The mechanical environment and anisotropic structure of the heart modulate cardiac function at the cellular,tissue and organ levels.During myocardial infarction(MI)and subsequent healing,however,this landscape changes...The mechanical environment and anisotropic structure of the heart modulate cardiac function at the cellular,tissue and organ levels.During myocardial infarction(MI)and subsequent healing,however,this landscape changes significantly.In order to engineer cardiac biomaterials with the appropriate properties to enhance function after MI,the changes in the myocardium induced by MI must be clearly identified.In this review,we focus on the mechanical and structural properties of the healthy and infarcted myocardium in order to gain insight about the environment in which biomaterial-based cardiac therapies are expected to perform and the functional deficiencies caused by MI that the therapy must address.From this understanding,we discuss epicardial therapies for MI inspired by the mechanics and anisotropy of the heart focusing on passive devices,which feature a biomaterials approach,and active devices,which feature robotic and cellular components.Through this review,a detailed analysis is provided in order to inspire further development and translation of epicardial therapies for MI.展开更多
基金We gratefully acknowledge funding from the National Institutes of Health,National Heart,Lung,and Blood Institute grant number R01 HL135091.
文摘The mechanical environment and anisotropic structure of the heart modulate cardiac function at the cellular,tissue and organ levels.During myocardial infarction(MI)and subsequent healing,however,this landscape changes significantly.In order to engineer cardiac biomaterials with the appropriate properties to enhance function after MI,the changes in the myocardium induced by MI must be clearly identified.In this review,we focus on the mechanical and structural properties of the healthy and infarcted myocardium in order to gain insight about the environment in which biomaterial-based cardiac therapies are expected to perform and the functional deficiencies caused by MI that the therapy must address.From this understanding,we discuss epicardial therapies for MI inspired by the mechanics and anisotropy of the heart focusing on passive devices,which feature a biomaterials approach,and active devices,which feature robotic and cellular components.Through this review,a detailed analysis is provided in order to inspire further development and translation of epicardial therapies for MI.
