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Gut flora in multiple sclerosis:implications for pathogenesis and treatment 被引量:2
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作者 Weiwei Zhang Ying Wang +2 位作者 Mingqin Zhu Kangding Liu Hong-Liang Zhang 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第7期1480-1488,共9页
Multiple sclerosis is an inflammatory disorder chara cterized by inflammation,demyelination,and neurodegeneration in the central nervous system.Although current first-line therapies can help manage symptoms and slow d... Multiple sclerosis is an inflammatory disorder chara cterized by inflammation,demyelination,and neurodegeneration in the central nervous system.Although current first-line therapies can help manage symptoms and slow down disease progression,there is no cure for multiple sclerosis.The gut-brain axis refers to complex communications between the gut flo ra and the immune,nervous,and endocrine systems,which bridges the functions of the gut and the brain.Disruptions in the gut flora,termed dys biosis,can lead to systemic inflammation,leaky gut syndrome,and increased susceptibility to infections.The pathogenesis of multiple sclerosis involves a combination of genetic and environmental factors,and gut flora may play a pivotal role in regulating immune responses related to multiple scle rosis.To develop more effective therapies for multiple scle rosis,we should further uncover the disease processes involved in multiple sclerosis and gain a better understanding of the gut-brain axis.This review provides an overview of the role of the gut flora in multiple scle rosis. 展开更多
关键词 gut flora gut-brain axis multiple sclerosis PATHOGENESIS treatment
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Grid System Analysis of Urban Flora of Bukhara City (Uzbekistan)
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作者 Abdulla M. Umedov Husniddin K. Esanov 《American Journal of Plant Sciences》 CAS 2024年第2期139-144,共6页
This article presents information on the study of the flora of Uzbekistan based on grid system mapping. The urban flora of the city of Bukhara was researched in it. As a result of research, the territory of Bukhara ci... This article presents information on the study of the flora of Uzbekistan based on grid system mapping. The urban flora of the city of Bukhara was researched in it. As a result of research, the territory of Bukhara city was divided into 85 indexes based on 1 × 1 km<sup>2</sup> grid mapping system. The diversity and density of species in the indexes are determined. The influence of anthropogenic factors on the diversity of species in the indexes is determined. 展开更多
关键词 Bukhara City Urban flora INDEX Grid Map System HERBARIUM Geoinformation
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Research Progress of Intestinal Flora in Colorectal Cancer
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作者 Wenli Wei Qing Zhang 《Journal of Biosciences and Medicines》 2024年第3期122-129,共8页
Colorectal cancer, as a common malignant tumor, has been increasing in incidence year by year and has become one of the leading causes of death worldwide. Meanwhile, researchers have found a close relationship between... Colorectal cancer, as a common malignant tumor, has been increasing in incidence year by year and has become one of the leading causes of death worldwide. Meanwhile, researchers have found a close relationship between dysbiosis of the gut microbiota and colorectal cancer, which has further triggered indepth exploration of the role of gut microbiota in the pathogenesis, diagnosis, and treatment of colorectal cancer. Studies have shown that there are specific microbial changes in colorectal cancer tissues, including enrichment or depletion of certain bacterial species, which may be associated with tumor growth, invasion, and metastasis. Additionally, gut microbiota has been found to be closely linked to tumor microenvironment, tumor immune response, chemotherapy drug metabolism, and other factors. In this context, it is imperative to study the gut microbiota in colorectal cancer. A comprehensive understanding of the interaction between gut microbiota and colorectal cancer is not only helpful in revealing novel mechanisms of colorectal cancer development, but also holds promise in providing new strategies and targets for early diagnosis, individualized treatment, and prevention of colorectal cancer. This review aims to thoroughly discuss the research progress of gut microbiota in colorectal cancer, including its compositional characteristics, its role in the occurrence and development of colorectal cancer, and its potential clinical applications. The goal is to provide references and insights for further research in this field. 展开更多
关键词 Intestinal flora Gut Microbiota Colorectal Cancer TREATMENT
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Intestinal flora: New perspective of type 2 diabetes
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作者 Yan Liu Jun Chang Li-Ding Bai 《World Journal of Clinical Cases》 SCIE 2024年第11期1996-1999,共4页
Diabetes comprises a group of metabolic diseases characterized by hyperglycemia stemming from various factors.Current diabetes management primarily focuses on blood glucose control,yet it is inherently progressive,nec... Diabetes comprises a group of metabolic diseases characterized by hyperglycemia stemming from various factors.Current diabetes management primarily focuses on blood glucose control,yet it is inherently progressive,necessitating increased reliance on exogenous blood glucose control methods over time.Therefore,there is an urgent need to explore novel intervention strategies addressing both diabetes and its complications.The human intestinal microbiota,often referred to as the"second genome",exhibits significant diversity and plays a pivotal role in insulin resistance,glucose and lipid metabolism,and inflammatory response.Notably,Li and Guo have elucidated the involvement of intestinal flora in the pathogenesis of type 2 diabetes mellitus(T2DM)and proposed a novel therapeutic approach targeting intestinal microbes.This advancement enhances our comprehension of the multifaceted and multi-target regulation of T2DM by intestinal microflora,thereby offering fresh avenues for understanding its pathogenesis and clinical management.This letter briefly summarizes the role of intestinal flora in T2DM based on findings from animal experiments and clinical studies.Additionally,it discusses the potential clinical applications and challenges associated with targeting intestinal flora as therapeutic interventions. 展开更多
关键词 Microbial metabolites Intestinal flora PROBIOTICS Insulin resistance Type 2 diabetes
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Effect of dietary supplementation with discardednutrient medium of Cordyceps militaris on layingperformance and diversity of intestinal flora in laying hens
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作者 XU Fangxu ZHANG Jinying +2 位作者 LI Bingxin LIU Yefei WANG Ze 《沈阳师范大学学报(自然科学版)》 CAS 2024年第2期186-192,共7页
The aim of the experiment was to explore the feasibility of discarded nutrient medium of Cordyceps militaris as feed in the production of laying hens. 100 g/kg, 200 g/kg, 300 g/kg of discarded nutrient medium of Cordy... The aim of the experiment was to explore the feasibility of discarded nutrient medium of Cordyceps militaris as feed in the production of laying hens. 100 g/kg, 200 g/kg, 300 g/kg of discarded nutrient medium of Cordyceps militaris were added to the basal diet of laying hens. The results showed that the optimal addition of discarded nutrient medium of Cordyceps militaris in the diet of laying hens was 10%. According to the results of measuring the conventional indicators of eggs, the weight of eggs produced by laying hens fed with discarded nutrient medium of Cordyceps militaris was higher than that of laying hens fed with ordinary laying hens. The content of interleukin-1(IL-1) in the experimental group was significantly higher than that in the control group, and the concentration of IL-1 increased by 141.5 pg/mL, which indicated that the application of discarded nutrient medium of Cordyceps militaris effectively improved the immunity of laying hens. The high-throughput analysis of the intestinal contents of the two groups of laying hens showed that the microbial population abundance of the intestinal tract of the experimental group was greater than that of control group, and the application of discarded nutrient medium of Cordyceps militaris increased the diversity of bacteria in the intestinal tract of laying hens. In addition, the sensitivity of some pathogenic bacteria in the intestinal tract of chickens to drugs was also increased, thereby reducing the use of antibiotics. The secondary utilization of discarded nutrient medium of Cordyceps militaris has great development and utilization prospects, which provided a scientific reference and basic theoretical basis for the development of discarded nutrient medium of Cordyceps militaris as feed in the production of laying hens. 展开更多
关键词 Cordyceps militaris discarded nutrient medium drug susceptibility intestinal flora laying hens
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Unraveling colorectal cancer prevention:The vitamin D-gut flora-immune system nexus
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作者 Zhi-Song Zhan Zu-Shun Zheng +3 位作者 Jing Shi Juan Chen Si-Yi Wu Shi-Yan Zhang 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第6期2394-2403,共10页
Colorectal cancer(CRC)is one of the most common cancers diagnosed in the world.Although environmental and genetic factors play a major role in the pathogenesis of CRC,extensive research has suggested that vitamin D ma... Colorectal cancer(CRC)is one of the most common cancers diagnosed in the world.Although environmental and genetic factors play a major role in the pathogenesis of CRC,extensive research has suggested that vitamin D may play a pivotal role in the development of CRC.Vitamin D,primarily obtained through sunlight exposure,dietary sources,and supplements,has long been recognized for its essential functions in maintaining health,including immune regulation.This article delves into the intricate relationship between vitamin D,the immune system,gut flora,and the prevention of CRC.It presents a synthesis of epidemiological data,experimental studies,and clinical trials,highlighting the mechanisms by which vitamin D influences immune cell function,cytokine production,and inflammation.By enhancing the immune system’s surveillance and antitumor activity,vitamin D may offer a promising avenue for CRC prevention.Furthermore,this comprehensive review delves into the prospective clinical applications of vitamin D supplementation and delineates the forthcoming avenues of research in this dynamic domain.Additionally,the paper tentatively outlines a spectrum of prophylactic impacts of vitamin D on CRC,emphasizing its significant potential in reducing CRC risk through shedding light on its mechanisms,encompassing antineoplastic mechanisms,influences on the immune system,and modulation of the gut microbiome. 展开更多
关键词 Colorectal cancer Vitamin D Immune system Gut flora IMMUNOMODULATION Microbial dysbiosis Cancer prevention
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Clinical characteristics and risk factors of post-operative intestinal flora disorder following laparoscopic colonic surgery:A propensityscore-matching analysis
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作者 Gan-Bin Li Chen-Tong Wang +7 位作者 Xiao Zhang Xiao-Yuan Qiu Wei-Jie Chen Jun-Yang Lu Lai Xu Bin Wu YiXiao Guo-Le Lin 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第5期1259-1270,共12页
BACKGROUND Intestinal flora disorder(IFD)poses a significant challenge after laparoscopic colonic surgery,and no standard criteria exists for its diagnosis and treatment.AIM To analyze the clinical features and risk f... BACKGROUND Intestinal flora disorder(IFD)poses a significant challenge after laparoscopic colonic surgery,and no standard criteria exists for its diagnosis and treatment.AIM To analyze the clinical features and risk factors of IFD.METHODS Patients with colon cancer receiving laparoscopic surgery were included using propensity-score-matching(PSM)methods.Based on the occurrence of IFD,patients were categorized into IFD and non-IFD groups.The clinical characteristics and treatment approaches for patients with IFD were analyzed.Multivariate regression analysis was performed to identify the risk factors of IFD.RESULTS The IFD incidence after laparoscopic surgery was 9.0%(97 of 1073 patients).After PSM,97 and 194 patients were identified in the IFD and non-IFD groups,respectively.The most common symptoms of IFD were diarrhea and abdominal,typically occurring on post-operative days 3 and 4.All patients were managed conservatively,including modulation of the intestinal flora(90.7%),oral/intravenous application of vancomycin(74.2%),and insertion of a gastric/ileus tube for decompression(23.7%).Multivariate regression analysis identified that preoperative intestinal obstruction[odds ratio(OR)=2.79,95%CI:1.04–7.47,P=0.041]and post-operative antibiotics(OR=8.57,95%CI:3.31–23.49,P<0.001)were independent risk factors for IFD,whereas pre-operative parenteral nutrition(OR=0.12,95%CI:0.06–0.26,P<0.001)emerged as a protective factor.CONCLUSION A stepwise approach of probiotics,vancomycin,and decompression could be an alternative treatment for IFD.Special attention is warranted post-operatively for patients with pre-operative obstruction or early use of antibiotics. 展开更多
关键词 Colon cancer Laparoscopy Intestinal flora disorder Clinical characteristics Risk factors
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The role of intestinal flora on tumorigenesis,progression,and the efficacy of PD-1/PD-L1 antibodies in colorectal cancer
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作者 Sen Wang Benling Xu +4 位作者 Yangyang Zhang Guangyu Chen Peng Zhao Quanli Gao Long Yuan 《Cancer Biology & Medicine》 SCIE CAS CSCD 2024年第1期65-82,共18页
Intestinal flora affects the maturation of the host immune system,serves as a biomarker and efficacy predictor in the immunotherapy of several cancers,and has an important role in the development of colorectal cancer(... Intestinal flora affects the maturation of the host immune system,serves as a biomarker and efficacy predictor in the immunotherapy of several cancers,and has an important role in the development of colorectal cancer(CRC).Anti-PD-1/PD-L1 antibodies have shown satisfactory results in MSI-H/d MMR CRC but performed poorly in patients with MSS/p MMR CRC.In recent years an increasing number of studies have shown that intestinal flora has an important impact on anti-PD-1/PD-L1 antibody efficacy in CRC patients.Preclinical and clinical evidence have suggested that anti-PD-1/PD-L1 antibody efficacy can be improved by altering the composition of the intestinal flora in CRC.Herein,we summarize the studies related to the influence of intestinal flora on anti-PD-1/PD-L1 antibody efficacy in CRC and discuss the potential underlying mechanism(s).We have focused on the impact of the intestinal flora on the efficacy and safety of anti-PD-1/PD-L1 antibodies in CRC and how to better utilize the intestinal flora as an adjuvant to improve the efficacy of anti-PD-1/PD-L1 antibodies.In addition,we have provided a basis for the potential of the intestinal flora as a new treatment modality and indicator for determining patient prognosis. 展开更多
关键词 Intestinal flora anti-PD-1/PD-L1 therapy colorectal cancer immune checkpoint inhibitor CD8~+T cell
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Correlation Analysis Between Children with Atopic Dermatitis and Asthma and Factors Affecting Intestinal Flora
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作者 Wei Chen Hanyue Dong Hongmin Li 《Journal of Clinical and Nursing Research》 2024年第5期233-243,共11页
Objective:In order to reveal the potential association between intestinal flora and atopic dermatitis with asthma,the study compares the changes in intestinal flora before and after treatment with antibiotics in child... Objective:In order to reveal the potential association between intestinal flora and atopic dermatitis with asthma,the study compares the changes in intestinal flora before and after treatment with antibiotics in children and explores the risk factors for the disease development in children.The differences between asthma-controlled children and healthy children were also analyzed to investigate whether there was a correlation between the level of control and intestinal flora in asthmatic children.Methods:367 children with atopic dermatitis and asthma were selected,and the control group was healthy children who did not have other skin diseases.Fecal samples were collected from healthy children and children with asthma,and the intestinal flora was tested at Beijing Nebula Medical Testing Laboratory Co.At the same time,50 children were selected according to the inclusion and exclusion criteria to take amide antibiotics during hospitalization,and stool samples were collected before and after taking antibiotics.Results:The proportion of Gram-positive cocci increased and the proportion of Gram-positive bacilli decreased after the administration of antibiotics in children with atopic dermatitis and asthma(P<0.05),and no significant difference was shown in the gender and age of the children(P>0.05).The proportion of family history of atopic dermatitis with asthma was higher in the experimental group(P<0.05).Conclusion:The use of antibiotics in children with atopic dermatitis with asthma showed a positive correlation with changes in intestinal flora.The use of antibiotics may lead to changes in intestinal flora and increase the risk of atopic dermatitis with asthma.Antibiotic use in infancy and childhood is also recognized as a risk factor for atopic dermatitis with asthma.Therefore,the use of antibiotics should be minimized in preventing and treating atopic dermatitis with asthma. 展开更多
关键词 Atopic dermatitis ASTHMA Intestinal flora ANTIBIOTICS Influencing factors
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Mangrove Flora of the World 被引量:15
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作者 王伯荪 梁士楚 +1 位作者 张炜银 昝启杰 《Acta Botanica Sinica》 CSCD 2003年第6期644-653,共10页
The species composition and characteristics of mangrove flora in the world were reviewed and discussed. The results suggested that the world's mangrove plants have 84 species (including 12 varieties) in 24 genera ... The species composition and characteristics of mangrove flora in the world were reviewed and discussed. The results suggested that the world's mangrove plants have 84 species (including 12 varieties) in 24 genera and 16 families. Of which, true mangrove plants have 70 species (including 12 varieties) in 16 genera and 11 families, and semi-mangrove plants 14 species in eight genera and five families. The Eastern Group has 74 species (including 12 varieties) in 18 genera and 14 families, characterized by the genera Aegiceras, Osbornia, Aegialitis, Bruguiera, Ceriops, Kandelia, Scyphiphora and Nypa etc. The Western Group has only 10 species in six genera and five families, characterized by the endemic one-species family, Pelliceraceae, and the genus Laguncularia. The mangrove flora of China is composed of 26 species (including one variety) in 15 genera and 12 families, four of which are endemic. Hainan is most rich in mangrove species, making up about 96.2% of the Chinese total; Guangdong ranks second, making up about 42.3%. It has been demonstrated that Rhizophora stylosa was mistaken for R. mucronata in Taiwan by previous authors. 展开更多
关键词 MANGROVE flora floral composition Rhizophora mucronata
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Study on Flora Components and Floristic Characteristic of Urban Forest in Nanjing 被引量:2
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作者 童丽丽 孔跃 +1 位作者 许晓岗 汤庚国 《Journal of Landscape Research》 2009年第1期11-15,18,共6页
Based on the thorough investigation of the components of urban forest in Nanjing and the collection of samples,it is concluded that there are 1 500 species(including subspecies) of vascular plants belonging to 572 gen... Based on the thorough investigation of the components of urban forest in Nanjing and the collection of samples,it is concluded that there are 1 500 species(including subspecies) of vascular plants belonging to 572 genera of 172 families,among which there are 63 species of ferns belonging to 36 genera of 25 families,1 437 species of seed plants belonging to 536 genera of 147 families.The characteristics are that the flora is rich in species,complex in geographic composition,and possess the distinct transferring quality from tropical to temperate zone.Besides,it is characterized with certain ancient nature,and the peculiar elements are comparatively simple. 展开更多
关键词 URBAN FOREST in NANJING flora flora component FLORISTIC CHARACTERISTIC
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Flora and ecological characteristics of rare plant communities on the southern slope of Shennongjia Mountain 被引量:5
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作者 邓红兵 江明喜 +1 位作者 吴金清 葛继稳 《Journal of Forestry Research》 SCIE CAS CSCD 2002年第1期21-24,82-83,共4页
According to the investigation of sampling area of 6800 m2 on the south slope of Shennongjia Mountain, there were 126 vascular plant species, belonging to 108 genera and 64 families, in the investigated rare plant com... According to the investigation of sampling area of 6800 m2 on the south slope of Shennongjia Mountain, there were 126 vascular plant species, belonging to 108 genera and 64 families, in the investigated rare plant communities, of which 9 rare plant species were recorded, accounting for 27.3% of the total rare plants. The communities were about 30 m in height and were divided into three layers as tree layer, shrub layer, and herb layer. The flora of the communities had obvious temperate character. Phanerophytes (accounted for 65.9%), Mesophyllous (62.7%), Papyraceous (84.1%), simple leaf (83.3%), un-entire leaf (69.8%) were dominant in life form, leaf size class, leaf texture, leaf form, and leaf margin respectively. According to important value of species, the communities were divided into three types as Davidia involucrata + Litsea pungens community, Cercidiphyllum japanicum + Padus wilsonii community, and Padus wilsonii + Acer mono community. The indexes of species diversity of tree layer had little difference among communities and evenness was high. The results indicated that the communities had complex structure and relative stability. 展开更多
关键词 Rare plant community flora Ecological characteristics Shennongjia Mountain
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Characteristics and Affinity of Tropical Flora in Southern China 被引量:6
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作者 朱华 M.C.Roos 《Forestry Studies in China》 CAS 2002年第1期18-24,共7页
The tropical flora in southern China is represented mainly by three regional flora, i.e. southern Yunnan (southwestern China), southwestern Guangxi (southwestern China) and Hainan Island (southern China). The floristi... The tropical flora in southern China is represented mainly by three regional flora, i.e. southern Yunnan (southwestern China), southwestern Guangxi (southwestern China) and Hainan Island (southern China). The floristic composition of each is concisely enumerated. Their geographical elements at generic level are analyzed. Furthermore, a comparison of floristic similarities between southern Yunnan and Hainan Island and Malay Peninsula and Brunei of western Malesia is made, based on existing regional flora treatments. The following is concluded: (1) The flora of southern China consists mainly of tropical floristic elements which contribute about 60% at the family level and more than 80 % at the generic level of its total flora. The dominant distribution type of the flora of southern China at the generic level is the tropical Asian distribution pattern. This reveals that the flora of southern China is of tropical nature with a strong tropical Asian affinity; (2) Most of the dominant families from the flora of southern China are also dominant in the Malesian flora. The floristic similarities between the regional flora of southern China and the regional flora of western Malesia are over 70% at the family level and more than 50% at the generic level. This suggests that the tropical flora of southern China belongs to the Malesian floristic region; (3) Situated at the northern margin of tropical Asia, on the other hand it is also obvious that the flora of southern China comprises less strictly tropical elements compared to the Malesian flora, and is consequently only a marginal type of the latter; (4) The close affinity of the flora of southern China to the Malesian flora can be explained by the geological history of southeast Asia. 展开更多
关键词 southern China flora floristic composition AFFINITY
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Effects of Different Vegetable Planting Modes on Soil Microbial Flora and Enzyme Activity 被引量:1
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作者 孟平红 肖厚军 +4 位作者 郭惊涛 蔡霞 潘德怀 付纪勇 李桂莲 《Agricultural Science & Technology》 CAS 2015年第10期2265-2268,2272,共5页
To investigate the effects of different vegetable growing regions and planting modes on soil quality,soils in high,medium and low altitude areas of Guizhou were respectively sampled under different vegetable efficient... To investigate the effects of different vegetable growing regions and planting modes on soil quality,soils in high,medium and low altitude areas of Guizhou were respectively sampled under different vegetable efficient planting modes,and the variations of soil microbial flora and enzyme activities were analyzed. The soil microbial count and total bacteria of the vegetable efficient cultivation mode were significantly higher than that of the control (traditional planting mode) in each planting area,and the microbial diversity index was also improved to varying de- grees.The soil phosphatase,catalase and urease activities of the vegetable efficient planting mode were higher than that of the control.The soil catalase and urease activities were higher than that of the control by 1.37-1.44 and 1.51-2.80 times. Application of vegetable efficient planting mode in different regions will help to im- prove the soil quality in a given period. 展开更多
关键词 VEGETABLE Efficient planting mode Growing region Soil microbial flora Soil enzyme activity Biodiversity index
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On Some Dispersed Cordaitean Cuticles from Cathaysian Flora in the Permian of China and Their Significance 被引量:1
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作者 李生盛 王士俊 贝月敏 《Acta Botanica Sinica》 CSCD 2003年第5期517-522,共6页
Although the research on Cordaites of the Cathaysian Flora in China started early in 1883, the study of the cordaitean cuticles began late in 1991. Up to now, four types of cordaitean cuticles in situ and three types ... Although the research on Cordaites of the Cathaysian Flora in China started early in 1883, the study of the cordaitean cuticles began late in 1991. Up to now, four types of cordaitean cuticles in situ and three types of dispersed ones have been reported from the Cathaysian Flora in China. However compared with the Euramerican Flora, the research work on cordaitean cuticles from the Cathaysian Flora in China is much more insufficient. In this paper, three kinds of dispersed cordaitean cuticles are described in detail from the Permian coal-bearing strata in China. Among these cuticles two kinds are collected from the roof shale of Coal Seam No. A(1) in Shanxi Formation (Lower Permian) in Xinzhuangzhi Coal Mine of Huainan, Anhui Province, southern border of North China Subprovince of the Cathaysian Flora in China. The third one was collected from Coal Seam No. 11 in the top of Longtan Formation (lower Upper Permian) in Dahebian Coal Mine of Shuicheng Mining District, Guizhou Province, South China Subprovince of the Cathaysian Flora in China. Comparison of these three kinds of cordaitean cuticles with the known ones from the Cathaysian Flora in China and from the Euramerican Flora is made. The authors consider that they are all new types of cordaitean cuticles. The significance they bear on palaeobotany is discussed. 展开更多
关键词 China Cathaysian flora PERMIAN cordaitean plants cuticle new types
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《逃离》中“Flora”意象的认知诗学解读 被引量:1
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作者 刘玉梅 《成都工业学院学报》 2014年第1期82-84,共3页
《逃离》中"Flora"和卡拉的意象图式在"图形—背景"不断更迭的过程中,被不断切断、重续,造成了两种意象图式的交织叠加、互为映射。并以此构造了精巧的叙事结构,悬念迭起的故事情节。在意象片断的重组与再续过程中,... 《逃离》中"Flora"和卡拉的意象图式在"图形—背景"不断更迭的过程中,被不断切断、重续,造成了两种意象图式的交织叠加、互为映射。并以此构造了精巧的叙事结构,悬念迭起的故事情节。在意象片断的重组与再续过程中,Flora的形象被不断重塑,其内涵不断丰富,最终形成了层次多重的意象原型,并推动了各角色意象图式的动态构建。 展开更多
关键词 《逃离》 flora意象 认知诗学
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中国种子植物区系定量化研究──Ⅲ.区系指数(Flora Index) 被引量:13
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作者 傅德志 左家哺 《热带亚热带植物学报》 CAS CSCD 1995年第4期23-29,共7页
本文从植物区系研究现状出发,依照吴征镒教授关于中国种子植物区系研究思想与方法,提出了用于植物区系比较研究的一个新指数-区系指数(FloraIndex),详细讨论了其意义并用实例介绍了其应用情况.
关键词 种子植物 植物区系 定量区系学 区系指数
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Study on Seed Plant Flora of Yunfeng Mountain,an Offshoot of Gaoligong Mountain Range
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作者 杨晓君 苏娟 +3 位作者 李荣春 罗祥英 李梦媛 马布平 《Agricultural Science & Technology》 CAS 2016年第2期443-448,共6页
In this paper, the flora in an area of 35 km2 of Yunfeng Mountain, an off- shoot of Gaoligong mountain range, were sampled and analyzed. The results showed that Yunfeng Mountain had a high diversity in seed plants, wh... In this paper, the flora in an area of 35 km2 of Yunfeng Mountain, an off- shoot of Gaoligong mountain range, were sampled and analyzed. The results showed that Yunfeng Mountain had a high diversity in seed plants, which covered 92 families, 247 genera and 431 species. Among the seed plants, the gymnosperms covered 4 families, 5 genera and 7 species, while the angiosperms covered 88 families, 242 genera and 424 species. The seed plants in Yunfeng Mountain had rich distribution types, and they formed a flora dominated by tropical and subtropical plants. 展开更多
关键词 Gaoligong Mountain Yunfeng Mountain Seed plant flora
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Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract
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作者 Xiao-Xiao Zhang Li Jia +6 位作者 Xiu-Jun Zhan Charity Ngina Qing-Rui Zhang Xiao-Ge Li Qi-Bao Jiang Shi Bai Miao-Miao Jiang 《Traditional Medicine Research》 2025年第1期1-11,共11页
Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&E.H.Wilson in C.S.Sargent,and it in traditional Chinese medicine has been known for promoting blood circulation and removing ... Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&E.H.Wilson in C.S.Sargent,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical practice.However,the anti-hyperlipidemia effect of SC is not fully understood.This paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating hyperlipidemia.Methods:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut microbiota.Secondly,we explored the potential mechanism of SC in treating hyperlipidemia by pathway analysis.Results:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to tissues.Compared to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s index.It also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically significant.Non-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the subjects.It was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and glycerophospholipids.The treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,respectively.Among these,14 common differential lipids were found in both serum and liver samples,and their KEGG enrichment pathways were largely consistent.Among them,the sphingolipid signaling pathway and the glycerophospholipid metabolic pathway were identified as key metabolic pathways that were regulated.Our gut microbiota analysis revealed that SC diminishes the abundance of Actinobacteria by altering the cecal flora in mice.Conclusion:This alteration leads to the downregulation of genes involved in triglyceride metabolism,which in turn changes lipid processing and reduces triglyceride levels.Consequently,SC effectively combats hyperlipidemia.Notably,SC impacts key metabolic pathways,including the sphingolipid signaling and glycerophospholipid metabolism.These findings underscore SC’s therapeutic potential,positioning it as a promising alternative for reducing the health risks associated with hyperlipidemia. 展开更多
关键词 HYPERLIPIDEMIA Sargentodoxae Caulis LIPIDOMICS intestinal flora
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运动对大学生肠道菌群影响的系统综述
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作者 刘昭志 黄丽 +4 位作者 田浩冬 李岚 陈晓 陶云飞 彭莉 《中国组织工程研究》 CAS 北大核心 2025年第11期2394-2401,共8页
背景:运动对肠道菌群的调节与人体健康密切相关,但肠道菌群涉及多方面因素影响,国内外研究尚缺乏有关运动对大学生肠道菌群影响的较为一致的证据。目的:探讨运动对大学生肠道菌群多样性和物种组成的影响。方法:通过系统检索PubMed、Web ... 背景:运动对肠道菌群的调节与人体健康密切相关,但肠道菌群涉及多方面因素影响,国内外研究尚缺乏有关运动对大学生肠道菌群影响的较为一致的证据。目的:探讨运动对大学生肠道菌群多样性和物种组成的影响。方法:通过系统检索PubMed、Web of Science、Embase、Medline、Cochrane Library、中国知网、万方、维普数据库,筛选后纳入8篇实证研究,对其采用半定量的方法进行分析。结果与结论:①在运动改变大学生肠道菌群物种多样性方面,高强度间歇训练和太极拳运动均能显著提升大学生肠道菌群的物种多样性,而有氧运动对大学生肠道菌群多样性的提升效果不显著;②在运动影响肠道菌群物种组成方面,3种运动方式均能显著改变大学生肠道中菌群的组成结构,可以提高瘤胃球菌、普氏粪杆菌、布劳提亚菌等有益菌的丰度,降低埃希氏菌属等有害菌的丰度;相较于高强度间歇训练,有氧运动和太极拳运动引起了更多有益菌丰度的提升;③除肠道菌群特征的变化外,运动还可以改善大学生体成分、心肺功能以及执行功能等,这些健康效益与运动引起的菌群变化密切相关,这些菌群可通过代谢调节、屏障功能以及神经调节对机体产生健康效益;④虽然目前已有研究证实了运动与肠道菌群存在关联,但运动影响肠道菌群的机制尚未明确,同时定位与宿主健康相关的菌群是未来以肠道菌群为治疗靶点的关键,这些均值得学者进一步关注和探究。 展开更多
关键词 运动干预 大学生 肠道菌群 菌群多样性 物种组成
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