BACKGROUND Unstable carotid atherosclerotic plaques are prone to cause ischemic stroke.Contrast-enhanced ultrasound(CEUS) is the primary method of assessing plaque stability, but CEUS cannot be a method for screening ...BACKGROUND Unstable carotid atherosclerotic plaques are prone to cause ischemic stroke.Contrast-enhanced ultrasound(CEUS) is the primary method of assessing plaque stability, but CEUS cannot be a method for screening for unstable plaque. The emergence of superb micro-vascular imaging(SMI) offers the possibility of clinically screening for unstable plaque AIM To investigate the value of SMI in predicting ischemic stroke in patients with carotid atherosclerotic plaques.METHODS Patients with carotid atherosclerotic plaques(luminal stenosis of 50%-70%) were enrolled into the present study. All patients received conservative medication.The patient's clinical baseline data, serological data, CEUS and SMI data were analyzed. All patients underwent a 3-year follow-up. The follow-up endpoint was the occurrence of ischemic stroke and patients were divided into stroke group and non-stroke group according to whether the prognosis occurred or not.Subsequently, the difference in clinical data was compared, the correlation of SMI and CEUS was analyzed, and multiple Cox regression and receiver operating characteristic curve were applied to investigate the value of SMI and CEUS in predicting cerebral arterial thrombosis in three years.RESULTS In this study, 43 patients were enrolled in the stroke group and 82 patients were enrolled in the non-stroke group. Cox regression revealed that SMI level(P =0.013) and enhancement intensity(P = 0.032) were the independent factors influencing ischemic stroke. There was a positive correlation between SMI level and enhancement intensity(r = 0.737, P = 0.000). The area under curve of SMI level predicting ischemic stroke was 0.878. The best diagnostic point was ≥ level Ⅱ, and its sensitivity and specificity was 86.05% and 79.27%. The area under curve of enhancement intensity predicting ischemic stroke was 0.890. The best diagnostic point was 9.92 db, and its sensitivity and specificity was 88.37% and89.02%. As the SMI level gradually increased, the incidence of ischemic stroke increased gradually(X^2 = 108.931, P = 0.000).CONCLUSION SMI can be used as a non-invasive method of screening for unstable plaques and may help prevent ischemic stroke.展开更多
目的探讨与分析颈部血管超声在早期颈内动脉闭塞患者侧支循环判断中的应用效果。方法2018年2月—2022年5月选择在镇巴县人民医院诊治的早期颈内动脉闭塞患者88例作为研究对象,所有患者都给予颈动脉超声检查,记录超声特征。同时所有患者...目的探讨与分析颈部血管超声在早期颈内动脉闭塞患者侧支循环判断中的应用效果。方法2018年2月—2022年5月选择在镇巴县人民医院诊治的早期颈内动脉闭塞患者88例作为研究对象,所有患者都给予颈动脉超声检查,记录超声特征。同时所有患者都给予脑血管数字减影检查,记录侧支循环形成并判断诊断价值。结果在88例患者中,脑血管数字减影判断为侧支循环形成38例(形成组),占43.18%。形成组性别、身体质量指数、收缩压、舒张压病程、性别、空腹血糖等与非形成组对比差异无统计学意义(P>0.05)。形成组颈部血管超声椎动脉与基底动脉血流速度明显高于非形成组(P<0.05)。形成组入院时国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分明显低于非形成组(P<0.05)。在88例患者中,颈部血管超声判断为侧支循环形成36例,Kappa=0.907(P<0.001)。颈部血管超声在早期颈内动脉闭塞患者侧支循环形成诊断的敏感性与特异性为92.11%(35/38)和98.00%(49/50)。结论早期颈内动脉闭塞患者多伴随有侧支循环形成,可改善患者的病情,提高椎动脉与基底动脉血流速度,颈部血管超声在早期颈内动脉闭塞患者侧支循环判断中具有重要价值。展开更多
基金Supported by Shanghai Jiading District Health and Family Planning Commission Health Planning Commission Scientific Research Project,No.KYXM,2015-KY-02
文摘BACKGROUND Unstable carotid atherosclerotic plaques are prone to cause ischemic stroke.Contrast-enhanced ultrasound(CEUS) is the primary method of assessing plaque stability, but CEUS cannot be a method for screening for unstable plaque. The emergence of superb micro-vascular imaging(SMI) offers the possibility of clinically screening for unstable plaque AIM To investigate the value of SMI in predicting ischemic stroke in patients with carotid atherosclerotic plaques.METHODS Patients with carotid atherosclerotic plaques(luminal stenosis of 50%-70%) were enrolled into the present study. All patients received conservative medication.The patient's clinical baseline data, serological data, CEUS and SMI data were analyzed. All patients underwent a 3-year follow-up. The follow-up endpoint was the occurrence of ischemic stroke and patients were divided into stroke group and non-stroke group according to whether the prognosis occurred or not.Subsequently, the difference in clinical data was compared, the correlation of SMI and CEUS was analyzed, and multiple Cox regression and receiver operating characteristic curve were applied to investigate the value of SMI and CEUS in predicting cerebral arterial thrombosis in three years.RESULTS In this study, 43 patients were enrolled in the stroke group and 82 patients were enrolled in the non-stroke group. Cox regression revealed that SMI level(P =0.013) and enhancement intensity(P = 0.032) were the independent factors influencing ischemic stroke. There was a positive correlation between SMI level and enhancement intensity(r = 0.737, P = 0.000). The area under curve of SMI level predicting ischemic stroke was 0.878. The best diagnostic point was ≥ level Ⅱ, and its sensitivity and specificity was 86.05% and 79.27%. The area under curve of enhancement intensity predicting ischemic stroke was 0.890. The best diagnostic point was 9.92 db, and its sensitivity and specificity was 88.37% and89.02%. As the SMI level gradually increased, the incidence of ischemic stroke increased gradually(X^2 = 108.931, P = 0.000).CONCLUSION SMI can be used as a non-invasive method of screening for unstable plaques and may help prevent ischemic stroke.
文摘目的探讨与分析颈部血管超声在早期颈内动脉闭塞患者侧支循环判断中的应用效果。方法2018年2月—2022年5月选择在镇巴县人民医院诊治的早期颈内动脉闭塞患者88例作为研究对象,所有患者都给予颈动脉超声检查,记录超声特征。同时所有患者都给予脑血管数字减影检查,记录侧支循环形成并判断诊断价值。结果在88例患者中,脑血管数字减影判断为侧支循环形成38例(形成组),占43.18%。形成组性别、身体质量指数、收缩压、舒张压病程、性别、空腹血糖等与非形成组对比差异无统计学意义(P>0.05)。形成组颈部血管超声椎动脉与基底动脉血流速度明显高于非形成组(P<0.05)。形成组入院时国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分明显低于非形成组(P<0.05)。在88例患者中,颈部血管超声判断为侧支循环形成36例,Kappa=0.907(P<0.001)。颈部血管超声在早期颈内动脉闭塞患者侧支循环形成诊断的敏感性与特异性为92.11%(35/38)和98.00%(49/50)。结论早期颈内动脉闭塞患者多伴随有侧支循环形成,可改善患者的病情,提高椎动脉与基底动脉血流速度,颈部血管超声在早期颈内动脉闭塞患者侧支循环判断中具有重要价值。
