This work is part of a large experimental study on the distribution of internal temperatures in two similar test cells, but with different systems of coverage. The main goal of this paper is to present results on an e...This work is part of a large experimental study on the distribution of internal temperatures in two similar test cells, but with different systems of coverage. The main goal of this paper is to present results on an experimental field to determine the influence of solar radiation on the internal environmental conditions of different roof systems. Dry bulb temperature and internal surface temperatures were measured in two test cells with different roof systems (green roof and conventional ceramic roof). Their thermal performances were compared on days with differing air mass domain, based on dynamic climatic approach. This research was based on the spatial and temporal approaches of dynamic climatology, from the climatic regime of the city of Itirapina, S^o Paulo State, analysed as representative episodes. Climatic data were provided by an automatic weather station and verified by satellite imagery, and the internal temperatures of the cells were collected by thermocouples installed on the surfaces of ceilings, floors, walls, and suspended inside the buildings. The results indicate that the solar radiation is mainly responsible for the great variations in temperature and its impact on indoor environments, since there were great differences in temperature inside comparing the two days of the experiment. This refutes the notion that the outside temperature is responsible for daily variations in temperature inside buildings.展开更多
Fuel cells are considered to be one of the ideal alternatives to traditional fossil energy conversion devices.Membrane electrodes are the core components in the hydrogen fuel cells.Our work reported the synthesis of t...Fuel cells are considered to be one of the ideal alternatives to traditional fossil energy conversion devices.Membrane electrodes are the core components in the hydrogen fuel cells.Our work reported the synthesis of the Pt/C catalysts with different Pt loading,and by changing the Nafion content,hot pressing temperature and hot pressing pressure,the catalyst coated membrane(CCM)spraying process was optimized.Moreover,the three-dimensional structure model of the single battery membrane electrode was studied quantitatively,and the porous membrane electrode with gradient distribution was fabricated under optimized processing conditions,with excellent electrical performance.展开更多
Background The initiation and expansion of China's national free antiretroviral therapy program has led to significant improvement of survival among its participants. Success of further scaling up treatment coverage ...Background The initiation and expansion of China's national free antiretroviral therapy program has led to significant improvement of survival among its participants. Success of further scaling up treatment coverage rests upon intensifying HIV screening and efficient linkage of care. Timely CD4 cell count testing after HIV diagnosis is necessary to determine whether a patient meets criteria for antiretroviral treatment, and represents a crucial link to engage HIV-infected patients in appropriate care, which has not been evaluated in China.Methods We evaluated all patients ≥16 years who tested HIV positive from 2005 to 2009 in Yunnan and Guangxi.Multivariate Logistic regression models were applied to identify factors associated with lack of CD4 cell count testing within 6 months after HIV diagnosis.Results A total of 83 556 patients were included. Over the study period, 30 635 (37%) of subjects received a CD4 cell count within 6 months of receiving the HIV diagnosis. The rate of CD4 cell count testing within 6 months of HIV diagnosis increased significantly from 7% in 2005 to 62% in 2009. Besides the earlier years of HIV diagnosis, negative predictors for CD4 cell count testing in multivariate analyses included older age, not married or unclear marriage status,incarceration, diagnosis at sexual transmitted disease clinics, mode of HIV transmission classified as men who have sex with men, intravenous drug users or transmission route unclear, while minority ethnicity, receipt of high school or higher education, diagnosis at voluntary counseling and testing clinics, and having HIV positive parents were protective.Conclusions Significant progress has been made in increasing CD4 testing among newly diagnosed HIV positive patients in Yunnan and Guangxi from 2005-2009. However, a sizable proportion of HIV positive patients still lack CD4testing within 6 months of diagnosis. Improving CD4 testing, particularly among patients with identified risk factors, is essential to link patients with ART services and optimize treatment coverage展开更多
Amniocentesis is an essential tool in obstetrics. Invasive testing remains the only modality for diagnostic genetic testing and the only way to provide comprehensive test-ing for chromosomal abnormalities. Despite inc...Amniocentesis is an essential tool in obstetrics. Invasive testing remains the only modality for diagnostic genetic testing and the only way to provide comprehensive test-ing for chromosomal abnormalities. Despite increasing use of cell free fetal deoxyribonucleic acid (DNA) testing, amniocentesis should still be offered to all women who desire more complete and accurate genetic testing. Counseling patients on the limitations of screening tests is of the upmost importance and amniocentesis should continue to be recommended to confrm positive results from cell free fetal DNA testing or in the case of failed cell free fetal DNA test. As cell free fetal DNA screening has not adequately been studied in multiple gestations, its use is not recommended in this population and invasive testing should be offered. Amniocentesis is also very useful in providing additional information in settings other than genetic testing the second and third trimester. If intraamniotic infection is suspected, but the clinical fndings are not enough to guide manage-ment, amniocentesis can provide testing that can both immediately clarify the picture (interleukin-6, gram stain, glucose levels) and finally confirm the presence of infection (culture). It can also be used to detect the presence of intrauterine viral infections. Additionally, amniocentesis may be used to test for markers of fetal lung maturity. The American Congress of Obstetricians and Gynecologists recommends that amniocentesis for this indication not be used in cases where late preterm delivery is indicated. It may be useful in guiding decision-making, however , when late preterm delivery is indicated, but when exact timing is unclear. Regardless of the indication, amniocentesis appears to be a relatively low risk procedure with minimal risk to the patient. Additional randomized controlled trials are not likely, as they are not feasible to due extremely high number of participants that would be needed to detect a difference in loss rates. Based on current literature, however, the risk of pregnancy loss from second trime-ster amniocentesis is low in both singleton and twin gestations. We counsel patients that technique has changed since the original studies in the 1970s and feel comfortable quoting a loss rate of 1/500-1/1000 based on contemporary data.展开更多
In this paper, a study of sandy soil compaction with different granulometry and moisture content has been performed, and soil mechanical property variations in moisture and granulometry have been investigated. Investi...In this paper, a study of sandy soil compaction with different granulometry and moisture content has been performed, and soil mechanical property variations in moisture and granulometry have been investigated. Investigations were performed to compare hydrostatic compression test (HCT) responses and evaluate the compression index, Cc, which is an indicator of the soil's susceptibility to compaction-induced damage. The experiments have been performed on 24 soil samples typologies. Each sample has been obtained by combining three types of soil granulometry (types A, B and C) with a relative content varying from 0% to 100% in 20% increments. Soil type A had a granulometry ranging between 0.5 mm and 1 mm, type B between 0.25 mm and 0.5 mm, and type C less than 0.25 mm. These samples were representative of a sandy soil, chemically inactive and had various granulometries and initial moisture contents. A cell for HCT has been set up to allow the initial volume measurement of the test pieces and the subsequent changes during HCT with an estimated error less than 0.1 cm3. All samples were pre-compacted and prepared in agreement with the actual standards. The experimental data are reported in diagrams, the data allowed comparison of the mechanical behaviors between the considered unsaturated soils and underlined how soil moisture and granulometry affect soil response during HCT. Furthermore, because of the methodology used, the equipment was very economical.展开更多
Background:The ingestion of golden thread contaminated with heavy metals through the food chain leads to detrimental effects to human health.During digestion,not all of the heavy metals could be released to the gastro...Background:The ingestion of golden thread contaminated with heavy metals through the food chain leads to detrimental effects to human health.During digestion,not all of the heavy metals could be released to the gastrointestinal tract and readily to be absorbed by human body.Thus,bioaccessibility is an important issue in health risk assessments.Aims and Objectives:The aims and objectives of this study were to investigate the bioaccessibility of Cd in golden thread and assess the associated health risks based on the exposure to bioaccessible Cd.Materials and Methods:Inductively coupled plasma mass spectrometry(ICP-MS)has been applied to determine the Cd content in golden thread.Physiologically based extraction test(PBET)digestion was performed in the in vitro/Caco2 cell model to investigate the bioaccessibility of Cd in golden thread.Furthermore,the target hazard quotient(THQ)was used to assess the risks of the total and the bioaccessible content of Cd in golden thread.Results:The results revealed that the total Cd content in six batches of golden thread ranged from 3.203 to 5.723 mg/kg.After uptake by Caco2 cells,the bioaccessibility of Cd ranged from 42.36%to 59.73%.The results of the risk assessment indicated that prior to uptake by Caco2 cells,the THQ values of Cd for all batches of golden thread were greater than 1.However,after uptake by Caco2 cells,the THQ values of Cd in all samples were less than 1,thus suggesting that the risks were at a safe level.Conclusion:This study was the first to perform health risk assessment with bioaccessible heavy metals present in traditional Chinese medicine by PBET digestion using an in vitro/Caco2 cell model,thus enabling us to obtain more accurate and objective results while allowing us to avoid unnecessary government intervention and to establish more reasonable limit standards for heavy metals.展开更多
Objective To test NK cell quantities and function in patients with positive BMMNC-Coombs test(CBCPC)and cytopenia and to explore how NK cell participate in the progress of this disease.Methods The percentage of CD3-CD...Objective To test NK cell quantities and function in patients with positive BMMNC-Coombs test(CBCPC)and cytopenia and to explore how NK cell participate in the progress of this disease.Methods The percentage of CD3-CD56+NK cell in peripheral blood lymphocytes,the expression of activating receptor(NKG2D,NKp46,NKp44),inhibitory receptor(CD158a,CD158b),per-展开更多
The element-release behavior of municipal solid waste incineration fly ash was explored through leaching test with continuous set-point pH(pH_(stat) test)and serial single reaction cell(SSRC)tests.First,the relationsh...The element-release behavior of municipal solid waste incineration fly ash was explored through leaching test with continuous set-point pH(pH_(stat) test)and serial single reaction cell(SSRC)tests.First,the relationship between element release and acid neutralizing capacity(ANC)consumption was examined with a pHstat test.Four types of release behaviors were identified which are characteristic for different elements:(1)release curves that were almost linear with ANC consumption(Ca,Zn,and Cd);(2)release that was significantly faster than ANC(Na,K,and Cl);(3)curves that featured a strong increase with ANC consumption,after a transient release,followed by an almost equal decrease(Si and S);and(4)release that is strongly retarded compared with ANC consumption(Cr,Cu,and Pb).In the SSRC system,it the existence of a pH front and a wash-out phenomenon is demonstrated.Combining the results from the SSRC test with the kinetic analysis of the ANC system in the pH_(stat) test,it was inferred that less than one-third of the ANC measured from a batch pH titration plays a neutralization role in a field situation.The methodologies described may provide a powerful set of tools for systematic evaluation of element release from solid wastes.展开更多
文摘This work is part of a large experimental study on the distribution of internal temperatures in two similar test cells, but with different systems of coverage. The main goal of this paper is to present results on an experimental field to determine the influence of solar radiation on the internal environmental conditions of different roof systems. Dry bulb temperature and internal surface temperatures were measured in two test cells with different roof systems (green roof and conventional ceramic roof). Their thermal performances were compared on days with differing air mass domain, based on dynamic climatic approach. This research was based on the spatial and temporal approaches of dynamic climatology, from the climatic regime of the city of Itirapina, S^o Paulo State, analysed as representative episodes. Climatic data were provided by an automatic weather station and verified by satellite imagery, and the internal temperatures of the cells were collected by thermocouples installed on the surfaces of ceilings, floors, walls, and suspended inside the buildings. The results indicate that the solar radiation is mainly responsible for the great variations in temperature and its impact on indoor environments, since there were great differences in temperature inside comparing the two days of the experiment. This refutes the notion that the outside temperature is responsible for daily variations in temperature inside buildings.
基金This work was financially supported by China Petrochemical Corporation(ST 20006-1,ST 20006-2).
文摘Fuel cells are considered to be one of the ideal alternatives to traditional fossil energy conversion devices.Membrane electrodes are the core components in the hydrogen fuel cells.Our work reported the synthesis of the Pt/C catalysts with different Pt loading,and by changing the Nafion content,hot pressing temperature and hot pressing pressure,the catalyst coated membrane(CCM)spraying process was optimized.Moreover,the three-dimensional structure model of the single battery membrane electrode was studied quantitatively,and the porous membrane electrode with gradient distribution was fabricated under optimized processing conditions,with excellent electrical performance.
文摘Background The initiation and expansion of China's national free antiretroviral therapy program has led to significant improvement of survival among its participants. Success of further scaling up treatment coverage rests upon intensifying HIV screening and efficient linkage of care. Timely CD4 cell count testing after HIV diagnosis is necessary to determine whether a patient meets criteria for antiretroviral treatment, and represents a crucial link to engage HIV-infected patients in appropriate care, which has not been evaluated in China.Methods We evaluated all patients ≥16 years who tested HIV positive from 2005 to 2009 in Yunnan and Guangxi.Multivariate Logistic regression models were applied to identify factors associated with lack of CD4 cell count testing within 6 months after HIV diagnosis.Results A total of 83 556 patients were included. Over the study period, 30 635 (37%) of subjects received a CD4 cell count within 6 months of receiving the HIV diagnosis. The rate of CD4 cell count testing within 6 months of HIV diagnosis increased significantly from 7% in 2005 to 62% in 2009. Besides the earlier years of HIV diagnosis, negative predictors for CD4 cell count testing in multivariate analyses included older age, not married or unclear marriage status,incarceration, diagnosis at sexual transmitted disease clinics, mode of HIV transmission classified as men who have sex with men, intravenous drug users or transmission route unclear, while minority ethnicity, receipt of high school or higher education, diagnosis at voluntary counseling and testing clinics, and having HIV positive parents were protective.Conclusions Significant progress has been made in increasing CD4 testing among newly diagnosed HIV positive patients in Yunnan and Guangxi from 2005-2009. However, a sizable proportion of HIV positive patients still lack CD4testing within 6 months of diagnosis. Improving CD4 testing, particularly among patients with identified risk factors, is essential to link patients with ART services and optimize treatment coverage
文摘Amniocentesis is an essential tool in obstetrics. Invasive testing remains the only modality for diagnostic genetic testing and the only way to provide comprehensive test-ing for chromosomal abnormalities. Despite increasing use of cell free fetal deoxyribonucleic acid (DNA) testing, amniocentesis should still be offered to all women who desire more complete and accurate genetic testing. Counseling patients on the limitations of screening tests is of the upmost importance and amniocentesis should continue to be recommended to confrm positive results from cell free fetal DNA testing or in the case of failed cell free fetal DNA test. As cell free fetal DNA screening has not adequately been studied in multiple gestations, its use is not recommended in this population and invasive testing should be offered. Amniocentesis is also very useful in providing additional information in settings other than genetic testing the second and third trimester. If intraamniotic infection is suspected, but the clinical fndings are not enough to guide manage-ment, amniocentesis can provide testing that can both immediately clarify the picture (interleukin-6, gram stain, glucose levels) and finally confirm the presence of infection (culture). It can also be used to detect the presence of intrauterine viral infections. Additionally, amniocentesis may be used to test for markers of fetal lung maturity. The American Congress of Obstetricians and Gynecologists recommends that amniocentesis for this indication not be used in cases where late preterm delivery is indicated. It may be useful in guiding decision-making, however , when late preterm delivery is indicated, but when exact timing is unclear. Regardless of the indication, amniocentesis appears to be a relatively low risk procedure with minimal risk to the patient. Additional randomized controlled trials are not likely, as they are not feasible to due extremely high number of participants that would be needed to detect a difference in loss rates. Based on current literature, however, the risk of pregnancy loss from second trime-ster amniocentesis is low in both singleton and twin gestations. We counsel patients that technique has changed since the original studies in the 1970s and feel comfortable quoting a loss rate of 1/500-1/1000 based on contemporary data.
文摘In this paper, a study of sandy soil compaction with different granulometry and moisture content has been performed, and soil mechanical property variations in moisture and granulometry have been investigated. Investigations were performed to compare hydrostatic compression test (HCT) responses and evaluate the compression index, Cc, which is an indicator of the soil's susceptibility to compaction-induced damage. The experiments have been performed on 24 soil samples typologies. Each sample has been obtained by combining three types of soil granulometry (types A, B and C) with a relative content varying from 0% to 100% in 20% increments. Soil type A had a granulometry ranging between 0.5 mm and 1 mm, type B between 0.25 mm and 0.5 mm, and type C less than 0.25 mm. These samples were representative of a sandy soil, chemically inactive and had various granulometries and initial moisture contents. A cell for HCT has been set up to allow the initial volume measurement of the test pieces and the subsequent changes during HCT with an estimated error less than 0.1 cm3. All samples were pre-compacted and prepared in agreement with the actual standards. The experimental data are reported in diagrams, the data allowed comparison of the mechanical behaviors between the considered unsaturated soils and underlined how soil moisture and granulometry affect soil response during HCT. Furthermore, because of the methodology used, the equipment was very economical.
基金financially supported by the 13th Five-Year National Significant New Drugs Creation Feature Subjects grant(2018ZX09735006)by the Project for Medicine and Medical Instruments Review and Approval System Reform grant(ZG2016-1)
文摘Background:The ingestion of golden thread contaminated with heavy metals through the food chain leads to detrimental effects to human health.During digestion,not all of the heavy metals could be released to the gastrointestinal tract and readily to be absorbed by human body.Thus,bioaccessibility is an important issue in health risk assessments.Aims and Objectives:The aims and objectives of this study were to investigate the bioaccessibility of Cd in golden thread and assess the associated health risks based on the exposure to bioaccessible Cd.Materials and Methods:Inductively coupled plasma mass spectrometry(ICP-MS)has been applied to determine the Cd content in golden thread.Physiologically based extraction test(PBET)digestion was performed in the in vitro/Caco2 cell model to investigate the bioaccessibility of Cd in golden thread.Furthermore,the target hazard quotient(THQ)was used to assess the risks of the total and the bioaccessible content of Cd in golden thread.Results:The results revealed that the total Cd content in six batches of golden thread ranged from 3.203 to 5.723 mg/kg.After uptake by Caco2 cells,the bioaccessibility of Cd ranged from 42.36%to 59.73%.The results of the risk assessment indicated that prior to uptake by Caco2 cells,the THQ values of Cd for all batches of golden thread were greater than 1.However,after uptake by Caco2 cells,the THQ values of Cd in all samples were less than 1,thus suggesting that the risks were at a safe level.Conclusion:This study was the first to perform health risk assessment with bioaccessible heavy metals present in traditional Chinese medicine by PBET digestion using an in vitro/Caco2 cell model,thus enabling us to obtain more accurate and objective results while allowing us to avoid unnecessary government intervention and to establish more reasonable limit standards for heavy metals.
文摘Objective To test NK cell quantities and function in patients with positive BMMNC-Coombs test(CBCPC)and cytopenia and to explore how NK cell participate in the progress of this disease.Methods The percentage of CD3-CD56+NK cell in peripheral blood lymphocytes,the expression of activating receptor(NKG2D,NKp46,NKp44),inhibitory receptor(CD158a,CD158b),per-
基金This research was partially funded by the National Natural Science Foundation of China(Grant No.20777044).
文摘The element-release behavior of municipal solid waste incineration fly ash was explored through leaching test with continuous set-point pH(pH_(stat) test)and serial single reaction cell(SSRC)tests.First,the relationship between element release and acid neutralizing capacity(ANC)consumption was examined with a pHstat test.Four types of release behaviors were identified which are characteristic for different elements:(1)release curves that were almost linear with ANC consumption(Ca,Zn,and Cd);(2)release that was significantly faster than ANC(Na,K,and Cl);(3)curves that featured a strong increase with ANC consumption,after a transient release,followed by an almost equal decrease(Si and S);and(4)release that is strongly retarded compared with ANC consumption(Cr,Cu,and Pb).In the SSRC system,it the existence of a pH front and a wash-out phenomenon is demonstrated.Combining the results from the SSRC test with the kinetic analysis of the ANC system in the pH_(stat) test,it was inferred that less than one-third of the ANC measured from a batch pH titration plays a neutralization role in a field situation.The methodologies described may provide a powerful set of tools for systematic evaluation of element release from solid wastes.