Cell migration plays a significant role in many biological activities,yet the physical mechanisms of cell migration are still not well understood.In this study,a continuum physics-based epithelial monolayer model incl...Cell migration plays a significant role in many biological activities,yet the physical mechanisms of cell migration are still not well understood.In this study,a continuum physics-based epithelial monolayer model including the intercellular interaction was employed to study the cell migration behavior in a confluent epithelial monolayer at constant cell density.The epithelial cell was modeled as isotropic elastic material.Through finite element simulation,the results revealed that themotile cellwas subjected to higher stress than the other jammed cells during the migration process.Cell stiffness was implied to play a significant role in epithelial cell migration behavior.Higher stiffness results in smaller displacement and lower migration speed.展开更多
基金This work is supported by a grant from National Institutes of Health(Grant No.SC2GM112575)a grant from the John L.Santikos Charitable Foundation of the San Antonio Area Foundation.
文摘Cell migration plays a significant role in many biological activities,yet the physical mechanisms of cell migration are still not well understood.In this study,a continuum physics-based epithelial monolayer model including the intercellular interaction was employed to study the cell migration behavior in a confluent epithelial monolayer at constant cell density.The epithelial cell was modeled as isotropic elastic material.Through finite element simulation,the results revealed that themotile cellwas subjected to higher stress than the other jammed cells during the migration process.Cell stiffness was implied to play a significant role in epithelial cell migration behavior.Higher stiffness results in smaller displacement and lower migration speed.
