Background: Breast cancer is the most frequently diagnosed cancer among women, making it a significant global public health issue. Although developed countries have a higher incidence of breast cancer, developing coun...Background: Breast cancer is the most frequently diagnosed cancer among women, making it a significant global public health issue. Although developed countries have a higher incidence of breast cancer, developing countries like Nigeria have a low incidence rate but higher rates of morbidity and mortality from the disease. Objective: This study explored how cues to action influenced the use of immunohistochemistry by women in Imo State and how many of them used immunohistochemistry (IHC) to diagnose their condition. Methodology: We used a descriptive study methodology for the investigation, and 121 participants were chosen at random from the 891 total population. The respondents were chosen through a systematic sampling procedure. Structured questionnaire was used as the data collection tool, and the statistical software for social science (SPSS) was used to analyze the data. Results: The mean age of the 121 participants in the study was 45.2 ± 0.7 years. The study found that awareness of IHC services is a significant influencing factor for the uptake and health personnel is the major source of awareness of IHC services. Cues to action particularly from health workers, as well as knowledge of any victim of breast cancer and user of IHC services, also significantly influenced uptake of the IHC services (P Conclusion: In our study, utilization of IHC services was also impacted by cues to action, particularly from healthcare professionals, as well as awareness of any breast cancer victims and those who used IHC services thus cues to action is a major predicator of immunohistochemistry uptake among women with breast cancer.展开更多
胃癌是最常见的恶性肿瘤之一,患者多采用手术、放化疗及免疫治疗,但临床疗效及预后欠佳。去整合素⁃金属蛋白酶(a disintegrin and metalloproteinase,ADAM)17作为ADAMs家族的重要成员,在胃癌组织中的表达显著高于癌旁组织,并通过介导EGF...胃癌是最常见的恶性肿瘤之一,患者多采用手术、放化疗及免疫治疗,但临床疗效及预后欠佳。去整合素⁃金属蛋白酶(a disintegrin and metalloproteinase,ADAM)17作为ADAMs家族的重要成员,在胃癌组织中的表达显著高于癌旁组织,并通过介导EGFR和TNF⁃α、TGF⁃β/Smad、Notch和Wnt、FoxM1⁃ADAM17以及EGFR/ERK/SP1等信号通路参与胃癌的发生发展,其高表达与预后不良密切相关,提示ADAM17可作为胃癌的生物学指标,预测胃癌发展,有望成为胃癌新的治疗靶点。本文就ADAM17在胃癌发展中的作用机制、治疗及预测研究进展作一综述,以期为胃癌临床诊疗提供新思路。展开更多
文摘Background: Breast cancer is the most frequently diagnosed cancer among women, making it a significant global public health issue. Although developed countries have a higher incidence of breast cancer, developing countries like Nigeria have a low incidence rate but higher rates of morbidity and mortality from the disease. Objective: This study explored how cues to action influenced the use of immunohistochemistry by women in Imo State and how many of them used immunohistochemistry (IHC) to diagnose their condition. Methodology: We used a descriptive study methodology for the investigation, and 121 participants were chosen at random from the 891 total population. The respondents were chosen through a systematic sampling procedure. Structured questionnaire was used as the data collection tool, and the statistical software for social science (SPSS) was used to analyze the data. Results: The mean age of the 121 participants in the study was 45.2 ± 0.7 years. The study found that awareness of IHC services is a significant influencing factor for the uptake and health personnel is the major source of awareness of IHC services. Cues to action particularly from health workers, as well as knowledge of any victim of breast cancer and user of IHC services, also significantly influenced uptake of the IHC services (P Conclusion: In our study, utilization of IHC services was also impacted by cues to action, particularly from healthcare professionals, as well as awareness of any breast cancer victims and those who used IHC services thus cues to action is a major predicator of immunohistochemistry uptake among women with breast cancer.
文摘胃癌是最常见的恶性肿瘤之一,患者多采用手术、放化疗及免疫治疗,但临床疗效及预后欠佳。去整合素⁃金属蛋白酶(a disintegrin and metalloproteinase,ADAM)17作为ADAMs家族的重要成员,在胃癌组织中的表达显著高于癌旁组织,并通过介导EGFR和TNF⁃α、TGF⁃β/Smad、Notch和Wnt、FoxM1⁃ADAM17以及EGFR/ERK/SP1等信号通路参与胃癌的发生发展,其高表达与预后不良密切相关,提示ADAM17可作为胃癌的生物学指标,预测胃癌发展,有望成为胃癌新的治疗靶点。本文就ADAM17在胃癌发展中的作用机制、治疗及预测研究进展作一综述,以期为胃癌临床诊疗提供新思路。
