State Engineering Research Center for Asic Design The National Engineering Research Center for ASIC Design is a national base for ASIC analysis and design.Its current research area includes:IC analysis/design methods,...State Engineering Research Center for Asic Design The National Engineering Research Center for ASIC Design is a national base for ASIC analysis and design.Its current research area includes:IC analysis/design methods,system development and application and commercial IC chip analysis. The center was established on the basis of the Microelectronic Design Center of Institute of Automation of the Chinese Academy of Sciences. As a pool of intelligent and technical resource,many researchers and experts on IC analysis/design and computer software/展开更多
Past 25 y have witnessed an exponential increase in knowledge and understanding of ocular diseases and their respective genetic underpinnings. As a result, scientists have mapped many genes and their variants that can...Past 25 y have witnessed an exponential increase in knowledge and understanding of ocular diseases and their respective genetic underpinnings. As a result, scientists have mapped many genes and their variants that can influence vision and health of our eyes. Based on these findings, it is becoming clear that an early diagnosis employing genetic testing can help evaluate patients＇ conditions for instituting treatment plan（s） and follow-up care to avoid vision complications later. For example, knowing family history becomes crucial for inherited eye diseases as it can benefit members in family who may have similar eye diseases or predispositions. Therefore, gathering information from an elaborate examination along with complete assessment of past medical illness by ophthalmologists followed by consultation with geneticists can help create a roadmap for making diagnosis and treatment precise and beneficial. In this review, we present an update on ocular genomic medicine that we believe has tremendous potential towards unraveling genetic implications in ocular diseases and patients＇ susceptibilities. We also discuss translational aspects of genetic ophthalmology and genome engineering that may help advance molecular diagnostics and therapeutics.展开更多
文摘State Engineering Research Center for Asic Design The National Engineering Research Center for ASIC Design is a national base for ASIC analysis and design.Its current research area includes:IC analysis/design methods,system development and application and commercial IC chip analysis. The center was established on the basis of the Microelectronic Design Center of Institute of Automation of the Chinese Academy of Sciences. As a pool of intelligent and technical resource,many researchers and experts on IC analysis/design and computer software/
基金Supported in part by NIH Heart,Lung,and Blood Institute(No.HLO74815)Institute of Neurological Disorders and Stroke(No.NS-084823)
文摘Past 25 y have witnessed an exponential increase in knowledge and understanding of ocular diseases and their respective genetic underpinnings. As a result, scientists have mapped many genes and their variants that can influence vision and health of our eyes. Based on these findings, it is becoming clear that an early diagnosis employing genetic testing can help evaluate patients＇ conditions for instituting treatment plan（s） and follow-up care to avoid vision complications later. For example, knowing family history becomes crucial for inherited eye diseases as it can benefit members in family who may have similar eye diseases or predispositions. Therefore, gathering information from an elaborate examination along with complete assessment of past medical illness by ophthalmologists followed by consultation with geneticists can help create a roadmap for making diagnosis and treatment precise and beneficial. In this review, we present an update on ocular genomic medicine that we believe has tremendous potential towards unraveling genetic implications in ocular diseases and patients＇ susceptibilities. We also discuss translational aspects of genetic ophthalmology and genome engineering that may help advance molecular diagnostics and therapeutics.
