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Assessing forest cover changes and fragmentation in the Himalayan temperate region: implications for forest conservation and management
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作者 Kaleem Mehmood Shoaib Ahmad Anees +6 位作者 Akhtar Rehman Aqil Tariq Qijing Liu Sultan Muhammad Fazli Rabbi Shao’an Pan Wesam Atef Hatamleh 《Journal of Forestry Research》 SCIE EI CAS CSCD 2024年第4期128-141,共14页
This study comprehensively assessed long-term vegetation changes and forest fragmentation dynamics in the Himalayan temperate region of Pakistan from 1989 to 2019.Four satellite images,including Landsat-5 TM and Lands... This study comprehensively assessed long-term vegetation changes and forest fragmentation dynamics in the Himalayan temperate region of Pakistan from 1989 to 2019.Four satellite images,including Landsat-5 TM and Landsat-8 Operational Land Imager(OLI),were chosen for subsequent assessments in October 1989,2001,2011 and 2019.The classified maps of 1989,2001,2011 and 2019 were created using the maximum likelihood classifier.Post-classification comparison showed an overall accuracy of 82.5%and a Kappa coefficient of 0.79 for the 2019 map.Results revealed a drastic decrease in closed-canopy and open-canopy forests by 117.4 and 271.6 km^(2),respectively,and an increase in agriculture/farm cultivation by 1512.8 km^(2).The two-way ANOVA test showed statistically significant differences in the area of various cover classes.Forest fragmentation was evaluated using the Landscape Fragmentation Tool(LFT v2.0)between 1989 and 2019.The large forest core(>2.00 km^(2))decreased from 149.4 to 296.7 km^(2),and a similar pattern was observed in medium forest core(1.00-2.00 km^(2))forests.On the contrary,the small core(<1.00 km^(2))forest increased from 124.8 to 145.3 km^(2) in 2019.The perforation area increased by 296.9 km^(2),and the edge effect decreased from 458.9 to 431.7 km^(2).The frequency of patches also increased by 119.1 km^(2).The closed and open canopy classes showed a decreasing trend with an annual rate of 0.58%and 1.35%,respectively.The broad implications of these findings can be seen in the studied region as well as other global ecological areas.They serve as an imperative baseline for afforestation and reforestation operations,highlighting the urgent need for efficient management,conservation,and restoration efforts.Based on these findings,sustainable land-use policies may be put into place that support local livelihoods,protect ecosystem services,and conserve biodiversity. 展开更多
关键词 Natural catastrophes Landsat Change detection Forest fragmentation Landscape fragmentation tool(LFT) AFFORESTATION REFORESTATION
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Pricing Catastrophe Options with Credit Risk in a Regime-Switching Model
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作者 XU Yajuan WANG Guojing 《应用概率统计》 CSCD 北大核心 2024年第4期572-587,共16页
In this paper,we consider the price of catastrophe options with credit risk in a regime-switching model.We assume that the macroeconomic states are described by a continuous-time Markov chain with a finite state space... In this paper,we consider the price of catastrophe options with credit risk in a regime-switching model.We assume that the macroeconomic states are described by a continuous-time Markov chain with a finite state space.By using the measure change technique,we derive the price expressions of catastrophe put options.Moreover,we conduct some numerical analysis to demonstrate how the parameters of the model affect the price of the catastrophe put option. 展开更多
关键词 PRICING catastrophe option credit risk REGIME-SWITCHING measure change
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List of 85 typical catastrophic landslides from March 2004 to February 2024
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作者 Rui-chen Chen Yong-shuang Zhang 《China Geology》 CAS CSCD 2024年第2期369-370,共2页
Landslides are one of the most dangerous natural hazards that cause significant property damage and loss of life.Landslides often destroy farmland,villages,houses,factories,schools,roads and other facilities,injuring ... Landslides are one of the most dangerous natural hazards that cause significant property damage and loss of life.Landslides often destroy farmland,villages,houses,factories,schools,roads and other facilities,injuring humans and livestock.Sometimes,entire towns are devastated by landslides.Due to their pervasiveness,varied triggering factors,and sudden occurrence,landslides are currently one of the most challenging natural disasters to prevent and mitigate. 展开更多
关键词 stated FARMLAND CATASTROPHIC
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Optical facet coatings for high-performance LWIR quantum cascade lasers atλ∼8.5μm
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作者 MA Yuan LIN Yu-Zhe +5 位作者 WAN Chen-Yang WANG Zi-Xian ZHOU Xu-Yan ZHANG Jin-Chuan LIU Feng-Qi ZHENG Wan-Hua 《红外与毫米波学报》 SCIE EI CAS CSCD 北大核心 2024年第4期497-502,共6页
We report on the performance improvement of long-wave infrared quantum cascade lasers(LWIR QCLs)by studying and optimizing the anti-reflection(AR)optical facet coating.Compared to the Al2O3 AR coat⁃ing,the Y_(2)O_(3)A... We report on the performance improvement of long-wave infrared quantum cascade lasers(LWIR QCLs)by studying and optimizing the anti-reflection(AR)optical facet coating.Compared to the Al2O3 AR coat⁃ing,the Y_(2)O_(3)AR coating exhibits higher catastrophic optical mirror damage(COMD)level,and the optical facet coatings of both material systems have no beam steering effect.A 3-mm-long,9.5-μm-wide buried-heterostruc⁃ture(BH)LWIR QCL ofλ~8.5μm with Y_(2)O_(3)metallic high-reflection(HR)and AR of~0.2%reflectivity coating demonstrates a maximum pulsed peak power of 2.19 W at 298 K,which is 149%higher than that of the uncoated device.For continuous-wave(CW)operation,by optimizing the reflectivity of the Y_(2)O_(3)AR coating,the maximum output power reaches 0.73 W,which is 91%higher than that of the uncoated device. 展开更多
关键词 quantum cascade lasers long-wave infrared optical facet coatings catastrophic optical mirror damage
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Subarachnoid hemorrhage misdiagnosed as acute coronary syndrome leading to catastrophic neurologic injury: A case report
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作者 Jun-Ming Lin Xiao-Jun Yuan +2 位作者 Guang Li Xin-Rong Gan Wen-Hua Xu 《World Journal of Clinical Cases》 SCIE 2024年第1期148-156,共9页
BACKGROUND Elevated levels of cardiac troponin and abnormal electrocardiogram changes are the primary basis for clinical diagnosis of acute coronary syndrome(ACS).Troponin levels in ACS patients can often be more than... BACKGROUND Elevated levels of cardiac troponin and abnormal electrocardiogram changes are the primary basis for clinical diagnosis of acute coronary syndrome(ACS).Troponin levels in ACS patients can often be more than 50 times the upper reference limit.Some patients with subarachnoid hemorrhage(SAH)also show electrocardiogram abnormalities,myocardial damage,and elevated cardiac biomarkers.Unlike ACS patients,patients with SAH only have a slight increase in troponin,and the use of anticoagulants or antiplatelet drugs is prohibited.Because of the opposite treatment modalities,it is essential for clinicians to distinguish between SAH and ACS.CASE SUMMARY A 56-year-old female patient was admitted to the emergency department at night with a sudden onset of severe back pain.The final diagnosis was intraspinal hematoma in the thoracic spine.We performed an emergency thoracic spinal canal hematoma evacuation procedure with the assistance of a microscope.Intraoperatively,diffuse hematoma formation was found in the T7-T10 spinal canal,and no obvious spinal vascular malformation changes were observed.Postoperative head and spinal magnetic resonance imaging(MRI)showed a small amount of SAH in the skull,no obvious abnormalities in the cervical and thoracic spinal canals,and no abnormal signals in the lumbar spinal canal.Thoracoab-dominal aorta computed tomography angiography showed no vascular malfor-mation.Postoperative motor system examination showed Medical Research Council Scale grade 1/5 strength in both lower extremities,and the patient experienced decreased sensation below the T12 rib margin and reported a Visual Analog Scale score of 3.CONCLUSION Extremely elevated troponin levels(more than 50 times the normal range)are not unique to coronary artery disease.SAH can also result in extremely high troponin levels,and antiplatelet drugs are contraindicated in such cases.Emergency MRI can help in the early differential diagnosis,as a misdiagnosis of ACS can lead to catastrophic neurological damage in patients with spontaneous spinal SAH. 展开更多
关键词 Acute coronary syndrome Spontaneous spinal subdural hematoma MISDIAGNOSIS Catastrophic neurological injury Case report
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This pain drives me crazy:Psychiatric symptoms in women with interstitial cystitis/bladder pain syndrome
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作者 Marianna Mazza Stella Margoni +62 位作者 Giuseppe Mandracchia Guglielmo Donofrio Alessia Fischetti Georgios D Kotzalidis Giuseppe Marano Alessio Simonetti Delfina Janiri Lorenzo Moccia Ilaria Marcelli Greta Sfratta Domenico De Berardis Ottavia Ferrara Evelina Bernardi Antonio Restaino Francesco Maria Lisci Antonio Maria D'Onofrio Caterina Brisi Flavia Grisoni Claudia Calderoni Michele Ciliberto Andrea Brugnami Sara Rossi Maria Chiara Spera Valeria De Masi Ester Maria Marzo Francesca Abate Gianluca Boggio Maria Benedetta Anesini Cecilia Falsini Anna Quintano Alberto Torresi Miriam Militenda Giovanni Bartolucci Marco Biscosi Sara Ruggiero Luca Lo Giudice Giulia Mastroeni Elisabetta Benini Luca Di Benedetto Romina Caso Francesco Pesaresi Francesco Traccis Luca Onori Luca Chisari Leonardo Monacelli Mariateresa Acanfora Eleonora Gaetani Monia Marturano Sara Barbonetti Elettra Specogna Francesca Bardi Emanuela De Chiara Gianmarco Stella Andrea Zanzarri Flavio Tavoletta Arianna Crupi Giulia Battisti Laura Monti Giovanni Camardese Daniela Chieffo Antonio Gasbarrini Giovanni Scambia Gabriele Sani 《World Journal of Psychiatry》 SCIE 2024年第6期954-984,共31页
BACKGROUND Interstitial cystitis/bladder pain syndrome(IC/BPS)is an at least 6-mo noninfectious bladder inflammation of unknown origin characterized by chronic suprapubic,abdominal,and/or pelvic pain.Although the term... BACKGROUND Interstitial cystitis/bladder pain syndrome(IC/BPS)is an at least 6-mo noninfectious bladder inflammation of unknown origin characterized by chronic suprapubic,abdominal,and/or pelvic pain.Although the term cystitis suggests an inflammatory or infectious origin,no definite cause has been identified.It occurs in both sexes,but women are twice as much affected.AIM To systematically review evidence of psychiatric/psychological changes in persons with IC/BPS.METHODS Hypothesizing that particular psychological characteristics could underpin IC/BPS,we investigated in three databases the presence of psychiatric symptoms and/or disorders and/or psychological characteristics in patients with IC/BPS using the following strategy:("interstitial cystitis"OR"bladder pain syndrome")AND("mood disorder"OR depressive OR antidepressant OR depression OR depressed OR hyperthymic OR mania OR manic OR rapid cyclasterisk OR dysthymiasterisk OR dysphoriasterisk).RESULTS On September 27,2023,the PubMed search produced 223 articles,CINAHL 62,and the combined PsycLIT/PsycARTICLES/PsycINFO/Psychology and Behavioral Sciences Collection search 36.Search on ClinicalTrials.gov produced 14 studies,of which none had available data.Eligible were peer-reviewed articles reporting psychiatric/psychological symptoms in patients with IC/BPS,i.e.63 articles spanning from 2000 to October 2023.These studies identified depression and anxiety problems in the IC/BPS population,along with sleep problems and the tendency to catastrophizing.CONCLUSION Psychotherapies targeting catastrophizing and life stress emotional awareness and expression reduced perceived pain in women with IC/BPS.Such concepts should be considered when implementing treatments aimed at reducing IC/BPS-related pain. 展开更多
关键词 Interstitial cystitis/bladder pain syndrome Psychiatric symptoms Psychological symptoms Catastrophizing ANXIETY DEPRESSION
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Deep learning algorithm featuring continuous learning for modulation classifications in wireless networks
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作者 WU Nan SUN Yu WANG Xudong 《太赫兹科学与电子信息学报》 2024年第2期209-218,共10页
Although modulation classification based on deep neural network can achieve high Modulation Classification(MC)accuracies,catastrophic forgetting will occur when the neural network model continues to learn new tasks.In... Although modulation classification based on deep neural network can achieve high Modulation Classification(MC)accuracies,catastrophic forgetting will occur when the neural network model continues to learn new tasks.In this paper,we simulate the dynamic wireless communication environment and focus on breaking the learning paradigm of isolated automatic MC.We innovate a research algorithm for continuous automatic MC.Firstly,a memory for storing representative old task modulation signals is built,which is employed to limit the gradient update direction of new tasks in the continuous learning stage to ensure that the loss of old tasks is also in a downward trend.Secondly,in order to better simulate the dynamic wireless communication environment,we employ the mini-batch gradient algorithm which is more suitable for continuous learning.Finally,the signal in the memory can be replayed to further strengthen the characteristics of the old task signal in the model.Simulation results verify the effectiveness of the method. 展开更多
关键词 Deep Learning(DL) modulation classification continuous learning catastrophic forgetting cognitive radio communications
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Climate change and the emergence and exacerbation of infectious diseases:A review
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作者 Amal Ali Asim Shaikh +1 位作者 Imran Sethi Salim Surani 《World Journal of Virology》 2024年第4期24-30,共7页
Experts expressed severe concerns over the possibility of increasing burden of infectious diseases as the planet’s climate began to change years ago.There have been increased rates of climate-related catastrophes and... Experts expressed severe concerns over the possibility of increasing burden of infectious diseases as the planet’s climate began to change years ago.There have been increased rates of climate-related catastrophes and as global temperatures rise,emergence of certain viruses has become a serious concern.Vectors are susceptible to changing temperatures as they exhibit innate responses to thermal stress to increase survivability.Climate change impacts virus reservoirs,increasing transmission rates of vectors.Vector-borne diseases have already witnessed increasing numbers compared to before.Certain non-endemic areas are encountering their first-ever infectious disease cases due to increasing temperatures.Tick-borne diseases are undergoing transformations provoking a heightened prevalence.Food-borne illnesses are expected to increase owing to warmer temperatures.It is important to recognize that climate change has a multivariable impact on the transmission of viruses.With climate change comes the potential of increasing interspecies interactions promoting jumps.These factors must be considered,and an informed strategy must be formulated.Adaptation and mitigation strategies are required to curb these diseases from spreading.Despite significant evidence that climate change affects infectious diseases,gaps in research exist.We conducted this review to identify the potential role climate change plays in the emergence of new viruses. 展开更多
关键词 Climate change Infectious disease EMERGENCE CATASTROPHE Vector-borne disease
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Assessment of the Indirect Cost of Drug Resistant Tuberculosis Treatment to Patients in a High Burden, Low Income Setting in Mozambique
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作者 Júlia Malache António Domingas Pacala +6 位作者 Isabelle Munyangaju Isaías Benzana Claudia Mutaquiha Dulce Osório Benedita José Edy Nacarapa Pereira Zindoga 《Journal of Tuberculosis Research》 2024年第2期91-104,共14页
Introduction: Tuberculosis is closely linked to poverty, with patients facing significant indirect treatment costs. Treating drug-resistant tuberculosis further increases these expenses. Notably, there is a lack of pu... Introduction: Tuberculosis is closely linked to poverty, with patients facing significant indirect treatment costs. Treating drug-resistant tuberculosis further increases these expenses. Notably, there is a lack of published data on the indirect costs incurred by patients with drug-resistant tuberculosis in Mozambique. Objective: To assess the indirect costs, income reduction, and work productivity incurred by patients undergoing diagnosis and treatment for Drug-Resistant Tuberculosis (DRTB) in Mozambique during their TB treatment. Methods: As part of a comprehensive mixed-methods study conducted from January 2021 to April 2023, this research utilized a descriptive cross-sectional approach, incorporating both quantitative and qualitative methods. The primary goal was to evaluate the costs incurred by the national health system due to drug-resistant TB. Additionally, to explore the indirect costs experienced by patients and their families during treatment, semi-structured interviews were conducted with 27 individuals who had been undergoing treatment for over six months. Results: All survey participants unanimously reported a significant decline in labour productivity, with 70.3% experiencing a reduction in their monthly income. Before falling ill, the majority of respondents (33.3%) earned up to $76.92 monthly, representing the minimum earnings range, while 29.2% had a monthly income above $230.77, the maximum earnings range. Among those who experienced income loss, the majority (22.2%) reported a decrease of up to $76.92 per month, and 18.5% cited a loss exceeding $230.77 per month. Notably, patients with Drug-Resistant Tuberculosis (DRTB) have not incurred the direct costs of the disease, as these are covered by the government. Conclusion: The financial burden of treating Drug-Resistant Tuberculosis (DRTB), along with the income reduction it causes, is substantial. Implementing a patient-centred, multidisciplinary, and multisector approach, coupled with strong psychosocial support, can significantly reduce the catastrophic costs DRTB patients incur. 展开更多
关键词 Economic Costs Drug Resistance TUBERCULOSIS Catastrophic Costs
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Hyper Catastrophe on 4-Dimensional Canards
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作者 Kiyoyuki Tchizawa Shuya Kanagawa 《Advances in Pure Mathematics》 2024年第4期196-203,共8页
When discovering the potential of canards flying in 4-dimensional slow-fast system with a bifurcation parameter, the key notion “symmetry” plays an important role. It is of one parameter on slow vector field. Then, ... When discovering the potential of canards flying in 4-dimensional slow-fast system with a bifurcation parameter, the key notion “symmetry” plays an important role. It is of one parameter on slow vector field. Then, it should be determined to introduce parameters to all slow/fast vectors. It is, however, there might be no way to explore for another potential in this system, because the geometrical structure is quite different from the system with one parameter. Even in this system, the “symmetry” is also useful to obtain the potentials classified by R. Thom. In this paper, via the coordinates changing, the possible way to explore for the potential will be shown. As it is analyzed on “hyper finite time line”, or done by using “non-standard analysis”, it is called “Hyper Catastrophe”. In the slow-fast system which includes a very small parameter , it is difficult to do precise analysis. Thus, it is useful to get the orbits as a singular limit. When trying to do simulations, it is also faced with difficulty due to singularity. Using very small time intervals corresponding small , we shall overcome the difficulty, because the difference equation on the small time interval adopts the standard differential equation. These small intervals are defined on hyper finite number N, which is nonstandard. As and the intervals are linked to use 1/N, the simulation should be done exactly. 展开更多
关键词 Canards Flying 4-Dimensional Slow-Fast System Hyper Catastrophe
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Research progress of pain catastrophizing in patients with lumbar disc herniation
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作者 Ting Xiong Long-Fan Piao 《Frontiers of Nursing》 2024年第3期253-258,共6页
Pain catastrophization is one of the negative emotional factors and an important psychological factor associated with patients with lumbar disc herniation(LDH).Currently,the concept of pain catastrophization of LDH is... Pain catastrophization is one of the negative emotional factors and an important psychological factor associated with patients with lumbar disc herniation(LDH).Currently,the concept of pain catastrophization of LDH is relatively mature abroad;however,there are only few research studies on this in China.To understand the status quo of pain catastrophization(PC)in patients with LDH and its influencing factors,the intervention measures of PC and their efficacy were further analyzed.In the present paper,the research status of PC at home and abroad is briefly expounded,and the influencing factors and clinical intervention measures for PC are analyzed.This paper reviews the concept of PC,the assessment tools,influencing factors,and the relevant intervention measures.In order to evaluate the pain degree of patients,understand the incidence of pain in patients,and improve the cure rate and quality of life of patients,the basic situation of patients with pain disaster is summarized to provide reference for medical personnel. 展开更多
关键词 lumbar disc herniation MEASURE NURSING PAIN pain catastrophizing pain factor
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Physical Analysis of Atmospheric Phenomena Associated with Climatic Storms: Approach Study Related to Climate Change on Earth
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作者 Wend Dolean Arsène Ilboudo 《Atmospheric and Climate Sciences》 2024年第4期355-367,共13页
Atmospheric phenomena are physical phenomena resulting from the correlation of atmospheric parameters of natural origin. They are associated with climatic storms and include lightning, thunder, global warming, wind, e... Atmospheric phenomena are physical phenomena resulting from the correlation of atmospheric parameters of natural origin. They are associated with climatic storms and include lightning, thunder, global warming, wind, evaporation, rain, clouds, and snow. The formation and evolution of these phenomena remain complex according to their natural reference parameters. The numerical models defined in this study are equations based on models of atmospheric parameters. Applied in the atmosphere, they yield the equation of the key atmospheric phenomena. The distribution of these phenomena across the entire planet is the origin of the formation of climatic regions. Indeed, the constants obtained are 275.16 km/s for the speed of lightning, 3.99 GJ for the discharge energy of a thunderbolt, 276.15˚K for the temperature of global warming, 3.993 Km/h for the formation speed of winds and cyclones, 2.9963 Km/h for the speed of evaporation, 278.16˚K for the formation of rain, 274.1596˚K for the formation of clouds, and 274.1632˚K for snow formation. Moreover, this research conducts an analytical study approach to the phenomenon of climate change in the current era of industrialization, specifically analyzing the direct effects of global warming on atmospheric phenomena. Thus, with a temperature of 53.45˚C, global warming is considered maximal and will lead to very abundant rain and snow precipitations with maximum PW at 12.5 and 11.1 g/cm2 of water, surface water evaporation fluxes significantly above normal at a speed of 6.55 Km/h, increasingly violent winds at speeds far exceeding 5.43 Km/h, and catastrophic climatic effects. In summary, the aim of this research is to define the main natural phenomena associated with global climatic storms and to study the real impact of climate change on Earth. 展开更多
关键词 Atmospheric Phenomenon Climate Change Climatic Catastrophe
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上海市耐多药结核病患者经济负担研究 被引量:2
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作者 刘方珉 吴春峰 +5 位作者 吴国柱 沈鑫 吴哲渊 陈静 宁晨曦 陈勇 《中国卫生资源》 CSCD 北大核心 2023年第1期42-49,共8页
目的基于上海市近年结核病诊疗费用减免政策,探索耐多药结核病(multidrug resistant tuberculosis,MDR-TB)患者疾病经济负担及其影响因素,为优化MDR-TB诊疗费用减免政策和综合管理模式提供依据。方法收集上海市2017—2019年确诊MDR-TB... 目的基于上海市近年结核病诊疗费用减免政策,探索耐多药结核病(multidrug resistant tuberculosis,MDR-TB)患者疾病经济负担及其影响因素,为优化MDR-TB诊疗费用减免政策和综合管理模式提供依据。方法收集上海市2017—2019年确诊MDR-TB患者情况和诊疗费用减免情况数据,开展针对疾病经济负担的问卷调查,建立涵盖患者人口和社会经济情况、临床特征、疾病经济负担和诊疗费用减免情况数据库,明确患者疾病经济负担和灾难性卫生支出(catastrophic health expenditure)发生情况。以多元线性回归法分析可能影响患者疾病经济负担的因素,以多因素logistic回归法分析不同比例下灾难性卫生支出发生的影响因素。结果196例纳入研究分析的MDR-TB患者平均年龄为(44±16)岁,男性139例(占70.9%),上海户籍占46.4%,49%的患者为家庭主要劳动力。治疗期间,患者自付诊疗费用中位数为4.0(四分位数区间2.0~6.5)万元。113例患者获得减免诊疗,减免费用中位数为2.6(四分位数区间1.3~4.9)万元。若自付费用占家庭年收入的40%及以上,有47.8%的患者会发生灾难性支出;若不考虑减免政策,有59.8%的患者发生灾难性卫生支出。上海户籍(OR=0.3,95%CI为0.1~1.0)、更低家庭收入水平(P_(trend)=0.002)、医疗保险类型[(农村合作医疗保险/外来人口综合保险(OR=13.3,95%CI为1.0~171.2),无医疗保险(OR=17.5,95%CI为2.7~113.0)]和既往结核病治疗史(OR=3.3,95%CI为1.1~10.0)可能影响灾难性卫生支出的发生。结论上海市MDR-TB患者的自付诊疗费用较高。医疗保障力度较小和家庭经济情况不佳的患者更易发生高额自付费用,导致灾难性卫生支出。上海市MDR-TB诊疗费用减免政策有效降低了患者的经济负担。 展开更多
关键词 耐多药结核病multidrug resistant tuberculosis MDR-TB 疾病经济负担disease financial burden 灾难性卫生支出catastrophic health expenditure 费用减免政策expense subsidy policy 社会保障social protection
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Estimation of economic burden throughout course of cervical squamous intraepithelial lesion and cervical cancer in China:A nationwide multicenter cross-sectional study 被引量:3
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作者 Hao Chen Xuelian Zhao +6 位作者 Shangying Hu Tingting You Changfa Xia Meng Gao Mingjie Dong Youlin Qiao Fanghui Zhao 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2023年第6期675-685,共11页
Objective: Cervical squamous intraepithelial lesion(SIL) and cervical cancer are major threats to females' health and life in China, and we aimed to estimate the economic burden associated with their diagnosis and... Objective: Cervical squamous intraepithelial lesion(SIL) and cervical cancer are major threats to females' health and life in China, and we aimed to estimate the economic burden associated with their diagnosis and treatment.Methods: A nationwide multicenter, cross-sectional, hospital-based survey was conducted in 26 qualified hospitals across seven administrative regions of China. We investigated females who had been pathologically diagnosed with SIL and cervical cancer, and included five disease courses(“diagnosis”, “initial treatment”,“chemoradiotherapy”, “follow-up” and “recurrence/progression/metastasis”) to estimate the total costs. The median and interquartile range(IQR) of total costs(including direct medical, direct non-medical, and indirect costs), reimbursement rate by medical insurance, and catastrophic health expenditures in every clinical stage were calculated.Results: A total of 3,471 patients in different clinical stages were analyzed, including low-grade SIL(LSIL)(n=549), high-grade SIL(HSIL)(n=803), cervical cancer stage ⅠA(n=226), ⅠB(n=610), ⅡA(n=487), ⅡB(n=282), Ⅲ(n=452) and Ⅳ(n=62). In urban areas, the estimated total costs of LSIL and HSIL were $1,637.7(IQR:$956.4-$2,669.2) and $2,467.1(IQR:$1,579.1-$3,762.3), while in rural areas the costs were $459.0(IQR:$167.7-$1,330.3) and $1,230.5(IQR:$560.6-$2,104.5), respectively. For patients with cervical cancer stage ⅠA,ⅠB, ⅡA, ⅡB, and Ⅲ-Ⅳ, the total costs were $15,034.9(IQR:$11,083.4-$21,632.4), $19,438.6(IQR:$14,060.0-$26,505.9), $22,968.8(IQR:$16,068.8-$34,615.9), $26,936.0(IQR:$18,176.6-$41,386.0) and $27,332.6(IQR:$17,538.7-$44,897.0), respectively. Medical insurance covered 43%-55% of direct medical costs for cervical cancer patients, while the coverage for SIL patients was 19%-43%. For most cervical cancer patients, the expense was catastrophic, and the extent of catastrophic health expenditure was about twice large for rural patients than that for urban patients in each stage.Conclusions: The economic burden of SIL and cervical cancer in China is substantial, with a significant proportion of the costs being avoidable for patients with LSIL. Even for those with medical insurance, catastrophic health expenditures are also a major concern for patients with cervical cancer, particularly for those living in rural areas. 展开更多
关键词 Squamous intraepithelial lesion cervical cancer economic burden MEDICARE catastrophic health expenditures
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The role of AFAP1-AS1 in mitotic catastrophe and metastasis of triple-negative breast cancer cells by activating the PLK1 signaling pathway 被引量:2
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作者 SHUIZHONG CEN XIAOJIE PENG +9 位作者 JIANWEN DENG HAIYUN JIN ZHINAN DENG XIAOHUA LIN DI ZHU MING JIN YANWEN ZHU PUSHENG ZHANG YUNFENG LUO HONGYAN HUANG 《Oncology Research》 SCIE 2023年第3期375-388,共14页
Triple-negative breast cancer(TNBC)is characterized by fast growth,high metastasis,high invasion,and a lack of therapeutic targets.Mitosis and metastasis of TNBC cells are two important biological behaviors in TNBC ma... Triple-negative breast cancer(TNBC)is characterized by fast growth,high metastasis,high invasion,and a lack of therapeutic targets.Mitosis and metastasis of TNBC cells are two important biological behaviors in TNBC malignant progression.It is well known that the long noncoding RNA AFAP1-AS1 plays a crucial role in various tumors,but whether AFAP1-AS1 is involved in the mitosis of TNBC cells remains unknown.In this study,we investigated the functional mechanism of AFAP1-AS1 in targeting Polo-like Kinase 1(PLK1)activation and participating in mitosis of TNBC cells.We detected the expression of AFAP1-AS1 in the TNBC patient cohort and primary cells by in situ hybridization(ISH),northern blot,fluorescent in situ hybridization(FISH)and cell nucleus/cytoplasm RNA fraction isolation.High AFAP1-AS1 expression was negatively correlated with overall survival(OS),disease-free survival(DFS),metastasis-free survival(MFS)and recurrence-free survival(RFS)in TNBC patients.We explored the function of AFAP1-AS1 by transwell,apoptosis,immunofluorescence(IF)and patient-derived xenograft(PDX)models in vitro and in vivo.We found that AFAP1-AS1 promoted TNBC primary cell survival by inhibiting mitotic catastrophe and increased TNBC primary cell growth,migration and invasion.Mechanistically,AFAP1-AS1 activated phosphorylation of the mitosis-associated kinase PLK1 protein.Elevated levels of AFAP1-AS1 in TNBC primary cells increased PLK1 pathway downstream gene expression,such as CDC25C,CDK1,BUB1 and TTK.More importantly,AFAP1-AS1 increased lung metastases in a mouse metastasis model.Taken together,AFAP1-AS1 functions as an oncogene that activates the PLK1 signaling pathway.AFAP1-AS1 could be used as a potential prognostic marker and therapeutic target for TNBC. 展开更多
关键词 TNBC AFAP1-AS1 Mitotic catastrophe METASTASIS PLK1
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Squeezing More Past Knowledge for Online Class-Incremental Continual Learning 被引量:1
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作者 Da Yu Mingyi Zhang +4 位作者 Mantian Li Fusheng Zha Junge Zhang Lining Sun Kaiqi Huang 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2023年第3期722-736,共15页
Continual learning(CL)studies the problem of learning to accumulate knowledge over time from a stream of data.A crucial challenge is that neural networks suffer from performance degradation on previously seen data,kno... Continual learning(CL)studies the problem of learning to accumulate knowledge over time from a stream of data.A crucial challenge is that neural networks suffer from performance degradation on previously seen data,known as catastrophic forgetting,due to allowing parameter sharing.In this work,we consider a more practical online class-incremental CL setting,where the model learns new samples in an online manner and may continuously experience new classes.Moreover,prior knowledge is unavailable during training and evaluation.Existing works usually explore sample usages from a single dimension,which ignores a lot of valuable supervisory information.To better tackle the setting,we propose a novel replay-based CL method,which leverages multi-level representations produced by the intermediate process of training samples for replay and strengthens supervision to consolidate previous knowledge.Specifically,besides the previous raw samples,we store the corresponding logits and features in the memory.Furthermore,to imitate the prediction of the past model,we construct extra constraints by leveraging multi-level information stored in the memory.With the same number of samples for replay,our method can use more past knowledge to prevent interference.We conduct extensive evaluations on several popular CL datasets,and experiments show that our method consistently outperforms state-of-the-art methods with various sizes of episodic memory.We further provide a detailed analysis of these results and demonstrate that our method is more viable in practical scenarios. 展开更多
关键词 Catastrophic forgetting class-incremental learning continual learning(CL) experience replay
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Fundamental and speculative components of the cryptocurrency pricing dynamics 被引量:1
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作者 Jiri Kukacka Ladislav Kristoufek 《Financial Innovation》 2023年第1期1694-1716,共23页
The driving forces behind cryptoassets’price dynamics are often perceived as being dominated by speculative factors and inherent bubble-bust episodes.Fundamental components are believed to have a weak,if any,role in ... The driving forces behind cryptoassets’price dynamics are often perceived as being dominated by speculative factors and inherent bubble-bust episodes.Fundamental components are believed to have a weak,if any,role in the price-formation process.This study examines five cryptoassets with different backgrounds,namely Bitcoin,Ethereum,Litecoin,XRP,and Dogecoin between 2016 and 2022.It utilizes the cusp catastrophe model to connect the fundamental and speculative drivers with possible price bifurcation characteristics of market collapse events.The findings show that the price and return dynamics of all the studied assets,except for Dogecoin,emerge from complex interactions between fundamental and speculative components,includ-ing episodes of price bifurcations.Bitcoin shows the strongest fundamentals,with on-chain activity and economic factors driving the fundamental part of the dynam-ics.Investor attention and off-chain activity drive the speculative component for all studied assets.Among the fundamental drivers,the analyzed cryptoassets present their coin-specific factors,which can be tracked to their protocol specifics and are economi-cally sound. 展开更多
关键词 Cryptocurrency Bitcoin Cusp catastrophe model CRASH
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Study of quantum well mixing induced by impurity-free vacancy in the primary epitaxial wafers of a 915 nm semiconductor laser
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作者 Tianjiang He Suping Liu +5 位作者 Wei Li Li Zhong Xiaoyu Ma Cong Xiong Nan Lin Zhennuo Wang 《Journal of Semiconductors》 EI CAS CSCD 2023年第10期70-76,共7页
Output power and reliability are the most important characteristic parameters of semiconductor lasers.However,catas-trophic optical damage(COD),which usually occurs on the cavity surface,will seriously damage the furt... Output power and reliability are the most important characteristic parameters of semiconductor lasers.However,catas-trophic optical damage(COD),which usually occurs on the cavity surface,will seriously damage the further improvement of the output power and affect the reliability.To improve the anti-optical disaster ability of the cavity surface,a non-absorption window(NAW)is adopted for the 915 nm InGaAsP/GaAsP single-quantum well semiconductor laser using quantum well mix-ing(QWI)induced by impurity-free vacancy.Both the principle and the process of point defect diffusion are described in detail in this paper.We also studied the effects of annealing temperature,annealing time,and the thickness of SiO_(2) film on the quan-tum well mixing in a semiconductor laser with a primary epitaxial structure,which is distinct from the previous structures.We found that when compared with the complete epitaxial structure,the blue shift of the semiconductor laser with the primary epi-taxial structure is larger under the same conditions.To obtain the appropriate blue shift window,the primary epitaxial struc-ture can use a lower annealing temperature and shorter annealing time.In addition,the process is less expensive.We also pro-vide references for upcoming device fabrication. 展开更多
关键词 catastrophic optical damage primary epitaxial structure impurity-free vacancy disordering quantum well intermixing non-absorption window
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Time to treat the climate and nature crisis as one in divisible global health emergency
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作者 Chris Zielinski 《General Psychiatry》 CSCD 2023年第5期440-442,共3页
Over 200 health journals call on the United Nations(UN),political leaders and health professionals to recognise that climate change and biodiversity loss are one indivisible crisis and must be tackled together to pres... Over 200 health journals call on the United Nations(UN),political leaders and health professionals to recognise that climate change and biodiversity loss are one indivisible crisis and must be tackled together to preserve health and avoid catastrophe.This overall environmental crisis is now so severe as to be a global health emergency. 展开更多
关键词 CATASTROPHE global preserve
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Assessing the Impact of Health Insurance on Household Financial Protection in Togo
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作者 Aboubakar Issa Yaovi Tossou Kodjo Evlo 《Health》 2023年第6期507-516,共10页
Context: To facilitate financial access to care for the population, health insurance mechanisms have been established, in particular the National Health Insurance Institute, which covers civil servants and their depen... Context: To facilitate financial access to care for the population, health insurance mechanisms have been established, in particular the National Health Insurance Institute, which covers civil servants and their dependents. In addition, other voluntary and community mechanisms have been developed. After several years of implementation, the level of catastrophic health expenditures among insured individuals shows that there is still a considerable level of financial risk associated with health care. This study aims to assess the impact of health insurance in Togo on insured populations. Methodology: The data used in this study come from the harmonized survey on household living conditions carried out in 2018 by the National Institute of Statistics, Economic and Demographic Studies. The propensity score matching method was used according to the following steps: estimation of propensity scores, verification of the conditional independence hypothesis (balancing property) and estimation of the average treatment effect on treated. Stata V14.2 software was used. Findings: The average effect of health insurance on household financial protection is −0.012 for the nearest neighbor method, −0.013 for the matching radius method, −0.015 for the Kernel and −0.016 for the stratification method. Results showed that health insurance contributes to reducing catastrophic health expenditures, but their effect remains very limited. This could be explained by the level of care package covered and the cost covered. Conclusion: Health insurance contributes to the reduction of catastrophic health expenses for households. However, it is important to widen the range of care covered and the cost covered. In addition, measures to extend this coverage to a larger proportion of the population will make it possible to have a greater impact. 展开更多
关键词 Impact Health Insurance Catastrophic Expenditure
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