Cancer pain is the most common and serious symptom of cancer, which seriously affects the quality of life of cancer patients. the most widely used three-step analgesia has received good effects, but the toxic side eff...Cancer pain is the most common and serious symptom of cancer, which seriously affects the quality of life of cancer patients. the most widely used three-step analgesia has received good effects, but the toxic side effects at the same time can be ignored. As a complementary therapy increasingly accepted around the world, traditional Chinese medicine (TCM) also plays an important role in cancer pain treatment. Traditional Chinese non-drug therapy has a good effect for cancer pain. In this mini-review, the commonly used traditional Chinese non-drug therapies such as acupuncture, moxibustion, acupoint catgut embedding and injection, massage, ear point pressing with coxherb seeds therapy, traditional music therapy were introduced.展开更多
Objective: Under the guidance of the theory of Miao medicine, the technical norm scheme for intervention of acupuncture and moxibustion for the treatment of cancer pain is proposed. Methods: The standard operation pro...Objective: Under the guidance of the theory of Miao medicine, the technical norm scheme for intervention of acupuncture and moxibustion for the treatment of cancer pain is proposed. Methods: The standard operation procedure of the intervention of the acupuncture and moxibustion acupuncture therapy for cancer pain was formulated according to the selection of acupoints in the Miao medicine Tianying acupoint, sputum manipulation method, and the routine operations such as medicine, acupuncture and canning. Results: A set of technical specifications for the treatment of cancer pain in a mobilized Miao doctor was sorted out. Conclusion: The sputum acupuncture treatment technique specification for cancer pain is easy to operate and easy to be applied in clinical application.展开更多
Bone metastasis,a life-threatening complication of advanced breast cancer,is often accompanied by debilitating pain(cancer-induced bone pain,CIBP)that severely impairs life quality and survival.The concurrent treatmen...Bone metastasis,a life-threatening complication of advanced breast cancer,is often accompanied by debilitating pain(cancer-induced bone pain,CIBP)that severely impairs life quality and survival.The concurrent treatment of bone metastases and CIBP remains a clinical challenge because the therapeutic options are limited.In this study,we construct a near-infrared light-activated nano-therapeutic system to meet this conundrum.In detail,sorafenib(SRF)and photosensitizer(chlorin e6,Ce6)are encapsulated into mesoporous hydroxyapatite nanoparticles(HANPs),which are further functionalized with hyaluronic acid(HA)to obtain HA-SRF/Ce6@HANPs system.The designed nanoplatform destroys tumor cells in vitro and in vivo via the synergism of SRF(interrupting the exchange of cystine/glutamate by inhibiting SLC7A11)and photodynamic therapy(PDT,inducing reactive oxygen species generation).The decrease in tumor burden and reduction of extracellular glutamate significantly attenuate CIBP in mice model with developing bone cancer.Moreover,the combination of HA-SRF/Ce6@HANPs and PDT inhibit osteoclasts activation,promote osteoblast differentiation and accelerate bone repair.Overall,the nanoagent with good biocompatibility may provide an effective therapy method for the concurrent treatment of breast cancer bone metastasis and CIBP.展开更多
In clinic, most patients with middle-late cancer suffer from cancer pain, which seriously affects the confidence and compliance of treatment. However, the side effects of the three-step analgesic therapy, which is wid...In clinic, most patients with middle-late cancer suffer from cancer pain, which seriously affects the confidence and compliance of treatment. However, the side effects of the three-step analgesic therapy, which is widely used at present, are gradually manifested, aggravating patients' resistance to treatment. The role of Moxibustion in relieving pain has been gradually recognized and used in various professional fields. Because of its advantages of non-toxic side effects, simple operation, economic benefits, pain relief and immunity enhancement, moxibustion has been paid more and more attention.展开更多
Requirements for intervention measures for lung cancer have increased in number and difficulty due to the progress of patients and influence of complex groups of symptom.The cure rate for patients with lung cancer has...Requirements for intervention measures for lung cancer have increased in number and difficulty due to the progress of patients and influence of complex groups of symptom.The cure rate for patients with lung cancer has improved with the vigorous development of new technologies in modern medicine.However,their mental health status and physical quality of life have continued to warrant scholarly attention.The field of cognitive behavior therapy(CBT)provides innovative ideas for addressing this issue.Thus,the study reviews the origin and concept of CBT,CBT technology,and effect of its application to patients with lung cancer to provide a feasible reference for intervention on physical and mental adverse symptoms in patients with lung cancer.展开更多
Bone metastases(BM)are a common complication in advanced cancer patients,significantly contributing to morbidity and mortality due to their ability to cause pain,fractures,and spinal cord compression.Radiation therapy...Bone metastases(BM)are a common complication in advanced cancer patients,significantly contributing to morbidity and mortality due to their ability to cause pain,fractures,and spinal cord compression.Radiation therapy(RT)is vital in managing these complications by targeting metastatic lesions to ease pain,improve mobility,and reduce the risk of skeletal-related events such as fractures.Evidence supports the effectiveness of RT in pain relief,showing its ability to provide significant palliation and lessen the need for opioid painkillers,thereby enhancing the overall quality of life(QoL)for patients with BM.However,optimizing RT outcomes involves considerations such as the choice of radiation technique,dose fractionation schedules,and the integration of supportive care measures to mitigate treatment-related side effects like fatigue and skin reactions.These factors highlight the importance of personalized treatment planning tailored to individual patient needs and tumor characteristics.This mini-review aims to provide comprehensive insights into the multifaceted impacts of RT on pain management and QoL enhancement in BM patients,with implications for refining clinical practices and advancing patient care through the synthesis of findings from various studies.展开更多
基金National Natural Science Foundation of China Regional Science Fund Project, Gehua Jieyu Recipe synergistically inhibits VEGF and Wnt signaling pathways to block the angiogenesis of liver cancer microenvironment in ethanol-induced HBV transgenic mice, project document number: 81673862The National Natural Science Foundation of China, based on the P53-GADD45 pathway, studied the regulation mechanism of Tujia medicine Oriental sputum on autophagy and apoptosis of hepatoma cells, project document number: 81660833+1 种基金National Natural Science Foundation of China Regional Science Fund Project: HIF-1a /SDF-1a axis regulates the role of Warburg effect in the inhibition of colorectal cancer liver metastasis by Qiling Ointment, project document number:81760814Guizhou Provincial Department of Education: Yang Zhu, Guizhou Province,"Traditional Chinese Medicine oncology" graduate tutor studio, project number: Teaching and research GZS [2016] 08, Guizhou Provincial Department of Science and Technology: Guizhou Province high-level innovative talent training program (100 levels), project number: Teaching and research (2016) 4032. Guizhou Provincial Organization Department: Guizhou Province TCM (traditional chinese medical) Tumor Inheritance and Technology Innovation Talent Base, Project number: Leading by Guizhou [2018] 3.
文摘Cancer pain is the most common and serious symptom of cancer, which seriously affects the quality of life of cancer patients. the most widely used three-step analgesia has received good effects, but the toxic side effects at the same time can be ignored. As a complementary therapy increasingly accepted around the world, traditional Chinese medicine (TCM) also plays an important role in cancer pain treatment. Traditional Chinese non-drug therapy has a good effect for cancer pain. In this mini-review, the commonly used traditional Chinese non-drug therapies such as acupuncture, moxibustion, acupoint catgut embedding and injection, massage, ear point pressing with coxherb seeds therapy, traditional music therapy were introduced.
文摘Objective: Under the guidance of the theory of Miao medicine, the technical norm scheme for intervention of acupuncture and moxibustion for the treatment of cancer pain is proposed. Methods: The standard operation procedure of the intervention of the acupuncture and moxibustion acupuncture therapy for cancer pain was formulated according to the selection of acupoints in the Miao medicine Tianying acupoint, sputum manipulation method, and the routine operations such as medicine, acupuncture and canning. Results: A set of technical specifications for the treatment of cancer pain in a mobilized Miao doctor was sorted out. Conclusion: The sputum acupuncture treatment technique specification for cancer pain is easy to operate and easy to be applied in clinical application.
基金financially supported by the National Natural Science Foundation of China(No.82001189)The Project Tackling of Key Scientific and Technical Problems of Henan Provine(No.232102311163).
文摘Bone metastasis,a life-threatening complication of advanced breast cancer,is often accompanied by debilitating pain(cancer-induced bone pain,CIBP)that severely impairs life quality and survival.The concurrent treatment of bone metastases and CIBP remains a clinical challenge because the therapeutic options are limited.In this study,we construct a near-infrared light-activated nano-therapeutic system to meet this conundrum.In detail,sorafenib(SRF)and photosensitizer(chlorin e6,Ce6)are encapsulated into mesoporous hydroxyapatite nanoparticles(HANPs),which are further functionalized with hyaluronic acid(HA)to obtain HA-SRF/Ce6@HANPs system.The designed nanoplatform destroys tumor cells in vitro and in vivo via the synergism of SRF(interrupting the exchange of cystine/glutamate by inhibiting SLC7A11)and photodynamic therapy(PDT,inducing reactive oxygen species generation).The decrease in tumor burden and reduction of extracellular glutamate significantly attenuate CIBP in mice model with developing bone cancer.Moreover,the combination of HA-SRF/Ce6@HANPs and PDT inhibit osteoclasts activation,promote osteoblast differentiation and accelerate bone repair.Overall,the nanoagent with good biocompatibility may provide an effective therapy method for the concurrent treatment of breast cancer bone metastasis and CIBP.
基金National Natural Science Foundation of China(81673862,81660833,81760814).
文摘In clinic, most patients with middle-late cancer suffer from cancer pain, which seriously affects the confidence and compliance of treatment. However, the side effects of the three-step analgesic therapy, which is widely used at present, are gradually manifested, aggravating patients' resistance to treatment. The role of Moxibustion in relieving pain has been gradually recognized and used in various professional fields. Because of its advantages of non-toxic side effects, simple operation, economic benefits, pain relief and immunity enhancement, moxibustion has been paid more and more attention.
文摘Requirements for intervention measures for lung cancer have increased in number and difficulty due to the progress of patients and influence of complex groups of symptom.The cure rate for patients with lung cancer has improved with the vigorous development of new technologies in modern medicine.However,their mental health status and physical quality of life have continued to warrant scholarly attention.The field of cognitive behavior therapy(CBT)provides innovative ideas for addressing this issue.Thus,the study reviews the origin and concept of CBT,CBT technology,and effect of its application to patients with lung cancer to provide a feasible reference for intervention on physical and mental adverse symptoms in patients with lung cancer.
文摘Bone metastases(BM)are a common complication in advanced cancer patients,significantly contributing to morbidity and mortality due to their ability to cause pain,fractures,and spinal cord compression.Radiation therapy(RT)is vital in managing these complications by targeting metastatic lesions to ease pain,improve mobility,and reduce the risk of skeletal-related events such as fractures.Evidence supports the effectiveness of RT in pain relief,showing its ability to provide significant palliation and lessen the need for opioid painkillers,thereby enhancing the overall quality of life(QoL)for patients with BM.However,optimizing RT outcomes involves considerations such as the choice of radiation technique,dose fractionation schedules,and the integration of supportive care measures to mitigate treatment-related side effects like fatigue and skin reactions.These factors highlight the importance of personalized treatment planning tailored to individual patient needs and tumor characteristics.This mini-review aims to provide comprehensive insights into the multifaceted impacts of RT on pain management and QoL enhancement in BM patients,with implications for refining clinical practices and advancing patient care through the synthesis of findings from various studies.
