Objective:To explore relationships between CANX expression,prognosis and immune infiltration of acute myeloid leukemia(AML)patients.Methods:The TIMER database was used to compare the CANX expression among a variety of...Objective:To explore relationships between CANX expression,prognosis and immune infiltration of acute myeloid leukemia(AML)patients.Methods:The TIMER database was used to compare the CANX expression among a variety of TCGA tumor and normal tissue samples.The difference of CANX expression between AML and normal samples was found by R software.The Kaplan-Meier method and Log-Rank test were used to assess the relationship between CANX expression and patient survival.The R software was used to find correlations between CANX expression,clinical characteristics,drug sensitivity,and immune infiltration in AML.Results:The differential expression of CANX in 13 tumor and normal tissue samples were statistically significant(P<0.05).The high CANX expression was associated with a favorable prognosis(P<0.05),which was validated in GSE37642.The expression of CANX was correlated with age,survival status,FAB stage,and karyotype(P<0.05).High CANX expression,low age and favorable karyotype were independent predictors of a favorable prognosis(P<0.05).CANX expression may affect the sensitivity of AML patients to multiple drugs(P<0.05).The expression of CANX was positively correlated with that of M1 macrophages and CD8 T cells.Conclusion:CANX may be used as a novel potential biomarker,and could benefit AML patients by predicting patient prognosis and providing precise treatment indications.展开更多
The development of space-based Automatic Dependent Surveillance-Broadcast (ADS-B) will allow surveillance of aircraft in areas not covered by radar or ground-based ADS-B systems. In September 2016, the Canadian Advanc...The development of space-based Automatic Dependent Surveillance-Broadcast (ADS-B) will allow surveillance of aircraft in areas not covered by radar or ground-based ADS-B systems. In September 2016, the Canadian Advanced Nanospace eXperiment-7 (CanX-7) satellite was launched into a 690 km sun synchronous orbit with an ADS-B receiver payload. The first phase of ADS-B data collection took place over the North Atlantic between 4 and 31 October. A preliminary assessment of the data indicates that the average ADS-B signal strength is close to the calculated receiver detection threshold of D94.5 ± 0.5 dBm. The pattern of received ADS-B reception appears to be consistent with a signal propagation model developed for the CanX-7 mission. Future work includes the comparison of coincidental flight plan data for the operations area and an analysis of the payload antenna pattern.展开更多
The CanX-7 Automatic Dependent Surveillance-Broadcast (ADS-B) nanosatellite mission collected more than four million ADS-B messages between October 2016 and April 2017. An analysis of data collected over the north Atl...The CanX-7 Automatic Dependent Surveillance-Broadcast (ADS-B) nanosatellite mission collected more than four million ADS-B messages between October 2016 and April 2017. An analysis of data collected over the north Atlantic Ocean from 05 to 28 Oct included 20,707 position messages in which the angle from satellite nadir to aircraft was determined. The proximity of the received signal strength to the noise floor of the sensor allowed for an analysis of optimal aircraft-satellite orientation for ADS-B transmission detection. The results showed a significant disparity between descending and ascending passes of the satellite. For descending passes, the average nadir angle was 50.1°?with 90% of the contacts greater than 40°. The ascending passes had an average nadir angle of 31.6°?with only 24.8% of the contacts exceeding 40°. The evidence suggests that the satellite magnetic torquer may not have been fully aligned with the north magnetic pole as the satellite moved northward, resulting in ascending pass nadir angles that were not reflective of the full range of values. Further analysis of the descending passes showed agreement with an ADS-B signal propagation model with peak reception at nadir angles of 51°?± 8°. For space-based ADS-B operations, the results support the replacement of the current aircraft upper quarter-wave monopole to an antenna that will transmit more energy directly above the airframe.展开更多
目的观察CCAAT/增强子结合蛋白同源蛋白(CHOP)及钙联蛋白(CNX)在内侧颞叶癫痫小鼠海马区域中表达的时间和空间分布。方法采用海人酸(KA)诱导内侧颞叶癫痫小鼠模型,免疫印迹和免疫荧光技术检测CHOP和CNX在急性期(12、24 h)小鼠海马CA3区...目的观察CCAAT/增强子结合蛋白同源蛋白(CHOP)及钙联蛋白(CNX)在内侧颞叶癫痫小鼠海马区域中表达的时间和空间分布。方法采用海人酸(KA)诱导内侧颞叶癫痫小鼠模型,免疫印迹和免疫荧光技术检测CHOP和CNX在急性期(12、24 h)小鼠海马CA3区的表达量及分布差异,并与注射PBS的正常小鼠进行对照。结果免疫印迹检测结果显示,KA注射后12 h小鼠海马中的CHOP(F=1.136,P=0.4069)和CNX表达量(F=2.378,P=0.2087)与对照组差异没有统计学意义,KA注射后24 h注射侧海马中的CHOP(F=8.510,P=0.0362)和CNX表达量(F=6.968,P=0.0497)明显高于对照组。免疫荧光结果显示,KA注射后12 h CHOP的表达主要集中于CA3区,注射后24 h在CA1和CA3区表达水平均升高;KA注射后24 h CHOP蛋白(F=24.480,P=0.0057)和CNX蛋白(F=7.149,P=0.0478)的表达量显著高于对照组。结论伴随着癫痫发作的产生,CHOP蛋白表达量上升,提示神经元内质网应激水平不断增加,可能需要更多CNX作为分子伴侣帮助更多未折叠蛋白完成折叠过程。展开更多
基金National Natural Science Foundation of China(U1804191)。
文摘Objective:To explore relationships between CANX expression,prognosis and immune infiltration of acute myeloid leukemia(AML)patients.Methods:The TIMER database was used to compare the CANX expression among a variety of TCGA tumor and normal tissue samples.The difference of CANX expression between AML and normal samples was found by R software.The Kaplan-Meier method and Log-Rank test were used to assess the relationship between CANX expression and patient survival.The R software was used to find correlations between CANX expression,clinical characteristics,drug sensitivity,and immune infiltration in AML.Results:The differential expression of CANX in 13 tumor and normal tissue samples were statistically significant(P<0.05).The high CANX expression was associated with a favorable prognosis(P<0.05),which was validated in GSE37642.The expression of CANX was correlated with age,survival status,FAB stage,and karyotype(P<0.05).High CANX expression,low age and favorable karyotype were independent predictors of a favorable prognosis(P<0.05).CANX expression may affect the sensitivity of AML patients to multiple drugs(P<0.05).The expression of CANX was positively correlated with that of M1 macrophages and CD8 T cells.Conclusion:CANX may be used as a novel potential biomarker,and could benefit AML patients by predicting patient prognosis and providing precise treatment indications.
文摘The development of space-based Automatic Dependent Surveillance-Broadcast (ADS-B) will allow surveillance of aircraft in areas not covered by radar or ground-based ADS-B systems. In September 2016, the Canadian Advanced Nanospace eXperiment-7 (CanX-7) satellite was launched into a 690 km sun synchronous orbit with an ADS-B receiver payload. The first phase of ADS-B data collection took place over the North Atlantic between 4 and 31 October. A preliminary assessment of the data indicates that the average ADS-B signal strength is close to the calculated receiver detection threshold of D94.5 ± 0.5 dBm. The pattern of received ADS-B reception appears to be consistent with a signal propagation model developed for the CanX-7 mission. Future work includes the comparison of coincidental flight plan data for the operations area and an analysis of the payload antenna pattern.
文摘The CanX-7 Automatic Dependent Surveillance-Broadcast (ADS-B) nanosatellite mission collected more than four million ADS-B messages between October 2016 and April 2017. An analysis of data collected over the north Atlantic Ocean from 05 to 28 Oct included 20,707 position messages in which the angle from satellite nadir to aircraft was determined. The proximity of the received signal strength to the noise floor of the sensor allowed for an analysis of optimal aircraft-satellite orientation for ADS-B transmission detection. The results showed a significant disparity between descending and ascending passes of the satellite. For descending passes, the average nadir angle was 50.1°?with 90% of the contacts greater than 40°. The ascending passes had an average nadir angle of 31.6°?with only 24.8% of the contacts exceeding 40°. The evidence suggests that the satellite magnetic torquer may not have been fully aligned with the north magnetic pole as the satellite moved northward, resulting in ascending pass nadir angles that were not reflective of the full range of values. Further analysis of the descending passes showed agreement with an ADS-B signal propagation model with peak reception at nadir angles of 51°?± 8°. For space-based ADS-B operations, the results support the replacement of the current aircraft upper quarter-wave monopole to an antenna that will transmit more energy directly above the airframe.
文摘目的观察CCAAT/增强子结合蛋白同源蛋白(CHOP)及钙联蛋白(CNX)在内侧颞叶癫痫小鼠海马区域中表达的时间和空间分布。方法采用海人酸(KA)诱导内侧颞叶癫痫小鼠模型,免疫印迹和免疫荧光技术检测CHOP和CNX在急性期(12、24 h)小鼠海马CA3区的表达量及分布差异,并与注射PBS的正常小鼠进行对照。结果免疫印迹检测结果显示,KA注射后12 h小鼠海马中的CHOP(F=1.136,P=0.4069)和CNX表达量(F=2.378,P=0.2087)与对照组差异没有统计学意义,KA注射后24 h注射侧海马中的CHOP(F=8.510,P=0.0362)和CNX表达量(F=6.968,P=0.0497)明显高于对照组。免疫荧光结果显示,KA注射后12 h CHOP的表达主要集中于CA3区,注射后24 h在CA1和CA3区表达水平均升高;KA注射后24 h CHOP蛋白(F=24.480,P=0.0057)和CNX蛋白(F=7.149,P=0.0478)的表达量显著高于对照组。结论伴随着癫痫发作的产生,CHOP蛋白表达量上升,提示神经元内质网应激水平不断增加,可能需要更多CNX作为分子伴侣帮助更多未折叠蛋白完成折叠过程。
