We aimed to establish gestation age specific reference intervals for Doppler indices of fetal cardiac function from 12 to 40 weeks of pregnancy. In a cross-sectional observational study of singleton pregnancies, exami...We aimed to establish gestation age specific reference intervals for Doppler indices of fetal cardiac function from 12 to 40 weeks of pregnancy. In a cross-sectional observational study of singleton pregnancies, examinations were performed in 221 women evenly distributed across each week of pregnancy. Blood flow through the four cardiac valves was examined with Doppler. For the atrioventricular valves, velocity and duration of early (E) and atrial (A) waves and the interval (a) between E/A complexes was recorded. For the outflow valves, the duration (b), peak and average velocity of flow in systole was measured. Myocardial performance index (MPI) was calculated as (a - b)/b. Outlet valve diameters were measured and cardiac outputs were calculated. Gestation age specific ranges were constructed for all these parameters. We demonstrated that the cardiac output, peak systolic and time-averaged velocity increase with advancing gestation. However the MPI and E/A ratios show little change across gestation. Fetal cardiac physiology can be studied and Doppler indices reliably measured as early as the late first trimester of pregnancy. Establishing gestation age specific ranges for various cardiac indices throughout pregnancy will help the study of development of fetal cardiac function.展开更多
To explore the feasibility of using tissue Doppler imaging technique for the evaluation of fetus＇s left ventrieular diastolic function, and to confirm its reliability by comparing it with traditional methods, this st...To explore the feasibility of using tissue Doppler imaging technique for the evaluation of fetus＇s left ventrieular diastolic function, and to confirm its reliability by comparing it with traditional methods, this study examined 61 pregnant women in whom satisfactory images were obtained of fetal eehoeardiography. The peak velocity of blood stream were measured, including E, A and E/A at mitral valve orifice on the four chamber view with pulse wave. And then tissue Doppler imaging mode was employed to measure the velocity of mitral valve annulus including Ea, Aa, Sa and Ea / Aa. Correlation analysis was conducted between the velocity of orifice and that of annulus in terms of gestation age. And then correlation analysis was performed between above data and gestation ages. A positive correlation was found between the velocity of orifice and that of annulus, and the velocity increased with the gestation age. The change was the most significant between the 28th and the 34th week of gestation age. Our study showed that it is feasible to evaluate the fetus＇s left ven trieular diastole function by tissue Doppler imaging. Its stability can avoid the influence of fetal heart rates and preload.展开更多
Objectives: Two methods have been described to assess fetal cardiac output (CO). It has usually been calculated by using 2D ultrasound to measure the diameter of outflow valves and Doppler ultrasound to measure flow v...Objectives: Two methods have been described to assess fetal cardiac output (CO). It has usually been calculated by using 2D ultrasound to measure the diameter of outflow valves and Doppler ultrasound to measure flow velocity through the valves. Recently CO has been assessed using 3D spatio-temporal image correlation (STIC) to measure stroke volume. We aimed to compare the reproducibility of these techniques. Methods: In 27 women with singleton pregnancies, examinations were performed in three gestational age groups: 13 - 15, 19 - 21 and >30 weeks of gestation. Each mother was scanned once. Using 2D pulsed wave Doppler the duration of flow and average flow velocity in systole were measured through aortic and pulmonary valves. We averaged values from three consecutive Doppler complexes. The outlet valve diameters were measured and the cardiac output was calculated for each valve. The measurements were repeated to assess reproducibility. In the same women, we acquired STIC volumes of the fetal heart. The volume measurements were made using the 3D Slice method by one observer. Using 2 mm slices the circumference of the ventricles was traced at the end of systole and diastole to calculate ventricular volume before and after contractions to calculate stroke volume and hence cardiac output. The measurements were repeated to assess reproducibility. Results: The root mean square difference of log (CO) of repeat measurements ranged between 0.12 and 0.21 using Doppler compared to 0.7 to 1.47 using STIC. The differences in reproducibility reached statistical significance for both sides of the heart at all but one gestation. Conclusions: We found that Doppler assessment of fetal cardiac output was more reproducible than measurement using STIC.展开更多
文摘We aimed to establish gestation age specific reference intervals for Doppler indices of fetal cardiac function from 12 to 40 weeks of pregnancy. In a cross-sectional observational study of singleton pregnancies, examinations were performed in 221 women evenly distributed across each week of pregnancy. Blood flow through the four cardiac valves was examined with Doppler. For the atrioventricular valves, velocity and duration of early (E) and atrial (A) waves and the interval (a) between E/A complexes was recorded. For the outflow valves, the duration (b), peak and average velocity of flow in systole was measured. Myocardial performance index (MPI) was calculated as (a - b)/b. Outlet valve diameters were measured and cardiac outputs were calculated. Gestation age specific ranges were constructed for all these parameters. We demonstrated that the cardiac output, peak systolic and time-averaged velocity increase with advancing gestation. However the MPI and E/A ratios show little change across gestation. Fetal cardiac physiology can be studied and Doppler indices reliably measured as early as the late first trimester of pregnancy. Establishing gestation age specific ranges for various cardiac indices throughout pregnancy will help the study of development of fetal cardiac function.
文摘To explore the feasibility of using tissue Doppler imaging technique for the evaluation of fetus＇s left ventrieular diastolic function, and to confirm its reliability by comparing it with traditional methods, this study examined 61 pregnant women in whom satisfactory images were obtained of fetal eehoeardiography. The peak velocity of blood stream were measured, including E, A and E/A at mitral valve orifice on the four chamber view with pulse wave. And then tissue Doppler imaging mode was employed to measure the velocity of mitral valve annulus including Ea, Aa, Sa and Ea / Aa. Correlation analysis was conducted between the velocity of orifice and that of annulus in terms of gestation age. And then correlation analysis was performed between above data and gestation ages. A positive correlation was found between the velocity of orifice and that of annulus, and the velocity increased with the gestation age. The change was the most significant between the 28th and the 34th week of gestation age. Our study showed that it is feasible to evaluate the fetus＇s left ven trieular diastole function by tissue Doppler imaging. Its stability can avoid the influence of fetal heart rates and preload.
文摘Objectives: Two methods have been described to assess fetal cardiac output (CO). It has usually been calculated by using 2D ultrasound to measure the diameter of outflow valves and Doppler ultrasound to measure flow velocity through the valves. Recently CO has been assessed using 3D spatio-temporal image correlation (STIC) to measure stroke volume. We aimed to compare the reproducibility of these techniques. Methods: In 27 women with singleton pregnancies, examinations were performed in three gestational age groups: 13 - 15, 19 - 21 and >30 weeks of gestation. Each mother was scanned once. Using 2D pulsed wave Doppler the duration of flow and average flow velocity in systole were measured through aortic and pulmonary valves. We averaged values from three consecutive Doppler complexes. The outlet valve diameters were measured and the cardiac output was calculated for each valve. The measurements were repeated to assess reproducibility. In the same women, we acquired STIC volumes of the fetal heart. The volume measurements were made using the 3D Slice method by one observer. Using 2 mm slices the circumference of the ventricles was traced at the end of systole and diastole to calculate ventricular volume before and after contractions to calculate stroke volume and hence cardiac output. The measurements were repeated to assess reproducibility. Results: The root mean square difference of log (CO) of repeat measurements ranged between 0.12 and 0.21 using Doppler compared to 0.7 to 1.47 using STIC. The differences in reproducibility reached statistical significance for both sides of the heart at all but one gestation. Conclusions: We found that Doppler assessment of fetal cardiac output was more reproducible than measurement using STIC.
