Microorganisms,physical factors such as temperature or mechanical injury,and chemical factors such as free monomers from composite resin are the main causes of dental pulp diseases.Current clinical treatment methods f...Microorganisms,physical factors such as temperature or mechanical injury,and chemical factors such as free monomers from composite resin are the main causes of dental pulp diseases.Current clinical treatment methods for pulp diseases include the root canal therapy,vital pulp therapy and regenerative endodontic therapy.Regenerative endodontic therapy serves the purpose of inducing the regeneration of new functional pulp tissues through autologous revascularization or pulp tissue engineering.This article first discusses the current clinical methods and reviews strategies as well as the research outcomes regarding the pulp regeneration.Then the in vivo models,the prospects and challenges for regenerative endodontic therapy were further discussed.展开更多
基金funded by the National Natural Science Foundation of China(Grant No.82270968&82170943)the Top Youth Talent in Medicine Program of Hubei Province,China.
文摘Microorganisms,physical factors such as temperature or mechanical injury,and chemical factors such as free monomers from composite resin are the main causes of dental pulp diseases.Current clinical treatment methods for pulp diseases include the root canal therapy,vital pulp therapy and regenerative endodontic therapy.Regenerative endodontic therapy serves the purpose of inducing the regeneration of new functional pulp tissues through autologous revascularization or pulp tissue engineering.This article first discusses the current clinical methods and reviews strategies as well as the research outcomes regarding the pulp regeneration.Then the in vivo models,the prospects and challenges for regenerative endodontic therapy were further discussed.
