目的:探讨随诊间血压变异性对脑卒中复发的影响。方法回顾性分析12所医院进行的西洛他唑和阿司匹林预防脑卒中复发试验中698例患者的每次随诊血压,通过Cox比例风险回归模型,计算随诊间血压变异性对脑卒中复发影响的风险比。结果随诊...目的:探讨随诊间血压变异性对脑卒中复发的影响。方法回顾性分析12所医院进行的西洛他唑和阿司匹林预防脑卒中复发试验中698例患者的每次随诊血压,通过Cox比例风险回归模型,计算随诊间血压变异性对脑卒中复发影响的风险比。结果随诊间收缩压标准差与平均收缩压相关( r=0.282,P=0.000),变异系数与平均收缩压相关( r=0.128,P=0.001);调整平均收缩压后,收缩压标准差 H R:3.641,95% C I:2.368~5.599,收缩压变异系数 H R:3.327,95% C I:2.130~5.195,收缩压独立均值变异(V IM ) H R:3.657,95% C I:2.320~5.763,差异有统计学意义( P=0.000)。平均舒张压 H R:4.149,95% C I:2.381~7.229( P=0.000),舒张压标准差、舒张压变异系数、舒张压V IM差异无统计学意义( P>0.05)。调整平均脉压后,脉压标准差 H R:4.973,95% C I:3.295~7.506,脉压变异系数 HR:6.410,95%:CI:3.898~10.538,差异有统计学意义(P=0.000)。结论随诊间收缩压和脉压变异性均是影响脑卒中复发的因素;但随诊间舒张压变异性不是影响脑卒中复发的因素。展开更多
糖尿病血管病变是糖尿病致残、致死的主要原因,然而目前多种治疗策略对糖尿病血管病变的防治仍未取得理想的结果。哺乳动物雷帕霉素靶蛋白(mechanistic target of rapamycin kinase,mTOR)是一种存在于真核生物中的丝氨酸/苏氨酸蛋白激酶...糖尿病血管病变是糖尿病致残、致死的主要原因,然而目前多种治疗策略对糖尿病血管病变的防治仍未取得理想的结果。哺乳动物雷帕霉素靶蛋白(mechanistic target of rapamycin kinase,mTOR)是一种存在于真核生物中的丝氨酸/苏氨酸蛋白激酶,在多种生物过程中发挥着重要作用。研究发现mTOR可通过调节细胞增殖、调亡、自噬、氧化应激及炎性反应等路径参与糖尿病血管病变的发生发展。文章就mTOR对糖尿病相关动脉粥样硬化、糖尿病肾病及糖尿病视网膜病变中的影响及相关机制进行综述,为糖尿病血管病变的防治提供新策略。展开更多
Background Circulating trimethylamine N-Oxide (TMAO) level has been linked to adverse cardiovascular outcome and mortality in the general population, and atherosclerosis is a window of the cardiovascular disease. Th...Background Circulating trimethylamine N-Oxide (TMAO) level has been linked to adverse cardiovascular outcome and mortality in the general population, and atherosclerosis is a window of the cardiovascular disease. Therefore, the present study was designed to investigate the relationship between TMAO level and atherosclerosis in untreated essential hypertension patients. Methods We measured serum TMAO level in atherosclerosis, subclinical atherosclerosis and controls matched by age and sex. The link between serum TMAO level and CIMT was subsequently assessed. Results The level of serum TMAO was significantly higher in atherosclerosis pa- tients than in controls. Serum TMAO level was positively correlated with carotid intima media thickness (r = 0.783, P 〈 0.001), and logistic regression indicated that TMAO was a risk factor of atherosclerosis (OR, 1.904; 95% CI, 1.197- 2.733, P 〈 0.001). Conclusions Serum TMAO concentration positively correlates to carotid intima media thickness, and should be a good predicted biomarker for atherosclerosis.展开更多
文摘目的:探讨随诊间血压变异性对脑卒中复发的影响。方法回顾性分析12所医院进行的西洛他唑和阿司匹林预防脑卒中复发试验中698例患者的每次随诊血压,通过Cox比例风险回归模型,计算随诊间血压变异性对脑卒中复发影响的风险比。结果随诊间收缩压标准差与平均收缩压相关( r=0.282,P=0.000),变异系数与平均收缩压相关( r=0.128,P=0.001);调整平均收缩压后,收缩压标准差 H R:3.641,95% C I:2.368~5.599,收缩压变异系数 H R:3.327,95% C I:2.130~5.195,收缩压独立均值变异(V IM ) H R:3.657,95% C I:2.320~5.763,差异有统计学意义( P=0.000)。平均舒张压 H R:4.149,95% C I:2.381~7.229( P=0.000),舒张压标准差、舒张压变异系数、舒张压V IM差异无统计学意义( P>0.05)。调整平均脉压后,脉压标准差 H R:4.973,95% C I:3.295~7.506,脉压变异系数 HR:6.410,95%:CI:3.898~10.538,差异有统计学意义(P=0.000)。结论随诊间收缩压和脉压变异性均是影响脑卒中复发的因素;但随诊间舒张压变异性不是影响脑卒中复发的因素。
文摘糖尿病血管病变是糖尿病致残、致死的主要原因,然而目前多种治疗策略对糖尿病血管病变的防治仍未取得理想的结果。哺乳动物雷帕霉素靶蛋白(mechanistic target of rapamycin kinase,mTOR)是一种存在于真核生物中的丝氨酸/苏氨酸蛋白激酶,在多种生物过程中发挥着重要作用。研究发现mTOR可通过调节细胞增殖、调亡、自噬、氧化应激及炎性反应等路径参与糖尿病血管病变的发生发展。文章就mTOR对糖尿病相关动脉粥样硬化、糖尿病肾病及糖尿病视网膜病变中的影响及相关机制进行综述,为糖尿病血管病变的防治提供新策略。
基金supported by the grants from Guangdong Natural Science Foundation(No.2015A030313660)Technology Project Foundation of Guangzhou(No.2014y2-00140/No.1563000381/No.201604020018,/No.201604020186)+1 种基金Technology Project Foundation of Guangdong Province(No.2014B020212008)National Natural Science Foundation of China(No.81300230)
文摘Background Circulating trimethylamine N-Oxide (TMAO) level has been linked to adverse cardiovascular outcome and mortality in the general population, and atherosclerosis is a window of the cardiovascular disease. Therefore, the present study was designed to investigate the relationship between TMAO level and atherosclerosis in untreated essential hypertension patients. Methods We measured serum TMAO level in atherosclerosis, subclinical atherosclerosis and controls matched by age and sex. The link between serum TMAO level and CIMT was subsequently assessed. Results The level of serum TMAO was significantly higher in atherosclerosis pa- tients than in controls. Serum TMAO level was positively correlated with carotid intima media thickness (r = 0.783, P 〈 0.001), and logistic regression indicated that TMAO was a risk factor of atherosclerosis (OR, 1.904; 95% CI, 1.197- 2.733, P 〈 0.001). Conclusions Serum TMAO concentration positively correlates to carotid intima media thickness, and should be a good predicted biomarker for atherosclerosis.