In the past two decades, photoluminescent semiconductor quantum dots（QDs） have received intensive attention for a variety of promising properties and applications, especially for their potential application in cellu...In the past two decades, photoluminescent semiconductor quantum dots（QDs） have received intensive attention for a variety of promising properties and applications, especially for their potential application in cellular imagingE. QDs with high quantum yield have been prepared based on cad mium（zinc） selenide（sulfide） and related coreshell compo sites. However, the release of Cd2＋, S2 and Se2 ions in evitably causes serious health and environmental concerns. Therefore, many efforts have been devoted to developing be nign alternatives with enhanced photoluminescence, such as silicon nanoparticles and nanowires. Carbonbased nanomaterials, including carbon nano tubes（CNTs） and carbogenic nanoparticles（CNPs）, represent an exciting new type of alternative to the aforementioned QDs with high quantum yield. CNPs are superior to QDs in chemi cally inertness, biocompatibility and photostability. After the report on the photoluminescence of carbon dots prepared by laser ablation with graphite as carbon sourcetill, several strate gies have been developed for the preparation of luminescent CNPs. For instance, luminescent CNPs were prepared by Liu et al.021 with candle soot via oxidative acid treatment, and the resulting CNPs with different emission colors were isolated by means of electrophoretic separation. Hu et al. employed an improved onestep approach for the synthesis of luminescent CNPs by laser irradiating a suspension of carbon materials in organic solvents of diamineterminated oligomeric poly（ethylene glycol）（PEG1500N）. More recently, luminescent carbogenic dots have been obtained by Peng and Travas via surface passivation of carbogenic dots in an aqueous solution with carbohydrates as the starting materials. Carbogenic nano particlesloaded magnesiumaluminophosphate solid phosphors.展开更多
Nicotinoylamino acid compounds 4, 5, 9a, 9b, 9c, 10a and 10b were synthesized with nicotinoyl chloride or nicotinoyl azide as acetylating agents of amino acid esters or amino acids. The compounds were tested for their...Nicotinoylamino acid compounds 4, 5, 9a, 9b, 9c, 10a and 10b were synthesized with nicotinoyl chloride or nicotinoyl azide as acetylating agents of amino acid esters or amino acids. The compounds were tested for their radiosensitizing activity in Leukemia cell line（L1210） and compared with nicotinamide; among them, compounds 9a and 9c showed significant radiosensitizing effects, the sensitizer enhancement ratio（SER） was 1.64 and 1.58, respectively, while nicotinamide did not show good radiosensitizing effect under the same conditions. Compound 9c was alone tested for radiosensitization in LA 795 cell-bearing T-739 mice, or hyperthermia and breathing carbogen（5%CO2＋95%O2） were together tested for radiosensitization. The results showed that radiation-induced growth delay was enhanced by 9c alone or by the combination of hypertheimia and carbogen. The tumor-bearing mice were irradiated locally by total 10 Gy, and the tumors grew to three times that of the original volume in an average of 5.8 d. The mice were given i.p. compound 9c at 1000 mg/kg 60 min before irradiation and treated at 43 ℃ for 30 min after irradiation or treated with breathing carbogen for 5 min before radiation or with hyperthmia（43 ℃） for 30 min after irradiation; the time required for the tumor to grow to three times the orginal volume was in an average of 12.9 and 13 d, respectively.展开更多
To present spectral domain optical coherence tomography(OCT)findings during treatment in a case of acute isolated cilioretinal artery occlusion(CLRAO)reversed with intravenous systemic administration of mannitol and c...To present spectral domain optical coherence tomography(OCT)findings during treatment in a case of acute isolated cilioretinal artery occlusion(CLRAO)reversed with intravenous systemic administration of mannitol and carbogen inhalation.Close monitoring with OCT thickness topographic map and cross section scans,every 12 hours,during treatment and till complete reversal of retinal nerve fiber layer edema.Fundus photography and fluorescein angiography(FFA)were used to illustrate occlusion and recanalization.After 72 hours of therapy,visual acuity improved from counting fingers(CF)to 7/10,Snellen’s chart.Consecutively OCT scans showed that the initial macular edema was gradually restored to typical 72 hours of treatment initiation.FFA performed after treatment confirmed recanalization of the cilioretinal artery.Early intervention with the combined intravenous administration of mannitol and carbogen inhalation can reverse acute onset loss of vision due to CLRAO.The reflectivity of retinal layers differs significantly regarding stages of acute CLRAO.In our case report increased reflectivity of the innermost layers of the retina was illustrated and a corresponding reduction in the outer retina and the retinal pigment epithelium and choriocapillaris layers.Macular thickness follow-up data recorded the course of intracellular edema to normal.展开更多
基金Supported by the National Natural Science Foundation of China（Nos.21071060, 20731003） and the National Basic Research Program of China（No.2007CB613303）.
文摘In the past two decades, photoluminescent semiconductor quantum dots（QDs） have received intensive attention for a variety of promising properties and applications, especially for their potential application in cellular imagingE. QDs with high quantum yield have been prepared based on cad mium（zinc） selenide（sulfide） and related coreshell compo sites. However, the release of Cd2＋, S2 and Se2 ions in evitably causes serious health and environmental concerns. Therefore, many efforts have been devoted to developing be nign alternatives with enhanced photoluminescence, such as silicon nanoparticles and nanowires. Carbonbased nanomaterials, including carbon nano tubes（CNTs） and carbogenic nanoparticles（CNPs）, represent an exciting new type of alternative to the aforementioned QDs with high quantum yield. CNPs are superior to QDs in chemi cally inertness, biocompatibility and photostability. After the report on the photoluminescence of carbon dots prepared by laser ablation with graphite as carbon sourcetill, several strate gies have been developed for the preparation of luminescent CNPs. For instance, luminescent CNPs were prepared by Liu et al.021 with candle soot via oxidative acid treatment, and the resulting CNPs with different emission colors were isolated by means of electrophoretic separation. Hu et al. employed an improved onestep approach for the synthesis of luminescent CNPs by laser irradiating a suspension of carbon materials in organic solvents of diamineterminated oligomeric poly（ethylene glycol）（PEG1500N）. More recently, luminescent carbogenic dots have been obtained by Peng and Travas via surface passivation of carbogenic dots in an aqueous solution with carbohydrates as the starting materials. Carbogenic nano particlesloaded magnesiumaluminophosphate solid phosphors.
基金the National Natural Science Foundation of Tianjin,China(No.043610411)
文摘Nicotinoylamino acid compounds 4, 5, 9a, 9b, 9c, 10a and 10b were synthesized with nicotinoyl chloride or nicotinoyl azide as acetylating agents of amino acid esters or amino acids. The compounds were tested for their radiosensitizing activity in Leukemia cell line（L1210） and compared with nicotinamide; among them, compounds 9a and 9c showed significant radiosensitizing effects, the sensitizer enhancement ratio（SER） was 1.64 and 1.58, respectively, while nicotinamide did not show good radiosensitizing effect under the same conditions. Compound 9c was alone tested for radiosensitization in LA 795 cell-bearing T-739 mice, or hyperthermia and breathing carbogen（5%CO2＋95%O2） were together tested for radiosensitization. The results showed that radiation-induced growth delay was enhanced by 9c alone or by the combination of hypertheimia and carbogen. The tumor-bearing mice were irradiated locally by total 10 Gy, and the tumors grew to three times that of the original volume in an average of 5.8 d. The mice were given i.p. compound 9c at 1000 mg/kg 60 min before irradiation and treated at 43 ℃ for 30 min after irradiation or treated with breathing carbogen for 5 min before radiation or with hyperthmia（43 ℃） for 30 min after irradiation; the time required for the tumor to grow to three times the orginal volume was in an average of 12.9 and 13 d, respectively.
文摘To present spectral domain optical coherence tomography(OCT)findings during treatment in a case of acute isolated cilioretinal artery occlusion(CLRAO)reversed with intravenous systemic administration of mannitol and carbogen inhalation.Close monitoring with OCT thickness topographic map and cross section scans,every 12 hours,during treatment and till complete reversal of retinal nerve fiber layer edema.Fundus photography and fluorescein angiography(FFA)were used to illustrate occlusion and recanalization.After 72 hours of therapy,visual acuity improved from counting fingers(CF)to 7/10,Snellen’s chart.Consecutively OCT scans showed that the initial macular edema was gradually restored to typical 72 hours of treatment initiation.FFA performed after treatment confirmed recanalization of the cilioretinal artery.Early intervention with the combined intravenous administration of mannitol and carbogen inhalation can reverse acute onset loss of vision due to CLRAO.The reflectivity of retinal layers differs significantly regarding stages of acute CLRAO.In our case report increased reflectivity of the innermost layers of the retina was illustrated and a corresponding reduction in the outer retina and the retinal pigment epithelium and choriocapillaris layers.Macular thickness follow-up data recorded the course of intracellular edema to normal.
