期刊文献+
共找到3篇文章
< 1 >
每页显示 20 50 100
Interaction between castanospermine an immunosuppressant and cyclosporin A in rat cardiac transplantation 被引量:2
1
作者 Adrian D Hibberd David A Clark +1 位作者 Paul R Trevillian Patrick Mcelduff 《World Journal of Transplantation》 2016年第1期206-214,共9页
AIM: To investigate the interaction between castanospermine and cyclosporin A(Cs A) and to provide an explanation for it.METHODS: The alkaloid castanospermine was prepared from the seeds of Castanospermum austral cons... AIM: To investigate the interaction between castanospermine and cyclosporin A(Cs A) and to provide an explanation for it.METHODS: The alkaloid castanospermine was prepared from the seeds of Castanospermum austral consistently achieving purity. Rat heterotopic cardiac transplantation and mixed lymphocyte reactivity were done using genetically inbred strains of PVG(donor) and DA(recipient). For the mixed lymphocyte reaction stimulator cells were irradiated with 3000 rads using a linear accelerator. Cyclosporin A was administered by gavage and venous blood collected 2 h later(C_2). The blood levels of Cs A(Neoral) were measured by immunoassay which consisted of a homogeneous enzyme assay(EMIT) on Cobas Mira. Statistical analyses of interactions were done by an acceleratedfailure time model with Weibull distribution for allograft survival and logistic regression for the mixed lymphocyte reactivity.RESULTS: Castanospermine prolonged transplant survival times as a function of dose even at relatively low doses. Cyclosporin A also prolonged transplant survival times as a function of dose particularly at doses above 2 mg/kg. There were synergistic interactions between castanospermine and Cs A in the prolongation of cardiac allograft survival for dose ranges of Cs A by castanospermine of(0 to 2) mg/kg by(0 to 200) mg/kg(HR = 0.986; 95%CI: 0.981-0.992; P < 0.001) and(0 to 3) mg/kg by(0 to 100) mg/kg(HR = 0.986; 95%CI: 0.981-0.992; P < 0.001) respectively. The addition of castanospermine did not significantly increase the levels of cyclosporin A on day 3 or day 6 for all doses of Cs A. On the contrary, cessation of castanospermine in the presence of Cs A at 2 mg/kg significantly increased the Cs A level(P = 0.002). Castanospermine inhibited mixed lymphocyte reactivity in a dose dependent manner but without synergistic interaction. CONCLUSION: There is synergistic interaction between castanospermine and Cs A in rat cardiac transplantation. Neither the mixed lymphocyte reaction nor the metabolism of Cs A provides an explanation. 展开更多
关键词 CARDIAC transplantation castanospermine CYCLOSPORIN A Positive INTERACTION Mixed LYMPHOCYTE reaction
下载PDF
1—Deoxy—6—epi—castanospermine的不对称全合成
2
作者 徐一鸣 周维善 《合成化学》 CAS CSCD 1997年第A10期558-558,共1页
关键词 Castanospermin 类似物 抗肿瘤药
下载PDF
Design and concise synthesis of gem-difluoromethylenated analogue of 7-epi-castanospermine 被引量:3
3
作者 Xin-Yi Jiang Xiu-Hua Xu Feng-Ling Qing 《Chinese Chemical Letters》 SCIE CAS CSCD 2014年第8期1115-1120,共6页
A novel gem-difluoromethylenated castanospermine analogue B was designed and synthesized, starting from 3-bromo-3,3-difluoropropene and L-(-)-malic acid. The key steps involve substitution cyclization reaction and R... A novel gem-difluoromethylenated castanospermine analogue B was designed and synthesized, starting from 3-bromo-3,3-difluoropropene and L-(-)-malic acid. The key steps involve substitution cyclization reaction and RCM reaction to construct the aza fused bicyclic framework. 展开更多
关键词 lndolizidine castanospermine gem-Difluoromethylene CYCLIZATION DIHYDROXYLATION
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部