Studies on mechanism of Sialy Lewis-X antigen in liver metastases of human colorectal carcinoma

INTRODUCTIONSialyl Lewis-X antigen ,correlated with carcinoma, is a group of carbohydrate antigen containing oligosaccharide expressed of embryonic tisue and glycoproteins on cell surface of embryonic tissue[1].The SLeX antigen located on cell surface is synthesized principally by two enzymes ,al ,3fucosyltransfrease and a2, 3sialyctransferase.In adults ,SLeX antigen is expressed principally on the surfaces of granulocytic cells and some tumor cells .

Activity of boanmycin against colorectal cancer

INTRODUCTIONBoanmycin (Bleomycin A6, BAM ), a newantitumor antibiotic, was isolated from manycomponents of bleomycin (BLM) produced bystreptomyces pingyangensis which were obtainedfrom a soil sample collected in Pingyang County,Zhejiang Province, China. Boanmycin has a similarchemical structure to that of BLM, but the terminalamine moiety is different[ 1].

全反式维甲酸诱导LoVo细胞分化的动物实验研究

研究经全反式维甲酸（ATRA）诱导分化的结肠癌细胞株（LoVo细胞）在裸鼠体内的致瘤性。方法：将ATRA作用下经5次和10次传代的LoVo细胞接种于裸鼠皮下，观察移植瘤生长情况。用扫描电镜观察肿瘤细胞的超微结构，用免疫组化法分析肿瘤细胞癌胚抗原（CEA）的表达及分泌粘液的性质。结果：经5次传代实验组与对照组裸鼠均有移植瘤形成，但实验组移植瘤生长明显受抑制（P＜0．05）。经10次传代实验组裸鼠移植瘤形成抑制率为4／6（P＜0．01）。对照组与实验组移植瘤细胞的形态结构无明显区别，CEA均呈阳性且分泌酸性粘液。结论：ATRA可抑制裸鼠体内移植瘤的生长和形成并呈时间相关性，移植瘤形成可能是LoVo细胞分化不完全所致。