Calcium-independent phospholipase A<sub>2</sub> (iPLA<sub>2</sub>) belongs to the group VI family of phospholipase superfamily (PLA<sub>2</sub>) that catalyses the hydrolysis of gly...Calcium-independent phospholipase A<sub>2</sub> (iPLA<sub>2</sub>) belongs to the group VI family of phospholipase superfamily (PLA<sub>2</sub>) that catalyses the hydrolysis of glycerophospholipids at the sn-2 ester bond, producing unesterified fatty acids and 2-lysophospholipids. Research interests on iPLA<sub>2</sub> have not been as significant as those on secretary PLA<sub>2</sub> and cytosolic PLA<sub>2</sub>. However, more efforts have been made recently on understanding the expression, regulation and biological function of iPLA<sub>2</sub>. iPLA<sub>2</sub> plays important roles in several biological processes, including signal transduction, phospholipid remodelling, eicosanoid formation, cell proliferation, cell differentiation and apoptosis. Modulation of iPLA<sub>2</sub> activity can have prominent effects on cellular metabolism, central nervous system and cardiovascular functions. Thus, dysregulation iPLA<sub>2</sub> can play a vital role in the pathogenesis of several diseases. The aim of this review is to provide the current understanding of the structure, function and regulation of group VI iPLA<sub>2</sub> and highlight its potential mechanisms of action in mediating several neurological disorders and cancer.展开更多
Objective:The purpose of this study is to examine the expression ofserum high-sensitivity C-reactive protein(hs-CRP)and lipoprotein-associated phospholipase A2(Lp-PLA2)in patients with arrhythmia and its significance....Objective:The purpose of this study is to examine the expression ofserum high-sensitivity C-reactive protein(hs-CRP)and lipoprotein-associated phospholipase A2(Lp-PLA2)in patients with arrhythmia and its significance.Methods:We selected 136 arrhythmia patients(observation group)who were treated at our hospital from February 2016 to March 2018.Among these patients,50 had premature ventricular contractions,42 had atrial fibrillation,24 had atrial flutter,and 20 had ventricular tachycardia.Simultaneously,we selected 120 healthy volunteers as the control group.We measured serum levels of hs-CRP and Lp-PLA2 in these subjects.Results:The levels of Lp-PLA2 and hs-CRP of the observation group were 210.06±30.46 pg/mL and 13.54±3.16,respectively,which were significantly higher than those of the control group(P<0.05).The serum levels of Lp-PLA2 and hs-CRP of patients with atrial flutter were 260.87±32.24 and 19.84±5.10 pg/mL,respectively,which were significantly higher than those of patients with premature ventricular contractions,atrial fibrillation,and ventricular tachycardia(P<0.05).Serum levels of Lp-PLA2 and hs-CRP were posi-tively correlated(r=0.413,P<0.05).Conclusion:Serum levels of hs-CRP and Lp-PLA2 in arrhythmia patients were significantly elevated and showed some association with the type of arrhythmia.展开更多
文摘Calcium-independent phospholipase A<sub>2</sub> (iPLA<sub>2</sub>) belongs to the group VI family of phospholipase superfamily (PLA<sub>2</sub>) that catalyses the hydrolysis of glycerophospholipids at the sn-2 ester bond, producing unesterified fatty acids and 2-lysophospholipids. Research interests on iPLA<sub>2</sub> have not been as significant as those on secretary PLA<sub>2</sub> and cytosolic PLA<sub>2</sub>. However, more efforts have been made recently on understanding the expression, regulation and biological function of iPLA<sub>2</sub>. iPLA<sub>2</sub> plays important roles in several biological processes, including signal transduction, phospholipid remodelling, eicosanoid formation, cell proliferation, cell differentiation and apoptosis. Modulation of iPLA<sub>2</sub> activity can have prominent effects on cellular metabolism, central nervous system and cardiovascular functions. Thus, dysregulation iPLA<sub>2</sub> can play a vital role in the pathogenesis of several diseases. The aim of this review is to provide the current understanding of the structure, function and regulation of group VI iPLA<sub>2</sub> and highlight its potential mechanisms of action in mediating several neurological disorders and cancer.
文摘Objective:The purpose of this study is to examine the expression ofserum high-sensitivity C-reactive protein(hs-CRP)and lipoprotein-associated phospholipase A2(Lp-PLA2)in patients with arrhythmia and its significance.Methods:We selected 136 arrhythmia patients(observation group)who were treated at our hospital from February 2016 to March 2018.Among these patients,50 had premature ventricular contractions,42 had atrial fibrillation,24 had atrial flutter,and 20 had ventricular tachycardia.Simultaneously,we selected 120 healthy volunteers as the control group.We measured serum levels of hs-CRP and Lp-PLA2 in these subjects.Results:The levels of Lp-PLA2 and hs-CRP of the observation group were 210.06±30.46 pg/mL and 13.54±3.16,respectively,which were significantly higher than those of the control group(P<0.05).The serum levels of Lp-PLA2 and hs-CRP of patients with atrial flutter were 260.87±32.24 and 19.84±5.10 pg/mL,respectively,which were significantly higher than those of patients with premature ventricular contractions,atrial fibrillation,and ventricular tachycardia(P<0.05).Serum levels of Lp-PLA2 and hs-CRP were posi-tively correlated(r=0.413,P<0.05).Conclusion:Serum levels of hs-CRP and Lp-PLA2 in arrhythmia patients were significantly elevated and showed some association with the type of arrhythmia.
