Cellular senescence is a form of permanent cell cycle arrest that can be triggered by a variety of cell-intrinsic and extrinsic stimuli, including telomere shortening,DNA damage, oxidative stress, and exposure to chem...Cellular senescence is a form of permanent cell cycle arrest that can be triggered by a variety of cell-intrinsic and extrinsic stimuli, including telomere shortening,DNA damage, oxidative stress, and exposure to chemotherapeutic agents and ionizing radiation. Although the induction of apoptotic cell death is a desirable outcome in cancer therapy, mutations and/or deficiencies in the apoptotic signaling pathways have been frequently identified in many human cancer types,suggesting the importance of alternative apoptosis-independent therapeutic approaches for cancer treatment. A growing body of evidence has documented that senescence induction in tumor cells is a frequent response to many anticancer modalities including cyclin-dependent kinases 4/6 small molecule inhibitor-based targeted therapeutics and T helper-1 cytokine-mediated immunotherapy. This review discusses the recent advances and clinical relevance of therapy-induced senescence in cancer treatment.展开更多
In this editorial,the authors tried to evaluate the present state of cellular therapy in orthopedic field.The topics the authors try to cover include not only the clinical trials but the various research areas as well...In this editorial,the authors tried to evaluate the present state of cellular therapy in orthopedic field.The topics the authors try to cover include not only the clinical trials but the various research areas as well.Both the target diseases for cellular therapy and the target cells were reviewed.New methods to activate the cells were interesting to review.Most advanced clinical trials were also included because several of them have advanced to phase Ⅲ clinical trials.In the orthopedic field,there are many diseases with a definite treatment gap at this time.Because cellular therapies can regenerate damaged tissues,there is a possibility for cellular therapies to become disease modifying drugs.It is not clear whether cellular therapies will become the standard of care in any of the orthopedic disorders,however the amount of research being performed and the number of clinical trials that are on-going make the authors believe that cellular therapies will become important treatment modalities within several years.展开更多
文摘Cellular senescence is a form of permanent cell cycle arrest that can be triggered by a variety of cell-intrinsic and extrinsic stimuli, including telomere shortening,DNA damage, oxidative stress, and exposure to chemotherapeutic agents and ionizing radiation. Although the induction of apoptotic cell death is a desirable outcome in cancer therapy, mutations and/or deficiencies in the apoptotic signaling pathways have been frequently identified in many human cancer types,suggesting the importance of alternative apoptosis-independent therapeutic approaches for cancer treatment. A growing body of evidence has documented that senescence induction in tumor cells is a frequent response to many anticancer modalities including cyclin-dependent kinases 4/6 small molecule inhibitor-based targeted therapeutics and T helper-1 cytokine-mediated immunotherapy. This review discusses the recent advances and clinical relevance of therapy-induced senescence in cancer treatment.
文摘In this editorial,the authors tried to evaluate the present state of cellular therapy in orthopedic field.The topics the authors try to cover include not only the clinical trials but the various research areas as well.Both the target diseases for cellular therapy and the target cells were reviewed.New methods to activate the cells were interesting to review.Most advanced clinical trials were also included because several of them have advanced to phase Ⅲ clinical trials.In the orthopedic field,there are many diseases with a definite treatment gap at this time.Because cellular therapies can regenerate damaged tissues,there is a possibility for cellular therapies to become disease modifying drugs.It is not clear whether cellular therapies will become the standard of care in any of the orthopedic disorders,however the amount of research being performed and the number of clinical trials that are on-going make the authors believe that cellular therapies will become important treatment modalities within several years.
