Objective Brachial-ankle pulse wave velocity （baPWV） is widely used as a simple noninvasive measure of arterial softness. The aim of this study was to evaluate the usefulness of baPWV as a predictor of the carotid a...Objective Brachial-ankle pulse wave velocity （baPWV） is widely used as a simple noninvasive measure of arterial softness. The aim of this study was to evaluate the usefulness of baPWV as a predictor of the carotid artery atherosclerosis in the elderly. Methods A total of 721 elderly participants （mean ~ SD age, 70.3 -4- 5.6years） were enrolled in the current study. All participant underwent both baPWV measurement and B-mode ultrasound for the intima-media thickness. Carotid atherosclerosis （CAS） was defined as the present of carotid plaque or and/or intima media thickness for at least 1.1 mm. Results A multivariate logistic regression analysis reveals that age, sex, brachial-ankle pulse wave velocity, smoking and LDL-C level showed a significant correlation with the presence of CAS. The odds ratios of CAS associated with a 500cm/s increase of brachial-ankle pulse wave velocity were 2.378 [95% confidence interval, 1.36 to 4.00, P〈0.05], 3.733 [95% confidence interval, 1.729 to 8.058, P〈0.01], 4.438 [95% confidence interval, 1.659 to 11.803, P〈0.01]. The baPWV significantly correlated with IMT by bivariate correlation analysis （r=-0.39; p=0.001）. After adjusting for factors influencing, baPWV all the same correlated with IMT （r=-0.35; p=0.001）.Conclusion These results indicate that brachial-ankle PWV is an independent predictor of CAS in the elderly.It also means that the direct measurement of arterial stiffness by this simple method may be of great help for the evaluation of carotid artherosclerosis, at least in the elderly展开更多
The incidence of ischemic stroke in patients with diabetes is increasing. While brachial-ankle pulse wave velocity （BaPWV） and ankle-bra- chial index （ABI） are known to be associated with ischemic cardiovascular a...The incidence of ischemic stroke in patients with diabetes is increasing. While brachial-ankle pulse wave velocity （BaPWV） and ankle-bra- chial index （ABI） are known to be associated with ischemic cardiovascular and cerebrovascular diseases, whether these measures predict the risk of ischemic cerebrovascular disease in diabetic patients remains unclear. 117 patients with type 2 diabetes were enrolled in this study. According to the results of head magnetic resonance imaging, the patients were divided into a diabetes-only group （n = 55） and a diabetes and ischemic stroke group （n = 62）. We then performed ABI and BaPWV examinations for all patients. Compared with the diabe- tes-only group, we found decreased ABI and increased BaPWV in the diabetes and ischemic stroke group. Multivariate logistic regression analyses revealed that BaPWV and ABI were risk factors for ischemic stroke in patients with type 2 diabetes. Our findings indicate that decreased ABI and increased BaPWV are objective indicators of increased risk of ischemic stroke in patients with type 2 diabetes.展开更多
Background Increased plasma level of Lp-PLA2 is a potential risk factor for atherosclerosis. Nevertheless, whether Lp-PLA2 has effects on both vascular function and structure changes is still unclear. Method One hundr...Background Increased plasma level of Lp-PLA2 is a potential risk factor for atherosclerosis. Nevertheless, whether Lp-PLA2 has effects on both vascular function and structure changes is still unclear. Method One hundred and eighty-six outpatient subjects without overt cardiovascular disease were enrolled and anthropomet- ric data, plasma level of Lp-PLA2 and other related laboratory parameters were collected. Measurements of pulse wave velocity （PWV） and carotid intima-media thickness （CIMT） were performed by an experienced investigator. According to plasma level of Lp-PLA2, all the subjects were divided into two groups as follows： 〈 200 ng/mL （n = 96） and ≥200 ng/mL （n = 90）. Result Body mass index, smoking, diabetic mellitus, systolic blood pressure, and LDL-C level were positive correlation with plasma level of Lp-PLA2, while use of statins was negatively correlative. Both PWV and CIMT positively correlated with smoking, systolic blood pressure, LDL-C level and plasma level of Lp-PLA2, while negatively correlated with HDL-C level and usage of statins. CIMT in the group with plasma level of Lp-PLA2 〈 200 ng/mL （0.9 ± 0.2 mm, n = 96） was sig- nificantly less than that with plasma level of Lp-PLA2≥200 ng/mL （1.2 ±0.4 mm, n = 90, P = 0.32）, and similar finding was also observed in PWV （9.1± 0.5 m/s vs 12.7 ± 0.4 m/s, P = 0.38）. Conclusion Our present study shows that in subjects without overt CVD, increased plasma level of Lp-PLA2 is associated with vascular function （PWV） and structure （CIMT） deterioration.展开更多
目的通过无创检测动脉弹性指数探讨外周动脉弹性与心室舒张功能变化的相关性。方法回顾性分析2020年6月—2021年6月上海市XX区中心医院就诊的390例疑似冠心病(Coronary heart disease,CHD)并完善冠状动脉造影(Coronary angiography,CAG...目的通过无创检测动脉弹性指数探讨外周动脉弹性与心室舒张功能变化的相关性。方法回顾性分析2020年6月—2021年6月上海市XX区中心医院就诊的390例疑似冠心病(Coronary heart disease,CHD)并完善冠状动脉造影(Coronary angiography,CAG)患者的临床资料,根据冠状动脉病变程度分为对照组(n=73)、冠状动脉粥样硬化组(n=128)和CHD组(n=189)三组。采用相关性分析及多元线性回归分析动脉弹性指数与心功能指标的关系。结果冠状动脉粥样硬化组二尖瓣舒张早期血流峰值与二尖瓣环速度之比(Ratio of peak mitral valve blood flow during early diastolic period to mitral ring velocity,E/e')、颈-股脉搏波传导速度(Carotid-femoral pulse wave conduction velocity,cfPWV)、左心室等容舒张松弛时间常数T均高于对照组,左心室射血分数(Left ventricular ejection fraction,LVEF)低于对照组,差异有统计学意义(P<0.05);CHD组LVEF低于对照组,左心室压力上升最大速度(Maximum velocity of left ventricular rise,LV+dp/dtmax)、左心室压力下降最大速度(Maximum velocity of left ventricular descent,LV-dp/dtmax)均慢于对照组,差异有统计学意义(P<0.05);E/e'、左心房容积指数(Left atrial volume index,LAVI)、左心室质量指数(Left ventricular mass index,LVMI)、E峰减速时间(Deceleration time,DT)、T均高于对照组,cfPWV快于对照组,差异有统计学意义(P均<0.05);CHD组LVEF、左心室舒张末期容积(Left ventricular end-diastolic volume,LVEDV)低于冠状动脉粥样硬化组,LV+dp/dtmax、LV-dp/dtmax均慢于冠状动脉粥样硬化组,E/e'、LAVI、DT、T均高于冠状动脉粥样硬化组,cfPWV快于冠状动脉粥样硬化组,差异有统计学意义(P均<0.05)。调整性别、年龄、吸烟史、高血压病史、糖尿病病史、血脂指标、肌酐、肌钙蛋白I(Cardiac troponin,cTnI)、B型利尿钛(B-type natriuretic peptide,BNP)、体表面积(Body surface area,BSA)评分等相关因子后,Partial分析显示,cfPWV与T(r=0.42,P<0.001)、E/e'(r=0.26,P<0.001)、LAVI(r=0.22,P<0.001)呈正相关,与LV-dp/dtmax(r=-0.12,P=0.02)呈负相关,而与其他指标不相关。线性回归分析,结果显示,E/e'、LAVI、T、LV+dp/dtmax是cfPWV的影响因素。结论cfPWV与CHD患者左心室舒张功能减退显著相关,可作为预测左室舒张功能减退的敏感指标。展开更多
文摘Objective Brachial-ankle pulse wave velocity （baPWV） is widely used as a simple noninvasive measure of arterial softness. The aim of this study was to evaluate the usefulness of baPWV as a predictor of the carotid artery atherosclerosis in the elderly. Methods A total of 721 elderly participants （mean ~ SD age, 70.3 -4- 5.6years） were enrolled in the current study. All participant underwent both baPWV measurement and B-mode ultrasound for the intima-media thickness. Carotid atherosclerosis （CAS） was defined as the present of carotid plaque or and/or intima media thickness for at least 1.1 mm. Results A multivariate logistic regression analysis reveals that age, sex, brachial-ankle pulse wave velocity, smoking and LDL-C level showed a significant correlation with the presence of CAS. The odds ratios of CAS associated with a 500cm/s increase of brachial-ankle pulse wave velocity were 2.378 [95% confidence interval, 1.36 to 4.00, P〈0.05], 3.733 [95% confidence interval, 1.729 to 8.058, P〈0.01], 4.438 [95% confidence interval, 1.659 to 11.803, P〈0.01]. The baPWV significantly correlated with IMT by bivariate correlation analysis （r=-0.39; p=0.001）. After adjusting for factors influencing, baPWV all the same correlated with IMT （r=-0.35; p=0.001）.Conclusion These results indicate that brachial-ankle PWV is an independent predictor of CAS in the elderly.It also means that the direct measurement of arterial stiffness by this simple method may be of great help for the evaluation of carotid artherosclerosis, at least in the elderly
文摘The incidence of ischemic stroke in patients with diabetes is increasing. While brachial-ankle pulse wave velocity （BaPWV） and ankle-bra- chial index （ABI） are known to be associated with ischemic cardiovascular and cerebrovascular diseases, whether these measures predict the risk of ischemic cerebrovascular disease in diabetic patients remains unclear. 117 patients with type 2 diabetes were enrolled in this study. According to the results of head magnetic resonance imaging, the patients were divided into a diabetes-only group （n = 55） and a diabetes and ischemic stroke group （n = 62）. We then performed ABI and BaPWV examinations for all patients. Compared with the diabe- tes-only group, we found decreased ABI and increased BaPWV in the diabetes and ischemic stroke group. Multivariate logistic regression analyses revealed that BaPWV and ABI were risk factors for ischemic stroke in patients with type 2 diabetes. Our findings indicate that decreased ABI and increased BaPWV are objective indicators of increased risk of ischemic stroke in patients with type 2 diabetes.
文摘Background Increased plasma level of Lp-PLA2 is a potential risk factor for atherosclerosis. Nevertheless, whether Lp-PLA2 has effects on both vascular function and structure changes is still unclear. Method One hundred and eighty-six outpatient subjects without overt cardiovascular disease were enrolled and anthropomet- ric data, plasma level of Lp-PLA2 and other related laboratory parameters were collected. Measurements of pulse wave velocity （PWV） and carotid intima-media thickness （CIMT） were performed by an experienced investigator. According to plasma level of Lp-PLA2, all the subjects were divided into two groups as follows： 〈 200 ng/mL （n = 96） and ≥200 ng/mL （n = 90）. Result Body mass index, smoking, diabetic mellitus, systolic blood pressure, and LDL-C level were positive correlation with plasma level of Lp-PLA2, while use of statins was negatively correlative. Both PWV and CIMT positively correlated with smoking, systolic blood pressure, LDL-C level and plasma level of Lp-PLA2, while negatively correlated with HDL-C level and usage of statins. CIMT in the group with plasma level of Lp-PLA2 〈 200 ng/mL （0.9 ± 0.2 mm, n = 96） was sig- nificantly less than that with plasma level of Lp-PLA2≥200 ng/mL （1.2 ±0.4 mm, n = 90, P = 0.32）, and similar finding was also observed in PWV （9.1± 0.5 m/s vs 12.7 ± 0.4 m/s, P = 0.38）. Conclusion Our present study shows that in subjects without overt CVD, increased plasma level of Lp-PLA2 is associated with vascular function （PWV） and structure （CIMT） deterioration.
文摘目的通过无创检测动脉弹性指数探讨外周动脉弹性与心室舒张功能变化的相关性。方法回顾性分析2020年6月—2021年6月上海市XX区中心医院就诊的390例疑似冠心病(Coronary heart disease,CHD)并完善冠状动脉造影(Coronary angiography,CAG)患者的临床资料,根据冠状动脉病变程度分为对照组(n=73)、冠状动脉粥样硬化组(n=128)和CHD组(n=189)三组。采用相关性分析及多元线性回归分析动脉弹性指数与心功能指标的关系。结果冠状动脉粥样硬化组二尖瓣舒张早期血流峰值与二尖瓣环速度之比(Ratio of peak mitral valve blood flow during early diastolic period to mitral ring velocity,E/e')、颈-股脉搏波传导速度(Carotid-femoral pulse wave conduction velocity,cfPWV)、左心室等容舒张松弛时间常数T均高于对照组,左心室射血分数(Left ventricular ejection fraction,LVEF)低于对照组,差异有统计学意义(P<0.05);CHD组LVEF低于对照组,左心室压力上升最大速度(Maximum velocity of left ventricular rise,LV+dp/dtmax)、左心室压力下降最大速度(Maximum velocity of left ventricular descent,LV-dp/dtmax)均慢于对照组,差异有统计学意义(P<0.05);E/e'、左心房容积指数(Left atrial volume index,LAVI)、左心室质量指数(Left ventricular mass index,LVMI)、E峰减速时间(Deceleration time,DT)、T均高于对照组,cfPWV快于对照组,差异有统计学意义(P均<0.05);CHD组LVEF、左心室舒张末期容积(Left ventricular end-diastolic volume,LVEDV)低于冠状动脉粥样硬化组,LV+dp/dtmax、LV-dp/dtmax均慢于冠状动脉粥样硬化组,E/e'、LAVI、DT、T均高于冠状动脉粥样硬化组,cfPWV快于冠状动脉粥样硬化组,差异有统计学意义(P均<0.05)。调整性别、年龄、吸烟史、高血压病史、糖尿病病史、血脂指标、肌酐、肌钙蛋白I(Cardiac troponin,cTnI)、B型利尿钛(B-type natriuretic peptide,BNP)、体表面积(Body surface area,BSA)评分等相关因子后,Partial分析显示,cfPWV与T(r=0.42,P<0.001)、E/e'(r=0.26,P<0.001)、LAVI(r=0.22,P<0.001)呈正相关,与LV-dp/dtmax(r=-0.12,P=0.02)呈负相关,而与其他指标不相关。线性回归分析,结果显示,E/e'、LAVI、T、LV+dp/dtmax是cfPWV的影响因素。结论cfPWV与CHD患者左心室舒张功能减退显著相关,可作为预测左室舒张功能减退的敏感指标。
