Analysis of sp Pillar Stability Experiment: Continuous thermo-mechanical model development and calibration

The paper describes an analysis of thermo-mechanical （TM） processes appearing during the Aspo Pillar Stability Experiment （APSE）. This analysis is based on finite elements with elasticity, plasticity and dam- age mechanics models of rock behaviour and some least squares calibration techniques. The main aim is to examine the capability of continuous mechanics models to predict brittle damage behaviour of gran- ite rocks. The performed simulations use an in-house finite element software GEM and self-developed experimental continuum damage MATLAB code. The main contributions are twofold. First, it is an inverse analysis, which is used for （1） verification of an initial stress measurement by back analysis of conver- gence measurement during construction of the access tunnel and （2） identification of heat transfer rock mass properties by an inverse method based on the known heat sources and temperature measurements. Second, three different hierarchically built models are used to estimate the pillar damage zones, i.e. elas- tic model with Drucker-Prager strength criterion, elasto-plastic model with the same yield limit and a combination of elasto-plasticity with continuum damage mechanics. The damage mechanics model is also used to simulate uniaxial and triaxial compressive strength tests on the ,Aspo granite.

Calibration chain design based on integrating sphere transfer radiometer for SI-traceable on-orbit spectral radiometric calibration and its uncertainty analysis

In order to satisfy the requirement of SI-traceable on-orbit absolute radiation calibration transfer with high accuracy for satellite remote sensors,a transfer chain consisting of a fiber coupling monochromator（FBM） and an integrating sphere transfer radiometer（ISTR） was designed in this paper.Depending on the Sun,this chain based on detectors provides precise spectral radiometric calibration and measurement to spectrometers in the reflective solar band（RSB） covering 300–2500 nm with a spectral bandwidth of 0.5–6 nm.It shortens the traditional chain based on lamp source and reduces the calibration uncertainty from 5% to 0.5% by using the cryogenic radiometer in space as a radiometric benchmark and trap detectors as secondary standard.This paper also gives a detailed uncertainty budget with reasonable distribution of each impact factor,including the weak spectral signal measurement with uncertainty of 0.28%.According to the peculiar design and comprehensive uncertainty analysis,it illustrates that the spectral radiance measurement uncertainty of the ISTR system can reach to 0.48%.The result satisfies the requirements of SI-traceable on-orbit calibration and has wider significance for expanding the application of the remote sensing data with high-quality.

Relative flux calibration for the Guoshoujing Telescope (LAMOST)

This paper presents a relative flux calibration method for the Guoshoujing Telescope （LAMOST）, which may be applied to connect a blue spectrum to a red spectrum to build the whole spectrum across the total wavelength range （3700 ～ 9000 A）. In each spectrograph, we estimate the effective temperatures of selected stars using a grid of spectral line indices in the blue spectral range and a comparison with stellar atmosphere models. For each spectrograph, stars of types A and F are selected as pseudo-standard stars, and the theoretical spectra are used to calibrate both the blue （3700 ～ 5900 A） and red spectrograph arms （5700 ～ 9000 A）. Then the spectral response function for these pseudo-standard stars could be used to correct the raw spectra provided by the other fibers of the spectrograph, after a fiber efficiency function has been derived from twilight flat-field exposures. A key problem in this method is the fitting of a pseudo stellar continuum, so we also give a detailed description of this step. The method is tested by comparing a small sample of LAMOST spectra calibrated in this way on stars also observed by the Sloan Digital Sky Survey. The result shows that the T eff estimation and relative flux calibration method are adequate.

New Calibration Technology for Safety Valves of Utility Boiler

Butterfly spring-relief valve, a crucial safety attachment of pressure vessel, is used to prevent pressuresystem from exceeding allowable limit value. Safe, expeditious and accurate calibration of safety valves is consequentlyof vital importance to safe and economic operation of generating units. NSH CALIBRATOR could complete, not only theon-line performance and parameter tests of safety valves within two to five seconds with opening pressure of safetyvalves and steam medium pressure automatically recorded, but also could complete the on-line adjustment of safetyvalves verified unqualified. It saves energy consumption, decreases noise pollution and improves accuracy and efficiencyof safety valve calibration.[

Error analysis and calibration for underwater sound intensity measuring system

Based on measuring the cross-spectrum density of sound pressure between two hydrophones, the facility for underwater sound intensity measurement is investigated and designed. According to the principle of two-hydrophone method for intensity measurement, the error analysis is carried out. Given the method of sound intensity measurement calibration for this underwater sound intensity measurement facility, the uncertainty of intensity measurement by this facility is evaluated. It is shown that the analysis and evaluation are agreeable to the experimental results.

Surrogate potency assays:Comparison of binding profiles complements dose response curves for unambiguous assessment of relative potencies

Surface plasmon resonance(SPR) systems are widely used for detailed characterization of antibody activities including antigen and Fc-receptor binding. During the later stages of development, where the focus is to ensure that established critical quality attributes(CQAs) are maintained during cell culture,purification and formulation processes, analysis is simplified, and relative potencies are often determined. Here, simulation of binding data revealed that relative potency values, determined via parallel line analysis(PLA) and half maximal effective concentration(EC50) analysis accurately reflect changes in active concentration only if binding kinetics remain unchanged. Changes in the association rate constant shifted dose response curves, and therefore relative potencies, in the same way as changes in analyte concentration do. However, for interactions characterized by stable binding, changes in the dissociation rate constant did not result in any shift, suggesting that this type of change may go unnoticed in the dose response curve. Thus, EC50 and PLA analyses of dose response curves obtained with an anti-TNF-α antibody were complemented with the Biacore functionality for sensorgram comparison analysis, whereby changes in antigen and Fc-receptor binding profiles could be detected. Next, analysis of temperature stressed TNF-α antibody revealed that calibration free concentration analysis(CFCA) data correlated perfectly with relative potency values. Together, these results demonstrate that combinations of SPR based dose response curves, sensorgram comparison and CFCA can be used to strengthen the confidence in relative potency assessments, and suggest that SPR can potentially be used as a surrogate potency assay in the quality control of biotherapeutic medicines.

Method study and uncertainty analysis of calibration coefficients validation based on the Inner Mongolia test site

Calibration coefficients validation is the foundation for ascertaining the sensor performance and carrying out the quantitative application.Based on the analysis of the differences between the calibration and validation,two calibration coefficients validation methods were introduced in this paper.Taking the HJ-1A satellite CCD1 camera as an example,the uncertainties of calibration coefficients validation were analyzed.The calibration coefficients validation errors were simulated based on the measured data at an Inner Mongolia test site.The result showed that in the large view angle,the ground directional reflectance variation and the atmospheric path variation were the main error sources in calibration coefficients validation.The ground directional reflectance correction and atmospheric observation angle normalization should be carried out to improve the validation accuracy of calibration coefficients.

A diagnostic method for distribution networks based on power supply safety standards

In order to overcome the shortages of diagnostic method for distribution networks considering the reliability assessment,this paper proposed a method based on power supply safety standards.It profoundly analyzed the security standard of supply for urban power networks,and established quantitative indicators of load groups based on different fault conditions.Then a method suitable for diagnostic evaluation of urban distribution networks in China was given.In the method,“N-1”calibration analysis of the distribution network was conducted.Then the results are compared with quantitative indicators of load groups on different conditions deriving the diagnostic conclusions and the standard revision is discussed.The feasibility and accuracy of the method is finally verified in the case study.