Restored intestinal integrity,nutrients transporters,energy metabolism,antioxidative capacity and decreased harmful microbiota were associated with IUGR piglet's catch-up growth before weanling

Background:Intrauterine growth restriction(IUGR)is a major inducer of higher morbidity and mortality in the pig industry and catch-up growth(CUG)before weanling could significantly restore this negative influence.But there was limited knowledge about the underlying mechanism of CUG occurrence.Methods:Eighty litters of newborn piglets were divided into normal birth weight(NBW)and IUGR groups according to birth weight.At 26 d,those piglets with IUGR but over average body weight of eighty litters of weaned piglets were considered as CUG,and the piglets with IUGR still below average body weight were considered as NCUG.This study was conducted to systemically compare the intestinal difference among NBW,CUG and NCUG weaned piglets considering the crucial role of the intestine for piglet growth.Results:The results indicated that the m RNA expression of nutrients(amino acids,glucose,and fatty acids)transporters,and mitochondrial electron transport chain(ETC)I were upregulated in CUG piglets'gut with improved morphology compared with those NCUG,as well as the ratio of P-AMPK/AMPK protein expression which is the indicator of energy metabolism.Meanwhile,CUG piglet's gut showed higher antioxidative capacity with increased SOD and GSHPx activity,decreased MDA levels,as well as higher m RNA expressions of Nrf2,Keap1,SOD,and GSH-Px.Furthermore,inflammatory parameters including TNF-α,IL-1β,IL-6,and IL-12 factors,and the activation of MAPK and NF-κB signaling pathways were significantly elevated in the NCUG intestine,while the protein expression of ZO-1,Occludin and Claudin-1 was reduced.The alpha diversity of fecal microbiota was higher in CUG piglets in contrast with NCUG piglets,and the increased beneficial bacteria and decreased pathogenic bacteria was also observed in CUG piglets.Conclusions:CUG piglet's intestine showed comprehensive restoration including higher nutrients transport,energy metabolism,antioxidant capacity,and intestinal physical barrier,while lower oxidative stress,inflammatory response,and pathogenic microbiota.

Scientific Catch-Up in Asian Economies: A Case Study for Solar Cell

A significant structural change in the pattern of economic development in Asian economies has been observed in recent years. We have seen many cases in which the Asian economies became the center of the world-wide production in an extremely short period of time after a new product entered the market. Also in the science, the number of papers written by Asian researchers has been increasing dramatically. In this situation, the existing studies cannot sufficiently explain the driving force and the mechanism of catch-up or economic growth. Therefore, it is now required to model this new type of economic development. In this paper we analyzed their scientific catch-up status using scientific papers on solar cells to clarify the structural change. After mid 1990s, knowledge creation has been accelerated in the field of solar cell. Now more than three thousand papers are published annually. We found as a result that the catch-up process in Asian economies had progressed rapidly, that some economies had a larger share of scientific papers in the frontier field of advanced science than in the matured fields, and that the strategy largely changed from area to area. A “parallel-running-type growth model” has thus been emerging in Asia. Responding to the significant changes in development model, we have to re-design the framework of economic cooperation. There is a need for further horizontal collaboration among major Asian economies and developed economies. We also showed that bibliometrics is an effective method for presuming a detailed national strategy that is not known to the outside.

A Solow-Swan Model with Technological Overflow and Catch-up

By introducing the logistic-like technology, the classical Solow-Swan model is extended to inquire the technological overflow and catch-up of the developing economy in this paper. The improved model is described by a two-dimensional dynamical system. It is proved that the model has a unique equilibrium which is a sink and the solution of the equation is globally asymptotically stable. And the classical Solow-Swan model is a special case of the model given here. The economic growth patterns are discussed by phase portrait analysis at the end of this paper.

Distortions, Growth Catch-up, and Sustainable Growth

A distortion is a departure from the allocation of economic resources from the state in which each agent maximizes his/her own welfare. Distortions can be divided into endogenous distortion(i.e. market imperfections) and policy-imposed distortion. The relationship between distortion and development is complex, thus favorable distortion would only be possible under certain conditions, where, as argued in this paper, four crucial mechanisms may play roles — advantage of backwardness, second-best principle, coordination failure and political economy perspective. Empirically, both international experience and evidence from China suggest that distortions have a positive effect on total factor productivity(TFP) in the early stages of development, but with increasing income levels this role gradually diminishes. Especially in the phases of middle and high income, the negative effects of distortions are significant and become an important factor leading to the middle-income trap. Therefore, reducing and correcting distortions is the key to achieving sustainable growth. Regarding China, it is necessary to eliminate the distortions in a clear way and let the market play the decisive role in resource allocation. Otherwise, in the name of "growth catch-up," the policy-imposed distortion will occur frequently, and the direction of market-oriented reform will become blurred and swing. Mitigating unfavorable distortions is largely a process of exploring the favorable borderline of government and market, which constitutes a major challenge for all economies.

Seroprevalence of Viral Hepatitis Markers B in Secondary School in Abidjan: Advocacy for a Catch-Up Vaccination

Aim: To determine the prevalence of HBs antigen in secondary schools, to appreciate the vaccination coverage of viral hepatitis B and to propose a vaccine catch-up strategy. Materials and Methods: This was a prospective cross-sectional study conducted over a two-month period from April 24 to June 24, 2006 among students aged 10 - 15, in two schools (one public and the other private) of the city of Abidjan selected at random. The assay of serum markers of viral hepatitis B of the samples collected after 5 ml peripheral venous sampling was carried out in the viral serology and bacteriology unit of the Pasteur institute of Ivory Coast using the ELISA technique (Enzyme-Linked-Immunosorbant-Assay). The ELISA technique is an enzyme immunoassay technique that can detect an antigen or an antibody by highlighting the antigen-antibody reaction. Results: Of the 282 students who participated in our study, 5.3% of students (n = 15) were infected with the hepatitis B virus. The majority of students (79.1%, n = 223) did not have no contact with the hepatitis B virus. Only 7.8% (n = 22) of the students were vaccinated against viral hepatitis B. Conclusion: The low immunization coverage and the high prevalence of seronegative students reflect the need for a vaccine catch-up policy for adolescents born before the introduction of vaccination against the viral hepatitis B virus in the Expanded Program on Immunization.

Identification of Technology Catch-up Path from the Perspective of Technology Leapfrogging

Objective To propose a method to identify the shortest catch-up path by using patent data based on the perspective of technology leapfrogging so as to provide a reference for the catch-up strategy formulation by the governments of the developing countries.Methods Firstly,the international patent classification(IPC)co-occurrence network was used to screen key technologies,and the TOP 5 countries and China were located from the aspects of technology life cycle and technological innovation capabilities.Next,the technology development path based on the ordered clustering algorithm and the main IPC number was set up.Finally,the Dijkstra algorithm was applied to identify the shortest catch-up path.Results and Conclusion Applying this method to the current biopharmaceutical industry with the most potential for development,the shortest catch-up paths are found in the selected C12N15,C07K14 and C12Q1 technology fields,proving the feasibility of the method.

《生长减缓婴幼儿的追赶生长:指导临床医师的专家建议》解读

生长减缓是帮助早期识别营养问题的重要临床表现,尽早识别和干预婴幼儿生长减缓对改善其近远期健康结局意义重大。之前发表的相关指南和专家共识对生长减缓缺乏统一的定义,影响临床识别、评估与规范管理。2023年3月,Journal of Pediatric Gastroenterology and Nutrition杂志发表了《生长减缓婴幼儿的追赶生长:指导临床医师的专家建议》,不仅阐述了追赶生长的重要性,还针对如何适当地定义、评估和管理生长减缓制定了切实可行的共识建议,对临床医生具有现实的指导价值。本文结合我国临床现状,对该“建议”进行解读,以期为我国临床医师管理生长减缓婴幼儿提供指导和参考。

政策协调、不确定性与大型技术系统创新——中国核电技术赶超的案例研究

后发国家技术赶超需要实现“市场规模”和“技术自主”的双重目标,但现实中这一进程普遍面临技术依赖的“追赶者陷阱”的问题。论文采用个案内过程追踪的研究方法和“政策子系统”的分析视角,基于中国核电50年的技术赶超历程,解释了后发国家如何通过政策协调实现大型技术系统的技术赶超。研究发现,大型技术系统的创新绩效与其所在政策子系统的特性密切相关,核电政策子系统具有碎片化的结构和行为目标,需要同步进行政府部门间协调和政府对市场协调,协调机制主要包括国家意志、行政指令、共识信号和市场竞争等。政策协调通过降低大型技术系统中产业主体面临的供需不确定性,解决产业主体专用化投资不足的激励困境。跳出“追赶者陷阱”的关键在于建立国产化率目标硬约束与多种协调机制。研究进一步深化了对技术赶超中政府角色的认识,弥补了已有文献对于大型技术系统产业管理体制研究不足的理论缺口,对新型举国体制下提高系统创新能力有一定的启示。

新中国成立以来我国产业政策演进的历史考察及经验启示

新中国成立以来,基于发展逻辑差异,党领导政府推进我国产业政策发展经历了三个阶段,即赶超逻辑主导的中国特色产业政策先声阶段、发展市场机制的中国特色产业政策体系构建阶段、高水平赶超逻辑引领的新时代中国特色产业体系阶段。我国产业政策实践地推动了社会生产力的解放和发展,并在新的质态维度催生新质生产力,同时积累了丰富经验且为我国产业政策部署实施提供了基本遵循,即坚持以党的绝对领导为根本原则,坚持以科技创新推动产业创新,坚持以完善新型举国体制带动产业变革,坚持以新型工业化转换经济增长动能,坚持在应用基础研究和前沿研究中开创产业发展新局面。

并购情境下基于智力资本整合的技术追赶机理———沈阳机床并购德国希斯案例分析

跨国并购被认为是后发企业获取创新资源实现技术追赶的有效捷径。对被并方资源形式拥有并不等于技术能力提升,有效内化并购资源才能支持后发企业技术能力跃升。但文献对“并购-技术追赶”的资源整合的动态机制缺乏充分理论解释。将沈阳机床并购德国希斯的整合实践作为案例样本,借鉴与组织技术转移和创新关联性较强的“智力资本”概念体系,探索基于并购的“智力资本整合-技术追赶”内在机理。研究发现:①基于并购的技术追赶遵循“吸收模仿-集成创造-主导领先”发展路径;②“并购追赶”导向下智力资本整合呈现“人力资本整合主导-社会资本整合主导-组织资本整合主导”演进轨迹;③智力资本整合效应呈现“逆向吸收效应-多元融合效应-能力重构效应”动态转变。

早产小于胎龄儿校正0~24月龄追赶生长的纵向研究

目的了解早产小于胎龄儿(small for gestational age,SGA)和适于胎龄儿(appropriate for gestational age,AGA)校正0~24月龄期间生长发育状况和差异,为早产儿早期健康干预提供依据。方法回顾性选取2019年7月—2022年7月在广州市妇女儿童医疗中心定期保健的824例早产儿作为研究对象,其中SGA 144例,AGA 680例。分析和比较SGA组和AGA组出生及校正0~24月龄的体格发育数据。结果SGA组在校正0~18月龄期间的体重和身长均落后于同月龄AGA组(P<0.05),而校正24月龄时,两组的体重和身长比较差异无统计学意义(P>0.05)。校正24月龄时,85%(34/40)SGA早产儿和79%(74/94)AGA早产儿完成追赶生长。按胎龄分层分析的结果显示:胎龄<34周SGA亚组体重、身长在校正0~9月龄与胎龄<34周和≥34周AGA亚组比较差异有统计学意义(P<0.05);胎龄≥34周SGA亚组体重、身长分别在校正0~18月龄和校正0~12月龄与胎龄<34周和≥34周AGA亚组比较差异有统计学意义(P<0.05)。胎龄<34周和≥34周SGA早产儿追赶生长分别主要发生在校正0~12月龄、校正0~18月龄。结论SGA早产儿生命早期体格发育落后于AGA早产儿,但在校正24月龄时实现追赶生长的比例高于AGA早产儿。胎龄<34周SGA早产儿实现追赶生长的时间早于胎龄≥34周SGA早产儿。

企业复杂核心技术的后发追赶及动力机制——基于华为无线网络技术的纵向案例研究

基于技术组合创新理论,通过对华为无线网络技术后发追赶的纵向案例研究,建立复杂核心技术创新的五阶段模型,从复杂性和核心性两个方面建构复杂核心技术,分析复杂核心技术创新及后发追赶的主要困境与动力机制。研究发现,根据技术创新范围、规模、复杂性与核心性形成过程,复杂核心技术创新过程分为产品原型、市场准入、边缘市场、核心技术及核心市场5个阶段;复杂核心技术的高市场转换成本导致后发者面临巨大困境以及先发者存在路径依赖,后发追赶需要长期大规模的研发投入,分别解决技术复杂性和核心性;技术复杂性和核心性均来源于技术组合创新以及市场需求,技术复杂性为核心性提供整体优势和经济动力,技术核心性进一步增强技术复杂性,形成技术的多层次网络结构与整体优势。研究结论完善了复杂核心技术创新的后发追赶理论,对后发企业实现关键核心技术突破具有重要的实践意义。

专利侵权风险管理对后发企业技术赶超的影响研究

本文以中国后发企业2022—2023两年追踪的调研问卷数据为样本,实证分析专利侵权风险管理对后发企业技术赶超的影响,以及技术创新的中介作用,技术能力、知识产权保护的调节作用。研究发现:专利侵权风险管理正向影响后发企业技术赶超;技术创新在专利侵权风险管理与后发企业技术赶超中发挥部分中介作用,且该作用兼具当期效应与时滞效应;技术能力以及知识产权保护能够显著影响专利侵权风险管理对技术创新的作用。研究结果在考虑内生性问题以及稳健性检验后依然成立,为专利侵权风险管理的创新驱动效应提供实证依据,引导中国后发企业在繁茂的“专利丛林”中砥砺前行。

基于专利布局的中日人工智能技术竞争分析

在中日首个自贸协定——RCEP背景下,中日人工智能产业的竞争与交流将更为密切。国家间专利布局比较是分析技术竞争及科技战略的重要方法,对两国专利布局竞争态势的研究可以为中国在新阶段取得更大经济效益与社会效益提供方向。以专利信息为依据,基于专利布局与技术追赶理论,从技术竞争力与专利布局两方面对中日人工智能产业发展态势进行比较研究,对未来中国在人工智能领域的追赶方式进行分析。研究表明,中国人工智能产业发展总体已超过日本,人才后备力量充足,应用层产业位居世界前列,但基础层技术落后于日本。最后从技术热点和市场布局两方面提出未来中国人工智能技术追赶策略。

数字化转型、动态能力与制造业企业后发追赶

数字化转型是未来经济增长的引擎,如何在数字经济背景下实现后发追赶是企业发展的核心议题。然而,企业数字化转型和后发追赶之间的关系机制尚未得到充分探索。本文基于2012~2022年制造业上市企业的相关数据,从理论和实证层面探讨数字化转型对企业后发追赶的影响。研究结果如下:(1)数字化转型对企业的技术追赶和市场追赶有积极且显著的影响,在使用工具变量法、倾向评分匹配和其他稳健性检验后,结果仍然有效。此外,数字化转型对市场追赶的提升作用比技术追赶更强;(2)机制检验发现,数字化转型主要通过提升动态能力的途径促进企业后发追赶;(3)异质性检验发现,相较于非国有企业和非高技术产业企业,数字化转型对国有企业和高技术产业企业追赶的促进作用更强。本文拓展了企业后发追赶研究的视角,并为企业制定数字化转型和追赶策略提供了依据。

视频头脉冲测试中扫视波参数的重要性分析

本综述旨在全面讨论视频头脉冲中扫视波(catch-up saccades,CS)的参数、机制以及其与前庭功能和相关疾病的联系,从而验证CS在临床评估前庭功能及相关疾病中的关键作用。本文详细描述了CS的参数特征、生理机制以及产生的条件,并深入分析其在前庭-眼反射以及颈眼反射的角色。借助头脉冲抑制模型中的CS,结合动态视敏度以及步态和平衡功能,进一步探讨CS与前庭功能的紧密联系。此外,本文还从不同年龄段、前庭功能损伤、梅尼埃病及前庭性偏头痛等角度,剖析了CS的表现及其在各种疾病背景下的重要性。总之,CS对于维持视觉的稳定性,评估前庭功能的损伤程度以及前庭康复阶段均具有重要价值。

中国人工智能发展的空间极化与国际追赶——基于技术-产业双重视角

人工智能是引领未来技术和产业变革、构筑国家竞争优势的重要领域。在技术-产业框架内讨论人工智能内涵,选取人工智能专利指标、人工智能企业数目、全球人工智能发展指数衡量人工智能技术和产业发展,分析新发展格局下中国人工智能国际国内发展现状与特征。国内跨区域比较发现,人工智能技术和产业分布高度不均衡,具有“东强西弱、南多北少、高度集中、梯度分布”特征,且技术集中度高于企业集中度,存在空间极化现象。跨国比较发现,中国人工智能技术和产业发展整体处于领先地位,专利数量和海外布局不弱于美国,但是专利质量、顶尖企业和人才落后于美国,存在“木桶效应”,尤其是AI人才。在新发展格局下推动人工智能发展,有必要统筹国内与国际,既要平衡区域人工智能发展水平,多措并举缩小区域“数字鸿沟”,也要立足和巩固比较优势,补足人才短板,融入人工智能全球创新网络。