Many tumors contain phenotypic and functionally diverse populations of cancer cells that differ in terms of metastatic and angiogenic potential,as well as medication resistance.Tumor recurrence and metastasis are two ...Many tumors contain phenotypic and functionally diverse populations of cancer cells that differ in terms of metastatic and angiogenic potential,as well as medication resistance.Tumor recurrence and metastasis are two of the most difficult aspects of cancer treatment and even with conventional therapies(such as chemotherapy and radio-therapy),satisfactory results have not been obtained.The main source of cancer stem cell tumorigenesis is CSCs,which,by dividing cells,produce the same daughter cells and differentiate into different types and can create tumor tissue from a single cell.They are responsible for the development of cancer,progression,metastasis,recurrence,and treatment resistance,and are recognized to have a role in the failure of conventional therapy and tumor recurrence.To resolve this quandary,careful identification of CSC molecular targets and comprehensive disclosure of the underlying processes of CSC immune system properties are required.Traditional cancer therapies are insufficient to kill all intracellular cells,particularly those with great resistance to therapy,such as CSC.Targeting CSC metabolism has been proposed as a novel treatment strategy for preventing the development of different malignancies.In this study,the identification of cancer stem cell populations,the role of CSCs in drug resistance,metastasis,hypoxia,and the role of Nrf2 in CSC tumorigenesis has been reviewed.展开更多
文摘Many tumors contain phenotypic and functionally diverse populations of cancer cells that differ in terms of metastatic and angiogenic potential,as well as medication resistance.Tumor recurrence and metastasis are two of the most difficult aspects of cancer treatment and even with conventional therapies(such as chemotherapy and radio-therapy),satisfactory results have not been obtained.The main source of cancer stem cell tumorigenesis is CSCs,which,by dividing cells,produce the same daughter cells and differentiate into different types and can create tumor tissue from a single cell.They are responsible for the development of cancer,progression,metastasis,recurrence,and treatment resistance,and are recognized to have a role in the failure of conventional therapy and tumor recurrence.To resolve this quandary,careful identification of CSC molecular targets and comprehensive disclosure of the underlying processes of CSC immune system properties are required.Traditional cancer therapies are insufficient to kill all intracellular cells,particularly those with great resistance to therapy,such as CSC.Targeting CSC metabolism has been proposed as a novel treatment strategy for preventing the development of different malignancies.In this study,the identification of cancer stem cell populations,the role of CSCs in drug resistance,metastasis,hypoxia,and the role of Nrf2 in CSC tumorigenesis has been reviewed.
