Centrally located hepatocellular carcinoma(HCC)is sited in the central part of the liver and adjacent to main hepatic vascular structures.This special location is associated with an increase in the difficulty of surge...Centrally located hepatocellular carcinoma(HCC)is sited in the central part of the liver and adjacent to main hepatic vascular structures.This special location is associated with an increase in the difficulty of surgery,aggregation of the recurrence disease,and greater challenge in disease management.This review summarizes the evolution of our understanding for centrally located HCC and discusses the development of treatment strategies,surgical approaches and recurrence prevention methods.To improve patient survival,a multi-disciplinary modality is greatly needed throughout the whole treatment period.展开更多
目前,对于剩余肝脏体积不达标的肝癌病人,手术策略是通过诱导刺激健侧肝脏增生和病侧肝脏萎缩来实现二次肝切除。近年来,联合肝脏离断及门脉结扎的二次肝切除术(associating liver partition and portal vein ligation for staged hepat...目前,对于剩余肝脏体积不达标的肝癌病人,手术策略是通过诱导刺激健侧肝脏增生和病侧肝脏萎缩来实现二次肝切除。近年来,联合肝脏离断及门脉结扎的二次肝切除术(associating liver partition and portal vein ligation for staged hepatectomy,ALPPS)的问世为解决这一难题提供了新的办法。随着相关研究的不断进展,在常规ALPPS的基础上出现了多种改良术式,其中选择性肝血管阻断的方法,因具有比传统ALPPS安全性更佳、抑制肿瘤生长效果更好以及更易推广等优势,在医学界广受关注。展开更多
文摘Centrally located hepatocellular carcinoma(HCC)is sited in the central part of the liver and adjacent to main hepatic vascular structures.This special location is associated with an increase in the difficulty of surgery,aggregation of the recurrence disease,and greater challenge in disease management.This review summarizes the evolution of our understanding for centrally located HCC and discusses the development of treatment strategies,surgical approaches and recurrence prevention methods.To improve patient survival,a multi-disciplinary modality is greatly needed throughout the whole treatment period.
文摘目前,对于剩余肝脏体积不达标的肝癌病人,手术策略是通过诱导刺激健侧肝脏增生和病侧肝脏萎缩来实现二次肝切除。近年来,联合肝脏离断及门脉结扎的二次肝切除术(associating liver partition and portal vein ligation for staged hepatectomy,ALPPS)的问世为解决这一难题提供了新的办法。随着相关研究的不断进展,在常规ALPPS的基础上出现了多种改良术式,其中选择性肝血管阻断的方法,因具有比传统ALPPS安全性更佳、抑制肿瘤生长效果更好以及更易推广等优势,在医学界广受关注。
