The effect of ginsenoside Rb 1 on cardiomyocyte apotosis after ischemia (30 min ) and reperfusion (6 h) in rats was observed. The ischemia/ reperfusion heart mo del was established by ligating left anterior descendin...The effect of ginsenoside Rb 1 on cardiomyocyte apotosis after ischemia (30 min ) and reperfusion (6 h) in rats was observed. The ischemia/ reperfusion heart mo del was established by ligating left anterior descending branch of coronary arte ry in Wistar rats. The apoptotic cardiomyocytes were examined under transmission electron microscopy and counted by in situ nick end labeling (TUNEL) method and light microscopy. Results showed that (1) The apoptotic cardiomyocytes were found in ischemic regions in the ischemia/reperfusion group, but not in the sh am oper ating group under transmission electron microscopy; (2) The number of apoptotic cells were 134.45±45.61/field in the ischemia/reperfusion group, 0/field in the sham operating group and 51.65±13.71/field in the ginsenoside Rb 1 treated group. The differences were significant among the three groups ( P <0.01). It was concluded that myocardial ischemia reperfusion could induce cardiomyocyte a poptosis, and ginsenoside Rb 1 could significantly inhibit cardiomyocyte apopto sis induced by ischemia reperfusion in rats, indicating that ginsenoside Rb 1 could inhibit cardiomyocyte apoptosis induced by ischemia reperfusion, thus alleviating ischemia reperfusion injury.展开更多
Previously we have shown that a four-dimensional Kerr-Bolt black hole in non-extremal and also in extremal cases could be described by a holographic two-dimensional （2D） conformal field theory （CFT） [Ghezelbash A ...Previously we have shown that a four-dimensional Kerr-Bolt black hole in non-extremal and also in extremal cases could be described by a holographic two-dimensional （2D） conformal field theory （CFT） [Ghezelbash A M, Kamali V and Setare M R 2010 Phys. Rev. D 82 124051; Setare M R and Kamali V 2010 JHEP 10 074]. Motivated by recent work [Chen C M, Huang Y M, Sun J R, Wu M F and Zou S J 2010 Phys. Rev. D 82 066004], we show that there is another holographic description for these black holes. The first description is called the J-picture, whose construction is based on the black hole angular momentum. The new description is called the Q-picture, whose constructions originate from the nut charge of the black hole. Similar to the previous cases [Ghezelbash A M, Kamali V and Setare M R 2010 Phys. Rev. D 82 124051; Setare M R and Kamali V 2010 JHEP 10 0741, we show that this new picture for a low frequency limit of the wave equation of a massless charged scalar field in the background of a Kerr-Bolt black hole can be written as the Casimir of SL（2, R） symmetry. Our result shows that the entropy of the black hole is reproduced by the Cardy formula. In addition, the absorption cross section is consistent with the finite temperature absorption cross section for a two-dimensional CFT.展开更多
基金a grantfrom the NaturalScience Foundation of Hubei Province (Serial No.2 0 0 0 J0 5 0 )
文摘The effect of ginsenoside Rb 1 on cardiomyocyte apotosis after ischemia (30 min ) and reperfusion (6 h) in rats was observed. The ischemia/ reperfusion heart mo del was established by ligating left anterior descending branch of coronary arte ry in Wistar rats. The apoptotic cardiomyocytes were examined under transmission electron microscopy and counted by in situ nick end labeling (TUNEL) method and light microscopy. Results showed that (1) The apoptotic cardiomyocytes were found in ischemic regions in the ischemia/reperfusion group, but not in the sh am oper ating group under transmission electron microscopy; (2) The number of apoptotic cells were 134.45±45.61/field in the ischemia/reperfusion group, 0/field in the sham operating group and 51.65±13.71/field in the ginsenoside Rb 1 treated group. The differences were significant among the three groups ( P <0.01). It was concluded that myocardial ischemia reperfusion could induce cardiomyocyte a poptosis, and ginsenoside Rb 1 could significantly inhibit cardiomyocyte apopto sis induced by ischemia reperfusion in rats, indicating that ginsenoside Rb 1 could inhibit cardiomyocyte apoptosis induced by ischemia reperfusion, thus alleviating ischemia reperfusion injury.
文摘Previously we have shown that a four-dimensional Kerr-Bolt black hole in non-extremal and also in extremal cases could be described by a holographic two-dimensional （2D） conformal field theory （CFT） [Ghezelbash A M, Kamali V and Setare M R 2010 Phys. Rev. D 82 124051; Setare M R and Kamali V 2010 JHEP 10 074]. Motivated by recent work [Chen C M, Huang Y M, Sun J R, Wu M F and Zou S J 2010 Phys. Rev. D 82 066004], we show that there is another holographic description for these black holes. The first description is called the J-picture, whose construction is based on the black hole angular momentum. The new description is called the Q-picture, whose constructions originate from the nut charge of the black hole. Similar to the previous cases [Ghezelbash A M, Kamali V and Setare M R 2010 Phys. Rev. D 82 124051; Setare M R and Kamali V 2010 JHEP 10 0741, we show that this new picture for a low frequency limit of the wave equation of a massless charged scalar field in the background of a Kerr-Bolt black hole can be written as the Casimir of SL（2, R） symmetry. Our result shows that the entropy of the black hole is reproduced by the Cardy formula. In addition, the absorption cross section is consistent with the finite temperature absorption cross section for a two-dimensional CFT.
