium phosphate cement （CPC） and bone morphogenetic protein, simplex CPC was taken as the control group, and the compound with the blending ratio of 1g CPC to 5mg rhBMP-2 was taken as the experimentation group to determine the setting time, compressive, strength, acute toxicological and sub acute toxicological properties. The osteogenic characteristic of compound rhBMP- 2/CPC was measured by making animal model of radio discontinuous defect. The setting time of the two groups meets the clinical requirements, and the compressive strength of the solidified body of bone cement increases along with increasing the immersion time. Compound rhBMP- 2/ CPC has a favorable ostengenic characteristic for animal model of radio discontinuous deject. The fundamental characteristics of the compound rhBMP- 2 phosphate bone cement are basically the same as that of CPC, and also have a favorable biosafety and osteogenesis.
基金the Natural Science Foundation of Science and Technology Commission of Shanghai Municipality (Nos.09JC1411700 and S30206)the Natural Science Foundation of Shanghai Jiaotong University School of Medicine(No.09XJ21030)
文摘The aim of the study was to analyze the histologic and ultrastructural changes after maxillary sinus augmentation with simultaneous implant placement using engineered bone graft material.In this study,calcium phosphate cement(CPC)scaffolds combined with goat bone marrow stromal cells(BMSCs)were used to fill goat sinus floor space after maxillary sinus floor elevation with simultaneous implant placement comparing with those not filled any grafted materials and used as controls.After a healing period of 3 months,the goat maxillary sinus membrane was examined using light microscopy and scanning electronic microscopy.The results showed that the connective tissue thickness and the epithelium thickness of mucosa were not statistically significant difference between two groups.The tissue engineered bone complex might be an ideal graft for the sinus floor elevation and have no influence on the sinus membrane under the histological and ultrastructural observation.
