Fruit colour is essential to seed dispersal,speciation,and biological diversity in global ecosystems.The relationship between fruit-colour variation and species diversification has long been of interest in evolutionar...Fruit colour is essential to seed dispersal,speciation,and biological diversity in global ecosystems.The relationship between fruit-colour variation and species diversification has long been of interest in evolutionary biology,but remains poorly understood at the genus level.Here,we used Callicarpa,a typical representative of pantropical angiosperm,to analyse whether fruit colours are correlated with biogeographic distribution,dispersal events,and diversification rate.We estimated a time-calibrated phylogeny for Callicarpa and reconstructed ancestral fruit colour.Utilizing phylogenetic methods,we estimated the major dispersal events across the phylogenetic tree and the most likely fruit colours related to each dispersal event,and tested whether the dispersal frequencies and distances of the four fruit colours between major biogeographical areas were equal.We then tested whether fruit colours are correlated with latitude,elevation,and diversification rate.Biogeographical reconstructions showed that Callicarpa originated in the East Asia and Southeast Asia during the Eocene(-35.53 Ma) and diverse species diverged mainly in the Miocene and lasted into the Pleistocene.Large-scale dispersal events were significantly associated with violet-fruited lineages.Furthermore,different fruit colours were markedly correlated with different latitudes and elevations(e.g.,violet fruits were correlated with higher latitudes and elevations;red fruits and black fruits with lower latitudes;white fruits with higher elevations).Notably,violet fruits were statistically associated with highest diversification rates,driving fruit colour variation among different regions globally.Our results contribute to further understanding why fruit colour is so variable at the genus level of angiosperms in different areas around the world.展开更多
Objective:To explore the anti-diabetic effects and its underlying mechanism of Annona muricata Linn fruit ethanol extract(AME).Methods:Streptozotocin-induced type 2 diabetic(T2DM)mouse model was constructed.Those diab...Objective:To explore the anti-diabetic effects and its underlying mechanism of Annona muricata Linn fruit ethanol extract(AME).Methods:Streptozotocin-induced type 2 diabetic(T2DM)mouse model was constructed.Those diabetic mice were randomly grouped and given 50 mg/kg acarbose or AME(200 mg/kg,100 mg/kg or 50 mg/kg)for four weeks.The body weight,postprandial blood glucose and glycosylated hemoglobin levels were measured during the administration.After the administration,a glucose tolerance test was performed,and the levels of triglycerides,cholesterol and low-density lipoproteins in mice were detected by biochemical test kits.The inhibitory activity of AME onα-glucosidase in vivo and in vitro was determined by enzyme inhibition tests.Results:AME significantly reduced weight gain,postprandial blood glucose,glycosylated hemoglobin and low-density lipoprotein levels in T2DM mice;enhanced glucose tolerance and pancreaticβ-cell function of T2DM mice;inhibitedα-glucosidase activity in mouse intestine in an noncompetitive manner.Conclusion:AME may noncompetitive inhibitα-glucosidase activity and reduce postprandial glucose intake to achieve a therapeutic and regulatory effect on type 2 diabetes.展开更多
基金funded by National Natural Science Foundation of China under Grant [31760045 and 31970220]Natural Science Foundation of Guangxi Province under Grant[2018GXNSFAA281132]。
文摘Fruit colour is essential to seed dispersal,speciation,and biological diversity in global ecosystems.The relationship between fruit-colour variation and species diversification has long been of interest in evolutionary biology,but remains poorly understood at the genus level.Here,we used Callicarpa,a typical representative of pantropical angiosperm,to analyse whether fruit colours are correlated with biogeographic distribution,dispersal events,and diversification rate.We estimated a time-calibrated phylogeny for Callicarpa and reconstructed ancestral fruit colour.Utilizing phylogenetic methods,we estimated the major dispersal events across the phylogenetic tree and the most likely fruit colours related to each dispersal event,and tested whether the dispersal frequencies and distances of the four fruit colours between major biogeographical areas were equal.We then tested whether fruit colours are correlated with latitude,elevation,and diversification rate.Biogeographical reconstructions showed that Callicarpa originated in the East Asia and Southeast Asia during the Eocene(-35.53 Ma) and diverse species diverged mainly in the Miocene and lasted into the Pleistocene.Large-scale dispersal events were significantly associated with violet-fruited lineages.Furthermore,different fruit colours were markedly correlated with different latitudes and elevations(e.g.,violet fruits were correlated with higher latitudes and elevations;red fruits and black fruits with lower latitudes;white fruits with higher elevations).Notably,violet fruits were statistically associated with highest diversification rates,driving fruit colour variation among different regions globally.Our results contribute to further understanding why fruit colour is so variable at the genus level of angiosperms in different areas around the world.
基金supported by 2020 College Students Innovation and Entrepreneurship Training Program(X202011810069)the National Natural Science Foundation of China(81460591)。
文摘Objective:To explore the anti-diabetic effects and its underlying mechanism of Annona muricata Linn fruit ethanol extract(AME).Methods:Streptozotocin-induced type 2 diabetic(T2DM)mouse model was constructed.Those diabetic mice were randomly grouped and given 50 mg/kg acarbose or AME(200 mg/kg,100 mg/kg or 50 mg/kg)for four weeks.The body weight,postprandial blood glucose and glycosylated hemoglobin levels were measured during the administration.After the administration,a glucose tolerance test was performed,and the levels of triglycerides,cholesterol and low-density lipoproteins in mice were detected by biochemical test kits.The inhibitory activity of AME onα-glucosidase in vivo and in vitro was determined by enzyme inhibition tests.Results:AME significantly reduced weight gain,postprandial blood glucose,glycosylated hemoglobin and low-density lipoprotein levels in T2DM mice;enhanced glucose tolerance and pancreaticβ-cell function of T2DM mice;inhibitedα-glucosidase activity in mouse intestine in an noncompetitive manner.Conclusion:AME may noncompetitive inhibitα-glucosidase activity and reduce postprandial glucose intake to achieve a therapeutic and regulatory effect on type 2 diabetes.