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The most important questions in cancer research and clinical oncology Question 2-5.Obesity-related cancers:more questions than answers 被引量:10
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作者 Ajit Venniyoor 《Chinese Journal of Cancer》 SCIE CAS CSCD 2017年第2期53-62,共10页
Obesity is recognized as the second highest risk factor for cancer. The pathogenic mechanisms underlying tobaccorelated cancers are well characterized and efective programs have led to a decline in smoking and related... Obesity is recognized as the second highest risk factor for cancer. The pathogenic mechanisms underlying tobaccorelated cancers are well characterized and efective programs have led to a decline in smoking and related cancers, but there is a global epidemic of obesity without a clear understanding of how obesity causes cancer. Obesity is heterogeneous, and approximately 25% of obese individuals remain healthy(metabolically healthy obese, MHO), so which fat deposition(subcutaneous versus visceral, adipose versus ectopic) is "malignant"? What is the mechanism of carcinogenesis? Is it by metabolic dysregulation or chronic inflammation? Through which chemokines/genes/signaling pathways does adipose tissue influence carcinogenesis? Can selective inhibition of these pathways uncouple obesity from cancers? Do all obesity related cancers(ORCs) share a molecular signature? Are there common(overlapping) genetic loci that make individuals susceptible to obesity, metabolic syndrome, and cancers? Can we identify precursor lesions of ORCs and will early intervention of high risk individuals alter the natural history? It appears unlikely that the obesity epidemic will be controlled anytime soon; answers to these questions will help to reduce the adverse efect of obesity on human condition. 展开更多
关键词 more questions than answers The most important questions in cancer research and clinical oncology Question 2-5.Obesity-related cancers THAN
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Cancer research in the era of next-generation sequencing and big data calls for intelligent modeling 被引量:2
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作者 Jari Yli-Hietanen Antti Ylipää Olli Yli-Harja 《Chinese Journal of Cancer》 SCIE CAS CSCD 2015年第10期423-426,共4页
We examine the role of big data and machine learning in cancer research.We describe an example in cancer research where gene-level data from The Cancer Genome Atlas(TCGA) consortium is interpreted using a pathway-leve... We examine the role of big data and machine learning in cancer research.We describe an example in cancer research where gene-level data from The Cancer Genome Atlas(TCGA) consortium is interpreted using a pathway-level model.As the complexity of computational models increases,their sample requirements grow exponentially.This growth stems from the fact that the number of combinations of variables grows exponentially as the number of variables increases.Thus,a large sample size is needed.The number of variables in a computational model can be reduced by incorporating biological knowledge.One particularly successful way of doing this is by using available gene regulatory,signaling,metabolic,or context-specific pathway information.We conclude that the incorporation of existing biological knowledge is essential for the progress in using big data for cancer research. 展开更多
关键词 cancer research Big data Mathematical modeling
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PROGRESS IN LIVER CANCER RESEARCH IN CHINA: A SUMMARY OF THE FOURTH NATIONAL CONFERENCE OF THE SOCIETY OF LIVER CANCER, CHINA ANTI-CANCER ASSOCIATION 被引量:2
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作者 任正刚 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2000年第1期79-80,共2页
关键词 HCC TACE CHINA ANTI-cancer ASSOCIATION PROGRESS IN LIVER cancer research IN CHINA A SUMMARY OF THE FOURTH NATIONAL CONFERENCE OF THE SOCIETY OF LIVER cancer
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Tumor organoids for cancer research and personalized medicine 被引量:1
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作者 Hui Yang Yinuo Wang +2 位作者 Peng Wang Ning Zhang Pengyuan Wang 《Cancer Biology & Medicine》 SCIE CAS CSCD 2022年第3期319-332,共14页
Organoids are three-dimensional culture systems generated from embryonic stem cells,induced pluripotent stem cells,and adult stem cells.They are capable of cell proliferation,differentiation,and self-renewal.Upon stim... Organoids are three-dimensional culture systems generated from embryonic stem cells,induced pluripotent stem cells,and adult stem cells.They are capable of cell proliferation,differentiation,and self-renewal.Upon stimulation by signal factors and/or growth factors,organoids self-assemble to replicate the morphological and structural characteristics of the corresponding organs.They provide an extraordinary platform for investigating organ development and mimicking pathological processes.Organoid biobanks derived from a wide range of carcinomas have been established to represent different lesions or stages of clinical tumors.Importantly,genomic and transcriptomic analyses have confirmed maintenance of intra-and interpatient heterogeneities in organoids.Therefore,this technology has the potential to revolutionize drug screening and personalized medicine.In this review,we summarized the characteristics and applications of organoids in cancer research by the establishment of organoid biobanks directly from tumor organoids or from genetically modified non-cancerous organoids.We also analyzed the current state of organoid applications in drug screening and personalized medicine. 展开更多
关键词 ORGANOIDS cancer research HETEROGENEITY personalized medicine clinical cancer therapy
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The Nanjing International Symposium of New Frontiers in Cancer Research(Nov 9-10,2007) 被引量:1
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《Journal of Nanjing Medical University》 2007年第5期348-348,F0003,共2页
The Nanjing International Symposium of New Frontiers in Cancer Research will be held on Nov 9-10, 2007. The purpose of this symposium is to stimulate a dialogue among basic and clinical cancer researchers between Chin... The Nanjing International Symposium of New Frontiers in Cancer Research will be held on Nov 9-10, 2007. The purpose of this symposium is to stimulate a dialogue among basic and clinical cancer researchers between China and other countries to speed up translation of new findings in basic cancer biology into disease prevention, diagnosis, and treatment. We hope to use this conference as a forum to create a unique opportunity for exchange in current discoveries, fostering multidisciplinary collaborations, and identification of future opportunities in cancer treatment and patient care. There will be four sessions in this symposium: 展开更多
关键词 USA The Nanjing International Symposium of New Frontiers in cancer research Nov 9-10 2007
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CHINESE JOURNAL OF CANCER RESEARCH
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《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2006年第1期F0003-F0004,共2页
关键词 SI MA HE DI Chinese Journal of cancer research ANNUAL CONTENTS OF VOLUME 18 SBEM PING Li ARF DNA JUN Cell
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CHINESE JOURNAL OF CANCER RESEARCH 2004 Volume 16 CONTENTS
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《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2004年第4期i001-i004,共4页
关键词 JUN CHINESE JOURNAL OF cancer research 2004 Volume 16 CONTENTS Li LINE HCC
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CHINESE JOURNAL OF CANCER RESEARCH 2005 Volume 17
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《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2005年第4期305-308,共4页
关键词 HCCR PING CHINESE JOURNAL OF cancer research Volume 17
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Chinese Journal of Cancer Research INDEX OF VOLUME 18
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《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2006年第4期316-318,共3页
关键词 CELL RNA Chinese Journal of cancer research INDEX OF VOLUME 18 GENE
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Chinese Journal of Cancer Research ANNUAL CONTENTS OF VOLUME 18
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《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2006年第4期312-315,共4页
关键词 CELL RNA Chinese Journal of cancer research INDEX OF VOLUME 18 GENE
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Clinical Oncology and Cancer Research欢迎投稿
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《中国肿瘤临床》 CAS CSCD 北大核心 2009年第5期252-252,共1页
《中国肿瘤临床》英文版期刊于2004年正式出版,主编郝希山院士。本刊为中国科协主管,中国抗癌协会主办的国家级期刊,中国抗癌协会(CACA)系列杂志(ISSN1672-7118,CN12-1359/R),双月刊。重点报道国内外肿瘤学科的最新研究成果和进展,为国... 《中国肿瘤临床》英文版期刊于2004年正式出版,主编郝希山院士。本刊为中国科协主管,中国抗癌协会主办的国家级期刊,中国抗癌协会(CACA)系列杂志(ISSN1672-7118,CN12-1359/R),双月刊。重点报道国内外肿瘤学科的最新研究成果和进展,为国内外肿瘤学科临床医生和研究人员提供全新的英文语种学术交流园地。 展开更多
关键词 Clinical Oncology and cancer research 英文版期刊 中国科学技术信息研究所 中国肿瘤临床 中国抗癌协会
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Clinical Oncology and Cancer Research欢迎投稿
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《中国肿瘤临床》 CAS CSCD 北大核心 2009年第2期119-119,共1页
《中国肿瘤临床》英文版期刊于2004年正式出版,主编郝希山院士。本刊为中国科协主管,中国抗癌协会主办的国家级期刊,中国抗癌协会(CACA)系列杂志(ISSN1672-7118,CN12-1359/R),双月刊。
关键词 Clinical Oncology and cancer research 英文版期刊 中国科学技术信息研究所 中国肿瘤临床 中国抗癌协会
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Clinical Oncology and Cancer Research欢迎投稿
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《中国肿瘤临床》 CAS CSCD 北大核心 2009年第4期229-229,共1页
《中国肿瘤临床》英文版期刊于2004年正式出版,主编郝希山院士。本刊为中国科协主管,中国抗癌协会主办的国家级期刊,中国抗癌协会(CACA)系列杂志(ISSN1672-7118,CN12-1359/R),双月刊。
关键词 Clinical Oncology and cancer research 英文版期刊 中国科学技术信息研究所 中国肿瘤临床 中国抗癌协会
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CHINESE JOURNAL OF CANCER RESEARCH Information for Authors
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《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2005年第3期F0003-F0004,共2页
关键词 In CHINESE JOURNAL OF cancer research Information for Authors
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CHINESE JOURNAL OF CANCER RESEARCH Information for Authors
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《Chinese Journal of Cancer Research》 SCIE CAS CSCD 1999年第4期313-314,共2页
关键词 CHINESE JOURNAL OF cancer research Information for Authors
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CHINESE JOURNAL OF CANCER RESEARCH Information for Authors
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《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2005年第1期F003-F004,共2页
Chinese Journal of Cancer Research, an international biomedical journal edited and published quarterly in English by Chinese Anti-Cancer Association (CACA), is a comprehensive academic journal, aiming to reflect prima... Chinese Journal of Cancer Research, an international biomedical journal edited and published quarterly in English by Chinese Anti-Cancer Association (CACA), is a comprehensive academic journal, aiming to reflect primarily the creative or innovative achievements in all fields of cancer research in China. The papers (original research articles or reviews, specially) of basic experiments, 展开更多
关键词 In CHINESE JOURNAL OF cancer research Information for Authors
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A “Stem Cells in Cancer” special issue in Translational Cancer Research
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作者 Nancy Q.Zhong Min Shen 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2013年第6期781-781,共1页
Somatic stem cells (SSCs), being essential in maintaining homeostasis of normal tissue, replenish dying cells and regenerate damaged tissues for organism. On the other hand, with the self-renewed ability, SSCs are i... Somatic stem cells (SSCs), being essential in maintaining homeostasis of normal tissue, replenish dying cells and regenerate damaged tissues for organism. On the other hand, with the self-renewed ability, SSCs are ideal cellular targets to be acquired in multiple mutations transforming SSCs to cancer stem cells (CSCs) which cause malignancies and even recurrence after cancer treatment if CSCs fail to be eradicated (1). 展开更多
关键词 special issue in Translational cancer research Stem Cells in cancer
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Chinese Journal of Cancer Research Guidelines for Authors
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《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2010年第3期F0003-F0003,共1页
Chinese Journal of Cancer Research (CJCR) is the official publication of Chinese Anti-Cancer Association (CACA). The Journal published quarterly in English focuses on the aspects of cancer research including mainl... Chinese Journal of Cancer Research (CJCR) is the official publication of Chinese Anti-Cancer Association (CACA). The Journal published quarterly in English focuses on the aspects of cancer research including mainly cancer etiology and epidemiology, cellular and molecular biology, biochemistry, immunology, molecular genetics, gene diagnosis and gene therapy, pathology of malignant tumor, research on anti-cancer drugs, imaging diagnosis of cancer, surgical oncology, medical oncology, radiation oncology and biological therapy of cancer, etc. 展开更多
关键词 Chinese Journal of cancer research Guidelines for Authors CJCR
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Chinese Journal of Cancer Research Guidelines for Authors
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《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2007年第4期F0003-F0003,共1页
Chinese Journal of Cancer Research (CJCR) is the official publication of Chinese Auti-Cancer Association (CACA). The Journal published quarterly in English focuses on the aspects of cancer research including mainl... Chinese Journal of Cancer Research (CJCR) is the official publication of Chinese Auti-Cancer Association (CACA). The Journal published quarterly in English focuses on the aspects of cancer research including mainly cancer etiology and epidemiology, cellular and molecular biology, biochemistry, immunology, molecular genetics, gene diagnosis and gene therapy, pathology of malignant tumor, research on anti-cancer drugs, imaging diagnosis of cancer, surgical oncology, medical oncology, radiation oncology and biological therapy of cancer, etc.. 展开更多
关键词 Chinese Journal of cancer research Guidelines for Authors CJCR
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Chinese Journal of Cancer Research Guidelines for Authors
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《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2007年第1期F0003-F0003,共1页
Chinese Journal of Cancer Research (CJCR) is the official publication of Chinese Auti-Cancer Association (CACA). The Journal published quarterly in English focuses on the aspects of cancer research including mainly ca... Chinese Journal of Cancer Research (CJCR) is the official publication of Chinese Auti-Cancer Association (CACA). The Journal published quarterly in English focuses on the aspects of cancer research including mainly cancer etiology and epidemiology, cellular and molecular biology, biochemistry, immunology, molecular genetics, gene diagnosis and gene therapy, pathology of 展开更多
关键词 Chinese Journal of cancer research Guidelines for Authors CJCR
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