睡眠呼吸暂停综合征与心律失常的相关性

目的探讨睡眠呼吸暂停综合征（OSAS）与心律失常间的相关性。方法对48例OSAS合并心律失常病人（OSAS组）和48例单纯鼾症病人（正常组）进行体质量指数（BMI）、呼吸暂停低通气指数（AHI）、血氧饱和度（SaO_2）、心率变异性（HRV）及心率震荡指标进行监测。结果 OSAS组BMI、震荡初始和正常组相比,差异无显著性（P〉0.05）;而HRV中的周期标准差平均值、NN50计数占RR周期间数的百分比、震荡斜率以及呼吸暂停低通气指数、SaO_2差异有显著性（t=-32.65~35.69,P〈0.05）。OSAS组病人房性心律失常、室性心律失常、窦性心律失常发生率显著高于正常组（χ~2=17.16~24.08,P〈0.05）。结论 OSAS病人受迷走神经活力降低、交感神经系统活力提高以及自主神经功能失调等因素的影响,导致心律失常的发病率明显提高,临床需引起重视,应及早预防并治疗。

Cardiomyopathy protection in Chagas Disease

There is some published evidence suggesting micro vascular endothelial dysfunction and dysautonomia involvement in Chagas disease in association with cardiomyocyte changes favoring disease progression. The combined treatment between angiotensin converting enzyme (ACE) inhibitor drugs;Simvastatin, muscarinic antibody immunoadsorbent together with fungicidal drugs would open therapeutic possibilities in this disease.