Objective: This study is to observe the effects of Salvia miltiorrhiza injection on blood pressure and cardiac function in rats with pregnancy-induced hypertension and preeclampsia. Methodology: Syncytiotrophoblast mi...Objective: This study is to observe the effects of Salvia miltiorrhiza injection on blood pressure and cardiac function in rats with pregnancy-induced hypertension and preeclampsia. Methodology: Syncytiotrophoblast microvilli (stbm) and l-arginine nitrosyl methyl ester were screened out via caudal vein injection. Twenty gestational hypertension-preeclampsia model SD (Sprague Dawley) rats successfully induced by L-NAME (L-arginine Nitrosyl methyl ester) were randomly divided into 2 groups (model group and Danshen injection group, n = 10). Then another 10 normal pregnant SD rats without model were selected as blank control group. The Salvia miltiorrhiza injection group was given Salvia miltiorrhiza injection (0.5 g?kg?1?d?1) through tail vein, and the control group and model group were given equal volume of normal saline through tail vein injection. All three groups were treated by tail vein injection once a day (d) for 7 days. After treatment, heart rate (HR), Systolic pressure (SP), diastolic pressure (DP) and mean arterial pressure (MAP) were measured by tail artery. Left ventricular end-diastolic diameter (LVDd) and Left ventricular end systolic diameter (LVDs) were recorded by echocardiography. Left ventricular end diastolic pressure (LVEDP), left ventricular systolic pressure (LVSP), left ventricular ejection fraction (left ventricular ejection) fraction, LVEF) and the maximum rate of increase/decrease of left ventricular pressure during isovolemic systole (+dp/dtmax/?dp/dtmax);Endothelin-1 (ET-1) levels in rat tail vein blood were detected by ELISA. Results: SP, DP, MP, HR, LVSP, LVDs and ?dp/dtmaxx were all decreased, plasma ET-1 expression was low, and LVDd, LVEDP, LVEF, and +dp/dtmax were all increased in the Salvia miltiorroot injection group, with statistical significance compared to the model group (p Conclusion: Salvia miltiorrhiza injection can improve the cardiac function and reduce blood pressure in rats with pregnancy-induced hypertension and preeclampsia, and the mechanism may be related to alleviating systemic arteriolar spasm by regulating ET-1 level.展开更多
Objective To determine whether reduction in central pressure augmentation and central systolic blood pressure by nitroglycerine (NTG) results from effects on pre-load or is due to arterial dilation. Methods We compare...Objective To determine whether reduction in central pressure augmentation and central systolic blood pressure by nitroglycerine (NTG) results from effects on pre-load or is due to arterial dilation. Methods We compared effects of NTG with those of lower body negative pressure (LBNP). Hemodynamic measurements were made at rest,during LBNP (10,20 and 30 mmHg,each for 15 min) and after NTG (10,30 and 100 μg/min,each dose for 15 min) in ten healthy volunteers. Cardiac pre-load,stroke volume and cardiac output were assessed by echocardiography. Central pressure augmentation and central systolic pressure were obtained by radial tonometry using a transfer function. Results LBNP (20 mmHg) and NTG (30 μg/min) reduced pre-load (as measured by the peak velocity of the S wave in the superior vena cava) to a similar degree [by (26.8±3.8)% and (23.9±3.4)%,respectively]. Compared to LBNP,NTG reduced systemic vascular resistance [by (32.9±7.5)%,P<0.01],decreased peripheral and central pressure augmentation [by (20.8±3.4)% units and (12.9±2.9)% units,respectively,each P<0.01]. Conclusion These results suggest that a reduction in pre-load does not explain reduction in pressure augmentation and central systolic blood pressure by NTG and that these effects are mediated through arterial dilation.展开更多
为研究北京市科技工作者精神压力与心脏损伤的关系,以155名北京市科技工作者为研究对象,测量相关指标。结果表明,样本群体中心血管疾病占比20.6%,抑郁占比35.9%,焦虑占比24.8%,失眠占比38.8%。在应对精神压力应激时,科技工作者血压、心...为研究北京市科技工作者精神压力与心脏损伤的关系,以155名北京市科技工作者为研究对象,测量相关指标。结果表明,样本群体中心血管疾病占比20.6%,抑郁占比35.9%,焦虑占比24.8%,失眠占比38.8%。在应对精神压力应激时,科技工作者血压、心率均较静息时明显升高,心率变异性指标中SDNN(Standard deviation of NN intervals,RR间期标准差)下降、LF/HF(low frequency/high frequency,低高频比值)升高,反映样本群体在精神压力应激时心脏交感副交感神经失衡。通过远程心电监测,发现科技工作者在居家时存在异常心电活动,包括各类心律失常、心电图ST-T改变(ST为心室肌除极过程,T为心室肌复极过程)等。基于以上结果,建议定期给科技工作者提供心脏心理的检测,必要时提供远程的心电监测,及时发现科技工作者的心脏心理问题,对有必要进行干预的人员,及早提供干预措施,以保障科技工作者的心脏心理健康。展开更多
目的探讨慢性心功能不全患者外周血单个核细胞(peripheral blood mononuclear cells,PBMCs)微小RNA(microRNAs,miRNAs)差异表达与患者脑血管疾病的关系。方法这是一项对2019年1月至2022年4月期间从西安交通大学第一附属医院出院的274例...目的探讨慢性心功能不全患者外周血单个核细胞(peripheral blood mononuclear cells,PBMCs)微小RNA(microRNAs,miRNAs)差异表达与患者脑血管疾病的关系。方法这是一项对2019年1月至2022年4月期间从西安交通大学第一附属医院出院的274例失代偿性心力衰竭患者的观察性研究。对患者进行随访,直到2023年1月,观察患者缺血性脑血管事件情况。miRNA微阵列用于分析基线循环miRNAs水平。通过实时定量聚合酶链反应(quantitative real time polymerase chain reaction,qRT-PCR)验证差异表达的miRNAs。采用受试者工作特征曲线(receiver operating characteristic curve,ROC)分析候选miRNAs对缺血性脑血管事件的预测价值。结果在随访期间[422(184~939)d],有24例患者发生缺血性脑血管事件。与未发生缺血性脑血管事件的患者相比,发生缺血性脑血管事件的患者服用抗凝剂、维生素K拮抗剂的患者比例显著降低,差异有统计学意义(P<0.05)。在两组基线PBMCs样本中分析了2549个miRNA的表达,并鉴定了20个差异表达的miRNAs(定义为FC>1.3和P<0.05)。qRT-PCR验证结果显示,与非缺血性脑血管事件患者相比,发生缺血性脑血管事件患者的PBMCs样本中hsa-miR-1273g-3p、hsa-miR-2861表达水平显著上调,hsa-miR-483-5p表达水平显著下调,差异有统计学意义(P<0.05)。ROC分析表明,hsa-miR-1273g-3p[曲线下面积(area under the curve,AUC)=0.745]预测心力衰竭患者缺血性脑血管事件的灵敏度和特异度分别为81%、56%,hsa-miR-2861(AUC=0.614)的灵敏度和特异度分别为76%、62%,hsa-miR-483-5p(AUC=0.821)的灵敏度和特异度分别为76%、80%。3种候选miRNAs联合的预测价值优于单独一种miRNA,其AUC、灵敏度和特异度分别为0.941、90%、98%。结论PBMCs中hsa-miR-1273g-3p、hsa-miR-2861表达水平上调和hsa-miR-483-5p表达水平下调可能与心力衰竭患者缺血性脑卒中风险增加有关。展开更多
文摘Objective: This study is to observe the effects of Salvia miltiorrhiza injection on blood pressure and cardiac function in rats with pregnancy-induced hypertension and preeclampsia. Methodology: Syncytiotrophoblast microvilli (stbm) and l-arginine nitrosyl methyl ester were screened out via caudal vein injection. Twenty gestational hypertension-preeclampsia model SD (Sprague Dawley) rats successfully induced by L-NAME (L-arginine Nitrosyl methyl ester) were randomly divided into 2 groups (model group and Danshen injection group, n = 10). Then another 10 normal pregnant SD rats without model were selected as blank control group. The Salvia miltiorrhiza injection group was given Salvia miltiorrhiza injection (0.5 g?kg?1?d?1) through tail vein, and the control group and model group were given equal volume of normal saline through tail vein injection. All three groups were treated by tail vein injection once a day (d) for 7 days. After treatment, heart rate (HR), Systolic pressure (SP), diastolic pressure (DP) and mean arterial pressure (MAP) were measured by tail artery. Left ventricular end-diastolic diameter (LVDd) and Left ventricular end systolic diameter (LVDs) were recorded by echocardiography. Left ventricular end diastolic pressure (LVEDP), left ventricular systolic pressure (LVSP), left ventricular ejection fraction (left ventricular ejection) fraction, LVEF) and the maximum rate of increase/decrease of left ventricular pressure during isovolemic systole (+dp/dtmax/?dp/dtmax);Endothelin-1 (ET-1) levels in rat tail vein blood were detected by ELISA. Results: SP, DP, MP, HR, LVSP, LVDs and ?dp/dtmaxx were all decreased, plasma ET-1 expression was low, and LVDd, LVEDP, LVEF, and +dp/dtmax were all increased in the Salvia miltiorroot injection group, with statistical significance compared to the model group (p Conclusion: Salvia miltiorrhiza injection can improve the cardiac function and reduce blood pressure in rats with pregnancy-induced hypertension and preeclampsia, and the mechanism may be related to alleviating systemic arteriolar spasm by regulating ET-1 level.
文摘Objective To determine whether reduction in central pressure augmentation and central systolic blood pressure by nitroglycerine (NTG) results from effects on pre-load or is due to arterial dilation. Methods We compared effects of NTG with those of lower body negative pressure (LBNP). Hemodynamic measurements were made at rest,during LBNP (10,20 and 30 mmHg,each for 15 min) and after NTG (10,30 and 100 μg/min,each dose for 15 min) in ten healthy volunteers. Cardiac pre-load,stroke volume and cardiac output were assessed by echocardiography. Central pressure augmentation and central systolic pressure were obtained by radial tonometry using a transfer function. Results LBNP (20 mmHg) and NTG (30 μg/min) reduced pre-load (as measured by the peak velocity of the S wave in the superior vena cava) to a similar degree [by (26.8±3.8)% and (23.9±3.4)%,respectively]. Compared to LBNP,NTG reduced systemic vascular resistance [by (32.9±7.5)%,P<0.01],decreased peripheral and central pressure augmentation [by (20.8±3.4)% units and (12.9±2.9)% units,respectively,each P<0.01]. Conclusion These results suggest that a reduction in pre-load does not explain reduction in pressure augmentation and central systolic blood pressure by NTG and that these effects are mediated through arterial dilation.
文摘目的 分析利拉鲁肽治疗冠心病合并2型糖尿病患者的临床效果。方法 102例冠心病合并2型糖尿病患者,应用电脑随机选择方式将患者分为对照组和观察组,每组51例。对照组给予二甲双胍治疗,观察组给予二甲双胍结合利拉鲁肽治疗。对比两组心功能指标(左室射血分数、左室舒张末内径、心排血量以及QT离散度)、血糖指标[空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)]、胰岛素抵抗情况[胰岛β细胞功能指数(HOMA-β)、胰岛素抵抗指数(HOMA-IR)]。结果 治疗后,观察组左室射血分数(56.10±9.06)%、左室舒张末内径(45.80±6.64)mm、心排血量(5.60±1.18)L/min、QT离散度(45.03±6.31)ms优于对照组的(50.50±7.90)%、(50.20±7.07)mm、(4.88±1.01)L/min、(53.77±8.50)ms(P<0.05)。治疗后,观察组2 h PG(7.28±1.30)mmol/L、FPG(6.06±0.27)mmol/L、HbA1c(5.88±0.32)%优于对照组的(8.71±1.20)mmol/L、(7.01±0.76)mmol/L、(6.65±0.52)%(P<0.05)。治疗后,观察组HOMA-β、HOMA-IR优于对照组(P<0.05)。结论 结合冠心病合并2型糖尿病患者实际情况应用二甲双胍结合利拉鲁肽治疗,能够有效改善患者的心功能指标、血糖指标及胰岛素抵抗情况,具有优良的应用前景,在今后的工作过程中能够进一步应用。
文摘为研究北京市科技工作者精神压力与心脏损伤的关系,以155名北京市科技工作者为研究对象,测量相关指标。结果表明,样本群体中心血管疾病占比20.6%,抑郁占比35.9%,焦虑占比24.8%,失眠占比38.8%。在应对精神压力应激时,科技工作者血压、心率均较静息时明显升高,心率变异性指标中SDNN(Standard deviation of NN intervals,RR间期标准差)下降、LF/HF(low frequency/high frequency,低高频比值)升高,反映样本群体在精神压力应激时心脏交感副交感神经失衡。通过远程心电监测,发现科技工作者在居家时存在异常心电活动,包括各类心律失常、心电图ST-T改变(ST为心室肌除极过程,T为心室肌复极过程)等。基于以上结果,建议定期给科技工作者提供心脏心理的检测,必要时提供远程的心电监测,及时发现科技工作者的心脏心理问题,对有必要进行干预的人员,及早提供干预措施,以保障科技工作者的心脏心理健康。
文摘目的探讨慢性心功能不全患者外周血单个核细胞(peripheral blood mononuclear cells,PBMCs)微小RNA(microRNAs,miRNAs)差异表达与患者脑血管疾病的关系。方法这是一项对2019年1月至2022年4月期间从西安交通大学第一附属医院出院的274例失代偿性心力衰竭患者的观察性研究。对患者进行随访,直到2023年1月,观察患者缺血性脑血管事件情况。miRNA微阵列用于分析基线循环miRNAs水平。通过实时定量聚合酶链反应(quantitative real time polymerase chain reaction,qRT-PCR)验证差异表达的miRNAs。采用受试者工作特征曲线(receiver operating characteristic curve,ROC)分析候选miRNAs对缺血性脑血管事件的预测价值。结果在随访期间[422(184~939)d],有24例患者发生缺血性脑血管事件。与未发生缺血性脑血管事件的患者相比,发生缺血性脑血管事件的患者服用抗凝剂、维生素K拮抗剂的患者比例显著降低,差异有统计学意义(P<0.05)。在两组基线PBMCs样本中分析了2549个miRNA的表达,并鉴定了20个差异表达的miRNAs(定义为FC>1.3和P<0.05)。qRT-PCR验证结果显示,与非缺血性脑血管事件患者相比,发生缺血性脑血管事件患者的PBMCs样本中hsa-miR-1273g-3p、hsa-miR-2861表达水平显著上调,hsa-miR-483-5p表达水平显著下调,差异有统计学意义(P<0.05)。ROC分析表明,hsa-miR-1273g-3p[曲线下面积(area under the curve,AUC)=0.745]预测心力衰竭患者缺血性脑血管事件的灵敏度和特异度分别为81%、56%,hsa-miR-2861(AUC=0.614)的灵敏度和特异度分别为76%、62%,hsa-miR-483-5p(AUC=0.821)的灵敏度和特异度分别为76%、80%。3种候选miRNAs联合的预测价值优于单独一种miRNA,其AUC、灵敏度和特异度分别为0.941、90%、98%。结论PBMCs中hsa-miR-1273g-3p、hsa-miR-2861表达水平上调和hsa-miR-483-5p表达水平下调可能与心力衰竭患者缺血性脑卒中风险增加有关。
