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CDR132L改善高血压合并高脂血症小鼠血管重构和功能
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作者 林俊敏 梁风金 +3 位作者 吴莹 许开祖 吴梅芳 林丽明 《中国动脉硬化杂志》 CAS 2024年第4期303-309,共7页
[目的]观察CDR132L(miR-132反义核苷酸)对高血压合并高脂血症小鼠血管重构和功能的影响,并探究其可能的作用机制。[方法]随机选择30只8周龄雄性C57BL/6小鼠,分为三组:对照组、模型组和CDR132L组,每组10只。对照组接受标准饲料喂养,模型... [目的]观察CDR132L(miR-132反义核苷酸)对高血压合并高脂血症小鼠血管重构和功能的影响,并探究其可能的作用机制。[方法]随机选择30只8周龄雄性C57BL/6小鼠,分为三组:对照组、模型组和CDR132L组,每组10只。对照组接受标准饲料喂养,模型组和CDR132L组给予N-硝基-L-精氨酸甲酯(L-NAME)和高脂食物联合喂养来诱导高血压和高脂血症。CDR132L组给予20 mg/kg CDR132L腹腔注射,1次/周,连续6周,对照组和模型组腹腔注射相同剂量的生理盐水溶液。尾套法测量小鼠尾动脉收缩压和舒张压,血脂、血糖检测由全自动生化分析仪完成,HE染色观察胸主动脉结构,血管环试验观察小鼠胸主动脉内皮依赖性舒张反应,定量基因扩增检测胸主动脉miR-132表达水平,Western blot检测胸主动脉Gab1和内皮型一氧化氮合酶(eNOS)蛋白表达水平。[结果]与对照组相比,模型组小鼠收缩压、舒张压、血清甘油三酯、血清总胆固醇和体质量均明显升高(P<0.05),胸主动脉内膜凹凸不平,血管壁厚度不均,中膜平滑肌细胞的排列呈现不规则状态,血管壁上存在大量脂肪积聚,胸主动脉内皮依赖性舒张反应减低(P<0.05),胸主动脉miR-132表达水平明显增加(P<0.05),Gab1和eNOS蛋白表达水平明显降低(P<0.05)。与模型组相比,CDR132L组小鼠收缩压、舒张压、血清甘油三酯、血清总胆固醇和体质量均无统计学差异(P>0.05),胸主动脉管腔内膜较完整光滑,血管壁厚度较均一,中膜平滑肌细胞的排列较为有序,血管壁仅存在少量脂肪积聚,胸主动脉内皮依赖性舒张反应增强(P<0.05),胸主动脉miR-132表达水平明显降低(P<0.05),Gab1和eNOS蛋白表达水平明显增加(P<0.05)。[结论]CDR132L能改善高血压合并高脂血症小鼠血管重构及内皮依赖性舒张功能,这一作用可能与其降低胸主动脉miR-132表达水平,进而上调胸主动脉Gab1和eNOS蛋白表达水平有关。 展开更多
关键词 cdr132L miR-132 高血压 高脂血症 血管重构 内皮舒张功能
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Detection of Turbulence Anomalies Using a Symbolic Classifier Algorithm in Airborne Quick Access Record(QAR)Data Analysis 被引量:1
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作者 Zibo ZHUANG Kunyun LIN +1 位作者 Hongying ZHANG Pak-Wai CHAN 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2024年第7期1438-1449,共12页
As the risks associated with air turbulence are intensified by climate change and the growth of the aviation industry,it has become imperative to monitor and mitigate these threats to ensure civil aviation safety.The ... As the risks associated with air turbulence are intensified by climate change and the growth of the aviation industry,it has become imperative to monitor and mitigate these threats to ensure civil aviation safety.The eddy dissipation rate(EDR)has been established as the standard metric for quantifying turbulence in civil aviation.This study aims to explore a universally applicable symbolic classification approach based on genetic programming to detect turbulence anomalies using quick access recorder(QAR)data.The detection of atmospheric turbulence is approached as an anomaly detection problem.Comparative evaluations demonstrate that this approach performs on par with direct EDR calculation methods in identifying turbulence events.Moreover,comparisons with alternative machine learning techniques indicate that the proposed technique is the optimal methodology currently available.In summary,the use of symbolic classification via genetic programming enables accurate turbulence detection from QAR data,comparable to that with established EDR approaches and surpassing that achieved with machine learning algorithms.This finding highlights the potential of integrating symbolic classifiers into turbulence monitoring systems to enhance civil aviation safety amidst rising environmental and operational hazards. 展开更多
关键词 turbulence detection symbolic classifier quick access recorder data
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环状RNA CDR1-AS通过靶向miR-1277对肺癌细胞增殖、凋亡和免疫因子表达的影响
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作者 王頔 郭兆刚 +1 位作者 亢野 徐然 《中国免疫学杂志》 CAS CSCD 北大核心 2024年第5期939-944,共6页
目的:探究环状RNA(circRNA)小脑变性相关蛋白1反义转录物(CDR1-AS)对肺癌细胞增殖、凋亡和免疫因子表达的影响及可能机制。方法:分别以癌旁组织、支气管上皮细胞BEAS-2B为对照,qRT-PCR检测肺癌组织、肺癌细胞系(NCI-H23、H1299、NCI-H4... 目的:探究环状RNA(circRNA)小脑变性相关蛋白1反义转录物(CDR1-AS)对肺癌细胞增殖、凋亡和免疫因子表达的影响及可能机制。方法:分别以癌旁组织、支气管上皮细胞BEAS-2B为对照,qRT-PCR检测肺癌组织、肺癌细胞系(NCI-H23、H1299、NCI-H446)中CDR1-AS、miR-1277表达。以肺癌H1299细胞为研究对象,分别转染CDR1-AS小干扰RNA(si-CDR1-AS)、miR-1277模拟物或共转染si-CDR1-AS与miR-1277抑制剂后,CCK-8实验、克隆形成实验、流式细胞术分别检测细胞活性、克隆形成数、细胞凋亡率,ELISA检测细胞培养上清液中免疫因子(TNF-α、IFN-γ)表达。双荧光素酶报告基因实验验证CDR1-AS与miR-1277的调控关系。结果:与癌旁组织或BEAS-2B细胞比较,肺癌组织或细胞系(NCI-H23、H1299、NCIH446)中CDR1-AS表达升高(P<0.05),miR-1277表达降低(P<0.05)。沉默CDR1-AS或过表达miR-1277后,H1299细胞活性、克隆形成数及TNF-α分泌量降低(P<0.05),细胞凋亡率、IFN-γ分泌量升高(P<0.05)。CDR1-AS靶向结合miR-1277,且沉默CDR1-AS的H1299细胞中miR-1277表达升高(P<0.05)。下调miR-1277逆转沉默CDR1-AS对H1299细胞增殖、凋亡及免疫因子表达的影响。结论:CDR1-AS在肺癌组织和细胞系中表达上调,沉默其表达可通过靶向上调miR-1277抑制肺癌H1299细胞增殖及肿瘤细胞免疫逃逸,并诱导细胞凋亡。 展开更多
关键词 肺癌 cdr1-AS miR-1277 增殖 凋亡 免疫逃逸
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乳腺癌组织中环状RNA CDR1as的表达及临床意义
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作者 石碧霞 陶爽 徐溪 《中国肿瘤外科杂志》 CAS 2024年第1期54-60,共7页
目的探讨环状RNA CDR1as在乳腺癌组织中的表达以及CDR1as在乳腺癌细胞中的调控作用,为乳腺癌治疗提供新靶点。方法选取江苏大学附属武进医院2022年6月至2023年6月收治的45例三阴性乳腺癌患者,采用实时定量聚合酶链反应(RT-qPCR)检测乳... 目的探讨环状RNA CDR1as在乳腺癌组织中的表达以及CDR1as在乳腺癌细胞中的调控作用,为乳腺癌治疗提供新靶点。方法选取江苏大学附属武进医院2022年6月至2023年6月收治的45例三阴性乳腺癌患者,采用实时定量聚合酶链反应(RT-qPCR)检测乳腺癌组织及其癌旁正常乳腺组织中CDR1as表达情况。购入人正常乳腺上皮MCF-10A细胞及乳腺癌细胞系MDA-MB-231、MDA-MB-468细胞,采用RT-qPCR检测CDR1as在乳腺正常细胞与癌细胞中的表达情况。通过体外实验验证CDR1as的环状特性,将特异性针对CDR1as的siRNA及过表达载体转入MDA-MB-231细胞,Ad-CDR1as为高表达组,shCDR1s为低表达组,Ad-CON/Si-NC为阴性对照组。并采用蛋白质印迹分析(Western-blot)法检测细胞PCNA蛋白表达水平,MTT法、CCK-8法检测细胞增殖能力的改变,Transwell实验、划痕实验检测乳腺癌细胞迁移、侵袭能力。结果CDR1as在三阴性乳腺癌患者中的表达在不同肿瘤大小、淋巴结转移、组织学分级及临床分期上差异有统计学意义。乳腺癌患者癌组织中CDR1as的表达高于癌旁正常组织。乳腺癌细胞系MDA-MB-231中CDR1as表达量高于MCF-10A细胞。敲低/过表达CDR1as后,CDR1as沉默后乳腺癌细胞的细胞增殖量明显减少,而CDR1as过表达促进细胞增殖,差异有统计学意义。Western-blot结果显示Ad-CDR1as组PCNA表达高于Ad-CON组,Transwell结果显示Ad-CDR1as组细胞侵袭量大于Ad-CON组,而沉默CDR1as后细胞侵袭量显著降低;划痕试验显示,Ad-CDR1as组细胞迁移能力高于Ad-CON组,而沉默CDR1as后细胞迁移能力显著减弱,差异均有统计学意义。结论CDR1as在三阴性乳腺癌患者癌组织中高表达,且与临床病理特征相关。CDR1as在三阴性乳腺癌细胞中高表达,并促进三阴性乳腺癌细胞的增殖、侵袭和迁移,CDR1as可能是治疗三阴性乳腺癌的潜在靶点。 展开更多
关键词 环状RNA cdr1as 三阴性乳腺癌 增殖 侵袭 转移
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迈瑞BC-6800 Plus全自动血液分析仪CDR通道模式检测电阻法血小板假性异常性能评价
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作者 凌秀婷 刘爱胜 +1 位作者 田丽 刘国栋 《生物医学工程与临床》 CAS 2024年第5期717-721,共5页
目的评价迈瑞BC-6800 Plus全自动血液分析仪(简称BC-6800 Plus分析仪)8倍倍增模式——利用光学法原理+半导体激光+RNA核酸荧光染色法(CDR)通道模式检测电阻法血小板(PLT)假性异常的性能。方法选择2021年2月至2023年5月BC-6800 Plus分析... 目的评价迈瑞BC-6800 Plus全自动血液分析仪(简称BC-6800 Plus分析仪)8倍倍增模式——利用光学法原理+半导体激光+RNA核酸荧光染色法(CDR)通道模式检测电阻法血小板(PLT)假性异常的性能。方法选择2021年2月至2023年5月BC-6800 Plus分析仪电阻法PLT假性异常标本89例,分别采用电阻法、CDR通道模式及手工计数法进行PLT检测,比较3种方法检测结果的差异性。同时采用CDR通道模式连续检测PLT 10次,评价其重复性,并以手工计数法为参照,评价其准确性和一致性。结果BC-6800 Plus分析仪CDR通道模式检测电阻法PLT假性升高标本结果[(231.81±57.75)×10^(9)/L]明显低于电阻法[(586.81±124.99)×10^(9)/L],而假性减少标本结果[(189.37±51.06)×10^(9)/L]明显高于电阻法[(43.52±20.10)×10^(9)/L],差异有统计学意义(P<0.05);但与手工计数法[(218.95±51.26)×10^(9)/L和(206.37±56.07)×10^(9)/L]差异无统计学意义(P>0.05);BC-6800 Plus分析仪CDR通道模式检测电阻法PLT假性升高和减少标本CV值分别为4.33%和5.20%,均<10.00%;以手工计数结果为靶值,BC-6800 Plus分析仪CDR通道模式检测电阻法PLT假性升高和减少标本Bias分别为7.56%和-5.28%,均<10.00%;经Pearman相关分析,BC-6800 Plus分析仪CDR通道模式检测电阻法PLT假性异常标本与手工计数法结果呈明显正相关(r_(升高标本)=0.9613,r_(减少标本)=0.9401,P<0.05)。结论BC-6800 Plus分析仪CDR通道模式检测电阻法PLT假性异常标本中PLT与手工计数法结果具有很好的一致性,且重复性好、正确度高,能解决红细胞(RBC)碎片、小RBC、大PLT及PLT聚集对PLT检测的干扰,值得临床推广应用。 展开更多
关键词 血液分析仪 假性异常 血小板 cdr通道模式 性能评价
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5-Aza-CdR通过Notch1通路对小鼠海马神经发生的影响
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作者 王报捷 苏丽晴 +4 位作者 张志勇 闫磊 王志广 包素雅 邵国 《中国比较医学杂志》 CAS 北大核心 2024年第1期34-39,共6页
目的研究5-Aza-CdR对Notch1通路影响及神经再生的影响,并通过小鼠主动回避行为实验来探讨5-Aza-CdR对小鼠学习记忆能力的影响。方法将60只6~8周龄SPF级ICR雄性小鼠分为两组,通过侧脑室注射(i.c.v)给一组小鼠注射5-Aza-CdR,另一组注射BS... 目的研究5-Aza-CdR对Notch1通路影响及神经再生的影响,并通过小鼠主动回避行为实验来探讨5-Aza-CdR对小鼠学习记忆能力的影响。方法将60只6~8周龄SPF级ICR雄性小鼠分为两组,通过侧脑室注射(i.c.v)给一组小鼠注射5-Aza-CdR,另一组注射BSA作为对照组。注射后24 h通过Real-time PCR和Western blot检测Notch1和HES1的mRNA和蛋白表达水平;通过激光共聚焦显微镜观察5-溴-2’-脱氧尿苷(BrdU)阳性细胞和海马DG中Notch1的表达;用MS-PCR检测Notch1甲基化变化;通过穿梭回避实验来评估小鼠的学习和记忆行为。结果注射5-Aza-CdR使海马Notch1通路活性增加并促进DG区神经细胞再生,降低Notch1启动子区甲基化水平,小鼠主动回避行为能力得到提升。结论5-Aza-CdR对小鼠主动回避行为的影响可能与Notch1通路影响海马神经再生有关。 展开更多
关键词 5-AZA-cdr 神经发生 NOTCH1 学习和记忆
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急性心肌梗死中环状RNA CDR1as位点筛选的研究
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作者 唐赛赛 孙秀梅 +3 位作者 王海凤 许梦婷 林浩 李文勇 《大医生》 2024年第2期46-49,共4页
目的 探讨PubMed筛选文献、千人基金组计划(1 000 genomes project)、Haploview软件联合应用于筛选与心肌梗死相关的单核苷酸多态性的文献的可行性。方法 使用PubMed网站检索并确定心血管疾病相关基因,1 000 genomes project网站检索中... 目的 探讨PubMed筛选文献、千人基金组计划(1 000 genomes project)、Haploview软件联合应用于筛选与心肌梗死相关的单核苷酸多态性的文献的可行性。方法 使用PubMed网站检索并确定心血管疾病相关基因,1 000 genomes project网站检索中国汉族人群CDR1as基因的单核苷酸多态性(SNP)数据。应用Haploview软件以最小等位基因频率(MAF)>0.05、r2> 0.8作为筛选标签SNPs指标。结果 CDR1as基因41个SNPs位点筛选出3个检测位点,分别为rs12688274、rs5907638、rs76284232。结论 通过PubMed、千人基因组计划和Haploview联合使用可实现标签SNPs筛选,值得进一步探究。 展开更多
关键词 环状RNA cdr1as 心肌梗死 位点筛选
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Chrysosplenium fallax Koldaeva(Chrysosplenium),a newly recorded species from China
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作者 Xiang Niyan Chen Xitang +2 位作者 Yang Tiange Liu Xihong Liu Hong 《植物科学学报》 CAS CSCD 北大核心 2024年第4期423-430,共8页
Chrysosplenium fallax Koldaeva,recently discovered and collected in Yanji,Jilin Province,repre-sents a newly recorded species of Saxifragaceae in China.This species,native to the Russian Far East,was first described a... Chrysosplenium fallax Koldaeva,recently discovered and collected in Yanji,Jilin Province,repre-sents a newly recorded species of Saxifragaceae in China.This species,native to the Russian Far East,was first described as a new species in 2021.Based on precise field investigations and specimen examination,we provide a comprehensive description of C.fallax and its seed micromorphology.Phylogenetic analysis based on chloroplast genomes of 45 Chrysosplenium species confirmed the systematic position of C.fallax in Chrysosplenium.Voucher specimens were deposited in the Herbarium of South-Central Minzu University(HSN). 展开更多
关键词 Chrysosplenium fallax Chrysosplenium Newly record PHYLOGENY China
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Machine learning for carbonate formation drilling: Mud loss prediction using seismic attributes and mud loss records
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作者 Hui-Wen Pang Han-Qing Wang +4 位作者 Yi-Tian Xiao Yan Jin Yun-Hu Lu Yong-Dong Fan Zhen Nie 《Petroleum Science》 SCIE EI CAS CSCD 2024年第2期1241-1256,共16页
Due to the complexity and variability of carbonate formation leakage zones, lost circulation prediction and control is one of the major challenges of carbonate drilling. It raises well-control risks and production exp... Due to the complexity and variability of carbonate formation leakage zones, lost circulation prediction and control is one of the major challenges of carbonate drilling. It raises well-control risks and production expenses. This research utilizes the H oilfield as an example, employs seismic features to analyze mud loss prediction, and produces a complete set of pre-drilling mud loss prediction solutions. Firstly, 16seismic attributes are calculated based on the post-stack seismic data, and the mud loss rate per unit footage is specified. The sample set is constructed by extracting each attribute from the seismic trace surrounding 15 typical wells, with a ratio of 8:2 between the training set and the test set. With the calibration results for mud loss rate per unit footage, the nonlinear mapping relationship between seismic attributes and mud loss rate per unit size is established using the mixed density network model.Then, the influence of the number of sub-Gausses and the uncertainty coefficient on the model's prediction is evaluated. Finally, the model is used in conjunction with downhole drilling conditions to assess the risk of mud loss in various layers and along the wellbore trajectory. The study demonstrates that the mean relative errors of the model for training data and test data are 6.9% and 7.5%, respectively, and that R2is 90% and 88%, respectively, for training data and test data. The accuracy and efficacy of mud loss prediction may be greatly enhanced by combining 16 seismic attributes with the mud loss rate per unit footage and applying machine learning methods. The mud loss prediction model based on the MDN model can not only predict the mud loss rate but also objectively evaluate the prediction based on the quality of the data and the model. 展开更多
关键词 Lost circulation Risk prediction Machine learning Seismic attributes Mud loss records
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广播电视工程中数字音频广播CDR技术的运用探索
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作者 刘思佳 《电声技术》 2024年第2期4-6,共3页
近年来,随着数字广播工作的持续推进,形成了完善的中国数字化广播(China Digital Radio,CDR)行业与技术标准,并被应用于广播电视工程。文章主要探索广播电视工程中数字音频广播CDR技术的运用,通过数字音频技术与广播电视工程的有机结合... 近年来,随着数字广播工作的持续推进,形成了完善的中国数字化广播(China Digital Radio,CDR)行业与技术标准,并被应用于广播电视工程。文章主要探索广播电视工程中数字音频广播CDR技术的运用,通过数字音频技术与广播电视工程的有机结合,推动广播电视质量的提升,满足观众多样化的需求,有助于新时代背景下广播电视工程的持续发展。 展开更多
关键词 广播电视工程 数字音频广播技术 中国数字化广播(cdr)
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New record of the feather star Palaeocomatella hiwia(Echinodermata:Crinoidea:Comatulida)from Zhenbei Seamount in South China Sea:new insights into the taxonomic position of Palaeocomatella
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作者 Shao’e SUN Zijie MEI +2 位作者 Zhongli SHA Jing WANG Nansheng CHEN 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2024年第1期244-251,共8页
One specimen belonging to the family Comatellinae was collected from the Zhenbei Seamount(332.5–478.2 m)in the South China Sea in July 2022.Based on the morphological characters,the specimen was identified as Palaeoc... One specimen belonging to the family Comatellinae was collected from the Zhenbei Seamount(332.5–478.2 m)in the South China Sea in July 2022.Based on the morphological characters,the specimen was identified as Palaeocomatella hiwia McKnight,1977.It is first recorded from China Sea and redescribed in detail.This specimen differs from the original description from New Zealand for never showing syzygy at br4+5 or br5+6 on interior and br1+2 on exterior arms.However,it is much conform to the redescription to specimens from Indonesia,with only differences in position of the second syzygy and distalmost pinnule comb.Specimen is deposited in the Institute of Oceanology,Chinese Academy of Sciences.Phylogenetic analyses based on the mitochondrial c oxidase subunit I(COI)and 16S rRNA genes indicated that P.hiwia was nested within the tribe Phanogeniini and clustered with Aphanocomaster pulcher.Furthermore,P.hiwia showed same morphological features in terms of mouth placement,comb location,and number of comb teeth rows as other genera of Phanogeniini.Therefore,we suggest that the genus Palaeocomatella should be put in the tribe Phanogeniini. 展开更多
关键词 new record Palaeocomatella hiwia McKnight 1977 South China Sea phylogenetic relationship TAXONOMY
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Development of Self-Rated Nursing Record Frequency for Delirium Care of Nurses in Acute Care Hospitals (NRDC-Acute)
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作者 Katsuhiko Hattori Kenichi Matsuda 《Open Journal of Nursing》 2024年第8期412-420,共9页
Background: Nursing records play an important role in multidisciplinary collaborations in delirium care. This study aims to develop a self-rated nursing record frequency scale for delirium care among nurses in acute c... Background: Nursing records play an important role in multidisciplinary collaborations in delirium care. This study aims to develop a self-rated nursing record frequency scale for delirium care among nurses in acute care hospitals (NRDC-Acute). Methods: A draft of the scale was developed after a literature review and meeting with researchers with experience in delirium care, and a master’s or doctoral degree in nursing. We identified 25 items on a 5-point Likert scale. Subsequently, an anonymous self-administered questionnaire survey was administered to 520 nurses from 41 acute care hospitals in Japan, and the reliability and validity of the scale were examined. Results: There were 232 (44.6%) respondents and 218 (41.9%) valid responses. The mean duration of clinical experience was 15.2 years (SD = 8.8). Exploratory factor analysis extracted 4 factors and 13 items for this scale. The model fit indices were GFI = 0.991, AGFI = 0.986, and SRMR = 0.046. The Cronbach’s alpha coefficient for the entire scale was .888. The four factors were named “Record of Pharmacological Delirium Care on Pro Re Nata (PRN)”, “Record of Non-Pharmacological Delirium Care”, “Record of Pharmacological Delirium Care on Regular Medication”, and “Record of Collaboration for Delirium Care”. Conclusion: The scale was relatively reliable and valid. Nurses in acute care hospitals can use this scale to identify and address issues related to the documentation of nursing records for delirium care. 展开更多
关键词 Acute Care Hospitals Delirium Care Nurses Nursing records Scale Development
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Impact of Laboratory Value Flowsheet in Electronic Health Record (EHR) Documentation Time
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作者 Isabel Rosado Pogozelski 《Open Journal of Nursing》 2024年第1期40-50,共11页
Research on the use of EHR is contradictory since it presents contradicting results regarding the time spent documenting. There is research that supports the use of electronic records as a tool to speed documentation;... Research on the use of EHR is contradictory since it presents contradicting results regarding the time spent documenting. There is research that supports the use of electronic records as a tool to speed documentation;and research that found that it is time consuming. The purpose of this quantitative retrospective before-after project was to measure the impact of using the laboratory value flowsheet within the EHR on documentation time. The research question was: “Does the use of a laboratory value flowsheet in the EHR impact documentation time by primary care providers (PCPs)?” The theoretical framework utilized in this project was the Donabedian Model. The population in this research was the two PCPs in a small primary care clinic in the northwest of Puerto Rico. The sample was composed of all the encounters during the months of October 2019 and December 2019. The data was obtained through data mining and analyzed using SPSS 27. The evaluative outcome of this project is that there is a decrease in documentation time after implementation of the use of the laboratory value flowsheet in the EHR. However, patients per day increase therefore having an impact on the number of patients seen per day/week/month. The implications for clinical practice include the use of templates to improve workflow and documentation as well as decreasing documentation time while also increasing the number of patients seen per day. . 展开更多
关键词 Electronic Health record EHR Laboratory Results Template Documentation Time
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Case Records as Medical Stories: A Song-dynasty Doctor’s Narration of His Own Medicine-Xu Shuwei (1080-1154)
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作者 Asaf Goldschmidt 《Chinese Medicine and Culture》 2024年第2期95-103,共9页
The key point in studying or teaching the history of Chinese medicine is on the doctrines underlying it and on its perception of the body,physiology,pathology,and its treatment.Namely,there is often a tendency to focu... The key point in studying or teaching the history of Chinese medicine is on the doctrines underlying it and on its perception of the body,physiology,pathology,and its treatment.Namely,there is often a tendency to focus on reading and analysing the classical canons and therapy-related texts including formularies and materia medica collections.However,focusing on these sources provides us with a one-sided presentation of Chinese medicine.These primary sources lack the clinical down-to-earth know-how that encompasses medical treatment,which are represented,for instance,in the clinical rounds of modern medical schools.Our traditional focus on the medical canons and formularies provides almost no clinical knowledge,leaving us with a one-sided narrative that ignores how medicine and healing are actually practiced in the field.This paper focuses on the latter aspect of medicine from a historical perspective.Using written and visual sources dating to the Song dynasty,clinical encounters between doctors and patients including their families are depicted based on case records recorded by a physician,members of the patient’s family,and bystanders.This array of case records or case stories will enable us to narrate the interaction between physicians and patients both from the clinical perspective and from the social interaction.This paper will also discuss visual depictions of the medical encounter to provide another perspective for narrating medicine during the Song dynasty.Medical case records and paintings depicting medical encounters are exemplary of the potential of Chinese primary sources for narrative medicine. 展开更多
关键词 Clinical encounter Medical practice Song dynasty Xu Shuwei Case records
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The Development of the “Monitoring Application for Inappropriate Expressions in Nursing Records”for PsyNACS©
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作者 Hirokazu Ito Yuko Yasuhara Tetsuya Tanioka 《Journal of Computer and Communications》 2024年第5期42-52,共11页
Lengthening periods of hospitalization, increasing numbers of patients with age-related complications, and a shortage of nursing staff have been of great concern in medical psychiatry in Japan. Under these circumstanc... Lengthening periods of hospitalization, increasing numbers of patients with age-related complications, and a shortage of nursing staff have been of great concern in medical psychiatry in Japan. Under these circumstances, countries such as Japan that face a super-aging society and a decline in the working-age population, have been recommended for use of advanced information and communications technology (ICT) to improve the efficiency of medical treatment and care. This study aims to develop the “Monitoring Application for Inappropriate Expressions in Nursing Records” for using PsyNACS<sup>©</sup>, which will enable psychiatric nursing plans to harness the advantages of ICT. The functions considered necessary are as follows: 1) identification of users who enter information;2) a necessary database for lists of inappropriate expressions;3) development of a matching function to recommend proper writing input and a warning function;and 4) a management function for an inappropriate expression list database. A demonstration experiment for developing the application in this study was conducted at a specialized psychiatric hospital. To introduce them to the application, nurses and nurse managers were informed about the system developed in this study, and a survey regarding their opinions on the functions of the application was conducted with ten nurse managers. The results were evaluated in terms of usefulness for nursing care, documentation, and the education of nurses from an ethical perspective. This study suggests that matching their input with an inappropriate expression database will allow nurses to record more appropriate expressions. From an ethical perspective, the ability to use appropriate expressions makes records more likely to withstand disclosure requests from patients and their families. 展开更多
关键词 PsyNACS© Monitoring Application Inappropriate Expressions Nursing records
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大黄素联合5AzA-cdR增强对胰腺癌细胞ppENK抑癌基因的去甲基化作用研究
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作者 陈亮 唐坚 +4 位作者 褚永权 叶剑宏 沈超 钱晓宇 姚旭枫 《全科医学临床与教育》 2024年第2期103-106,共4页
目的 研究大黄素联合5-氮-2’脱氧胞苷(5AzA-cdR)能否增强其对胰腺癌细胞抑癌基因前脑啡肽原(ppENK)的去甲基化作用。方法 选择Panc1细胞为研究对象,首先采用细胞计数实验(CCK-8)检测不同浓度大黄素对胰腺癌细胞的生长抑制情况,根据CCK-... 目的 研究大黄素联合5-氮-2’脱氧胞苷(5AzA-cdR)能否增强其对胰腺癌细胞抑癌基因前脑啡肽原(ppENK)的去甲基化作用。方法 选择Panc1细胞为研究对象,首先采用细胞计数实验(CCK-8)检测不同浓度大黄素对胰腺癌细胞的生长抑制情况,根据CCK-8结果选择最适大黄素用药的浓度,后将Panc1细胞分为四组:对照组、最适大黄素浓度组、5AzA-cdR组和大黄素联合5AzA-cdR用药组,采用斑点杂交实验(Dot-blot)检测四组对基因组5-甲基胞嘧啶(5mc)的影响,最后使用重亚硫酸盐测序PCR(BSP)检测四组对ppENK甲基化的影响。结果CCK-8显示,大黄素以浓度梯度和时间梯度抑制Panc1细胞生长;Dot-blot结果显示,最适大黄素浓度组和5AzAcdR组5 mc水平低于对照组,差异均有统计学意义(t分别=12.55、20.12,P均<0.05),5AzA-cdR组5 mc较最适大黄素浓度组下降明显,差异有统计学意义(t=17.76,P<0.05),大黄素联合5AzA-cdR用药组5 mc较对照组、最适大黄素浓度组以及5AzA-cdR组显著下降,差异有统计学意义(t分别=30.22、20.77、10.45,P均<0.05)。BSP结果显示,最适大黄素浓度组和5AzA-cdR组ppENK甲基化水平均低于对照组,差异均有统计学意义(t分别=14.27、21.34,P均<0.05),5AzA-cdR组ppENK甲基化水平较最适大黄素浓度组下降明显,差异有统计学意义(t=16.41,P<0.05),大黄素联合5AzA-cdR用药组ppENK甲基化水平较对照组、最适大黄素浓度组以及5AzA-cdR组显著下降,差异均有统计学意义(t分别=32.68、19.33、10.12,P均<0.05)。结论 大黄素联合5AzA-cdR可增加其对胰腺癌细胞抑癌基因ppENK的去甲基化作用。 展开更多
关键词 大黄素 胰腺癌 去甲基化 5-氮-2’脱氧胞苷
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数字音频广播CDR编码技术及应用探究
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作者 齐俊虎 《数字传媒研究》 2024年第7期48-50,69,共4页
传统广播由于受限于频谱资源的有限和信号传输质量不高,音质和服务覆盖范围存在一定的局限性。为了提高音质、增加节目数量以及实现更广范围的信号覆盖,数字音频广播应运而生。CDR编码技术便是为满足数字音频广播研发的,可以用于传输多... 传统广播由于受限于频谱资源的有限和信号传输质量不高,音质和服务覆盖范围存在一定的局限性。为了提高音质、增加节目数量以及实现更广范围的信号覆盖,数字音频广播应运而生。CDR编码技术便是为满足数字音频广播研发的,可以用于传输多个音频节目、数据服务以及其他附加信息,提供了更好的音质和更稳定的信号传输,使得数字音频广播具备了高保真音质、覆盖范围广、抗干扰能力强等优势。 展开更多
关键词 数字音频 广播系统 cdr编码技术 应用
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盐酸多奈哌齐治疗老年痴呆的临床效果及对CDR评分、MMSE评分、血清学指标的影响分析
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作者 文丽影 《中文科技期刊数据库(引文版)医药卫生》 2024年第10期0048-0051,共4页
探究老年痴呆的有效治疗方案。方法 抽选70例老年痴呆患者样本,随机分组为观察组(盐酸多奈哌齐治疗35例)、对照组(吡拉西坦治疗35例),比较两组治疗效果。结果 治疗后观察组患者临床有效率、MMSE评分、CDR评分、ADL评分、血清学指标、不... 探究老年痴呆的有效治疗方案。方法 抽选70例老年痴呆患者样本,随机分组为观察组(盐酸多奈哌齐治疗35例)、对照组(吡拉西坦治疗35例),比较两组治疗效果。结果 治疗后观察组患者临床有效率、MMSE评分、CDR评分、ADL评分、血清学指标、不良反应发生率均明显优于对照组。结论 老年痴呆患者采用盐酸多奈哌齐治疗效果显著,用药安全性较高,可在医疗机构中推广应用。 展开更多
关键词 盐酸多奈哌齐 老年痴呆 cdr评分 MMSE评分
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解铃须从系铃处——Records与Archives概念正史(二)
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作者 王岚 《档案管理》 北大核心 2024年第1期28-35,共8页
笔者的“四正”,从名分、本义、学理、法律上已弄清Records的含义,但坚持“Records文件观”者依旧质疑:若Records是档案,那Archives是什么?两者并列时又怎么翻译?还有人说Records是记录。既然是英语和法语带来的问题,循着英法档案历史... 笔者的“四正”,从名分、本义、学理、法律上已弄清Records的含义,但坚持“Records文件观”者依旧质疑:若Records是档案,那Archives是什么?两者并列时又怎么翻译?还有人说Records是记录。既然是英语和法语带来的问题,循着英法档案历史去寻找,才是解铃的关键:以英法八百年档案工作中重要人物和事件为主线,探求其档案的源流、本质、内含及演变,为档案概念正史。 展开更多
关键词 卷档 录卷归档 档案 皇家档案 馆藏档案 现行档案 概念 历史
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解铃须从系铃处——Records与Archives概念正史(三)
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作者 王岚 《档案管理》 北大核心 2024年第2期27-33,共7页
笔者的“四正”,从名分、本义、学理、法律上已弄清Records的含义,但坚持“Records文件观”者依旧质疑:若Records是档案,那Archives是什么?两者并列时又怎么翻译?还有人说Records是记录。既然是英语和法语带来的问题,循着英法档案历史... 笔者的“四正”,从名分、本义、学理、法律上已弄清Records的含义,但坚持“Records文件观”者依旧质疑:若Records是档案,那Archives是什么?两者并列时又怎么翻译?还有人说Records是记录。既然是英语和法语带来的问题,循着英法档案历史去寻找,才是解铃的关键:以英法八百年档案工作中重要人物和事件为主线,探求其档案的源流、本质、内含及演变,为档案概念正史。 展开更多
关键词 卷档 录卷归档 档案 皇家档案 馆藏档案 现行档案 概念 历史
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