Dear Editor,Iam Dr.Ping-Hong Lai,from the Jiangxi Eye Center,Jiangxi Provincial People＇s Hospital,Nanchang,Jiangxi Province,China.I would like to present the technique of subconjunctival M-shaped limbus incision for ...Dear Editor,Iam Dr.Ping-Hong Lai,from the Jiangxi Eye Center,Jiangxi Provincial People＇s Hospital,Nanchang,Jiangxi Province,China.I would like to present the technique of subconjunctival M-shaped limbus incision for a series of cases with hard cataracts.展开更多
Background Phacoemulsification yields successful outcomes in eyes with standard cataract. Though techniques have been improved, it is still challenging to perform phacoemulsification in cases of hard cataracts for dif...Background Phacoemulsification yields successful outcomes in eyes with standard cataract. Though techniques have been improved, it is still challenging to perform phacoemulsification in cases of hard cataracts for difficulty in nuclear management and much more complications. This study aimed at describing and evaluating the efficacy and safety of a peripheral radial chop technique to remove hard cataracts. Methods In this prospective study conducted between January 2003 and January 2004, 107 consecutive eyes with hard cataract underwent modified phacoemulsification surgery with peripheral radial chop technique by the Bausch ＆ Lomb Millennium phacoemulsifler with preset parameters of power less than 30%; vaccum, 150 mmHg; and bottle height, 85 cm when a DP8145 phaco tip was used, and vaccum, 380 mmHg; bottle height, 95 cm when a DP8245 phaco tip was used. Results The mean ultrasonic power was 14.7% （range 9% to 19%）, ultrasonic time was 1.98 minutes （range 1.55 to 3.18 minutes）. At 1, 7 and 30 days postoperatively, the eyes with uncorrected visual acuity 0.5 or better accounted for 76.42%, 87.16% and 90.67% respectively. At 1 month, the endothelial cell loss rate was 9.74% （range 8% to 17%）. There were 6 cases of posterior capsule rupture in an early period of study. No serious intraoperaUve or postoperative complications were noted. Conclusions The peripheral radial chop technique was effective without serious complications in hands of an experienced surgeon.展开更多
Summary： By using RT PCR and immunohistochemistry, the expressions of transforming growth factor 132 （TGF-β2） mRNA, proliferating cell nuclear antigen （PCNA） and fibronection （FN） protein in lens epithelial ce...Summary： By using RT PCR and immunohistochemistry, the expressions of transforming growth factor 132 （TGF-β2） mRNA, proliferating cell nuclear antigen （PCNA） and fibronection （FN） protein in lens epithelial cells （LECs） of age-related nuclear and cortex cataract were detected and compared. The results of RT-PCR revealed that the expression of TGF-β2 mRNA was higher in cortex cataract than in nuclear cataract. Immunohistochemistry demonstrated that the expression of PCNA protein was lower and the expression of FN protein was higher in cortex cataract than in nuclear cataract. It was suggested that TGF-β2 , PCNA and FN might take important parts in the process of age-related cataract. Cortex cataract was related to the transdifferentiation of LECs, and nuclear cataract to the proliferation of LECs.展开更多
To detect the pathogenesis of age-related cataract, we analyzed the expression of TGF-β2 mRNA, proliferation cell nuclear antigen （PCNA）, Bcl-2/Bax, fibronection （FN）, vimentin protein and the density of lens epi...To detect the pathogenesis of age-related cataract, we analyzed the expression of TGF-β2 mRNA, proliferation cell nuclear antigen （PCNA）, Bcl-2/Bax, fibronection （FN）, vimentin protein and the density of lens epithelial cells（LECs） of nuclear cataract, cortex cataract and normal LECs. Results showed that the expression level of TGF-β2 mRNA, FN and vimentin protein was higher in LECs of cortex cataract than that of nuclear cataract and normal lens. But the level of Bcl-2/Bax and PCNA was on the contrary. The density of LECs was （4250.63±275.05）/mm^2 in cortex cataract. It was （5438. 40±262.30）/mm^2 in nuclear cataract, and （5368.63 ±211.07）/mm^2 in normal LECs resepectively. There was significant difference between cortex and nuclear cataract （p〈0.05）. These suggested that TGF-β2 might take an important part in the process of age-related cataract. Age-related nuclear cataract was related to the proliferation LECs. While cortex cataract was related to the apoptosis and transdifferentiation of LECs.展开更多
BACKGROUND Complicated cataract surgery is challenging,especially in cases of hard nuclear cataract with severe anterior capsule organization.It is important to avoid the risk of surgery and improve the surgical skill...BACKGROUND Complicated cataract surgery is challenging,especially in cases of hard nuclear cataract with severe anterior capsule organization.It is important to avoid the risk of surgery and improve the surgical skills of surgeons.CASE SUMMARY A 60-year-old man presented with severe cataract and visual impairment.The anterior capsule of the lens was irregularly organized and pulled to the surrounding capsule,and white porcelain organized cord and brown-black lens nucleus were clearly visible.In phacoemulsification,maintaining the anterior capsule round and intact plays a key role in a successful surgery.In this case,if the conventional capsule treatment method was used,the anterior capsule would be torn.Therefore,we adopted a segmented anterior capsule treatment method,and a blasting method to release energy when dealing with the lens nucleus,and achieved good surgical results.CONCLUSION Complicated cataract surgery is challenging and requires precise skills.Operation plans should be made reasonably to predict the risk of surgery,and improve the visual quality of the patients.展开更多
The electronegativity and the hardness are two popular and useful theoretical descriptors of chemistry and physics successfully used by both physicists and chemists in correlating chemico-physical properties of atoms,...The electronegativity and the hardness are two popular and useful theoretical descriptors of chemistry and physics successfully used by both physicists and chemists in correlating chemico-physical properties of atoms, molecules and condensed matter physics. We have tried to explore the fundamental nature of the hardness and electronegativity of atoms and have observed that their fundamental nature is basically lying in electrostatics and manifest as the electron attracting power emanating from the nucleus of the atom. We have tried to correlate the periodic nature of variation of the electronegativity and the hardness to the electron attracting power of the nucleus from which they are originated and developed. We have developed the formulae for evaluating both electronegativity and hardness and found that they have the direct correlation with the effective nuclear charge of the atoms and hence their periodicity.展开更多
This study deals with an overview of the biomedical projects performed at iThemba LABS, particularly in relation to the spatial distribution of trace metals in hard human tissues from disadvantaged Sudanese communitie...This study deals with an overview of the biomedical projects performed at iThemba LABS, particularly in relation to the spatial distribution of trace metals in hard human tissues from disadvantaged Sudanese communities, such as kidney stone concretions, teeth and hair, undertaken at the iThemba LABS Nuclear Microprobe (NMP) facility. Relevant information about the ion beam techniques used for material characterization was discussed. The Particle Induced X-ray Emission (PIXE) technique was used to investigate the elemental composition of human hard tissues on a microscopic scale with the elemental mapping;complementary ion beam techniques are used to provide information on the major and minor components. Analysis of teeth sections by μ-PIXE showed that the levels of trace elements were enriched and/or depleted, this may associated with leaching and/or erosive processes. On the other hand the characterization of kidney stone concretions by μ-PIXE showed a marked difference of individuals from different region within Sudan.展开更多
文摘Dear Editor,Iam Dr.Ping-Hong Lai,from the Jiangxi Eye Center,Jiangxi Provincial People＇s Hospital,Nanchang,Jiangxi Province,China.I would like to present the technique of subconjunctival M-shaped limbus incision for a series of cases with hard cataracts.
文摘Background Phacoemulsification yields successful outcomes in eyes with standard cataract. Though techniques have been improved, it is still challenging to perform phacoemulsification in cases of hard cataracts for difficulty in nuclear management and much more complications. This study aimed at describing and evaluating the efficacy and safety of a peripheral radial chop technique to remove hard cataracts. Methods In this prospective study conducted between January 2003 and January 2004, 107 consecutive eyes with hard cataract underwent modified phacoemulsification surgery with peripheral radial chop technique by the Bausch ＆ Lomb Millennium phacoemulsifler with preset parameters of power less than 30%; vaccum, 150 mmHg; and bottle height, 85 cm when a DP8145 phaco tip was used, and vaccum, 380 mmHg; bottle height, 95 cm when a DP8245 phaco tip was used. Results The mean ultrasonic power was 14.7% （range 9% to 19%）, ultrasonic time was 1.98 minutes （range 1.55 to 3.18 minutes）. At 1, 7 and 30 days postoperatively, the eyes with uncorrected visual acuity 0.5 or better accounted for 76.42%, 87.16% and 90.67% respectively. At 1 month, the endothelial cell loss rate was 9.74% （range 8% to 17%）. There were 6 cases of posterior capsule rupture in an early period of study. No serious intraoperaUve or postoperative complications were noted. Conclusions The peripheral radial chop technique was effective without serious complications in hands of an experienced surgeon.
文摘Summary： By using RT PCR and immunohistochemistry, the expressions of transforming growth factor 132 （TGF-β2） mRNA, proliferating cell nuclear antigen （PCNA） and fibronection （FN） protein in lens epithelial cells （LECs） of age-related nuclear and cortex cataract were detected and compared. The results of RT-PCR revealed that the expression of TGF-β2 mRNA was higher in cortex cataract than in nuclear cataract. Immunohistochemistry demonstrated that the expression of PCNA protein was lower and the expression of FN protein was higher in cortex cataract than in nuclear cataract. It was suggested that TGF-β2 , PCNA and FN might take important parts in the process of age-related cataract. Cortex cataract was related to the transdifferentiation of LECs, and nuclear cataract to the proliferation of LECs.
基金Supported bythe Natural Science Foundation of Hubei Province(2000-J059)
文摘To detect the pathogenesis of age-related cataract, we analyzed the expression of TGF-β2 mRNA, proliferation cell nuclear antigen （PCNA）, Bcl-2/Bax, fibronection （FN）, vimentin protein and the density of lens epithelial cells（LECs） of nuclear cataract, cortex cataract and normal LECs. Results showed that the expression level of TGF-β2 mRNA, FN and vimentin protein was higher in LECs of cortex cataract than that of nuclear cataract and normal lens. But the level of Bcl-2/Bax and PCNA was on the contrary. The density of LECs was （4250.63±275.05）/mm^2 in cortex cataract. It was （5438. 40±262.30）/mm^2 in nuclear cataract, and （5368.63 ±211.07）/mm^2 in normal LECs resepectively. There was significant difference between cortex and nuclear cataract （p〈0.05）. These suggested that TGF-β2 might take an important part in the process of age-related cataract. Age-related nuclear cataract was related to the proliferation LECs. While cortex cataract was related to the apoptosis and transdifferentiation of LECs.
文摘BACKGROUND Complicated cataract surgery is challenging,especially in cases of hard nuclear cataract with severe anterior capsule organization.It is important to avoid the risk of surgery and improve the surgical skills of surgeons.CASE SUMMARY A 60-year-old man presented with severe cataract and visual impairment.The anterior capsule of the lens was irregularly organized and pulled to the surrounding capsule,and white porcelain organized cord and brown-black lens nucleus were clearly visible.In phacoemulsification,maintaining the anterior capsule round and intact plays a key role in a successful surgery.In this case,if the conventional capsule treatment method was used,the anterior capsule would be torn.Therefore,we adopted a segmented anterior capsule treatment method,and a blasting method to release energy when dealing with the lens nucleus,and achieved good surgical results.CONCLUSION Complicated cataract surgery is challenging and requires precise skills.Operation plans should be made reasonably to predict the risk of surgery,and improve the visual quality of the patients.
文摘The electronegativity and the hardness are two popular and useful theoretical descriptors of chemistry and physics successfully used by both physicists and chemists in correlating chemico-physical properties of atoms, molecules and condensed matter physics. We have tried to explore the fundamental nature of the hardness and electronegativity of atoms and have observed that their fundamental nature is basically lying in electrostatics and manifest as the electron attracting power emanating from the nucleus of the atom. We have tried to correlate the periodic nature of variation of the electronegativity and the hardness to the electron attracting power of the nucleus from which they are originated and developed. We have developed the formulae for evaluating both electronegativity and hardness and found that they have the direct correlation with the effective nuclear charge of the atoms and hence their periodicity.
文摘This study deals with an overview of the biomedical projects performed at iThemba LABS, particularly in relation to the spatial distribution of trace metals in hard human tissues from disadvantaged Sudanese communities, such as kidney stone concretions, teeth and hair, undertaken at the iThemba LABS Nuclear Microprobe (NMP) facility. Relevant information about the ion beam techniques used for material characterization was discussed. The Particle Induced X-ray Emission (PIXE) technique was used to investigate the elemental composition of human hard tissues on a microscopic scale with the elemental mapping;complementary ion beam techniques are used to provide information on the major and minor components. Analysis of teeth sections by μ-PIXE showed that the levels of trace elements were enriched and/or depleted, this may associated with leaching and/or erosive processes. On the other hand the characterization of kidney stone concretions by μ-PIXE showed a marked difference of individuals from different region within Sudan.
