A new synthetic method of leonurine was developed. Leonurine 1 was synthesized from the key intermediates 4 and 5, two compounds with high solubility in dichloromethane which allowed the synthetic procedure to be perf...A new synthetic method of leonurine was developed. Leonurine 1 was synthesized from the key intermediates 4 and 5, two compounds with high solubility in dichloromethane which allowed the synthetic procedure to be performed under mild conditions and afforded 1 with a good yield. Comparing the previous methods, the yield was increased from 30% to 54%, time consumed was significantly reduced as well.展开更多
基金National Science Foundation of China (Grant No. 21002013)New Teacher Foundation from Ministry of Education in China (Grant No. 20090071120)+2 种基金Foundation of State Key Laboratory of Natural and Biomimetic Drugs (K20100106)National Basic Research Program of China (973 Program,Grant No. 2010CB912600)STCSM (Grant No. 10431903200)
文摘A new synthetic method of leonurine was developed. Leonurine 1 was synthesized from the key intermediates 4 and 5, two compounds with high solubility in dichloromethane which allowed the synthetic procedure to be performed under mild conditions and afforded 1 with a good yield. Comparing the previous methods, the yield was increased from 30% to 54%, time consumed was significantly reduced as well.
