Diabetic neuropathy(DN)is the most common form of neuropathy worldwide,with its prevalence rising alongside diabetes,and being characterized by sensory,motor or autonomic symptoms.DN is considered to be an incurable c...Diabetic neuropathy(DN)is the most common form of neuropathy worldwide,with its prevalence rising alongside diabetes,and being characterized by sensory,motor or autonomic symptoms.DN is considered to be an incurable complication of diabetes,the management of which mainly consists of improving glycemic control,managing pain relief and ensuring continuous foot care.Although gabapentin,duloxetine and tricyclic antidepressants are commonly used to reduce patient symptoms,they do not affect the pathophysiology and progression of neuropathy.Furthermore,these drugs can have various side effects including insomnia,decreased appetite,arrhythmia,heart failure,and suicidal behavior.According to traditional Persian medicine,DN is recognized as a type of“Khadar”or“Esterkha”(a sensory or motor disorder,respectively)that occurs due to the accumulation of sugars in the peripheral nerves.Capparis spinosa L.,commonly known as the caper plant,has been recommended in authentic sources of traditional Persian medicine to treat such disorders.In this study,we reviewed the pharmacological properties of C.spinosa using the Web of Science,PubMed,Scopus and Google Scholar databases,and found that Capparis spinosa L.could affect several pathways involved in DN pathogenesis,including aldose reductase activity,the secretion of inflammatory mediators(IL-17,TNF-α,IL-1β,IL-6),oxidative stress,hyperlipidemia,hyperglycemia and advanced glycation end product formation.Based on these findings,we hypothesize that Capparis spinosa L.,may prevent the progression and reduce the symptoms of diabetic neuropathy,and so can be considered as a complementary treatment in this disorder.This hypothesis should be evaluated in well-designed in vitro and in vivo studies,and through clinical trials.展开更多
Textile dyes are dramatic sources of pollution and non-aesthetic disturbance of aquatic life and therefore represent a potential risk of bioaccumulation that can affect living species.It is imperative to reduce or eli...Textile dyes are dramatic sources of pollution and non-aesthetic disturbance of aquatic life and therefore represent a potential risk of bioaccumulation that can affect living species.It is imperative to reduce or eliminate these dyes from liquid effluents with innovative biomaterials and methods.Therefore,this research aims to highlight the performance of Capparis spinosa L waste-activated carbon(CSLW-AC)adsorbent to remove crystal violet(CV)from an aqueous solution.The mechanism of CV adsorption on CSLW-AC was evaluated based on the coupling of experimental data and different characterization techniques.The efficiency of the CSLW-AC material reflected by the equilibrium adsorption capacity of CV could reach more than 195.671 mg·g^(–1) when 0.5 g·L^(–1) of CSLW-AC(Particle size≤250μm)is introduced into the CV of initial concentration of 100 mg·L^(–1) at pH 6 and temperature 65℃ and in the presence of potassium ions after 60 min of contact time according to the one parameter at a time studies.The adsorption behavior of CV on CSLW-AC was found to be consistent with the pseudo-second-order kinetic model and Frumkin's linear isothermal model.The thermodynamic aspects indicate that the process is physical,spontaneous,and endothermic.The optimization of the process by the Box Behnken design of experiments resulted in an adsorption capacity approaching 183.544 mg·g^(–1)([CV]=100 mg·L^(–1) and[CSLW-AC]=0.5 g·L^(–1) at 35 min).The results of the Lactuca sativa seeds germination in treated CV(70%),adsorbent solvent and thermal regeneration(more than 5 cycles),and process cost analysis(1.0484 USD·L^(–1))tests are encouraging and promising for future exploitations of the CSLW-AC material in different industrial fields.展开更多
目的：建立刺山柑种子中没食子酸和芦丁的含量测定方法。方法采用Phnomenex色谱柱（250 mm ＆#215;4．6 mm ，5μm），以乙腈-2 mL · L -1磷酸溶液为流动相，流速为1．0 mL · min-1，检测波长为254 nm ，梯度洗脱。结果没食...目的：建立刺山柑种子中没食子酸和芦丁的含量测定方法。方法采用Phnomenex色谱柱（250 mm ＆#215;4．6 mm ，5μm），以乙腈-2 mL · L -1磷酸溶液为流动相，流速为1．0 mL · min-1，检测波长为254 nm ，梯度洗脱。结果没食子酸在1.4～14．0μg、芦丁在1.4～28．0μg范围内呈良好的线性关系，没食子酸平均回收率为99．9％，RSD为2．0％；芦丁平均回收率为100．6％， RSD为1．3％。结论 HPLC法测定没食子酸和芦丁的含量，方法简便可行，重复性和分离效果好，可为刺山柑的进一步开发利用及质量控制提供依据。展开更多
目的:通过研究刺山柑果提取物(Capparis spinosa fruit extract,CS)对干燥皮肤的改善作用,来探讨CS在皮肤护理中的作用,同时阐述其对于皮肤丝聚蛋白通路的调控机理。方法:于干燥皮肤上,通过多功能皮肤探头、皮肤胶带取样,检测不同浓度C...目的:通过研究刺山柑果提取物(Capparis spinosa fruit extract,CS)对干燥皮肤的改善作用,来探讨CS在皮肤护理中的作用,同时阐述其对于皮肤丝聚蛋白通路的调控机理。方法:于干燥皮肤上,通过多功能皮肤探头、皮肤胶带取样,检测不同浓度CS即时使用和持续使用下,皮肤含水量、经表皮失水率(Trans-epidermal water loss,TEWL)、鳞屑占比的变化。同时于低湿度环境培养下的重组表皮模型上,采用免疫荧光染色、CCK-8染色、高效液相法,分析CS对于丝聚蛋白降解相关指标的影响。结果:5%CS在使用后4 h可显著提升皮肤含水量,改善皮肤鳞屑占比。使用后7 d,1%、5%CS也可显著提升皮肤含水量,降低TEWL,改善皮肤鳞屑占比。3%CS涂抹于低湿度处理下的重组表皮模型上,4 h时可提升半胱天冬酶14、博来霉素水解酶表达量,促进吡咯烷酮羧酸(Pyrrolidone carboxylic acid,PCA)形成。24 h时改善细胞活力和皮肤结构,恢复皮肤含水量。结论:CS可通过调控丝聚蛋白通路来改善皮肤干燥状态,短时促进丝聚蛋白降解形成PCA,长效改善皮肤结构完整性和屏障功能。展开更多
文摘Diabetic neuropathy(DN)is the most common form of neuropathy worldwide,with its prevalence rising alongside diabetes,and being characterized by sensory,motor or autonomic symptoms.DN is considered to be an incurable complication of diabetes,the management of which mainly consists of improving glycemic control,managing pain relief and ensuring continuous foot care.Although gabapentin,duloxetine and tricyclic antidepressants are commonly used to reduce patient symptoms,they do not affect the pathophysiology and progression of neuropathy.Furthermore,these drugs can have various side effects including insomnia,decreased appetite,arrhythmia,heart failure,and suicidal behavior.According to traditional Persian medicine,DN is recognized as a type of“Khadar”or“Esterkha”(a sensory or motor disorder,respectively)that occurs due to the accumulation of sugars in the peripheral nerves.Capparis spinosa L.,commonly known as the caper plant,has been recommended in authentic sources of traditional Persian medicine to treat such disorders.In this study,we reviewed the pharmacological properties of C.spinosa using the Web of Science,PubMed,Scopus and Google Scholar databases,and found that Capparis spinosa L.could affect several pathways involved in DN pathogenesis,including aldose reductase activity,the secretion of inflammatory mediators(IL-17,TNF-α,IL-1β,IL-6),oxidative stress,hyperlipidemia,hyperglycemia and advanced glycation end product formation.Based on these findings,we hypothesize that Capparis spinosa L.,may prevent the progression and reduce the symptoms of diabetic neuropathy,and so can be considered as a complementary treatment in this disorder.This hypothesis should be evaluated in well-designed in vitro and in vivo studies,and through clinical trials.
文摘Textile dyes are dramatic sources of pollution and non-aesthetic disturbance of aquatic life and therefore represent a potential risk of bioaccumulation that can affect living species.It is imperative to reduce or eliminate these dyes from liquid effluents with innovative biomaterials and methods.Therefore,this research aims to highlight the performance of Capparis spinosa L waste-activated carbon(CSLW-AC)adsorbent to remove crystal violet(CV)from an aqueous solution.The mechanism of CV adsorption on CSLW-AC was evaluated based on the coupling of experimental data and different characterization techniques.The efficiency of the CSLW-AC material reflected by the equilibrium adsorption capacity of CV could reach more than 195.671 mg·g^(–1) when 0.5 g·L^(–1) of CSLW-AC(Particle size≤250μm)is introduced into the CV of initial concentration of 100 mg·L^(–1) at pH 6 and temperature 65℃ and in the presence of potassium ions after 60 min of contact time according to the one parameter at a time studies.The adsorption behavior of CV on CSLW-AC was found to be consistent with the pseudo-second-order kinetic model and Frumkin's linear isothermal model.The thermodynamic aspects indicate that the process is physical,spontaneous,and endothermic.The optimization of the process by the Box Behnken design of experiments resulted in an adsorption capacity approaching 183.544 mg·g^(–1)([CV]=100 mg·L^(–1) and[CSLW-AC]=0.5 g·L^(–1) at 35 min).The results of the Lactuca sativa seeds germination in treated CV(70%),adsorbent solvent and thermal regeneration(more than 5 cycles),and process cost analysis(1.0484 USD·L^(–1))tests are encouraging and promising for future exploitations of the CSLW-AC material in different industrial fields.
文摘目的：建立刺山柑种子中没食子酸和芦丁的含量测定方法。方法采用Phnomenex色谱柱（250 mm ＆#215;4．6 mm ，5μm），以乙腈-2 mL · L -1磷酸溶液为流动相，流速为1．0 mL · min-1，检测波长为254 nm ，梯度洗脱。结果没食子酸在1.4～14．0μg、芦丁在1.4～28．0μg范围内呈良好的线性关系，没食子酸平均回收率为99．9％，RSD为2．0％；芦丁平均回收率为100．6％， RSD为1．3％。结论 HPLC法测定没食子酸和芦丁的含量，方法简便可行，重复性和分离效果好，可为刺山柑的进一步开发利用及质量控制提供依据。
