The title compound (C19H25NO4, Mr = 331.40) was synthesized and its crystal structure was determined by single-crystal X-ray structure analysis. The compound belongs to space group P212121 with a = 7.738(2), b = 10.13...The title compound (C19H25NO4, Mr = 331.40) was synthesized and its crystal structure was determined by single-crystal X-ray structure analysis. The compound belongs to space group P212121 with a = 7.738(2), b = 10.131(2), c = 21.535(4) ? V = 1688.3(6) 3 and Z = 4. The final R and wR factors are 0.0557 and 0.1489, respectively for 2936 (I > 2s(I)) independent observable reflections. The result shows that the title compound is a tetracyclic alkaloid with four chiral centers, and the absolute configuration of the newly formed one is 6S. The piperidine ring is in chair conformation, while the other two aliphatic rings are in twist boat conformation. The title compound was the mainly isolated reduction product, which means that the hydrogen anion attacks the carbonyl group at the opposite side away from the phenyl group because of its steric effect.展开更多
基金This work was financially supported by theHongkongPolytechnikeUniversity
文摘The title compound (C19H25NO4, Mr = 331.40) was synthesized and its crystal structure was determined by single-crystal X-ray structure analysis. The compound belongs to space group P212121 with a = 7.738(2), b = 10.131(2), c = 21.535(4) ? V = 1688.3(6) 3 and Z = 4. The final R and wR factors are 0.0557 and 0.1489, respectively for 2936 (I > 2s(I)) independent observable reflections. The result shows that the title compound is a tetracyclic alkaloid with four chiral centers, and the absolute configuration of the newly formed one is 6S. The piperidine ring is in chair conformation, while the other two aliphatic rings are in twist boat conformation. The title compound was the mainly isolated reduction product, which means that the hydrogen anion attacks the carbonyl group at the opposite side away from the phenyl group because of its steric effect.
