Abstract Hyperpolarization-activated cyclic-nucleotide-gated ( HCN) channels in the heart modulate cardiac automaticity via the hyperpolarization-activated cation current (named If, Ih, or Iq). Recent studies have unv...Abstract Hyperpolarization-activated cyclic-nucleotide-gated ( HCN) channels in the heart modulate cardiac automaticity via the hyperpolarization-activated cation current (named If, Ih, or Iq). Recent studies have unveiled the molecular identity of HCN (HCN 1-4) channels. HCN isoforms are unevenly expressed in the heart, even in the sinoatrial node. Features of HCN currents have been characterized in cardiac and other types of cells or in cell lines transfected with the HCN isoforms. The factors modulating Ih and the physiological significance of HCN channels in the heart have been extensively investigated in recent years. The hypothesis for transplanting and/or creating biological pacemakers to replace diseased sinoatrial and/or atrioventricular nodes has been postulated and tested in animal models. Local overexpression of HCN2 channels in the left atrium or in the left conductive bundle branch of the left ventricle via gene delivery induced significant Ih and escape rhythms during vagal stimulation in canines. In addition, implantation of human mesenchymal stem cells with overexpression of HCN2 channels to the canine left ventricular wall was associated with formation of spontaneous escape rhythms of left-sided origin during vagal-stimulation-induced sinus arrest. This preliminary data suggest that the use of HCN channels may hold great promise in the development of biological pacemakers.展开更多
Noise,vibration and harshness(NVH)problems in vehicle engineering are always challenging in both traditional vehicles and intelligent vehicles.Although high accuracy manufacturing,modern structural roads and advanced ...Noise,vibration and harshness(NVH)problems in vehicle engineering are always challenging in both traditional vehicles and intelligent vehicles.Although high accuracy manufacturing,modern structural roads and advanced suspension technology have already significantly reduced NVH problems and their impacts;off-road condition,obstacles and extreme operating condition could still trigger NVH problems unexpectedly.This paper proposes a vehicular electronic image stabilization(EIS)system to solve the vibration problem of the camera and ensure the environment perceptive function of vehicles.Firstly,feature point detection and matching based on an oriented FAST and rotated BRIEF(ORB)algorithm are implemented to match images in the process of EIS.Furthermore,a novel improved random sampling consensus algorithm(i-RANSAC)is proposed to eliminate mismatched feature points and increase the matching accuracy significantly.And an adaptive Kalman filter(AKF)is applied to improve the adaptability of the vehicular EIS.Finally,an experimental platform based on a gasoline model car was established to validate its performance.The experimental results show that the proposed EIS system can satisfy vehicular performance requirements even under off-road condition with obvious obstacles.展开更多
In light of previous work [Phys. Rev. E 60 4000 （1999）], a modified coupled-map car-following model is proposed by considering the headways of two successive vehicles in front of a considered vehicle described by th...In light of previous work [Phys. Rev. E 60 4000 （1999）], a modified coupled-map car-following model is proposed by considering the headways of two successive vehicles in front of a considered vehicle described by the optimal velocity function. The non-jam conditions are given on the basis of control theory. Through simulation, we find that our model can exhibit a better effect as p = 0.65, which is a parameter in the optimal velocity function. The control scheme, which was proposed by Zhao and Gao, is introduced into the modified model and the feedback gain range is determined. In addition, a modified control method is applied to a mixed traffic system that consists of two types of vehicle. The range of gains is also obtained by theoretical analysis. Comparisons between our method and that of Zhao and Gao are carried out, and the corresponding numerical simulation results demonstrate that the temporal behavior of traffic flow obtained using our method is better than that proposed by Zhao and Gao in mixed traffic systems.展开更多
This paper discusses the dynamic behavior and its predictions for a simulated traffic flow based on the nonlinear response of a vehicle to the leading car＇s movement in a single lane. Traffic chaos is a promising fie...This paper discusses the dynamic behavior and its predictions for a simulated traffic flow based on the nonlinear response of a vehicle to the leading car＇s movement in a single lane. Traffic chaos is a promising field, and chaos theory has been applied to identify and predict its chaotic movement. A simulated traffic flow is generated using a car-following model（ GM model）, and the distance between two cars is investigated for its dynamic properties. A positive Lyapunov exponent confirms the existence of chaotic behavior in the GM model. A new algorithm using a RBF NN （radial basis function neural network） is proposed to predict this traffic chaos. The experiment shows that the chaotic degree and predictable degree are determined by the first Lyapunov exponent. The algorithm proposed in this paper can be generalized to recognize and predict the chaos of short-time traffic flow series展开更多
针对复杂产品装配序列规划耗时、效率低且错误率高等问题,提出了一种基于改进人工蜂群算法的装配序列规划解决方案。首先,综合考虑装配序列的可行性、复杂性、稳定性、重定向性、聚合性等多个因素,构建基于矩阵的装配关系模型及适应性...针对复杂产品装配序列规划耗时、效率低且错误率高等问题,提出了一种基于改进人工蜂群算法的装配序列规划解决方案。首先,综合考虑装配序列的可行性、复杂性、稳定性、重定向性、聚合性等多个因素,构建基于矩阵的装配关系模型及适应性评价函数;其次,通过调用SolidWorks中的应用程序接口(application program interface, API)获取装配对象的相关数据,生成装配关系矩阵,以求装配序列规划问题;最后,以冷藏车的典型零件为对象,验证该方法的可行性。该技术显著缩短了检查时间和减小了错误率,同时提高了效率。展开更多
文摘Abstract Hyperpolarization-activated cyclic-nucleotide-gated ( HCN) channels in the heart modulate cardiac automaticity via the hyperpolarization-activated cation current (named If, Ih, or Iq). Recent studies have unveiled the molecular identity of HCN (HCN 1-4) channels. HCN isoforms are unevenly expressed in the heart, even in the sinoatrial node. Features of HCN currents have been characterized in cardiac and other types of cells or in cell lines transfected with the HCN isoforms. The factors modulating Ih and the physiological significance of HCN channels in the heart have been extensively investigated in recent years. The hypothesis for transplanting and/or creating biological pacemakers to replace diseased sinoatrial and/or atrioventricular nodes has been postulated and tested in animal models. Local overexpression of HCN2 channels in the left atrium or in the left conductive bundle branch of the left ventricle via gene delivery induced significant Ih and escape rhythms during vagal stimulation in canines. In addition, implantation of human mesenchymal stem cells with overexpression of HCN2 channels to the canine left ventricular wall was associated with formation of spontaneous escape rhythms of left-sided origin during vagal-stimulation-induced sinus arrest. This preliminary data suggest that the use of HCN channels may hold great promise in the development of biological pacemakers.
基金National Natural Science Foundation of China(Grant Nos.52072072,52025121 and 51605087).
文摘Noise,vibration and harshness(NVH)problems in vehicle engineering are always challenging in both traditional vehicles and intelligent vehicles.Although high accuracy manufacturing,modern structural roads and advanced suspension technology have already significantly reduced NVH problems and their impacts;off-road condition,obstacles and extreme operating condition could still trigger NVH problems unexpectedly.This paper proposes a vehicular electronic image stabilization(EIS)system to solve the vibration problem of the camera and ensure the environment perceptive function of vehicles.Firstly,feature point detection and matching based on an oriented FAST and rotated BRIEF(ORB)algorithm are implemented to match images in the process of EIS.Furthermore,a novel improved random sampling consensus algorithm(i-RANSAC)is proposed to eliminate mismatched feature points and increase the matching accuracy significantly.And an adaptive Kalman filter(AKF)is applied to improve the adaptability of the vehicular EIS.Finally,an experimental platform based on a gasoline model car was established to validate its performance.The experimental results show that the proposed EIS system can satisfy vehicular performance requirements even under off-road condition with obvious obstacles.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11372166,11372147,61074142,and 11072117)the Scientific Research Fund of Zhejiang Province,China(Grant No.LY13A010005)+1 种基金the Disciplinary Project of Ningbo City,China(Grant No.SZXL1067)the K.C.Wong Magna Fund in Ningbo University,China,and the Government of the Hong Kong Administrative Region,China(Grant No.119011)
文摘In light of previous work [Phys. Rev. E 60 4000 （1999）], a modified coupled-map car-following model is proposed by considering the headways of two successive vehicles in front of a considered vehicle described by the optimal velocity function. The non-jam conditions are given on the basis of control theory. Through simulation, we find that our model can exhibit a better effect as p = 0.65, which is a parameter in the optimal velocity function. The control scheme, which was proposed by Zhao and Gao, is introduced into the modified model and the feedback gain range is determined. In addition, a modified control method is applied to a mixed traffic system that consists of two types of vehicle. The range of gains is also obtained by theoretical analysis. Comparisons between our method and that of Zhao and Gao are carried out, and the corresponding numerical simulation results demonstrate that the temporal behavior of traffic flow obtained using our method is better than that proposed by Zhao and Gao in mixed traffic systems.
文摘This paper discusses the dynamic behavior and its predictions for a simulated traffic flow based on the nonlinear response of a vehicle to the leading car＇s movement in a single lane. Traffic chaos is a promising field, and chaos theory has been applied to identify and predict its chaotic movement. A simulated traffic flow is generated using a car-following model（ GM model）, and the distance between two cars is investigated for its dynamic properties. A positive Lyapunov exponent confirms the existence of chaotic behavior in the GM model. A new algorithm using a RBF NN （radial basis function neural network） is proposed to predict this traffic chaos. The experiment shows that the chaotic degree and predictable degree are determined by the first Lyapunov exponent. The algorithm proposed in this paper can be generalized to recognize and predict the chaos of short-time traffic flow series
文摘针对复杂产品装配序列规划耗时、效率低且错误率高等问题,提出了一种基于改进人工蜂群算法的装配序列规划解决方案。首先,综合考虑装配序列的可行性、复杂性、稳定性、重定向性、聚合性等多个因素,构建基于矩阵的装配关系模型及适应性评价函数;其次,通过调用SolidWorks中的应用程序接口(application program interface, API)获取装配对象的相关数据,生成装配关系矩阵,以求装配序列规划问题;最后,以冷藏车的典型零件为对象,验证该方法的可行性。该技术显著缩短了检查时间和减小了错误率,同时提高了效率。
